Antidepressant Current Events

Antidepressant Current Events, Antidepressant News Articles.
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Aerobic exercise has antidepressant treatment effects
An analysis of randomized controlled clinical trials indicates that supervised aerobic exercise has large antidepressant treatment effects for patients with major depression. The systematic review and meta-analysis is published in Depression and Anxiety. (2018-10-18)

Antidepressant use begins years before Alzheimer's diagnosis
Antidepressants are frequently initiated in persons with Alzheimer's disease already before the diagnosis, shows a recent study from the University of Eastern Finland. (2016-03-04)

Depression and antidepressants are associated with an increased risk of VTE
In the first review of its kind, new research has found that depression and the use of antidepressants are each associated with an increased risk of venous thromboembolism (VTE). The study led by academics from the Musculoskeletal Research Unit at the University of Bristol has also shown that each of the various classes of antidepressant medications are associated with an increased risk of VTE. (2018-07-24)

Overprescribing of antidepressant medications may be common in elderly patients
In a Pharmacology Research & Perspectives study of individuals living in Olmsted County, Minnesota from 2005-2012, potential overprescribing of antidepressant medications occurred in nearly one-quarter of elderly residents. (2019-01-24)

Antidepressants commonly and increasingly prescribed for nondepressive indications
In a study appearing in the May 24/31 issue of JAMA, Jenna Wong, M.Sc., of McGill University, Montreal, Canada, and colleagues analyzed treatment indications for antidepressants and assessed trends in antidepressant prescribing for depression. (2016-05-24)

Discovery of hippocampal mossy cell involvement to maximize antidepressant effects
Professor Yong-Seok Oh's team at the DGIST Department of Brain-Cognitive Science clarified the expression of antidepressant efficacy by modulating hippocampal mossy cells. Expects to provide a basis to understand the mechanism of existing anti-depressants and contribute greatly to the development of next generation depression treatment. (2019-05-24)

New review of studies shows no link between prenatal antidepressant exposure and autism
A mother's use of antidepressants during pregnancy does not appear to increase her child's risk for autism, according to a new meta-analysis by Jeffrey Newport, M.D., published in the American Journal of Psychiatry. (2020-05-07)

Proof that antidepressants and breastfeeding can mix
Researchers have found that women on antidepressants are more successful at breastfeeding their babies if they keep taking the medication. (2014-04-10)

Pain common side effect of depression
Physical symptoms are nearly as common as emotional ones in patients suffering from depression, according to Indiana University School of Medicine research published in the August issue of the Journal of General Internal Medicine. (2004-08-24)

Antidepressant use increases hip fracture risk among elderly
Antidepressant use nearly doubles the risk of hip fracture among community-dwelling persons with Alzheimer's disease, according to a new study from the University of Eastern Finland. The increased risk was highest at the beginning of antidepressant use and remained elevated even four years later. The findings were published in the International Journal of Geriatric Psychiatry. (2017-01-11)

Antidepressant effects of ketamine
New preclinical evidence was put forward by investigators in a series of presentations at the recent meeting of the American College of Neuropsychopharmacology suggest that the a metabolite of ketamine can produce antidepressant-like effects in a mouse model of depression. The metabolite is produced when ketamine is broken down in the body. This finding may lead to further research to better understand ketamine's efficacy in depression and its potential side effects. (2016-12-08)

Novel mode of antidepressant action may help patients unresponsive to SSRIs
Research at Osaka University identified a novel mode of action for a potential antidepressant that also leads to nerve cell growth in the mouse hippocampus. The activator of a serotonin receptor uses a different mechanism to the most commonly used antidepressants, SSRIs. This is a promising finding for the millions of patients who do not respond well to current treatments. (2017-04-25)

Anti-inflammatory drugs reduce effectiveness of SSRI antidepressants
A study in mice and in a human population shows that use of anti-inflammatory drugs reduces the effectiveness of SSRIs, the most widely used class of antidepressant medications. (2011-04-25)

