Ancient Ohio Trail Current Events

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UC project puts Midwest mounds back on the map
Mammoth-sized earthworks built over three millennia by Native American peoples in the Midwest are now back on the map thanks to a University of Cincinnati project. (2008-08-25)

Overcoming why a new treatment is resisted by lung cancer
A promising agent for the treatment of cancer has so far had little effect on the most common lung tumours, but new research from The University of Manchester has suggested how this resistance might be overcome. (2015-07-29)

Is liver damage down the TRAIL for a promising cancer therapy?
Although TRAIL is a protein that is considered a promising cancer therapeutic because it can kill tumor cells, controversy surrounds whether or not it affects nontumor cells. A new study now shows that TRAIL alone does not kill mouse liver cells in vitro, but it does enhance both in vitro and in vivo liver cell death induced by signaling through another liver cell protein, indicating that TRAIL-based therapeutics might cause liver damage. (2006-09-01)

Overcoming tumor resistance to anti-cancer agent TRAIL
The TRAIL ligand is a promising anti-cancer agent that preferentially kills tumor cells without apparent damage to healthy cells. Many cancers exhibit resistance to TRAIL, however, thus limiting its therapeutic potential. According to a study in the March 22 issue of the Journal of Cell Biology, small molecules known to block Mcl-1 might represent a suitable means to overcome TRAIL resistance. (2010-03-22)

Anti-cancer compound could cause serious liver damage, report University of Pittsburgh scientists
An anti-cancer compound initially slated to enter clinical trials within months could harm patients, according to a University of Pittsburgh report in the May issue of Nature Medicine. The Pittsburgh scientists found that TNF-related apoptosis inducing ligand (TRAIL) causes catastrophic damage to human liver cells. (2000-04-30)

A new pathway to 'reprogram' killer cells
Killer cells of the immune system detect and kill infected cells or cancer cells. Researchers at the Institute of Pathology at the University of Bern have now discovered that the mechanism by which certain immune cells kill their target cells can also be used to control the killer cells themselves. This finding may be relevant to cancer immunotherapy. (2019-11-19)

Hot on the TRAIL of controlling inflammation in bacterial meningitis
In a study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, researchers at Charité-Universitätsmedizin Berlin report that the molecule known as TRAIL can limit excessive immune responses in bacterial meningitis, and as such may be of use to control inflammation of the spinal cord and brain, which causes brain cell death in this life-threatening disease. (2007-06-14)

Decreased breast cancer survival associated with high TRAIL-R2 expression
High expression of TRAIL-R2, a cell surface receptor that triggers cell death, has been shown to be associated with a decrease the survival rates of breast cancer patients according to a study published by Yale Cancer Center researchers in Clinical Cancer Research. (2005-07-22)

Scientists follow familiar TRAIL to new cancer therapy
A new study identifies a combination therapy that may sensitize human cancer cells to a promising treatment currently being used in clinical trials. The research, published in the July issue of the journal Cancer Cell, published by Cell Press, provides a pharmacological method for enhancing the potency and effectiveness of a tumor necrosis factor death receptor ligand against a variety of human cancers. (2007-07-09)

How cancers trick the immune system into helping rather than harming them
Scientists from Trinity College Dublin have identified a molecule that sends a 'wound-healing' message from tumour cells. If we can disrupt this messaging system, we may be able to fight certain cancers. (2017-02-16)

Immunex's TRAIL Molecule Shows Potential As Anti-Tumor Agent
A preclinical study published in the journal Nature Medicine today demonstrated that TRAIL (TNF-related apoptosis-inducing ligand) supresses tumor growth, and in some instances caused complete remission of tumors, by a direct and specific mechanism. The work described in the journal was conducted in mice by scientists at Immunex Corporation. (1999-02-02)

Breast cancer drug pushes colon cancer cells to their death
A new treatment for colon cancer that combines a chemotherapy agent approved to treat breast cancer and a cancer-fighting antibody is ready for clinical trials, according to Penn State College of Medicine researchers. (2011-06-08)

Ecotourism: Penguins can get used to people
Having houseguests can be a strain, but new research shows that penguins can quickly adapt to the stress of ecotourism. Experimental evidence that wild penguins get used to people visiting their breeding colony was presented by Brian Walker of the University of Washington in Seattle at the June 1999 Society for Conservation Biology meeting. (1999-06-28)

