Activation Current Events

Activation Current Events, Activation News Articles.
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Study finds readmission rates impacted by a patients' knowledge and skills
A study by physicians at Boston Medical Center has found that patients with a high degree of activation (possessing the knowledge, skills, confidence and inclination to assume responsibility for managing one's health and health-care needs) were less likely to be readmitted to the hospital within 30 days of discharge than those with a low level of activation. (2013-10-09)

Genetic link to cervical cancer
Certain combinations of genes that encode receptors on innate immune cells increase the risk of developing cervical cancer, according to a study by Mary Carrington and colleagues in the April 4 issue of The Journal of Experimental Medicine. (2005-04-04)

With a complement, the sperm gets the egg
In sperm, researchers have looked at the activation of the complement cascade, a cell-signaling pathway that is activated during immune reactions, but that was not known to contribute to normal physiological processes. They show, in the JCI, that a novel form of restricted complement activation occurs on the surface of viable sperm upon exposure to follicular fluid. The data suggest that this localized complement activation aids in the fusion process between the spermatozoa and egg. (2005-04-21)

A new anti-windup design paradigm for control systems with actuator saturation was developed
The traditional anti-windup scheme involves a single anti-windup loop designed for activation immediately at the occurrence of actuator saturation. In the September 2012 issue of SCIENCE CHINA Information Sciences, a new anti-windup design paradigm was developed that includes three anti-windup loops, simultaneously designed for immediate, delayed and anticipatory activations, and results in significantly improved closed-loop system performances. (2012-11-29)

Case Western Reserve University School of Medicine researchers receive $10.8 million
The Cleveland Immunopathogenesis Consortium, a group of researchers from 10 academic and research institutions across the United States and Canada led by physicians at Case Western Reserve University School of Medicine, have received a five-year, $10.8 million dollar grant from the National Institutes of Health to study how HIV infection results in the progressive immune deficiency that causes AIDS. (2008-07-30)

Gene variant leads to better memory via increased brain activation
Carriers of the so-called KIBRA T allele have better memories than those who don't have this gene variant. This means we can reject the theory that the brain of a non-bearer compensates for this. This is shown by researchers from Umeå University in the Journal of Neuroscience. (2011-10-17)

Critical molecular determinants for activation of calcium flux into cells revealed
Triggered by decreases in ER Ca2+ level, conformational changes of the endoplasmic reticulum (ER) luminal domain in STIM1 would switch on its cytoplasmic domain (CT) to engage and gate ORAI channels on plasma membrane, resulting in Ca2+ influx. (2017-05-31)

Study by NUS researchers unravels new interactions affecting TGF-β pathway in humans
Researchers from the Cancer Science Institute of Singapore at the National University of Singapore have delineated novel molecular interactions affecting the activity of the TGF-β pathway, a key cancer pathway in humans affecting cancer progression. (2015-12-20)

Dogs know a left-sided wag from a right
You might think a wagging tail is a wagging tail, but for dogs there is more to it than that. Dogs recognize and respond differently when their fellow canines wag to the right than they do when they wag to the left. The findings reported in the Cell Press journal Current Biology on Oct. 31 show that dogs, like humans, have asymmetrically organized brains, with the left and right sides playing different roles. (2013-10-31)

Protein kinase R and dsRNAs, new regulators of mammalian cell division
The research team of the Center for RNA Research at IBS has succeeded in revealing that the dsRNAs and Protein Kinase R regulate division of mammalian cells. (2014-12-01)

Oncogenic role for Bcl-3
In an upcoming G&D paper, Dr. Albert Baldwin and colleagues (UNC School of Medicine) lend new insight into an alternate mechanism of p53 inactivation in tumor cells. (2006-01-10)

Periodontal pathogens enhance HIV-1 promoter activation in T cells
Today, during the 39th Annual Meeting of the American Association for Dental Research, lead researcher O.A. Gonzalez (University of Kentucky, Lexington) will present a poster of a study titled (2010-03-05)

Parental controls on embryonic development?
Now, a new study published by Cell Press on Dec. 1 in the journal Developmental Cell suggests that the reach of parental control in the embryo may be longer than we thought. (2011-12-01)

