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Current Transplantation News and Events

Current Transplantation News and Events, Transplantation News Articles.
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Super-potent blood stem cells discovered in human embryos
In research recently published in Stem Cell Reports, Andrejs Ivanovs, Alexander Medvinsky (a.medvinsky@ed.ac.uk) and colleagues from the University of Edinburgh discovered that HSCs from early human embryos, when HSCs are just starting to form, are more robust at expanding than those from the cord blood. (2020-09-17)
EBMT trial shows improvements in treatment of Severe Aplastic Anaemia
The European Society for Blood and Marrow Transplantation (EBMT), Europe's collaborative peer network of professionals working in the field of stem cell transplantation and cellular therapy, announced today the results of the phase III RACE trial during EBMTs virtual 46th Annual Meeting. (2020-08-31)
A soft-hearted approach to healing
Researchers at the University of Tsukuba and Keio University have clarified the roles of matrix stiffness and mechanotransduction as well as the signaling pathways in the transformation of cardiac fibroblasts into contractile cardiomyocytes and show that soft substrates comparable to native myocardium improve the efficiency of this cardiac reprogramming. (2020-08-30)
Rejuvenating old organs could increase donor pool
Investigators from Brigham and Women's Hospital are leading efforts to breathe new life into older organs by leveraging a new class of drugs known as senolytics, which target and eliminate old cells. (2020-08-27)
Ratio of two proteins may add kidneys to the transplant donor pool
An investigation by researchers at Johns Hopkins Medicine, in collaboration with researchers at 13 other medical institutions in the United States, has shown that two proteins found in deceased donor urine can be measured to define which donor organs -- including those with AKI -- are the best candidates for saving the lives of patients with kidney failure. (2020-08-18)
Immune response to Sars-Cov-2 following organ transplantation
Even patients with suppressed immune systems can achieve a strong immune response to Sars-Cov-2. (2020-08-17)
Heart regeneration using stem cells: Why irregular heartbeats occur after transplantation
Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo elucidated why arrhythmia occurs post-transplant of hESC-CMs. (2020-08-05)
Move over Akita: Introducing 'Kuma mutant' mice for islet transplantation research
Scientists at the Tokyo Institute of Technology (Tokyo Tech) have used a gene editing technique to establish a novel mouse model of permanent neonatal diabetes--the immune-deficient Kuma mutant mice with a specific deletion in the Insulin2 (Ins2) gene. (2020-08-05)
Insights on the gut microbiome could shape more powerful, precise treatment
In a recently published study, investigators from Brigham and Women's Hospital explore how the dynamics of bacterial species may influence the success of fecal microbiota transplantation in treating recurrent C. difficile infection. (2020-07-31)
Kidney transplantation between people with HIV is safe, NIH study finds
Kidney transplantation from deceased donors with HIV to people living with both HIV and end-stage kidney disease is feasible and safe, investigators supported by the National Institutes of Health have found. (2020-07-23)
Healthy offspring from testicular tissue plantation in mice: Retinoic acid key
Germ cell depletion in recipient testis has adverse effects on spermatogenesis in orthotopically transplanted testis pieces via retinoic acid insufficiency. (2020-07-16)
New hope for kidney revival for transplant
Cell therapy delivered directly to the kidney can revive a 'marginal' organ, improving function and could offer new hope for providing more kidneys for transplant. (2020-07-14)
Human lungs rejected for transplant recovered using novel technique
A multidisciplinary team from Vanderbilt University Medical Center (VUMC) and Columbia University has demonstrated that injured human donor lungs declined for transplant can be recovered by cross-circulation between the human lung and a xenogeneic host. (2020-07-13)
A bioartificial system acts as 'dialysis' for failing livers in pigs
A bioartificial system that incorporates enhanced liver cells can act as an analogous form of dialysis for the liver in pigs, effectively carrying out the organ's detoxifying roles and preventing further liver damage in animals with acute liver failure. (2020-07-08)
Loss of intestinal goblet cells causes fatal disease after stem cell transplantation
Allogeneic stem cell transplantation can cause a loss of protective goblet cells from the colon's inner lining, which can be fatal. (2020-07-01)
A revolutionary new treatment alternative to corneal transplantation
A new approach in ophthalmology that offers a revolutionary alternative to corneal transplantation has just been developed by researchers and clinicians in North America, Europe, and Oceania. (2020-06-30)
Researchers have found a promising therapy for cardiac regeneration
New research gives information in order to understand safety, efficacy and mechanisms of action of a new cardiac therapy. (2020-06-30)
Study finds HCV-positive livers safe for transplantation; Patients cured afterward
UC researchers find similar results for positive outcomes when comparing patients receiving livers infected with hepatitis C to patients who receive livers without infection. (2020-06-22)
A novel radioisotope therapy for children with neuroblastoma
Researchers from Kanazawa University retrospectively analyzed children with refractory or relapsed high-risk neuroblastoma who were treated with high-dose 131I-metaiodobenzylguanidine at Kanazawa University Hospital. (2020-06-19)
