Accumulation Current Events

Accumulation Current Events, Accumulation News Articles.
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Doxorubicin-associated mitochondrial iron accumulation promotes cardiotoxicity
In this issue of the Journal of Clinical Investigation, Hossein Ardehali and colleagues at Northwestern University determined that doxorubicin accumulates within the mitochondria of cardiomyocytes and this accumulation promotes mitochondrial ROS production and iron accumulation. (2014-01-02)

What are the mechanisms of zooxanthella expulsion from coral?
Coral bleaching, which often results in the mass mortality of corals and in the collapse of coral reef ecosystems, has become an important issue around the world, with the number of coral reefs decreasing annually. Our research group with its collaborators demonstrated that corals more actively digest and expel damaged symbiotic zooxanthellae under conditions of thermal stress, and that this is likely to be a mechanism that helps corals to cope with environmental change. (2014-12-29)

Baicalin suppresses iron accumulation after substantia nigra injury
Findings published in Neural Regeneration Research indicate that baicalin down-regulated iron concentration, which positively regulated divalent metal transporter 1 expression and negatively regulated ferroportin 1 expression, and decreased iron accumulation in the substantia nigra. (2014-08-26)

New molecular structures associated with ALS
Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of the disease, as well as to propose new solutions to curb it. (2021-01-13)

A new breakthrough on the pathogenesis of fulminant hepatic failure
The expression and activity of LTC4S and mGST2 are up-regulated in a rat fulminant hepatic failure model, which is at least partly responsible for the accumulation of cysteinyl leukotrienes (cys-LTs) in liver. (2008-05-07)

An activated protein promotes α-synuclein aggregation in a Parkinson's disease model
In this month's issue of the JCI, a team led by Ted Dawson and Han Seok Ko at Johns Hopkins School of Medicine determined that activation of a protein called c-Abl exacerbates α-synuclein accumulation and the appearance of behavioral hallmarks of Parkinson's disease in mice. (2016-06-27)

Hurricane Michael's heavy rainfall measured by NASA
Some casualties resulted not only from Michael's destructive winds and storm surges but also from the blinding rain that Michael produced as it battered states from Florida northeastward through Virginia. NASA used satellite data to estimate how much rainfall occurred along Hurricane Michael's track from Oct. 7 to Oct. 12, 2018. (2018-10-15)

Queen's researcher finds new model of gas giant planet formation
Queen's University researcher Martin Duncan has co-authored a study that solves the mystery of how gas giants such as Jupiter and Saturn formed in the early solar system. (2015-08-19)

Glycogen accumulation in neurons causes brain damage and shortens the lives of flies and mice
Collaborative research by groups headed by scientists Joan J. Guinovart and Marco Milan at the Institute for Research in Biomedicine has revealed conclusive evidence about the harmful effects of the accumulation of glucose chains (glycogen) in fly and mouse neurons. These two animal models will allow scientists to address the genes involved in this harmful process and to find pharmacological solutions that allow disintegration of the accumulations or limitation of glycogen production. (2012-05-02)

Researchers find consistent mercury levels in arctic seals
Ringed seals and other Arctic marine mammals are important in the diet of Arctic Indigenous peoples. A study spanning 45 years of testing indicates that mercury concentrations in ringed seals from the Canadian Arctic have remained stable, showing very limited declines over time. (2020-10-07)

Urgent need for more research into prevalence of CJD
The first estimate of the number of people who are at increased risk of vCJD, but who have not developed symptoms, is published in this week's BMJ. (2002-09-19)

Carbon accumulation by Southeastern forests may slow
Carbon accumulation levels in the Southeastern US may be slowing due to forest dynamics and land use changes, according to findings of US Forest Service researchers published in the journal Scientific Reports, Friday. (2015-01-27)

The bassoon causing new brain disorder
Newly discovered gene mutations may help explain the cause of a disease that drastically impairs walking and thinking. (2018-03-22)

Elevated atmospheric CO2 increases soil carbon
An article in the current issue of Global Change Biology indicates that soils in temperate ecosystems might contribute more to partially offsetting the effects of rising atmospheric CO2 concentrations than earlier studies have suggested. (2005-12-05)

New aspects of globular glial tauopathy could help in the design of more effective drugs
This study, led by Dr. Isidre Ferrer, has described that protein inclusions that damage neurons and glial cells are responsible for the pathology showed by globular glial tauopathy patients. Likewise, these inclusions are composed of different types of proteins, and not only by tau. Moreover they can travel through neurons and glial cells spreading the damage. (2020-01-27)

