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Breast cancer drug shows promise for treating, preventing progestin-dependent tumors
Recent studies suggest that human breast cancer risk is increased by outside exposure to the hormone progestin, such as during hormone replacement therapy. Now, a University of Missouri study suggests that PRIMA-1, a small molecule drug that targets the most common mutated gene, p53, in human cancer cells, has potential as a novel chemotherapeutic treatment for progestin-accelerated human breast cancer. (2009-01-28)

New RNAi treatment targets eye inflammation
Scientists have developed a new RNA interference (RNAi) therapeutic agent that safely blocked ocular inflammation in mice, potentially making it a new treatment for human uveitis and diabetic retinopathy. (2017-02-13)

Compound reveals new link between signaling protein and cell migration
Biochemists at UIC report the protein RKIP, which regulates key signaling pathways in cells, also plays a role in controlling the active movement or migration of cells. The finding suggests possible new drug development strategies. (2005-09-26)

Scientists discover why cornea is transparent and free of blood vessels, allowing vision
Scientists at the Harvard Department of Ophthalmology's Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary (MEEI) are the first to learn why the cornea, the clear window of the eye, is free of blood vessels -- a unique phenomenon that makes vision possible. (2006-07-17)

Prostate cancer spurs new nerves
Prostate cancer -- and perhaps other cancers -- promotes the growth of new nerves and the branching axons that carry their messages, a finding associated with more aggressive tumors, said researchers from Baylor College of Medicine in the first report of the phenomenon that appears today in the journal Clinical Cancer Research. (2008-12-01)

Molecularly targeted drug slows tumor growth in patients
Researchers from the National Cancer Institute (NCI) reported today that the molecularly targeted drug bevacizumab slowed tumor growth in patients with metastatic renal cell carcinoma, the most common form of kidney cancer in adults. The findings from their randomized clinical trial were presented at the American Society for Clinical Oncology meeting in Orlando, Fla. (2002-05-19)

Stem cells may offer hope for tissue regeneration after heart attack
Two research letters in this week's issue of THE LANCET provide preliminary evidence that bone-marrow stem-cell transplantation could regenerate damaged cells in the heart after myocardial infarction (heart attack). (2003-01-02)

Scientists discover new way to target cancer
Scientists have discovered a new way to target cancer through manipulating a master switch responsible for cancer cell growth. The findings, published today in the journal Cancer Cell, reveal how cancer cells grow faster by producing their own blood vessels. (2011-12-12)

Moffitt Cancer Center researchers study use of dasatinib for patients with high-risk MDS
Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib for patients with higher-risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia resulting from MDS and have failed treatment with azanucleosides. (2013-03-21)

AACR awards $2.6 million in grants for metastatic colon cancer research
The American Association for Cancer Research announces the first 11 recipients of the new Jeannik M. Littlefield-AACR Grants in Metastatic Colon Cancer Research. The awards, ranging to $250,000, were established in February 2006, to support innovative research projects designed to accelerate the discovery and development of new agents to treat metastatic colon cancer. (2006-07-07)

Regular walnut consumption may reduce negative outcomes of H. pylori infection
A new animal study, published in the Journal of Clinical Biochemistry and Nutrition, suggests regular walnut consumption may be a promising intervention for reducing negative outcomes associated with Helicobacter pylori (H. pylori) infection, a widespread bacterial infection that affects more than half of the world's population. (2021-02-09)

Scientists investigate potential markers for a response to sunitinib in patients with metastatic RCC
Markers such as CA9, CD31, CD34 and VEGFR1/2 in the primary tumours might serve as predictors of a good response to a sunitinib treatment in patients with metastatic clear cell renal cell carcinoma, according to a new study to be presented at the 28th Annual EAU Congress currently on-going in Milan. (2013-03-18)

FASEB Science Research Conference: The Growth Hormone/Prolactin Family in Biology and Disease
The FASEB Science Research Conference entitled 'The Growth Hormone/Prolactin Family in Biology and Disease' focuses on the growth hormone (GH)/prolactin (PRL) family of hormones influence the progression of such major health problems as obesity, diabetes, aging, mental health and multiple cancers, in addition to their role in body growth and lactation. (2015-01-27)

2011 ASH Annual Meeting to highlight latest hematology research, clinical care breakthroughs
The American Society of Hematology will host more than 20,000 attendees from around the globe at its 53rd annual meeting December 10-13 at the San Diego Convention Center in San Diego, CA. The ASH annual meeting, the premier medical meeting for physicians and researchers in the field, will showcase the latest research and clinical advances in hematology. (2011-12-01)

