Angiogenesis Current Events

Angiogenesis Current Events, Angiogenesis News Articles.
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Enhancement of pancreatic cancer on dynamic CT: Does it correlate with angiogenesis and fibrosis?
Tumor angiogenesis has been recognized as a useful prognostic marker in human cancer, including pancreatic cancer. A recent study showed a significant correlation between enhancement on dynamic computed tomography (CT) and angiogenesis and fibrosis. Tumors with high angiogenesis tended to show high enhancement in the arterial dominant phase. However, dynamic CT features that are caused by angiogenesis may be modified by the extent of intratumoral fibrosis. (2009-07-16)

Tumor suppressor activity of PTEN
Using transgenic mice specifically lacking the PTEN gene in endothelial cells, Dr. Akira Suzuki and colleagues demonstrate that PTEN is required for normal cardiovascular development and that its loss enhanced tumor angiogenesis. (2005-08-16)

UNC scientists identify growth factor as possible cancer drug target
Scientists at the UNC Lineberger Comprehensive Cancer Center report finding a new angiogenesis protein, SFRP2, found in the blood vessels of numerous tumor sites, including breast prostate, lung, pancreas, ovarian, colon, kidney tumors and angiosarcomas. (2009-06-09)

Going to 'Wars' against cancer and heart disease
Wars2 was discovered to be involved in angiogenesis -- blood vessel formation, which is important in ensuring that all parts of the body get nutrients to sustain life. Rats and zebrafish where Wars2 was inhibited had impaired blood vessel formation. Treatments for cancer and diabetic eye disease may be developed to target Wars2 and inhibit blood vessel formation. (2016-07-08)

Methylation signaling controls angiogenesis and cancer growth
A study led by researchers at Boston University School of Medicine demonstrates a new mechanism involving a signaling protein and its receptor that may block the formation of new blood vessels and cancer growth. The findings are published in the December issue of Science Signaling. (2013-11-28)

Pazopanib shrinks lung cancers before surgery
Pazopanib, a new oral angiogenesis inhibitor, has demonstrated interesting activity in difficult to treat non-small-cell lung cancer, US researchers report. (2008-09-16)

New mechanism explains how the body prevents formation of blood vessels
Researchers at Uppsala University, in collaboration with colleagues in Sweden and abroad, have identified an entirely new mechanism by which a specific protein in the body inhibits formation of new blood vessels. Inhibiting the formation of new blood vessels is an important aspect of, for example, cancer treatment. The study is published in the November issue of the journal Molecular Cancer Research. (2009-11-11)

Protein could improve recovery from heart attacks
Angiogenesis is required during embryonic development and wound healing, as well as during disease processes such as tumor growth. The signals that direct angiogensis could represent novel targets for the development of therapies. This paper reveals that two related proteins- DKK1 and DKK2 play opposite roles in directing angiogenesis. Remarkably, injection of DKK2 improved vascular regeneration in a mouse model of myocardial infarction (heart attack). (2011-04-11)

A double block of blood vessels to starve cancerous tumors
A novel strategy of blocking the growth of blood vessels with antibodies should result in improved treatment of cancerous tumors, report researchers at the University of Helsinki. (2010-12-09)

Chemokines and angiostasis
Romagnani et al. report that human microvascular endothelial cells from a variety of normal tissues express the chemokine receptor CXCR3, several of whose ligands are strongly angiostatic. This pathway could provide an additional mechanism to block tumor angiogenesis. (2000-12-31)

UK researcher finds 'switching' compound for angiogenesis
For the second time in a week Dr. Jayakrishna Ambati, UK HealthCare physician and associate professor and vice chair of the Department of Ophthalmology and Visual Sciences, announced a discovery from his lab that will affect the future of macular degeneration treatment and research. (2006-02-02)

Angiogenesis Research May Lead To Treatments
Research on this process not only may lead to improved cancer treatments, but also may offer new approaches to treating a wide range of other medical problems, says Peter Polverini, U-M professor of dentistry and pathology who has been doing research on angiogenesis for 20 years. (1998-05-20)

Combination therapy reduces tumor resistance to radiation
Radiation is used to treat a variety of tumors as it causes hypoxia and tumor cell death. Recently, radiation-induced hypoxia was shown to trigger tumor resistance to radiation via the activation of new blood vessel formation (angiogenesis). In a new JCI study, researchers show that a combination of radiation treatment and the use of angiogenesis inhibitors such as canstatin is able to overcome HIF-1-dependent tumor survival and increase tumor cell death in mice. (2007-06-07)

