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Angiogenesis Current Events, Angiogenesis News Articles.
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The new frontier: Creating and marketing food products that prevent disease and obesity
Creating and promoting foods that contain natural inhibitors of unhealthy angiogenesis -- the formation of blood vessels that feed and promote disease, obesity and inflammation -- is the (2013-07-17)

AACR news: XL-184 (Cabozantinib) goes 12-for-12 in colorectal cancer explants
The novel c-MET and VEGFR2 inhibitor, XL-184 (Cabozantinib), resulted in a significant decrease in tumor growth in 12 out of 12 colorectal cancer patient-derived explants, with 8 of the explants exhibiting stable disease. The results of this preclinical work are presented at the AACR Annual Meeting 2013. (2013-04-08)

TSRI Scientists Discover Naturally-Occurring Mechanism Involved In Regulation Of Angiogenesis; New Anti-Cancer Therapeutic Agents Are Suggested
Scientists at The Scripps Research Institute have uncovered a naturally-occurring mechanism to help explain angiogenesis activity and developed a recombinant form of a protein fragment that blocks angiogenesis and tumor growth in an in vivo experimental model. This may provide a potentially novel therapeutic approach for diseases associated with neovascularization. (1998-02-06)

NIH researchers successfully stop blood vessel, tumor growth in mice
Scientists at the National Institutes of Health and other institutions have devised a new strategy to stop tumors from developing the new blood vessels they need to grow. Once thought to be extremely promising for the treatment of cancer, blocking molecules that stimulate new blood vessel growth (angiogenesis) has proven ineffective because tumor cells respond by producing more stimulatory molecules. (2020-03-11)

Scientists at the Scripps Research Institute design gene-tipped tumor regressor 'smartbombs'
A group of researchers from The Scripps Research Institute (TSRI) have demonstrated what, in principle, could be a new way of treating cancer and several other diseases where angiogenesis occurs. Angiogenesis, the formation and differentiation of new blood vessels, is a crucial process in cancer, and, when blocked, improves a patient's prognosis. (2002-06-27)

What roles does TSP-1 play in liver fibrogenesis?
A team, led by Dr Gülsüm Özlem Elpek from the University of Akdeniz, Turkey, has demonstrated that expression of Thrombospondin-1 (TSP-1) gradually increases with the severity of fibrosis and strongly correlates with angiogenesis during experimental liver fibrogenesis. (2008-05-20)

UC3M study applies math to describe tumor growth
Universidad Carlos III de Madrid (UC3M) has carried out a study that mathematically explains how tumors induce the growth of blood vessels. The study maintains that the tips of the blood vessels expand like a soliton, a solitary wave similar to a tsunami. (2016-10-17)

Growth Factor Contributes To Angiogenesis
A University of Michigan team has found that a natural substance known as vascular endothelial growth factor (VEGF) contributes to angiogenesis not only by stimulating blood vessel growth, but also by prolonging the survival of blood vessel cells. (1999-02-02)

Signal for inflammation linked to Ras-induced tumor growth
Cancer progression is dependent on the ability of tumor cells to interact with and favorably influence their environment. For instance, if a tumor is going expand, it is absolutely critical that new blood vessels are formed so that an adequate blood supply is in place to feed the growing tissue. A new research study demonstrates that a cytokine, a chemical signal that stimulates inflammation, plays a critical role in the initiation of new vasculature formation required to promote tumor progression. (2004-11-15)

Cancer researchers describe new class of angiogenesis proteins
Researchers at the Rebecca and John Moores UCSD Cancer Center, and colleagues from throughout the state, describe a new class of proteins that not only promotes therapeutic angiogenesis in an entirely new way, but also avoids vascular permeability - a troubling side effect seen with other agents now being tested. (2003-07-01)

Unique interplay between tumor and blood vessel cells promotes angiogenesis and tumor growth
Scientists now have a more complete understanding of how cancer cells send signals to surrounding tissues to promote development of the blood supply needed to support tumor growth. For the first time, it has been shown that signals expressed by tumor cells can directly interact with the outer membrane of adjacent blood vessel cells and influence growth and development. The research, published in the July issue of Cancer Cell, may provide a new and more efficient target for antiangiogenic therapy. (2005-07-18)

Blood vessel-on-a-chips show anti-cancer drug effects in human cells
Researchers at the Institute of Industrial Science, the University of Tokyo, and LIMMS/CNRS-IIS a joint French - Japanese research laboratory between the CNRS and the University of Tokyo, report new organ-on-a-chip technology to observe sprouting angiogenesis from a single blood vessel. VEGF stimulated new capillaries from the single vessel by activating NOTCH signaling, recapitulating biochemical events of the human angiogenesis. The chip also confirmed the effects of two FDA-approved anti-angiogenic drugs, demonstrating its applicability to drug discovery. (2018-01-30)

Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after ACI
Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after ACI. (2013-12-23)

Microbubbles can image blood vessel growth in tumors
Imagine being able to quickly detect and diagnose blood vessel growth in cancerous tumors, and even predict how fast the tumors might metastasize or spread. Researchers at the University of Virginia Health System are doing just that in animal models using millions of tiny microbubbles injected into the bloodstream, coupled with contrast-enhanced ultrasound, an inexpensive and widely-used technique using sound waves to (2003-07-15)

Cholesterol sets off chaotic blood vessel growth
A study at the University of California, San Diego School of Medicine identified a protein that is responsible for regulating blood vessel growth by mediating the efficient removal of cholesterol from the cells. Unregulated development of blood vessels can feed the growth of tumors. (2013-05-29)

CNIO researchers describe a new target for developing anti-angiogenic and anti-tumoral therapies
The antibody-based blocking of ephrinB2, a protein involved in angiogenesis and lymphoangiogenesis, may represent an effective strategy for the development of antiangiogenic and antitumoral therapies. (2012-05-10)

Novel imaging agent targets breast tumor development
Scientists presented new research at SNM's 58th Annual Meeting that has the potential to help physicians detect breast cancer by imaging the proliferation of blood vessels carrying oxygen and nutrients to breast tumors. (2011-06-06)

Scientists discover role for c-myc gene in tumor angiogenesis
The c-myc gene is commonly activated in a variety of human tumors. As a new report in the October 1 issue of Genes & Development shows, scientists are gaining a better understanding as to why. Dr. John Cleveland and colleagues at St. Jude Children's Research Hospital have discovered that c-Myc is essential for tumor development, as it regulates factors necessary for the growth of blood vessels into tumors - lending a new potential target to anti-angiogenic cancer therapies. (2002-09-30)

World-first discovery could help treat life-threatening tumors
WA researchers investigating how blood vessel growth keeps cancers alive have made a world-first discovery that could boost the chances of successfully treating life-threatening tumors. (2008-04-16)

New findings point to new target to block angiogenesis
Scientists at the Vanderbilt-Ingram Cancer Center have identified an unexpected participant in the process of blood vessel development. Reported in the Sept. 15 issue of the journal Cancer Research, their findings point to a new target for drugs that inhibit this process. (1999-09-15)

Study uncovers enzyme's double life, critical role in cancer blood supply
Studied for decades for their essential role in making proteins within cells, several amino acids known as tRNA synthetases were recently found to have an unexpected -- and critical -- additional role in cancer metastasis. University of Vermont researchers determined that threonyl tRNA synthetase leads a (2013-03-04)

University of North Carolina cardiologist named 2012 Judah Folkman Award recipient
Cam Patterson, MD, MBA, division chief of cardiology at the University of North Carolina at Chapel Hill School of Medicine has been named the recipient of the 2012 North America Vascular Biology Association Judah Folkman Award in Vascular Biology. (2011-10-06)

New angiogenesis finding may help fight cancer growth
A researcher at the University of Wisconsin-Madison School of Medicine and Public Health has discovered a new part of the complicated mechanism that governs the formation of blood vessels, or angiogenesis. (2006-09-28)

Scientists reveal new targets for anti-angiogenesis drugs
A new study describes a novel pathway of angiogenesis, the growth of new blood vessels. Targeting the new pathway, scientists identified two approaches that significantly reduced angiogenesis in mice. These discoveries may lead to novel treatments for diseases caused by excessive angiogenesis, including corneal graft rejection, age-related macular degeneration, cancer and diabetes. (2010-08-16)

A useful tool to detect in vivo angiogenesis in IBD patients: Narrow-band imaging
A research team from Italy investigated whether narrow-band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients. Their results showed NBI may be a novel modality for imaging of intestinal angiogenesis in IBD. (2010-05-20)

Castrate resistant prostate cancer: New therapeutic approaches
Today Dr. Martin Gleave of the Vancouver Prostate Centre in Canada gave a lecture about new approaches to treat castrate-resistant prostate cancer during the 24th Annual Congress of the European Association of Urology in Stockholm, Sweden. (2009-03-20)