Growing tumors put the pressure on nutrient-supplying blood vessels
Mechanical pressure caused by cancer growth plays a key role in the development and distribution of blood vessels in tumors, according to a new University College London study published in PLOS Computational Biology. (2017-01-26)

Other highlights in the February 2 JNCI
Other highlights in the February 2 JNCI include a finding that most colorectal cancer patients receive inadequate lymph node evaluation, an examination of the possible association between obesity and malignant lymphomas, a study of the reasons behind the high cure rate of Down syndrome children with a type of leukemia, and a review of the use of imaging in assessing angiogenesis drugs. (2005-02-01)

Final Phase I results reported on new cancer drug
Researchers at the Ireland Cancer Center at University Hospitals of Cleveland report promising results of Phase I studies of a new cancer drug (Combretastatin A4P) that destroys the blood vessels supporting tumor growth. Evidence of efficacy of this vascular targeting drug is presented in MRI (magnetic resonance imaging) blood flow studies from the first human trials of the drug in the U.S. (2001-10-31)

Other highlights in the June 19 issue of JNCI
Other highlights of the June 19 issue of JNCI include a study suggesting that genetic variations in enzymes may affect patient survival, a study suggesting that a gene in human herpesvirus may be involved in malignant transformation, and a review of the evidence supporting the use of microvessel density as a prognostic indicator as it relates to antiangiogenic therapy. (2002-06-18)

FSU researcher's 'mutant' proteins could lead to new treatment for heart disease
Heart damage due to blocked arteries remains the leading cause of disease and death in the Western world, but a Florida State University College of Medicine researcher is helping to open new pathways toward treating the problem. (2008-03-24)

Molecular pathways to cancer
There are several discrete steps that a cell must take in order to replicate independently and migrate to other sites. The one-day symposium will address these steps that a cell must take to overcome strict mechanisms that control cell proliferation. To submit abstract for Poster Session
(2000-03-13)

Fourth Annual International Conference on Cell Therapy for Cardiovascular Diseases
The Cardiovascular Research Foundation brings experts to New York City from around the world for the Fourth Annual International Conference on Cell Therapy for Cardiovascular Diseases. Dedicated to new advances in this emerging field, the three-day session will feature an in-depth review of cell-based therapies for myocardial repair and regeneration, angiogenesis and cutting-edge research findings. (2007-11-27)

New therapeutic avenue in the fight against chronic liver disease
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has introduced a novel targeted drug delivery system in the fight against cancer. (2019-01-18)

Potential new tool for cervical cancer detection and diagnosis
A team of researchers from Central South University in China have demonstrated that a technique known as photoacoustic imaging, which is already under investigation for detecting skin or breast cancers and for monitoring therapy, also has the potential to be a new, faster, cheaper and noninvasive method to detect, diagnose and stage cervical cancer with high accuracy. Their work appears in a new paper in the Optical Society journal Biomedical Optics Express. (2014-12-15)

Other highlights in the August 7 issue of JNCI
Other highlights include a study of stroma-tumor communication in the growth of human ovarian cancers, a study examining the performance of diagnostic mammography, a study on colon cancer survival rates in African-Americans and Caucasians, and a study of nonsteroidal anti-inflammatory drugs and risk of pancreatic cancer. (2002-08-06)

Combining 2 peptide inhibitors might block tumor growth
A new study suggests that combining two experimental anticancer peptide agents might simultaneously block formation of new tumor blood vessels while also inhibiting the growth of tumor cells. The findings suggest that the double hit can stifle tumor progression, avoid drug resistance and cause few side effects, say the researchers who developed the agents and evaluated their effectiveness in laboratory and animal tests. (2011-03-14)

GSK's Pazopanib shows positive results in patients with advanced RCC and ovarian cancer
GlaxoSmithKline today announced results from ongoing Phase II studies of pazopanib in advanced or metastatic renal cell carcinoma (RCC) and ovarian cancer. These trials were presented at the 43rd Annual Meeting of the American Society of Clinical Oncology in Chicago. The results observed in these trials with pazopanib support further investigations. (2007-06-02)

UMN researchers find the link between heart and blood cells in early development
New research from the University of Minnesota reveals endoglin as a critical factor in determining the fate of early undifferentiated cells during development. (2016-10-07)

