Antibodies Current Events

Antibodies Current Events, Antibodies News Articles.
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Heart-stopping antibodies
The immune system uses antibodies to target foreign, (2005-01-03)

New edition of classic manual provides insights into development and use of monoclonal antibodies
Just published by CSHL Press, the second edition of the classic lab manual (2013-09-18)

Predicting relapses in patients with autoimmune vascular disease
Patients with an autoimmune disorder called antineutrophil cytoplasmic antibody-associated vasculitis produce antibodies that damage blood vessels in the body. (2018-05-23)

Antibodies from an Ebola survivor reveal a potential new vaccine target
Researchers have harvested a robust collection of antibodies from a survivor of the recent Ebola outbreak, and one subset of antibodies was found to be particularly potent for neutralizing the virus in mice. (2016-02-18)

Antibodies can halve risk of transplant rejection
Giving interleukin-2 receptor antibodies to patients after a kidney transplant can halve the risk of rejection, concludes a study in this week's BMJ. (2003-04-10)

Influenza Nasal Spray Vaccine Produces Local Antibody Response
A recent study presented at the 1998 Society for Pediatric Research Annual Meeting showed that a nasal spray is a more effective method for immunizing against influenza. (1998-05-03)

Ancient gene found to control potent antibody response to retroviruses
A researcher at MIT's Koch Institute for Integrative Cancer research has identified a gene that controls the process by which antibodies gain their ability to combat retroviruses. Edward Browne shows that the gene TLR7 allows the antibody generating B cells to detect the presence of a retrovirus and promotes a process by which antibodies gain strength and potency, called a germinal center reaction. The findings are published in the open-access journal PLoS Pathogens on Oct. 6. (2011-10-06)

New tool for prognosis and choice of therapy for rheumatoid arthritis
In rheumatoid arthritis, antibodies are formed that affect the inflammation in the joints. In an article published today in the journal Annals of the Rheumatic Diseases, researchers at Uppsala University show that antibodies against the cartilage protein collagen II are associated with a good prognosis. (2017-03-23)

Insight into HIV immunity may lead to vaccine
The latest insights into immunity to HIV could help to develop a vaccine to build antibodies' defenses against the disease, a University of Melbourne, Australia, study has found. (2011-05-06)

Zika antibodies from infected patient thwart infection in mice
Researchers have identified neutralizing antibodies against Zika virus from an infected patient that fully protected mice from infection, adding to the current arsenal of antibodies in development for much needed antiviral therapies and vaccines. (2016-12-14)

Three new studies identify neutralizing antibodies against SARS-CoV-2
A trio of papers describes several newly discovered human antibodies that target the SARS-CoV-2 virus, isolated from survivors of SARS-CoV-2 and SARS-CoV infection. (2020-06-15)

Horse antibodies against the bird flu virus H5N1 are effective as treatment in mice
Antibodies against the bird flu virus H5N1, derived from horses, prevent mice infected with H5N1 from dying from the virus. A study published today in the open access journal Respiratory Research ((2006-03-27)

Twin antibodies show neutralizing activity against SARS-CoV-2
Scientists have identified a pair of neutralizing antibodies - isolated from a patient who recovered from COVID-19 - that bind to the glycoprotein spike of the SARS-CoV-2 virus, blocking the spike's ability to bind to the human ACE2 receptor and mediate viral entry into host cells. (2020-05-13)

Detection of antibodies could identify MS pats who do not respond well to interferon beta
Danish research published in this week's issue of THE LANCET highlights how the detection of antibodies to interferon beta-the first choice treatment for multiple sclerosis patients-could be important in identifying patients who do not respond well to interferon beta, with implications for the provision of alternative drug therapy. (2003-10-09)

Engineered anti-toxin antibodies improve efficacy
In this issue of the Journal of Clinical Investigation, Jeffrey Ravetch and colleagues at the Rockefeller University demonstrate that engineering the Fc domain of anti-toxin antibodies increases toxin neutralization activity through enhancing the interaction between toxin-targeting antibodies and the Fc receptor on immune cells. (2014-01-09)