Trajectories of antidepressant medication use during pregnancy
In an analysis of women who started pregnancy when taking antidepressant medications, investigators identified three trajectories of antidepressant dispensing during pregnancy: more than half stopped their treatment, a quarter maintained their treatment throughout pregnancy, and one-fifth discontinued it for a minimum of three months and then resumed it during the postpartum period. (2020-08-05)

Antidepressant medication does not increase the risk of autism
A large Danish study shows that pregnant women's use of antidepressant medication does not increase the risk of having children with autism. In this way the study refutes earlier studies, which had demonstrated a connection. (2013-11-22)

Why is ketamine an antidepressant?
Delving deep inside the neural circuitry of 'depressed' mice, researchers have revealed how ketamine works in cells to achieve its fast-acting antidepressant effect. (2019-04-11)

Study shows more seniors using antidepressants
Senior citizens, especially women, are more likely to use antidepressants as they get older, according to a study in the Journal of the American Geriatrics Society. (1999-12-12)

Nicotine shows anti-depressant effects in an animal model of depression
Scientists correlate behavioral findings in lab animals with chemical changes in the brain, and discuss nicotine's impact on the depressed brain. (2002-04-20)

Antipsychotics for treating adult depression linked with higher mortality
Rutgers researchers, together with colleagues at Columbia University, have reported an increased mortality risk in adults with depression who initiated augmentation with newer antipsychotic medications compared to a control group that initiated augmentation with a second antidepressant. (2020-09-30)

Prescriptions for antidepressants increasing among individuals with no psychiatric diagnosis
A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health examines national trends in antidepressant prescribing and finds much of this growth was driven by a substantial increase in antidepressant prescriptions by non-psychiatrist providers without any accompanying psychiatric diagnosis. (2011-08-04)

Having an abortion does not lead to depression
Having an abortion does not increase a woman's risk for depression, according to a new University of Maryland School of Public Health-led study of nearly 400,000 women. Previous research has found abortion does not harm women's mental health, yet studies claiming that it does have been used to justify state policies that restrict access to abortion in the US. This study's findings, published in JAMA Psychiatry, suggest those policies are misguided. (2018-05-30)

Researcher awarded $1.8 million grant to study gender differences in antidepressant effects
A Florida State University College of Medicine researcher is investigating why ketamine, used as an antidepressant for the last decade, requires a higher dosage to improve depression in males. (2013-08-15)

Arthritis drug boosts effectiveness of antidepressant medication, Loyola study finds
Giving severely depressed patients the arthritis drug celecoxib (Celebrex®) dramatically boosted the effectiveness of their antidepressant medication, a Loyola study has found. (2016-11-10)

The effects of St. John's Wort (Hypericum perforatum)
Hypericum (St.John's Wort) is a plant that has been widely used as an over the counter treatment for depression. In this article researchers from Australia have synthesized existing knowledge on the biochemical and biological effects of this plant that might help explain its reported antidepressant effects. (1999-08-31)

Antidepressant use increases risk of head injuries among persons with Alzheimer's disease
Antidepressant use is associated with an increased risk of head injuries and traumatic brain injuries among persons with Alzheimer's disease, according to a new study from the University of Eastern Finland. Antidepressant use has previously been linked with an increased risk of falls and hip fractures, but the risk of head injuries has not been studied before. The results were published in Alzheimer's Research & Therapy. (2017-08-09)

In treatment of depression, cognitive therapy and medication both effective
Cognitive therapy, when provided by an experienced therapist, may be as effective as antidepressant medications in the initial treatment of moderate to severe major depression, according to an article in the April issue of Archives of General Psychiatry, one of the JAMA/Archives journals. (2005-04-04)

