Amyotrophic Lateral Sclerosis Current Events

Amyotrophic Lateral Sclerosis Current Events, Amyotrophic Lateral Sclerosis News Articles.
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Genetic background of sporadic amyotrophic lateral sclerosis in the Chinese Han population
Daojun Hong and colleagues from Nanchang University further investigated the association of the MAPT gene with sporadic amyotrophic lateral sclerosis in the Chinese Han population. (2013-12-28)

Autophagy in the initial stage is unrelated to the composition of beclin 1 complex
Alteration of the autophagic process is involved in neurodegeneration. The beclin 1 complex is shown to play a key role in the initial stage of autophagy. (2014-03-24)

Over-activity of enzyme HDAC6 exacerbates symptoms of Amyotrophic Lateral Sclerosis
Scientists at VIB and KU Leuven have demonstrated in fruit-flies that over-activity of the enzyme HDAC6 in the nerve ends exacerbates the symptoms of the neurodegenerative condition Amyotrophic Lateral Sclerosis (ALS/ Lou Gehrig's Disease). Inhibition of this enzyme could offer a protective effect against ALS. (2014-06-26)

Yale School of Medicine Neuroscientist receives Javits Award
Stephen Strittmatter, M.D., professor of neurology and neurobiology at Yale School of Medicine and an internationally recognized leader in developmental biology, is a 2005 recipient of the Javits Award. (2005-09-20)

Amyotrophic lateral sclerosis may involve a form of sudden, rapid aging of the immune system
The results from a current study, published in the Journal of Cellular and Molecular Medicine, suggest that premature aging of the immune system appears to play a role in the development of ALS. The researchers found that thymic malfunction occurs simultaneously with motor neuron dysfunction, both in laboratory mice bred to mimic amyotrophic lateral sclerosis and in humans suffering from the disease. (2009-10-08)

Understanding the Noxious cause of Lou Gehrig's disease
There is no known cure for amyotrophic lateral sclerosis (ALS), often known as Lou Gehrig's disease and motor neuron disease. It is a progressive, fatal, neurodegenerative disease caused by degeneration of nerves that control voluntary muscle movement. A new study in the Journal of Clinical Investigation has provided insight into the mechanisms behind certain forms of the disease and identified potential targets for the development of drugs to treat individuals with these forms of ALS. (2007-09-13)

New molecular structures associated with ALS
Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome. The accumulation of these hybrids causes increased genomic damage and boosts genetic instability. This finding will make it possible to better understand the molecular basis of the disease, as well as to propose new solutions to curb it. (2021-01-13)

Antioxidant therapies may help in the fight against neurodegenerative diseases
A new review examines the potential of antioxidant approaches for the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis. (2016-08-01)

Protecting neurons could halt Alzheimer's, Parkinson's diseases
Scientists from two Texas universities have identified promising lead chemical compounds for the treatment of neurodegenerative disorders like Alzheimer's and Parkinson's diseases, major and growing health problems as the human life span increases. (2008-11-13)

Western University researchers identify new genetic mutation for ALS
Researchers at Western University in London, Canada, have identified a new genetic mutation for amyotrophic lateral sclerosis (ALS), opening the door to future targeted therapies. Dr. Michael Strong and colleagues found that mutations within the ARHGEF28 gene are present in ALS. When they looked across both familial and sporadic forms of the disease, they found that virtually all cases of ALS demonstrated abnormal inclusions of the protein that arises from this gene. (2013-01-15)

AAN Foundation, the ALS Association partner to finance Clinician Scientist Development Award
In collaboration with The ALS Association, the American Academy of Neurology Foundation has announced the Clinician Scientist Development Award to support research in amyotrophic lateral sclerosis (ALS). The Clinician Scientist Development Award will grant $75,000 per year for two years to an investigator who will focus on clinical research for ALS. (2005-08-29)

Poisoning from industrial compounds can cause similar effects to ALS
Researchers from the Bellvitge Biomedical Research Institute at the University of Barcelona have coordinated a research into how the IDPN nitrile causes neurological syndromes similar to those of the amyotrophic lateral sclerosis, a severe neuromuscular degenerative disease. The study, led by Jordi Llorens, has been recently published in Neuropathology and Applied Neurobiology journal. (2012-07-17)

Preserving nerve cells in motor neuron disease
A team of researchers, reporting in the Journal of Clinical Investigation, has identified a way to prevent symptom onset, weight loss and paralysis, and extend survival in a mouse model of amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), providing a new avenue of research for the development of therapeutics for ALS and other motor neuron diseases. (2010-09-20)

