Current Tumor News and Events

Current Tumor News and Events, Tumor News Articles.
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Stress hormones can reawaken sleeping tumor cells, raising risk of cancer recurrence
Stress hormones and immune cells called neutrophils may contribute to the recurrence of tumors years after treatment by awakening dormant cancer cells, suggests a study of mice and data from 80 patients with lung cancer. (2020-12-02)

IU researchers publish first article dedicated to Hoosier youth's donated tumor
Researchers at Indiana University School of Medicine have published their work about a specific type of childhood cancer in the peer-reviewed, international oncology journal, Cancers. This research involves a combination therapy that significantly slows tumor growth in models, which includes a model established from cells taken from tumors donated by Tyler Trent. (2020-12-01)

Telomere shortening protects against cancer
Researchers have found the first evidence that telomere shortening is not just a sign of aging, but a key component of the body's cancer prevention system. (2020-12-01)

New immunotherapeutic approach takes aim at cancer's enzyme shield
A Brigham team observed that in a range of mouse models, inhibiting the protein SerpinB9 with a small molecule reduced tumor growth both by weakening the tumor's defense mechanisms and by triggering cell death in the tumors themselves. (2020-12-01)

Penn researchers unlock the door to tumor microenvironment for CAR T cells
Combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack solid tumors, leading to significantly enhanced survival in mice. (2020-11-30)

Combination therapy might improve outcomes in treatment-resistant liver cancer
A combination cancer therapy that is effective against treatment-resistant hepatocellular carcinoma (HCC) by inhibiting tumor growth and increasing survival has been identified by researchers at Massachusetts General Hospital. The dual therapy -- which combines the multikinase inhibitor drug regorafenib to ''reprogram'' the tumor immune microenvironment, and programmed cell death 1 antibodies to stimulate anti-tumor immunity -- improved survival in mouse models of HCC beyond what each therapy could have achieved alone. (2020-11-30)

Scientists describe the role of a p53 target gene in lymphoma and lung cancer development
An international team of scientists has studied whether Zmat3 could have critical functions that p53, the most important gene in preventing cancer, uses to prevent cancer. Their findings have shifted the focus of how Zmat3 could function in tumor development. (2020-11-27)

First large-scale proteogenomic analysis offers insights into pediatric brain tumors
A comprehensive ''proteogenomic'' analysis of the proteins, genes, and RNA transcription involved in pediatric brain tumors has yielded a more complete understanding of these tumors, which are the leading cause of cancer-related deaths in children. The results could help physicians more accurately identify different types of tumors and methods for treating them. (2020-11-25)

How an infectious tumor in Tasmanian devils evolved as it spread
A transmissible cancer in the Tasmanian devil has evolved over the past two decades, with some lineages spreading and replacing others, according to a new study in the open access journal PLOS Biology by Young Mi Kwon, Kevin Gori, and Elizabeth Murchison of the University of Cambridge (UK) and colleagues. The evolutionary dynamics of the cancer help explain how this Australian marsupial has become so quickly endangered, and may shed light on the evolution of other forms of cancer. (2020-11-24)

Mediastinal tuberculoma mimicking malignant cardiac tumor
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0587, Yiqian Ding, Wei Li, Yanqiu Liu, Min Ye, Liangping Cheng, Donghong Liu, Hong Lin and Fengjuan Yao from The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China consider mediastinal tuberculoma mimicking malignant cardiac tumors. (2020-11-19)

A more sensitive way to detect circulating tumor cells
Breast cancer is the most frequently diagnosed cancer in women, and metastasis from the breast to other areas of the body is the leading cause of death in these patients. Detecting circulating tumor cells (CTCs) in the bloodstream could help doctors find and treat metastases at an earlier stage, increasing chances of survival. Now, researchers reporting in ACS Sensors have developed a method that could more sensitively detect CTCs within the complex environment of blood. (2020-11-18)

Immunotherapy for lung and other cancers may also be beneficial for rare skin cancer
New research from the University of North Carolina School of Medicine and the Lineberger Comprehensive Cancer Center found immunotherapies effective against lung cancer and melanoma may work against cutaneous angiosarcoma, a rare, highly aggressive skin tumor found primarily on the scalps of older White people. The researchers report tumor-infiltrating lymphocytes and the surface protein markers PD-1 and PD-L1 could help guide the choice of immunotherapy to fight cutaneous angiosarcomas. (2020-11-18)