Tiny tool to control growing blood vessels opens new potential in tumor research
Researchers at Uppsala University have developed a new tool that makes it possible to study the signals in the body that control the generation of blood vessels. The researchers' findings, published in the new issue of Lab on a Chip, enable scientists to determine what signals in the body attract or repel blood vessels, knowledge that is extremely interesting in tumor research. (2009-02-21)

Flipping the angiogenic switch
A new paper in the Sept. 15 issue of Genes & Development reveals how pancreatic tumors get the blood supply they need to thrive and spread. (2006-09-14)

Anti-Angiogenesis: A New Weapon In Cancer Therapy
As reported this week, Dr. Judah Folkman's work in cutting off a tumor's blood supply seems critical to the removal of tumors and the prevention of metastases. Related work is being done by Ribozyme Pharmaceuticals, using an anti-VEGF receptor ribozyme to inhibit angiogenesis and restrain tumor growwth. (1998-05-04)

Caution urged in research with angiogenesis therapy
Using gene therapy to spur new blood vessel growth and improve blood flow is a promising treatment for clogged arteries leading to the heart or legs. However, the technique, called angiogenesis, should be pursued with caution, researchers write in a (2001-07-02)

New target for the fight against cancer as a result of excessive blood vessel formation
New blood vessel formation (angiogenesis) stimulates the growth of cancer and other diseases. Anti-angiogenic inhibitors slow down cancer growth by disrupting the blood supply to the tumor. To date, the success of these treatments is limited by resistance, poor efficiency and harmful side effects. In the leading scientific journal Cell, Peter Carmeliet (VIB-KU Leuven) and his team reported that sugar metabolism (a process that we call glycolysis) also plays an essential role in the formation of new blood vessels. (2013-08-01)

Giving smaller doses of chemotherapy more frequently may attack tumor blood supply
Radiation oncologists at Thomas Jefferson University Hospital are rethinking how to give chemotherapy, taking advantage of its unique properties. They are giving chemotherapy more frequently than usual and in tinier doses, targeting the process by which a new blood supply is created feeding tumor growth, called angiogenesis. (2001-03-26)

Gold nanoparticles bring scientists closer to a treatment for cancer
Scientists at the University of Southampton have developed smart nanomaterials, which can disrupt the blood supply to cancerous tumors. (2011-07-07)

Zoledronic acid zings cervical cancer
Cervical cancer is the second most common cancer among women worldwide. In the September 1 issue of the Journal of Clinical Investigation, researchers from the University of California, San Francisco, found that a drug called zoledronic acid, which is currently used in the treatment of patients with bone metastases, was able to slow cervical cancer progression and growth in a mouse model. These data indicate this approved drug may be useful for cervical cancer treatment. (2004-09-01)

The mechanics of anti-tumor activity outlined
Inhibiting the growth and the angiogenic properties of cancer is an important modality for cancer treatment and research. In an article published today in the April issue of Cancer Cell (Vol. 3, No. 4, pg. 363), Winship Cancer Institute (WCI) researchers report that 2-methoxyestradiol (2ME2) inhibits tumor growth and angiogenesis by suppressing hypoxia-inducible factor-1 (HIF). (2003-04-22)

Intrinsic eye protein halts angiogenesis
Dr. Jayakrishna Ambati, of the University of Kentucky, and Dr. Balamurali Ambati, of the Medical College of Georgia, have jointly published a paper in the journal Nature detailing major research discoveries in corneal avascularity and angiogenesis. (2006-10-18)

Dartmouth study suggests caution against using certain drugs to unclog heart arteries
Dartmouth Medical School cardiology researchers have discovered a new mechanism for what drives the growth of muscle tissue in the lining of injured heart vessels that can eventually lead to blockage. Their study, reported in the October 19 issue of the journal Circulation, raises important questions about the use of drugs that promote or prevent angiogenesis - the formation of blood vessels - to treat the condition. (2004-10-11)

A newly identified mechanism can be targeted to boost angiogenesis
Scientists of the National Center for Cardiovascular Research (CNIC) have discovered a cellular and molecular mechanism that can be exploited to induce productive and sustained angiogenesis in tissues that have become ischemic due to reduced blood supply. (2019-05-01)

New molecular imaging agent targets cornerstone of cancerous tumors
A study introduced at SNM's 58th Annual Meeting may lead to the next wave of cancer imaging by helping to develop a molecular imaging agent that detects many malignant cancers' incessant development of blood vessels -- a process called angiogenesis. (2011-06-06)

A study demonstrates that p38 protein regulates the formation of new blood vessels
Ángel R. Nebreda's team (IRB Barcelona) publishes a study in the journal Nature Communications addressing the role of the p38 protein in angiogenesis--the formation of new blood vessels--a critical process that fuels tumour cells and allows them to grow and eventually develop metastases. A greater understanding of how new blood vessel formation is regulated could help to improve chemotherapy treatments for cancer, as well as to develop more efficient angiogenic therapies for other diseases. (2019-07-17)