Encouraging results for drug that steps up when Gleevec fails
A new pill that targets several molecules implicated in the growth of cancer has shown promise in combating gastrointestinal tumors that no longer respond to the targeted drug Gleevec, according to a study led by scientists at Dana-Farber Cancer Institute. (2004-06-06)

Scientists reveal new target for anti-lymphangiogenesis drugs
In an emerging field of research, a study in Nature Communications reveals a mechanism in the regulation of lymphangiogenesis. Scientists identified a new target for drug treatment to prevent conditions caused by lymphangiogenesis, which include some blinding eye diseases, organ transplant rejection, and cancer metastasis. (2016-04-12)

No need to draw blood -- smart photonic contact lens for diabetic diagnosis and retinopathy treatment
Sei Kwang Hahn and his research team from POSTECH developed a smart LED contact lens. They are preparing for commercialization of wearable medical devices with PHI Biomed Company and Stanford University. (2020-01-10)

FASEB SRC announces conference registration open for: Liver Biology: Fundamental Mechanisms & Translational Applications
The Federation of American Societies for Experimental Biology announces the opening of registration for the Science Research Conference: Liver Biology: Fundamental Mechanisms & Translational Applications. (2012-01-30)

A study reveals how respiratory tubes and capillaries form
Scientists at the Institute for Research in Biomedicine (IRB Barcelona) and CSIC report on the formation of the small-diameter respiratory tubes of the fly Drosophila, a process that resembles the development of the finest blood vessels, the capillaries, in mammals. These tubes or capillaries, formed by a single cell, connect the main tubes of the respiratory system with organs and tissues, thereby providing oxygen. The study has been published in the journal Current Biology, part of the Cell group. (2010-02-08)

Study provides clues to alcohol's cancer connection
For the first time scientists have demonstrated a model that may explain how alcohol stimulates tumor growth. Their study says alcohol fuels the production of a growth factor that stimulates blood vessel development in tumors, and that chronic ethanol increased tumor size and levels of the angiogenic factor and levels of the angiogenic factor and vascular endothelial growth factor (VEGF) in an experimental model. (2004-12-13)

HMS/Mass. Eye and Ear researchers awarded prestigious Champalimaud Vision Award
Six Harvard Medical School researchers were among the recipients of the 2014 Antonio Champalimaud Vision Award, the highest distinction in ophthalmology and visual science. (2014-09-10)

New method for anticancer drug discovery developed
Researchers have developed a new strategy to identify potential anticancer compounds. The system makes it possible to screen for compounds that can selectively kill cells that carry specific mutations often found in cancer cells, such as those in cell cycle checkpoint proteins. The findings appear in the Jan. 16 issue of the Journal of the National Cancer Institute. (2002-01-15)

Control of blood vessels a possible weapon against obesity
Mice exposed to low temperatures develop more blood vessels in their adipose tissue and metabolize body fat more quickly, according to a new study from Karolinska Institutet. Scientists now hope to learn how to control blood vessel development in humans in order to combat obesity and diabetes. (2009-01-07)

UT Austin professor honored with prestigious mathematics award
Mary F. Wheeler, of the University of Texas at Austin, will be awarded the Theodore von Kármán Prize at the SIAM Annual Meeting for her seminal research in numerical methods for partial differential equations, her leadership in the field of scientific computation and service to the scientific community, and for her pioneering work in the application of computational methods to the engineering sciences, most notably in geosciences. (2009-06-30)

Being a smoker at time of prostate cancer diagnosis linked with increased risk of death
Men who are diagnosed with prostate cancer and who are also smokers have an associated increased risk of all-cause, cardiovascular and prostate cancer-specific death, according to a study in the June 22/29 issue of JAMA. These patients also had an increased likelihood of prostate cancer recurrence. (2011-06-21)

Corvas presents 3-D molecular structure of matriptase, first structural insight into new class of protease cancer targets
Corvas International, Inc. reported that Company scientists and collaborators have solved the three-dimensional molecular structure of the functional domain of matriptase, a newly identified serine protease target for breast and prostate cancer drug development. This new structural information is expected to facilitate the design of drugs that block or otherwise exploit the activity of matriptase and related proteases. (2001-08-27)

Reviving the protector: new tactic against medulloblastoma
Scientists have a new tactic with potential for fighting medulloblastoma, the most common and most aggressive form of brain tumor in children. (2018-06-11)

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