A new development in the relief of spasms related to amyotrophic lateral sclerosis
A team of researchers from Strasbourg, directed by Luc Dupuis, have recently discovered the origin of spasms - a disabling symptom of amyotrophic lateral sclerosis. The degeneration of serotonin-releasing neurons is responsible for these sensations. In the longer term, researchers imagine that molecules acting on serotonin receptors present in the brain could eliminate spasticity in patients. (2012-11-06)

Zebra fish point the way towards new therapies for amyotrophic lateral sclerosis
Leuven scientists (VIB/KU Leuven) are using zebrafish as a model in their search for genes that play a role in the mechanism of amyotrophic lateral sclerosis (ALS). As a result, they have identified a molecule that could be the target for a future ALS treatment (2012-08-27)

ALS drug may help treat prostate cancer
Researchers have discovered a new use for an old drug as a potential treatment for prostate cancer. The findings are published in the journal The Prostate. (2018-10-03)

2 BUSM faculty receive Alzheimer's disease grants
David Harris, M.D., Ph.D., chair and professor of biochemistry and Benjamin Wolozin, M.D., Ph.D., professor of pharmacology and experimental therapeutics and neurology at Boston University School of Medicine, have received Massachusetts Neuroscience Consortium Awards. (2013-07-11)

Therapeutic opportunities in neurodegenerative diseases
This conference will examine the latest research efforts towards understanding and treating neurodegenerative diseases such as Alzheimer's Disease, Parkinson's Disease, amyotrophic lateral sclerosis, and prion diseases. (2000-11-14)

Stem cells may hold promise for Lou Gehrig's disease
Apparent stem cell transplant success in mice may hold promise for people with amyotrophic lateral sclerosis, or Lou Gehrig's disease. The results of the study were released today and will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16-23, 2013. (2013-01-09)

New stem cell-based screen reveals promising drug for Lou Gehrig's disease
A study published on April 18th in Cell Stem Cell has revealed a novel stem-cell-based approach to screen for effective treatments of ALS, also called Lou Gehrig's disease, which are sorely lacking. (2013-04-18)

Mechanism behind upper motor degeneration revealed
Scientists have pinpointed the electrophysiological mechanism behind upper motor neuron disease, unlocking the door to potential treatments for amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, such as Hereditary Spastic Paraplegia and Primary Lateral Sclerosis. (2020-05-21)

Understanding the molecular mechanisms of ALS
Scientists have revealed more details of the molecular mechanism behind neuronal cell death in amyotrophic lateral sclerosis (ALS), a step forward to find ways to control progression of the disease. (2017-12-26)

Mouse study: Signal overload in Alzheimer brains
In studies with mice that develop the equivalent of Alzheimer's disease that runs in families, Johns Hopkins researchers have shown that brain cells' signals confuse the movement of implanted neuronal stem cells. (2004-10-25)

NIH researchers link cases of ALS and FTD to a Huntington's disease-associated mutation
A study led by researchers at the National Institutes of Health has made a surprising connection between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two disorders of the nervous system, and the genetic mutation normally understood to cause Huntington's disease. This large, international project, which included a collaboration between the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), opens a potentially new avenue for diagnosing and treating some individuals with FTD or ALS. (2020-12-04)

Neuralstem chief scientific officer to take part in World Stem Cell Summit plenary session
Neuralstem CSO Dr. Karl Johe is scheduled to participate in a panel on stem cells and the FDA at World Stem Cell Summit. (2010-10-01)

Discovery helps explain progression of Lou Gehrig's disease, offers new therapy approach
Researchers have discovered a previously unknown type of neural cell that appears to be closely linked to the progression of amytrophic lateral sclerosis, or Lou Gehrig's disease, that they believe will provide an important new approach to therapies. There is now no treatment for this disease, which causes progressive death of motor neurons, serious debility, paralysis and ultimately death within a few years. (2011-10-17)

Researchers perform thousands of mutations to understand amyotrophic lateral sclerosis
Researchers from IBEC and CRG in Barcelona use a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results. Results showed that aggregation of TDP-43 is not harmful but actually protects cells, changing our understanding of ALS and opening the door to radically new therapeutic approaches. (2019-09-23)

Meditation benefits patients with ALS
An eight-week mindfulness-based meditation program led to improved quality of life and psychological well-being in clinical trial of patients with amyotrophic lateral sclerosis (ALS). (2017-02-23)