Liver perfusion could save 7 in 10 rejected donor livers
A major study investigating the effectiveness of liver perfusion as a technique to improve the function of donor livers that would have otherwise been rejected has shown that up to 7 in every 10 could be used after just 4-6 hours of the assessment. (2020-06-17)
For babies born with a rare immune deficiency, a unique new test to better target care
A new test developed at CHU Sainte-Justine in Montreal will enable better management of patients with severe combined immunodeficiency (SCID). (2020-06-17)
Fred Hutch and University of Washington experts: Treat COVID-19 earlier to save lives
Infectious disease experts from Fred Hutchinson Cancer Research Center and UW Medicine are advocating for earlier actions to reduce hospitalizations and deaths from COVID-19. (2020-06-16)
Women are not more likely to die of cirrhosis than men, despite fewer liver transplants
Prior studies suggested women might have higher mortality of cirrhosis of the liver than men. (2020-06-04)
Kidney transplantations: Better results with larger case volumes
Kidney transplantations: better results with larger case volumes. Survival probabilities increase in hospitals where kidneys are transplanted more frequently. (2020-05-25)
Kidney transplants: Better results can be inferred from a larger number of cases
Kidney transplants: Better results can be derived with larger numbers of cases. (2020-05-22)
Critical window for re-infection with HIV after stem cell transplantation
So far, allogeneic stem cell transplantation for the treatment of severe blood cancers has been the only medical intervention to have cured at least three people infected with the HI virus. (2020-05-14)
Immune system discovery paves way to lengthen organ transplant survival
A new discovery in mice shows the innate immune system has 'memory,' previously thought to be a unique feature of the adaptive immune system. (2020-05-08)
Researchers have found accumulation of gene mutations in chronic Graft-versus-host disease
Mutations in white blood cells can contribute to abnormal immune profile after hematopoietic stem cell transplantation. (2020-05-07)
UB investigators uncover cellular mechanism involved in Krabbe disease
Researchers determined which cells are involved in Krabbe disease and by which mechanism. (2020-05-05)
Research suggests new therapeutic target for kidney diseases
Researchers have published a new study that suggests a signaling pathway called ROBO2 is a therapeutic target for kidney diseases, specifically kidney podocyte injury and glomerular diseases. (2020-05-04)
Landmark 30-year study on Crigler-Najjar syndrome underscores the need for new therapies
A new study summarizes more than 30 years of clinical experience and describes the clinical course of 28 individuals homozygous for damaging mutations in the UGT1A1 gene who were born between 1984 and 2015 with Crigler-Najjar syndrome. (2020-04-16)
Researchers restore sight in mice by turning skin cells into light-sensing eye cells
Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision, sidestepping the need for stem cells. (2020-04-15)
Researchers successfully repair stroke-damaged rat brains
Researchers at Lund University in Sweden have succeeded in restoring mobility and sensation of touch in stroke-afflicted rats by reprogramming human skin cells to become nerve cells, which were then transplanted into the rats' brains. (2020-04-08)
New 'more effective' stem cell transplant method could aid blood cancer patients
Researchers at UCL have developed a new way to make blood stem cells present in the umbilical cord 'more transplantable', a finding in mice which could improve the treatment of a wide range of blood diseases in children and adults. (2020-03-26)
For clogged and hardened hearts, a mussel is the solution
Prof. Hyung Joon Cha and his research team developed a stem cell therapy on myocardial infarction, using proteins that can be found in mussels, mussel adhesive proteins. (2020-03-25)
Distance to transplant center and likelihood of being considered for transplantation
In an analysis of information on adults who began treatment for kidney failure at any Georgia, North Carolina, or South Carolina dialysis facility, the distance from a patient's residence to the nearest transplant center did not appear to affect the likelihood of transplant-related referrals and evaluations. (2020-03-24)
UCI team demonstrates ability to supercharge cells with mitochondrial transplantation
UCI researchers have shown that they can give cells a short-term boost of energy through mitochondrial transplantation. (2020-03-23)
Early blood marker may predict future risk of kidney transplant failure
In a study of kidney transplant recipients, the composition of certain immune cells in the blood 1 year after kidney transplantation was linked with a patient's subsequent risk of kidney transplant failure. (2020-03-12)
PET imaging offers new insights into post-transplant care for heart patients
Myocardial blood flow (MBF) and myocardial flow reserve (MFR) have been identified as accurate indicators for graft failure after cardiac transplantation, according to research published in The Journal of Nuclear Medicine. (2020-03-05)
Study reveals improving survival rates after liver transplantation in the UK
In the past two decades, death rates after liver transplantation have dropped by more than half in the UK, according to a recent analysis of almost 10,000 liver transplant recipients published in BJS (British Journal of Surgery). (2020-03-04)
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