Scientists find new vessel for detecting autism
Evidence of autism may be found in the composition and malfunction of the brain's blood vessels, a team of scientists has found. Their research sheds new light on the causes of autism, which previously had pointed to neurological make-up rather than to the vascular system, and identifies a new target for potential therapeutic intervention. (2015-12-16)

New approaches to endometriosis treatment -- mouse experiments point the way
Possible new directions for the treatment of endometriosis, a painful condition associated with infertility that affects up to 15 percent of women of reproductive age, will be outlined in the presentation of two experimental studies at the 23rd Annual Meeting of the European Society of Human Reproduction and Embryology (Tuesday, July 3). Both concern targeting angiogenesis -- the formation of new blood vessels -- which is encourages endometriosis by providing a rich blood supply. (2007-07-02)

Morphine blocks tumor growth
Current research suggests that taking morphine can block new blood vessel and tumor growth. The related report by Koodie et al., (2010-07-28)

New target discovered for treatment of cancer
Researchers at the Swedish medical university Karolinska Institutet have discovered a new way of blocking the formation of blood vessels and halting the growth of tumors in mice. A substance that exploits this mechanism could be developed into a new treatment for cancer. (2010-01-11)

Common treatment for cancer pain stimulates breast tumor growth in mice
Morphine, which is routinely given to cancer patients to manage severe pain, actually stimulates signals in endothelial cells that in turn prompt tumors to grow in mice. (2002-08-01)

Protein controls blood vessel formation, offers new drug target
A protein called CIB1 discovered by researchers at the University of North Carolina at Chapel Hill School of Medicine appears to play a major role in controlling new blood vessel growth, offering a target for drug treatments to help the body repair itself after injury and control unwanted blood vessel growth. (2007-12-04)

Cell molecule identified as central player in the formation of new blood vessels
Scientists at the University of North Carolina at Chapel Hill School of Medicine have identified a cellular protein that plays a central role in the formation of new blood vessels. The molecule is the protein Shc, and new blood vessel formation, or angiogenesis, is seriously impaired without it. (2011-11-28)

Researchers Demonstrate That COX-2 Inhibits Angiogenisis In Tumor Cells
Aspirin's preventive effects on colon cancer may result from its influence on the development of blood vessels needed for tumor growth. (1998-05-29)

Is the zebra fish leading us to new therapies?
A little over a year ago, VIB, the D. Collen Research Foundation, and the K.U.Leuven invested in the acquisition of a new technology provided by the zebra fish. This small aquarium fish can be used to aid the study of the function of human genes. That this investment is reaping returns is evident from the study that VIB researchers at the K.U.Leuven are publishing today in the renowned journal Nature. (2004-10-28)

Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
Angiogenesis inhibitors that block a tumor's development of an independent blood supply have been touted as effective cancer fighters that result in fewer side effects than traditional chemotherapy. However, a new study by researchers at UCLA's Jonsson Cancer Center showed that one method of blocking blood supply development could result in serious and potentially deadly side effects. (2007-08-23)

S1P1 essential for tumor growth and is blocked by RNA interference
Tumor growth requires new blood ves-sel growth, which is a process called angiogenesis. There are many factors involved in the nor-mal growth and stabilization of new blood vessels. In the Journal of Clinical Investigation October 15 issue, University of Connecticut Health Science Center researchers, identified a new player, S1P1, that is essential for tumor angiogenesis and developed an anti-tumor growth strategy involving interference RNA technology that blocked S1P1 and successfully inhibited tumor growth in mice. (2004-10-15)

A coordinated response to cardiac stress
In this issue of the Journal of Clinical Investigation, Daniela Tirziu and researchers at Yale University identified a molecular mechanism by which the growth of new blood vessels (angiogenesis) and heart muscle growth are coordinated. (2013-03-01)

UCLA scientists prove through genetic analysis that protein plays a role in regulating tumor blood supply formation
A genetic analysis of a protein believed to affect the formation of blood vessels has proved that Thrombospondin-1 does indeed regulate a tumor's ability to form the independent blood supply that cancers need to grow and thrive, UCLA researchers report. (2001-10-17)

Experimental anti-cancer synthetic molecule targets tumor cell growth and angiogenesis
A recent study conducted by three French CNRS (Centre National de la Recherche Scientifique) laboratories describes a new candidate anti-cancer drug, HB-19. In contrast to conventional anti-cancer drugs, HB-19 has a dual mechanism of action by independently targeting tumor cell growth and tumor. The molecular target of HB-19 is nucleolin expressed on the surface of all activated cells, in particular rapidly growing tumor cells and endothelial cells that play a key role in angiogenesis. (2008-06-17)

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