New prognostic markers for colon cancer identified
The study recently published by MedUni Vienna and collaborative partners nominates ILSs as novel prognostic players orchestrating the pathobiology of metastatic colorectal cancer. (2020-11-11)

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows. (2020-11-10)

New cancer drugs saved over 1.2 million people in the US over 16 years, new study shows
More than 1.2 million people in the US prevented facing death following a cancer diagnosis, between the year 2000 and 2016, thanks to ever improving treatment options -- a large new national study shows. (2020-11-09)

Perspectives of tumor treatment: Researchers investigate combination of carbon ion and immunotherapy
It is still a glance into the future: The combination of carbon ion and immune therapy could become an effective tool in the fight against cancer. Promising results for the potential benefit of this treatment combination have now been published in the journal ''International Journal of Radiation Oncology, Biology, Physics'' of the American Society for Therapeutic Radiation Oncology. The authors are an international team, led by the Biophysics Department at the GSI Helmholtzzentrum für Schwerionenforschung. (2020-11-09)

A better test for the tumor-targeting of CAR-T therapies
Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies, in which the immune system's T cells are extracted from a patient, engineered to target a specific tumor-associated molecule and then grown and reinfused for cancer treatment. (2020-11-06)

Antiangiogenic therapy can cause malignancy in kidney cancers
In some cases, this type of therapy increases the invasiveness and metastasis of kidney tumors. The study led by IDIBELL and the ICO identifies a biomarker that could predict the malignant response of patients to therapy. (2020-11-05)

Precision chemo-immunotherapy for pancreatic cancer?
Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis. Now, a preclinical study from the lab of Marsha Moses, PhD at Boston Children's Hospital, reports marked and lasting tumor regression in a mouse model, using a highly selective, potent, engineered antibody-drug combination. (2020-11-05)

'Time machine' offers new pancreatic cancer drug testing approach
Drug resistance is a major reason why pancreatic cancer has a five-year survival rate of only about 10%. If scientists tested potential drugs on multiple tumor cell subtypes rather than on just one subtype, they may be able to catch resistance better, suggests a ''time machine'' developed by Purdue University engineers. (2020-10-29)

Researchers find source of breast tumor heterogeneity and pathway that limits emergence
A team of researchers led by Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center has identified mammary basal cells as a contributing source to the development of heterogeneous tumor cell subpopulations and found that activation of the PKA signaling pathway can curtail their emergence, providing opportunities for new therapeutic approaches to breast cancer. (2020-10-28)

New imaging technique doubles visibility of brain tumors in scans
A new three-dimensional imaging technique has been developed that greatly improves the visibility of brain tumors in magnetic resonance imaging scans. The technique will potentially enable earlier diagnosis of tumors when they are smaller and more treatable. (2020-10-28)

New cancer diagnostics: A glimpse into the tumor in 3D
A new technique could initiate a revolution in pathology: Tumor tissue is made transparent and illuminated with a special ultramicroscope. This makes it possible to analyze all the tissue removed in 3D without the need for slicing up the tumor. That way, the reliability of the diagnosis can be significantly increased. (2020-10-27)

Cancer cells mediate immune suppression in the brain
Notre Dame researchers showed that one type of cell important for immunity, called a myeloid cell, can suppress the immune response -- which has the effect of allowing breast cancer cells to metastasize to the brain to form secondary tumor cells there. (2020-10-27)

How to prevent the spread of tumor cells via the lymph vessels
Scientists from the German Cancer Research Center and the Mannheim Medical Faculty of the University of Heidelberg identified a new way to block the dangerous spread of tumor cells via lymphatic vessels. They discovered that an antibody against a signaling molecule of the vascular system causes the lymphatic vessels in the tumor to die, suppresses metastasis and thus prolongs the survival of the mice. (2020-10-26)

Destroying cancer cells with non-surgical ultrasound treatment
Dr. Ki Joo Pahk's research team at the Korea Institute of Science and Technology Center for Bionics confirmed the possibility of precisely fractionating target tumor cells, as though it is cut out using a knife, without causing heat damage to any other part of the body by using high-intensity focused ultrasound. (2020-10-26)

New technology tracks role of macrophages in cancer spread
A Morgridge imaging study of macrophages -- immune cells that are important to human health, but paradoxically can help some cancers grow and spread -- is offering better ways to understand these cells and target them with immunotherapies. (2020-10-26)