Effective preventive drug against bird flu developed in the mouse
Researchers have developed what could be used as an effective preventive drug against bird flu. In a study published today in the open access journal Respiratory Research, researchers have created antibodies against the avian flu virus H5N1 that work in mice both as a preventive drug, or prophylaxis, when administered before infection, and as a treatment for bird flu. (2006-10-12)

Antibodies from human survivors of Andes hantavirus protect rodents against infection
Jose Garrido and colleagues have isolated antibodies from human survivors of Andes hantavirus (ANDV) infection that protected hamsters against the deadly disease. (2018-11-21)

Immune molecules target swine- and avian-origin influenza
Immune molecules known as antibodies that protect against influenza virus infection target the highly variable influenza protein HA. It is thought the antibodies generated by an individual's immune system protect against only a few closely related influenza viruses. However, new research indicates that some individuals vaccinated with seasonal influenza vaccine produce antibodies that can target the forms of HA used by the deadly H5N1 avian influenza virus and the recent swine-origin pandemic H1N1 influenza virus. (2010-04-12)

Studying nearly 300 recently identified antibodies to SARS-CoV-2 reveals a common theme
An analysis of nearly 300 recently identified human SARS-CoV-2 antibodies uncovered a gene frequently used in antibodies that most effectively target the virus. (2020-07-13)

Antibodies from plants protect against anthrax
Scientists have produced, in tobacco plants, human antibodies that could be used to treat anthrax exposure. They report their findings today at the 2005 American Society for Microbiology Biodefense Research Meeting. (2005-03-22)

Antibody combination puts HIV on the ropes
Researchers have shown that a combination of three antibody drugs can completely suppress HIV in infected mice. The antibodies were isolated from a patient whose immune system mounted an unusually effective response against the virus. (2017-01-25)

Previous exposure to flaviviruses increases effects of Zika
Prior infection with dengue or West Nile virus can enhance the effects of Zika infection, a new study using human samples tested in mice finds. (2017-03-30)

Vanderbilt researchers identify potent antibodies against HIV
Researchers at Vanderbilt University have isolated antibodies with a loop-like structure that binds tightly to HIV and disables it -- even in people who have never been infected by the virus. Using computer modeling, they re-engineered and optimized the antibodies' neutralizing capacity. (2016-04-06)

Ushering an antibody cocktail, designed to reduce antibody resistance, to trial as COVID-19 therapy
Following two studies that screened thousands of human antibodies to SARS-CoV-2 to identify highly potent pairs, in which the antibodies bind non-overlapping regions of the viral target, a resultant antibody cocktail is being tested in human trials. (2020-06-15)

Scientists detect long-lived antibodies in both blood and saliva of patients with COVID-19
Two separate studies have documented the persistence of antibodies that target SARS-CoV-2 in hundreds of patients with COVID-19 at least 3 months after symptom onset. (2020-10-08)

Chopped up proteins trigger autoimmunity
Dutch biochemist Geurt Schilders has mapped several proteins that can regulate the activity of the human exosome and which play a role in the degradation of RNA molecules. (2008-01-24)

Exhausted B cells fail to fight HIV
HIV tires out the cells that produce virus-fighting proteins known as antibodies, according to a human study that will be published online July 14 in the Journal of Experimental Medicine. (2008-07-14)

New longitudinal study documents antibody responses to COVID-19 5 months after symptom onset
A new 5-month longitudinal analysis of 254 COVID-19 patients who displayed a wide range of disease severity - from asymptomatic to deadly illness - suggests that IgA and IgM antibodies to the SARS-CoV-2 virus disappear quickly during convalescence. (2020-12-07)

Preexisting antibodies targeting SARS-CoV-2 discovered in small proportion of uninfected individuals
Scientists have detected preexisting antibody-driven immunity against SARS-CoV-2 in a small proportion of individuals who were uninfected at the time of sampling. (2020-11-06)