US clinics avoiding government oversight of 'stem cell' treatments
Clinics across the United States are advertising stem cell treatments that attempt to take advantage of what they perceive as exceptions in FDA regulations, according to bioethicist Leigh G. Turner, Ph.D., associate professor, University of Minnesota Center for Bioethics and School of Public Health. (2015-05-01)

Next generation ALS drug silences inherited form of the disease in animal models
NIH-funded researchers delayed signs of amyotrophic lateral sclerosis (ALS) in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1 (SOD1). The results suggest the newer version of the drug may be effective at treating an inherited form of the disease caused by mutations in SOD1. (2018-07-25)

National Tropical Botanical Garden reports possible dietary link and neurodegenerative disease
Dr. Paul Alan Cox, director of the National Tropical Botanical Garden Institute for Ethnobotany has confirmed a dietary link to a Western Pacific neurodegenerative disease, amyotrophic lateral sclerosis-Parkinsonism dementia complex (ALS-PDC). He found that a neurotoxin produced by cyanobacteria accumulates and becomes more potent as it moves through the food chain of the Chamorro people of Guam. The process, known as biomaginifcation, lead to hypothesis that the dietary habits may have a link to the disease. (2003-11-10)

Pilot study tests possible diagnostic tools for amyotrophic lateral sclerosis
New animal research has shown that measuring copper concentrations and isotope ratios in blood and other tissue may allow early diagnosis of amyotrophic lateral sclerosis (ALS -- also known as Motor Neuron Disease). At present, there is no test for this disease, meaning that the illness needs to develop before care can begin. The work is being presented at the Goldschmidt conference in Yokohama, Japan. (2016-06-28)

Physical and cognitive fitness may affect ALS risk
New research suggests that physical fitness, body mass index (BMI), IQ, and stress resilience in young adulthood may have effects on the risk of developing amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. (2016-11-07)

Mouse model of neuromuscular disease identifies key player in motor neuron death
Scientists have created a new mouse model for SBMA. This study examines the pathology and points to a possible therapeutic strategy for this and other motor neuron diseases. The researchers determined that the abnormal androgen receptor in transgenic mice interfered with production of vascular endothelial growth factor (VEGF) that is important for the health and survival of motor neurons. Interestingly, VEGF could rescue SBMA-like motor neurons grown in the laboratory. (2004-03-03)

New treatment hope for amyotrophic lateral sclerosis
A previously unknown link between the immune system and the death of motor neurons in Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, has been discovered by scientists at the CHUM Research Centre and the University of Montreal. (2015-06-10)

Disarm Therapeutics presents new data validating role of SARM1 in axonal degeneration
Data presented at Neuroscience 2018 demonstrates genetic deletion of SARM1 protects axons in the central and peripheral nervous systems with a corresponding reduction of blood neurofilament-light (NF-L), a clinically validated biomarker of axonal degeneration (2018-11-03)

BUSM researcher receives prestigious Massachusetts Neuroscience Consortium award
Carmela Abraham, Ph.D., professor of biochemistry and pharmacology at Boston University School of Medicine, was one of six recipients of this year's Massachusetts Neuroscience Consortium Award out of nearly 60 applicants. The grant was awarded to her for her work on multiple sclerosis and the role of the life extension protein Klotho in the limited repair of white matter in the disease. (2014-12-05)

Neurological disorders are linked to elevated suicide rates
A newly published study in JAMA shows that people with neurological disorders have a 75% higher suicide rate than people with no neurological disorders. Still, suicide deaths are rare events. While the suicide rate for the general population is around 20 per 100,000, the rate for people with neurological disorders is around 40 per 100,000 person-years. The study is based on the data covering the entire population of Denmark and followed over 37 years. (2020-02-04)

Conclusions on brain-machine interfaces for communication and rehabilitation
In the journal Nature Reviews Neurology the researcher Ander Ramos of Tecnalia together with Niel Birbaumer, lecturer at the University of Tübingen, have expounded how brain-machine interfaces use brain activity to control external devices, thus enabling seriously disabled patients to interact with the environment. (2016-10-04)

Low muscle strength identified as early risk factor for ALS
Low muscle strength during the later teen years has been identified as a risk factor for much later onset of the neurological disease known as ALS, or amyotrophic lateral sclerosis. A study at Sahlgrenska Academy published in the Journal of Neurology also links low blood counts at a young age to ALS. (2018-02-02)

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