Stress-Driven Recrystallization Of A Distorted Protein Crystal -- Mass Transport Without Thermal Activation
The stress-induced reordering of a protein crystal, distorted by electron irradiation, was observed by scientists at the Fritz Haber Institute of the Max Planck Society in Berlin, Germany at very low temperatures, where thermal activation is absent (Nature 6 May 1999). (1999-05-11)

Existing drugs may limit damage caused by HIV
Yale researchers have identified four drugs that may help minimize the long-term health effects of HIV infection, they report June 23 in the Journal of Clinical Investigation. (2020-06-23)

New clues to the structural dynamics of BK channels
BK channels (large-conductance, Ca2+-dependent K+ channels) are essential for the regulation of important biological processes such as smooth muscle tone and neuronal excitability. New research shows that BK channel activation involves structural rearrangements formerly not understood. The study appears in the August 2011 issue of the Journal of General Physiology. (2011-07-14)

Inhibition of mast cell survival as a novel therapy for allergic diseases
Allergic diseases are caused by reactive mast cells. They are long-lived and survive the allergic reaction thereby prolonging the symptoms. The inhibition of a gene that regulates mast cell survival is a possible novel therapy for allergic diseases directly targeting the mast cells. (2001-12-03)

Glue inside the cell
Ubiquitin is a small protein, which can be attached to other cellular proteins. A study headed by the Junior Group of Dr. Daniel Krappmann (GSF - National Research Center for Environment and Health, Institute of Toxicology) in collaboration with Dr. Jürgen Ruland (TU Munich) and Dr. Claus Scheidereit (Max-Delbrück-Center , Berlin) now reports a novel finding about ubiquitination as a key event for the activation of an immune response. (2007-10-19)

A step forward in obtaining blood stem cells in laboratory
An international study led by researchers from IMIM has revealed that the intensity or efficiency of the activation of a protein called Notch, which is involved in the different phases of embryonic development, determines the fate of cells, i.e. if cells will form the aorta artery or blood (hematopoietic) stem cells. For artery cells, many Notch molecules need to be activated, whereas for hematopoietic cells many fewer are needed. (2015-10-14)

Promoting hair growth
In the July 1st issue of Genes & Development, Dr. Elaine Fuchs and colleagues at the Rockefeller University determine the effect of Wnt signaling on stem cells of the mouse hair follicle in vivo. (2005-06-15)

Shining light on orphan receptors
Harald Janovjak reports first use of artificial light-switch to control a natural receptor in Nature Chemical Biology. (2015-10-15)

UC study looks at the influence of fat when gut bacteria is reduced by antibioticsm
A study led by University of Cincinnati (UC) lipid metabolism researchers lends additional insight into how bacteria in the gut, or lack thereof, influences intestinal mast cells (MMC) activation and perhaps fat absorption. (2016-09-08)

PXR: A stepping stone from environmental chemical to cancer?
Several chemicals that can accumulate to high levels in our body (for example BPA and some pesticides) have been recently linked to an increased risk of cancer and/or impaired responsiveness to anticancer drugs. Researchers have now identified a potential mechanistic link between environmental exposure to these foreign chemicals (xenogens) and cancer drug therapy response and survival. (2011-07-11)

'Patient activation' may improve quality of life in individuals with kidney disease
In individuals with chronic kidney disease who received online peer mentoring, improved patient activation correlated with improvements in various aspects of quality of life. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-23)

Research team reverse way potassium channels work from bacteria to human
Research develops a better understanding of and exerts an unparalleled control of protein molecules. (2018-06-20)

Explaining heart failure as a cause of diabetes
Either heart failure or diabetes alone is bad enough, but oftentimes the two conditions seem to go together. Now, researchers reporting in the January Cell Metabolism appear to have found the culprit that leads from heart failure to diabetes and perhaps a novel way to break that metabolic vicious cycle. (2012-01-03)

Drug to treat ADHD has similar effect on children with reading disorders
The drug methylphenidate (brand name Ritalin) increased activity in brains of children with attention-deficit/hyperactivity disorder (ADHD) as well as those with a reading disorder, researchers at Yale report in the American Journal of Psychiatry. (2004-12-13)