Scientists identify a key molecule that blocks abnormal blood vessel growth in tumors
A new and better understanding of blood vessel growth and vascular development (angiogenesis) in cancer has been made possible by research carried out by a team of scientists from Moffitt Cancer Center, the University of Florida, Harvard University, Yale University and the Children's Hospital of Los Angeles. (2011-09-21)

Popular arthritis drug may enhance radiation effects against cancer
Researchers at Jefferson Medical College have shown in the laboratory that a popular arthritis drug may enhance the effects of radiation against tumor cells. Using various laboratory tests and a number of different models, the scientists showed Vioxx, which is a cox-2 inhibitor, interferes with angiogenesis, a process by which a tumor's growth is fed by the development of blood vessels. (2001-11-07)

Mechanism found that 'protects' aggressive melanoma from angiogenesis inhibitors
Northwestern University researchers have discovered a mechanism that may help to explain how angiogenesis inhibitors work on normal, blood vessel-forming endothelial cells, but not on insidious, aggressive melanoma cells that masquerade as endothelial-like cells by forming their own vascular networks, called (2004-10-07)

Collaborative Research Provides New Information About Interleukin-12's Role In Angiogenesis
Interleukin-12 (IL-12), a cytokine discovered at The Wistar Institute in the mid-1980s, is known to engage in potent anti-tumor activities. Until recently, however, the biological events governing its behavior were little understood. New information shows that IL-12 provokes a series of events that ultimately interfere with tumor angiogenesis, or the formation of blood vessels that nourish and enlarge tumors. (1998-07-23)

Dr. Judah Folkman honored with American Heart Association/Novartis award
Judah Folkman, M.D., is the winner of this year's Novartis Award for Hypertension Research. He is a pioneer in the field of angiogenesis, which is how the body generates new blood vessels. (2003-09-17)

Novel Therapeutic Approach To Treatment Of Arthritic Disease
Scientists at The Scripps Research Institute have studied an investigational anti-angiogenesis treatment -- previously employed against various forms of cancer -- to assess its impact on arthritic disease in an animal model. Their results, published in the January 1, 1999, issue of The Journal of Clinical Investigation, provides evidence for a central pathogenic contribution of angiogenic blood vessels to the maintenance and severity of arthritic disease. (1998-12-31)

Hinder handing the message -- stopping tumors from creating new blood vessels
Researchers from Tokyo Medical and Dental University (TMDU) have found that vasohibin-1 (VASH1), a protein known to prevent the formation of new blood vessels, acts by changing the conditions of microtubules which bring blocking the certain signal from outside through encumbering transport of its message to the inner of cell. The unique function of this protein can inhibit tumor cells from spreading throughout the body, making it a notable finding for cancer therapeutic research. (2020-12-14)

Researchers find new mechanism for growing new blood vessels
Cardiology researchers at Beth Israel Deaconess Medical Center have discovered a potentially more potent way to grow new blood vessels in the heart to bypass clogged arteries. The findings may have potential applications in treating coronary artery disease and peripheral vascular disease. (2000-01-04)

How new blood vessels sprout
IBS biologists discovered a key regulator of normal as well as pathological formation of new blood vessels. (2017-08-29)

Researchers identify unusual molecular switch for common form of advanced breast cancer
New evidence demonstrates that a novel molecular switch is involved in the development of a common form of advanced breast cancer, known as locally advanced breast cancer. The research, published by Cell Press in the Nov. 9, 2007 issue of Molecular Cell, provides an exciting paradigm shift in the understanding of a key event in breast cancer development and presents new therapeutic opportunities for this deadly disease. (2007-11-08)

Researchers gain new insights into how tumor cells are fed
Researchers have gained a new understanding of the way in which growing tumors are fed and how this growth can be slowed via angiogenesis inhibitors that eliminate the blood supply to tumors. This represents a step forward towards developing new anti-cancer drug therapies. The results of this study have been published today in the September issue of the American Journal of Pathology. (2011-08-08)

MGH study identifies new inhibitor of tumor angiogenesis and growth
A research team based at the Massachusetts General Hospital has shown that a natural factor called thrombospondin-2 (TSP- 2) inhibits the development of certain tumors in a mouse model by preventing the development of blood vessels, a process called angiogenesis. TSP-2 now joins a growing list of anti-angiogenesis factors being studied and in some instances tested as possible anti-cancer drugs. (1999-12-20)

Targeting cancerous vessels
By lowering the level of a neuronal protein, researchers halted the growth of blood vessels that tumors rely on for survival. The findings are reported online in the Journal of Experimental Medicine on Jan. 4. (2010-01-04)

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