Fratricide of HBV-specific CD8 T cells by NK cells mediated through the TRAIL pathway
A new study presented today at the International Liver Congress shows a novel pathway where activated natural killer cells expressing death ligands may excessively down-modulate the antiviral immune response in chronic HBV patients. (2011-04-01)

Compound stimulates tumor-fighting protein in cancer therapy
A compound that stimulates the production of a tumor-fighting protein may improve the usefulness of the protein in cancer therapy, according to a team of researchers. (2013-02-06)

'Flying carpet' technique uses graphene to deliver one-two punch of anticancer drugs
An international team of researchers has developed a drug delivery technique that utilizes graphene strips as 'flying carpets' to deliver two anticancer drugs sequentially to cancer cells, with each drug targeting the distinct part of the cell where it will be most effective. The technique was found to perform better than either drug in isolation when tested in a mouse model targeting a human lung cancer tumor. (2015-01-06)

Happy Camp Fire in California and 790 Fire in Oregon
The Aqua satellite captured this image of two fire areas in Oregon and California on Sept. 6, 2014. (2014-09-10)

Mushroom compound appears to improve effectiveness of cancer drugs
A compound isolated from a wild, poisonous mushroom growing in a southwest China forest appears to help a cancer killing drug fulfill its promise, researchers report. (2011-10-11)

Fox Chase Cancer Center researchers: Selenium will have critical role in prostate cancer treatment
Researchers at Fox Chase Cancer Center in Philadelphia have come a step closer to understanding selenium's molecular role in causing prostate cancer cells to self-destruct. According to data to be presented at the 96th Annual Meeting of the American Association for Cancer Research in Anaheim, Calif., selenium helps malignant cells overcome their resistance to TRAIL-induced apopstosis (self-inflicted cell death). (2005-04-20)

Hot on the TRAIL of graft vs. host disease
In this issue of the Journal of Clinical Investigation, Arnab Ghosh and colleagues at Memorial Sloan-Kettering Cancer Center found that expression of a protein that causes cell death, TRAIL, in transplanted cells was critical for an effective anti-tumor response. (2013-05-15)

Killing cancer in the heat of the moment
Researchers from Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) have developed a new method that modifies the surface of nanorods, making them more efficient in transporting cancer-killing genes into cells. (2017-07-08)

Cellular soldiers designed to kill cancer cells that get loose during surgery
Biomedical engineers at Vanderbilt University have discovered a method to track down and kill escaping cancer cells during tumor removal surgeries. The method, which uses the body's own defenses in the form of modified lipid nanoparticles adhered to white blood cells, could preventing metastasis and save lives. (2019-07-24)

Researchers identify a new biomarker for personalized treatments against cancer
Many treatments against cancer, such as TRAIL, aim to trigger a type of cell death known as apoptosis. A team at IRB Barcelona, headed by Antonio Zorzano, has demonstrated that the protein TP53INP2 induces apoptosis in chemotherapy treatments. (2019-04-16)

New research finds that homeowners and city planners should 'hit the trail'
Two University of Cincinnati researchers will present interdisciplinary research at a national conference on planning and development of communities. (2011-10-11)

Scientists delve into 'hotspot' volcanoes along Pacific Ocean Seamount Trail
Nearly half a mile of rock retrieved from beneath the seafloor is yielding new clues about how underwater volcanoes are created and whether the hotspots that led to their formation have moved over time. (2011-02-15)

Neural stem cells carry cancer-fighting protein to track and destroy brain tumor cells
Researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute in Los Angeles have combined a special protein (TRAIL) that targets cancer cells with neural stem cells (NSC) to track and attack malignant brain tumor cells. With its tumor-tracking capabilities and natural cancer-killing properties, the experimental NSC-TRAIL combination may offer new hope for treating gliomas a particularly deadly type of brain tumor. (2002-12-15)

Research holds revelations about an ancient society's water conservation, purification
UC research on hinterland hydrology will be presented at the annual meeting of the Association of American Geographers. (2013-04-09)