Afternoon slump in reward response
Activation of a reward-processing brain region peaks in the morning and evening and dips at 2 p.m., finds a study of healthy young men published in The Journal of Neuroscience. This finding may parallel the drop in alertness people tend to feel in mid-afternoon. (2017-08-21)

Receptor-dependent protein activation - without a receptor
Essential for triggering cellular reactions to hormones and neurotransmitters, activation of G-proteins was believed to be exclusively caused by receptors linking the inside of a cell with its surroundings. Now Dr. Jürgen Knoblich and his group at the Research Institute of Molecular Pathology, Vienna (Austria), provide strong evidence for G-Protein activation solely by an intracellular protein with no receptor involved - opening up possibilities for the optimisation of many therapeutics. (2001-10-18)

Enlightening cancer cells
Joint EMBO Journal paper by IST Austria and Vienna Medical University groups on engineered cell surface receptors activated by light. Small algal protein domains serve as synthetic light sensors in human cells. First application of optogenetics to cancer research. (2014-07-01)

Gut microbiome may contribute to HIV transmission in high-risk men
Gut microbes from high HIV-risk men who have sex with men drive immune activation in mice and HIV infection in cells, according to a study published April 4 in the open-access journal PLOS Pathogens by Brent Palmer and Catherine Lozupone of the University of Colorado Anschutz, and colleagues. (2019-04-04)

Continuously tracking fear response could improve mental health treatment
If continuously monitored, fear can be used as a tool to improve mental health treatment, reports University of Houston researcher Rose Faghih, who has created a new algorithm for continuously monitoring the fear response using stress sweat and heart rate. (2020-05-19)

Traditional Chinese medical herb may offer new anti-obesity strategy
Overweight and obesity have become a severe public health problem around the world. Chinese scientists from the Institute of Zoology suggest in a new study that burning energy by activation of brown adipose tissue (BAT) might be an alternative strategy for combating obesity. (2019-11-21)

Reproduction without fertilization?
As published in Genes & Development, scientists have discovered that the expression of one gene in a single gamete can initiate the cascade of events normally associated with fertilization. Dr. William Snell and colleagues determined that the abnormal expression of the gene, gsp1, in gametes induces zygotic development without gamete fusion. (2001-10-14)

Molecular defect for 1 form of male factor infertility uncovered
New data, to be published in the Journal of Clinical Investigation, have uncovered one molecular defect underlying the failure of sperm from some patients to initiate successful fertilization through the in vitro fertilization technique ICSI, which is used to treat male factor infertility. (2008-10-16)

Chemists identify genetic mutation that opens door in combatting age-related diseases
Researchers at the University of Surrey, in collaboration with the Universities of Reading and Cologne, and the Royal Berkshire Hospital, have discovered that it is possible to stop the activation of a group of proteins (NADPH Oxidase) known to cause most of the diseases of ageing. This will potentially pave the way for the development of drugs to treat a range of age-related diseases. (2016-12-15)

A little anxiety pays sometimes, study shows
Anxiety gets a lot of bad press. Dwelling on the negative can lead to chronic stress and anxiety disorders and phobias, but evolutionarily speaking, anxiety holds some functional value. In humans, learning to avoid harm is necessary not only for surviving in the face of basic threats (such as predators or rotten food), but also for avoiding more complex social or economic threats (such as enemies or questionable investments). (2008-04-03)

Abnormal hyperactivation in the brain may be an early sign of Alzheimer's
A research team led by UdeM psychology and neuroscience professor Sylvie Belleville has just targeted an early biomarker of the disease. (2021-01-21)

PCSK9 inhibition could ameliorate cardiovascular disease by immune mechanisms
PCSK9 inhibition could ameliorate atherosclerosis and thus cardiovascular disease by immune mechanisms that are unrelated to lowering of low-density lipoprotein (LDL) cholesterol, according to research presented today at ESC Congress. (2017-08-28)

Insomnia suffers need increased brain activation to maintain normal daily function
According to a research abstract that will be presented on Tuesday, June 9, at SLEEP 2009, the 23rd Annual Meeting of the Associated Professional Sleep Societies, patients suffering from chronic primary insomnia have higher levels of brain activation compared to normal sleepers during a working memory test. (2009-06-09)

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