Measures needed to reduce bloodborne infections in Irish prisons
There is an urgent need for increased infection control and harm reduction measures to reduce the transmission of hepatitis B and C viruses, and HIV in Irish prisons, concludes a study in this week's BMJ. (2001-11-22)

Human antibodies against spores found by researchers suggest new tool to detect and treat anthrax
Human antibodies against Bacillus spores, of which one species is the cause of anthrax, have been identified by researchers at The Scripps Research Institute (TSRI). These antibodies could be used to detect the presence of anthrax and other harmful spores in powders and to protect those exposed against lethal infections. In the current issue of Proceedings of the National Academy of Sciences, scientists Bin Zhou, Peter Wirsching, and Kim D. Janda describe the antibodies. (2002-04-15)

New lipid-lowering drugs help patients reduce LDL cholesterol
A recent analysis indicates that adding new therapies called anti-PCSK9 antibodies to other lipid-lowering treatments can help patients lower their LDL cholesterol levels. (2016-08-01)

The SARS-CoV-2 receptor binding domain may provide a specific and sensitive target for population
A new analysis of blood sera taken from 63 COVID-19 patients, 71 controls, and various coronavirus-exposed animals provides strong support for the use of the SARS-CoV-2 virus' receptor-binding domain (RBD) as an antigen for reliable tests to detect antibodies to the virus. (2020-06-11)

Sugar governs how antibodies work in the immune system
Antibodies protect the body against diseases -- but can also harm their own organism if the reactions are misdirected. Researchers from the University of Zurich have now discovered that a particular sugar in the antibodies determines whether one of the body's own cells is destroyed or not. This result could lead to new treatment possibilities for patients with autoimmune diseases. (2015-10-06)

New antibodies for cancer treatment
A research team at Aarhus University, Denmark, has developed 10 new antibodies that can possibly be used in the battle against cancer. They work by inhibiting the body's blood vessel formation close to the tumor, which is thereby cut off from oxygen and nutrient supply. Up to now, the researchers have tested some of the antibodies on mice and, in the laboratory they have succeeded in using them to stop the development of malignant tumors. (2015-01-20)

Mice with human body's defenses
Therapeutic antibodies can be an efficient alternative when common drugs do not work anymore. However, antibodies obtained from blood of animals such as mice could not be used: The human immune system recognizes them as foreign and rejects them. In an international cooperation, scientists from the Helmholtz Centre for Infection Research in Braunschweig, Germany, have now succeeded in developing a promising approach to solve this problem. (2010-10-05)

ETH Zurich researchers develop antibody test
A person's immune system can form antibodies against sugar molecules on the malaria pathogen, which protect against serious illness. A new blood test developed by a team of ETH Zurich and Swiss Tropical Institute researchers headed by Professor Peter Seeberger enables these antibodies to be detected. The researchers' work was published online in the journal Nature Chemical Biology on March 2, 2008. (2008-03-03)

A key to pregnancy-associated malaria
A malaria protein that traps infected cells in the placenta may provide a promising new target for a vaccine against pregnancy-associated malaria (PAM). Salanti and colleagues show that the malaria protein VAR2CSA is displayed on malaria-infected cells that bind to the placenta, as they report in the November 1 issue of The Journal of Experimental Medicine. This causes a dangerous infection, which puts both mother and developing child at risk. (2004-11-01)

Killer immune cells that halt malaria could hold key to new vaccines
Scientists have revealed that immune cells called natural killer (NK) cells may play a key role in ridding the body of malaria-infected blood cells, a study in eLife reports. (2018-06-26)

Bacterial proteins cause autoimmunity in the antiphospholipid syndrome
Blank and colleagues previously found a sixth amino acid antigenic determinant associated with antibodies from people with the autoimmune disorder antiphospholipid syndrome (APS). Since close matches to this short sequence exist in proteins from a variety of common human pathogens, they set out to test the possibility that molecular mimicry between the bacterial proteins and the endogenous host protein explains the loss of self-tolerance in APS patients. (2002-03-13)

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