Association of excessive daytime sleepiness in older adults and biomarker of Alzheimer's disease
Excessive daytime sleepiness in a group of older adults without dementia was associated with increased accumulation of a brain protein that is an important biomarker for Alzheimer's disease. (2018-03-12)

Energy from sunlight: Further steps towards artificial photosynthesis
Chemists from the universities of Basel and Zurich in Switzerland have come one step closer to generating energy from sunlight: for the first time, they were able to reproduce one of the crucial phases of natural photosynthesis with artificial molecules. Their results have been published by the journal Angewandte Chemie (international edition). (2016-06-24)

West Nile virus triggers brain inflammation by inhibiting protein degradation
West Nile virus (WNV) inhibits autophagy -- an essential system that digests or removes cellular constituents such as proteins -- to induce the aggregation of proteins in infected cells, triggering cell death and brain inflammation (encephalitis), according to Hokkaido University researchers. (2020-01-23)

Steroid links fat accumulation with egg development
New work from Carnegie's Allan Spradling and Matthew Sieber focuses on the accumulation of triglyceride and a certain kind of steroids called sterols during oocyte development. They were able to identify an insect steroid hormone that is crucial to both lipid metabolism and egg production in fruit flies. Since nutrition and metabolism are closely linked with reproductive health, the research could help decipher certain disease processes. (2015-03-19)

OSA is associated with less visceral fat accumulation in women than men
A new study from researchers in Japan indicates that obstructive sleep apnea (OSA) is independently associated with visceral (abdominal) fat accumulation only in men, perhaps explaining gender differences in the impact of OSA on cardiovascular disease and mortality. (2013-05-22)

Overweight + gene mutation = elevated liver values in children
A study carried out at the Institute of Biomedicine of the University of Eastern Finland shows that a common mutation in the PNPLA3 gene combined with overweight results in elevated ALAT values in children. The ALAT value is an indicator of liver metabolism. (2014-06-17)

The reasons behind aerosol pollution over the eastern slope of the Tibetan Plateau
The aerosol optical depth over the eastern slope of the Tibetan Plateau (ESTP) is extremely large -- and even more so than some important industrialized regions and deserts, which is the result of a combination of human activities and natural conditions. (2019-08-08)

Antarctic Mesoscale Prediction System precipitation products prove to be reliable
The Antarctic Mesoscale Prediction System (AMPS) is a key tool--specifically, for studying precipitation over the region. Moreover, the products generated by AMPS will be used more widely if shown to hold up to careful scrutiny. (2017-04-10)

Oxidative stress makes difference between metabolically abnormal and healthy obesities
Scientists at Osaka University clarified that deletion of adipose oxidative stress (Fat ROS) decreased lipid accumulation in the liver, clinically improving insulin resistance and inducing metabolically healthy obesity. In fact, Fat ROS suppressed lipid accumulation and increased ectopic lipid accumulation in the liver, worsening insulin resistance. (2018-04-25)

Newly identified antibodies effectively treat Alzheimer's-like disease in mice
Alzheimer's disease is characterized by the accumulation of particular toxic proteins in the brain that are believed to underlie the cognitive decline in patients. A new study conducted in mice suggests that newly identified antibody treatments can prevent the accumulation of one of these of these toxic components, called tau proteins. The findings suggest that these antibodies may provide a basis for a promising therapy for patients with Alzheimer's disease and other neurodegenerative disorders. (2013-09-26)

Fatty tissue accumulated in the neck linked to heart problems, study finds
Researchers from the University of Granada warn that an accumulation of fatty tissue in the neck (both the double chin and the deeper deposits, located between muscles and around the cervical vertebrae) is a predictor of central and overall adiposity, cardiometabolic risk, and a pro-inflammatory profile in sedentary young adults (2021-02-17)

Macrophage accumulation of triglycerides yields insights into atherosclerosis
A research report appearing in the Journal of Leukocyte Biology (http://www.jleukbio.org) helps explain how specific immune cells, called macrophages, accumulate triglycerides to support their function. Because a characteristic finding in atherosclerosis is the accumulation of fat in macrophages in the arterial wall, understanding how macrophages accumulate triglycerides may lead to new approaches toward slowing or stopping the development of atherosclerosis. (2012-10-01)