Risk of suicide, suicide attempt similar across types of antidepressant medication
Among adults beginning antidepressant therapy, the risk of suicide or suicide attempts does not appear to vary by individual type or class of medication, according to a report in the May issue of Archives of General Psychiatry, one of the JAMA/Archives journals. (2010-05-03)

FDA warnings affected prescriptions of antidepressants to youth
US Food and Drug Administration warnings regarding the risk of suicidal thoughts and behaviors in children and adolescents taking antidepressants appear to have had modest and targeted effects on the intended populations, according to a report in the January issue of Archives of General Psychiatry, one of the JAMA/Archives journals. (2008-01-07)

New drug shows potential as a different kind of antidepressant in mouse trials
A potential new antidepressant and antianxiety treatment with a unique mechanism of action has been developed by scientists at the University of Bath. (2017-11-06)

Weight gain following antidepressant use examined
Bottom line: A modest differences exist between antidepressants with regard to weight gain among patients. (2014-06-04)

Study compares switching meds vs. an additional med for patients unresponsive to an antidepressant
Among patients unresponsive to an antidepressant medication, adding the antipsychotic aripiprazole modestly increased the likelihood of remission from depression compared to switching to the antidepressant bupropion, according to a study published by JAMA. (2017-07-11)

Antidepressants stimulate new nerve cells in adult monkeys, may have implications for humans
In adult monkeys, an antidepressant treatment has induced new nerve cell growth in the hippocampus, a brain area responsible for learning and memory. A similar process may occur in humans, the research suggests, and may help explain the effectiveness of antidepressant treatments. (2007-05-04)

Study finds association between antidepressant use in pregnancy and diagnosis of psychiatric disorde
Antidepressant use during pregnancy is associated with increased risk of psychiatric disorder diagnosis in children compared to children born to mothers with no record of antidepressant use during pregnancy, finds a study published in The BMJ today. (2017-09-06)

UT Southwestern researchers uncover why ketamine produces a fast antidepressant response
UT Southwestern Medical Center scientists are shedding new light on why the anesthetic drug ketamine produces a fast-acting antidepressant response in patients with treatment-resistant depression. (2011-06-16)

A tiny molecule may help battle depression
Levels of a small molecule found only in humans and in other primates are lower in the brains of depressed individuals, according to researchers at McGill University and the Douglas Institute. This discovery may hold a key to improving treatment options for those who suffer from depression. (2014-06-08)

Regular follow-up important during antidepressant treatment
Because individuals can react differently to antidepressant medications, regular follow-up is important during the first few weeks of treatment, according to an editorial by Group Health psychiatrist and researcher Greg Simon, M.D., M.P.H. Simon's advice, published in the November issue of the American Journal of Psychiatry, comes amidst several recent conflicting studies on the link between antidepressant use and suicide risk in children and adolescents. (2006-11-01)

Most off-label antidepressant prescriptions lack strong scientific evidence
Most off-label antidepressant prescriptions lack strong scientific evidence, finds a study published by The BMJ today. (2017-02-21)

Drug combination for treatment resistant depression no more effective than single
A large clinical trial published in the British Medical Journal today, looked at the effectiveness of adding mirtazapine to an SSRI or SNRI in patients who remain depressed after at least six weeks of conventional (SSRI or SNRI) antidepressant treatment. They found that this combination was no more effective in improving depression than placebo and call on doctors to rethink its use. (2018-11-01)

High-fat diet may cause changes in the brain that lead to anxiety and depression
A new study in mice reveals that increased body weight and high blood sugar as a result of consuming a high-fat diet may cause anxiety and depressive symptoms and measurable changes in the brain. (2015-10-19)

New study rebuts the claim that antidepressants do not work
A theory that has gained considerable attention in international media, including Newsweek and the CBS broadcast 60 minutes, suggest that antidepressant drugs, such as the SSRIs, do not exert any actual antidepressant effect. A research group at the Sahlgrenska Academy has now analyzed data from clinical trials and can rebut this theory. (2017-08-18)

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