Oncotarget: Survival after resection of brain metastases: A matched cohort analysis
The cover for issue 32 of Oncotarget features Figure 2, ''This figure depicts overall survival and local in-brain recurrence-free survival in the study's subgroups,'' by Hussein, et al. which reported that the aim of the present study is to assess whether the use of 5-ALA has an impact on local recurrence or survival compared to conventional white light microscopic tumor resection. (2020-10-25)

Oncotarget: A novel format for recombinant antibody-interleukin-2 fusion proteins
Oncotarget recently published ''A novel format for recombinant antibody-interleukin-2 fusion proteins exhibits superior tumor-targeting properties in vivo which reported that here, the authors describe four novel formats for the L19-IL2 fusion, featuring different arrangements of antibody and IL2. (2020-10-23)

Rapid method of isolating tumor-targeting T cells could propel personalized cancer treatment
When it comes to defeating cancer, some immune cells are mightier than others. But even the best-trained eye and today's advanced scientific tools have trouble discerning the most powerful tumor-fighting cells from the rest. A new technique developed by Scripps Research scientist Peng Wu, PhD, aims to change that--offering a new platform that could propel personalized cancer treatments that have been hindered due to the challenges of isolating the most useful immune cells in patients. (2020-10-22)

DrugCell: New experimental AI platform matches tumor to best drug combo
UC San Diego researchers use experimental artificial intelligence system called DrugCell to predict the best approach to treating cancer. (2020-10-22)

Cutting cancer off at the head
Using a 2 ml blood sample from 100 gastric cancer patients, researchers succeeded in identifying cancer cells circulating in the bloodstream and trace them back to their origin tumor by detecting an overexpression of fibroblast growth factor receptor (FGFR2) in both the cancer cells and the tumor. This new diagnostic method may allow for real-time detection of the growth patterns of the cancer, leading to quicker and more accurate preventative action -- essentially cutting the cancer`s potential metastasizing off at the head. (2020-10-21)

Tumor DNA in spinal fluid could help doctors better monitor childhood brain cancer
Researchers have demonstrated that a new liquid biopsy approach overcomes traditional barriers to quickly and efficiently diagnose and monitor high-grade pediatric gliomas. (2020-10-21)

Highly effective tumor detection strategy for common childhood brain tumors
A team of scientists at Texas A&M University, Baylor College of Medicine and Texas Children's Hospital have developed a way to more accurately both detect and monitor a common type of pediatric brain cancer, setting the stage for giving clinicians a real-time view into how the cancer responds to treatment. (2020-10-21)

Immunotherapy combo halts rare, stage 4 sarcoma in teen
The patient, whose tumor responded within two weeks after receiving the combination, resumed normal activity and was in a complete remission at the time of the report. (2020-10-16)

Calcium bursts kill drug-resistant tumor cells
Multidrug resistance (MDR) -- a process in which tumors become resistant to multiple medicines -- is the main cause of failure of cancer chemotherapy. Tumor cells often acquire MDR by boosting their production of proteins that pump drugs out of the cell, rendering the chemotherapies ineffective. Now, researchers reporting in ACS' Nano Letters have developed nanoparticles that release bursts of calcium inside tumor cells, inhibiting drug pumps and reversing MDR. (2020-10-16)

Oncotarget: Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance
Oncotarget Volume 11, Issue 29 reported that Immunosuppressive chemoresistance is a major burden in lung cancer. (2020-10-15)

Moffitt researchers discover specific molecules that promote cancer progression
In a new article published in the journal Nature Communications, Moffitt Cancer Center researchers describe how the protein TAp63 controls levels of RNA molecules, which subsequently connects the activities of p53 and AKT to promote disease progression. (2020-10-15)

Pancreatic cancer: Subtypes with different aggressiveness discovered
To date, no targeted personalized therapies for pancreatic cancer exist. Heidelberg Scientists have now succeeded for the first time in defining two differently aggressive molecular subtypes of pancreatic carcinoma. This provides new insights into the origin of the tumors. In the more aggressive group of tumors, a phenomenon known as 'viral mimicry' leads to a cancer-promoting inflammatory reaction. This could possibly be the basis for the development of a targeted, subtype-oriented therapy. (2020-10-15)

Breakthrough blood test developed for brain tumors
Genetic mutations that promote the growth of the most common type of adult brain tumors can be accurately detected and monitored in blood samples using an enhanced form of liquid biopsy developed by researchers at Massachusetts General Hospital (MGH). (2020-10-14)

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