Vanderbilt study shows salt fights infection
Researchers at Vanderbilt University and in Germany have found that sodium -- salt -- accumulates in the skin and tissue in humans and mice to help control infection. (2015-03-03)

Tropical trees maintain high carbon accumulation rates into old age
Tropical trees maintain high carbon accumulation rates into old age, according to a study published Aug. 16, 2017, in the open-access journal PLOS ONE by Michael Köhl from the Universität Hamburg, Germany, and colleagues. (2017-08-16)

A mouse model brings new perspectives on Lafora disease
Using a mouse model, researchers at IRB Barcelona have demonstrated a link between abnormal sugar accumulation and the neuronal degeneration characteristic of Lafora disease. The study may contribute to understanding the origin and progression of Lafora and other neurodegenerative pathologies. (2011-08-29)

Lots of low-fat food is better than small portions of high-fat food
Dutch research has shown that a diet of low-fat products is better than smaller portions of normal high-fat food for preventing diabetes in obese people. Mice put on a low-fat diet were more sensitive to insulin than mice that received the same amount of energy in the form of high-fat food. (2004-02-05)

New information on the pathological mechanisms of Alzheimer's disease
Researchers at the University of Helsinki have discovered a mechanism by which harmful tau protein aggregates are transmitted between neurons. Alongside amyloid plaques, tau aggregates in the brain are a significant factor in the progression of Alzheimer's disease. (2018-11-20)

Mechanisms of neuronal cell death in AGE-exposed retinas -- research and literature review
Gradual accumulation of glycated proteins, lipids and nucleic acid is a common process in normal aging, however rise in blood glucose levels, an increase of oxidative stress over time triggering further protein modification and resulting in impairment of defense mechanisms. AGEs accumulation in various tissues under diabetic conditions plays an important role in the development of neuronal and vascular complications such as diabetic retinopathy. (2017-05-25)

Mutation discovered to protect against Alzheimer's disease in mice
Researchers at the RIKEN Center for Brain Science have discovered a mutation that can protect against Alzheimer's disease in mice. Published in the scientific journal Nature Communications, the study found that a specific mutation can reduce the characteristic accumulation of the amyloid-beta peptide that occurs. (2018-05-16)

Consuming probiotics for a month helps diminish fat accumulation in the liver, new study says
Spanish scientists have demonstrated through an experiment on obese rats that the consumption of probiotics during thirty days helps diminish the accumulation of fat in the liver. This new finding, published today by the journal PLOS ONE, is a great step forward on the fight agains the Non-Alcolohic Fatty Liver Disease, which is closely related to obesity and diabetes. (2014-07-18)

Protein inhibitor tangles with Alzheimer's disease
A hallmark of Alzheimer's disease (AD) is the abnormal accumulation of phosphorylated forms of a protein known as tau. In a new study, Mayo Clinic researchers have now shown in mice that a drug that inhibits the function of the protein Hsp90 (EC102) reduces the amount of phosphorylated tau in the brain. Unlike many drugs, EC102 is able to cross the blood-brain barrier, making it a highly promising therapeutic candidate for AD. (2007-02-15)

New study raises questions about the number of people in the UK who could be incubating vCJD
A team of UK scientists found that 3 out of 12,674 stored appendix and tonsil samples showed evidence of the prion protein associated with vCJD, but urge caution about the way these results are interpreted. The research is published this week in The Journal of Pathology. (2004-05-21)

Greenland Ice Sheet is being shaped by its past
A stiff upper layer of ice that formed atop of the Greenland Ice Sheet during the Holocene era may be causing the deceleration of ice flow within, a new study suggests. (2016-02-04)

NASA's IMERG analyzed Tropical Storm Usagi's rainfall
When Tropical Cyclone 33W, also known as Usagi strengthened to hurricane intensity as it approached Vietnam from the South China Sea it dropped a lot of rain. Although the storm weakened to tropical storm intensity when coming ashore in Vietnam, it continued to generate a lot of rain, and NASA added up that heavy rainfall. (2018-11-29)

Synergistic interaction enhances pathogenesis of Parkinson's disease
Scientists have identified a synergistic interaction that disrupts normal intracellular transport mechanisms and leads to the accumulation of neuron-damaging clumps of protein associated with Parkinson's disease (PD), a neurodegenerative disorder that is characterized by a specific loss of neurons in the midbrain and brainstem. The research, published by Cell Press in the Dec. 24 issue of the journal Neuron, identifies a new potential therapeutic option for preventing PD-associated neuropathology. (2009-12-23)

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