Genetically engineered MSCs kill metastatic lung cancer cells in mice
Researchers in London have demonstrated the ability of adult stem cells from bone marrow (mesenchymal stem cells, or MSCs) to deliver a cancer-killing protein to tumors. The genetically engineered stem cells are able to home to the cancer cells, both in culture and in mouse models, and deliver TNF-related apoptosis-inducing ligand, destroying the tumor cells while sparing normal cells. (2009-05-19)

More cars -- more traffic jams? Not for ants!
Rather than slowing down, ants speed up in response to a higher density of traffic on their trails, according to new research published in Springer's journal The Science of Nature -- Naturwissenschaften. When the researchers increased the supply of food by leaving food next to the trail, ants accelerated their speed by 50 percent. This was despite more than double the density of traffic. (2015-04-22)

Largest fossil cockroach found: Site preserves incredible detail
Geologists at Ohio State University have found the largest-ever complete fossil of a cockroach, one that lived 55 million years before the first dinosaurs. The cockroach, along with hundreds of other fossil plants and animals from a coalmine in eastern Ohio, could help scientists better understand the diversity of ancient life and how the Earth's climate has changed throughout history. (2001-11-07)

Inuit are on the right track
Inuit trails are more than merely means to get from A to B. In reality, they represent a complex social network spanning the Canadian Arctic and are a distinctive aspect of the Inuit cultural identity. And what is remarkable is that the Inuit's vast geographic knowledge has been passed through many generations by oral means, without the use of maps or any other written documentation. These findings were just published in Springer's journal Human Ecology. (2009-02-04)

Walking trails boost exercise, improve health at low cost
Exercise is a well known but little used path to better health, so how can communities get more arms and legs pumping before too many hearts stop pumping? Build walking trails, say researchers, and they will come -- especially women and people with lower incomes. (2000-03-15)

High levels of TRAIL protein in breast milk might contribute to anticancer activity
The benefits of breast milk are well known, but why breastfeeding protects against various forms of cancer remains a mystery. A new study in the Journal of Human Lactation (published by SAGE) found high levels of cancer-fighting TNF-related apoptosis inducing ligand (TRAIL) in human milk, which might be one source of breast milk's anticancer activity. (2012-04-23)

Geologist Finds Evidence Supporting Mysterious Ancient Sea
University of Cincinnati geologist Warren Huff and his collaborators have evidence from ancient volcanic ash beds which supports the notion of an ancient Iapetus Ocean. Other geologists have argued that North and South America were too close together to allow the ocean to exist. In contract, Huff's evidence indicates the two continents were literally poles apart. (1997-10-22)

Dietary intervention primes triple-negative breast cancer for targeted therapy
A diet that starves triple-negative breast cancer cells of an essential nutrient primes the cancer cells to be more easily killed by a targeted antibody treatment, UW Carbone Cancer Center scientists report in a recent publication. (2015-07-14)

The strange effects of thinking healthy food is costlier
Consumers believe healthy food must be more expensive than cheap eats and that higher-priced food is healthier -- even when there is no supporting evidence, according to new research. The results mean not only that marketers can charge more for products that are touted as healthy, but that consumers may not believe that a product is healthy if it doesn't cost more, researchers say. (2016-12-19)

Study of bees by UC San Diego biologist provides insight into evolution of bee communication
A team of biologists working in Brazil may have found the clues to resolving the longstanding mystery of why some species of bees, such as honey bees, communicate the location of food with dances in their hives and why other bees simply leave scent trails from the food source to the nest. (2003-09-22)

A dog in the hand scares birds in the bush
New research showing that dog-walking in bushland significantly reduces bird diversity and abundance will lend support to bans against the practice in sensitive bushland and conservation areas. Until now, arguments and debate about the ecological impacts of dog-walking have remained subjective and unresolved because experimental evidence has been lacking. (2007-09-04)

Safeguard found for potential cancer therapy
Researchers who had been advancing a promising cancer treatment, called TRAIL, found a new obstacle looming when the journal Nature Medicine published a study last spring that identified a fatal flaw: The treatment destroys healthy human liver cells. Now Penn researchers have found a solution to that crucial problem, re-opening (2000-11-16)

NRL-camera aboard NASA spacecraft confirms asteroid phenomenon
A US Naval Research Laboratory-built camera mounted on the NASA Parker Solar Probe revealed an asteroid dust trail that has eluded astronomers for decades. (2019-12-11)

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