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Antidepressant Current Events, Antidepressant News Articles.
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New drug can ease the side effects of medication against severe depression
Today, severe depressions require a high dose of antidepressants. However, the high dose may also cause serious side effects. Now, researchers from the University of Copenhagen have found a substance that may ease the side effects while preserving the therapeutic effect. (2020-03-20)

Intervention does not improve depression symptoms
Among depressed patients evaluated in a primary care setting, use of an interactive multimedia computer program immediately prior to a primary care visit resulted in the increased receipt of antidepressant prescription recommendation, mental health referral, or both; however, it did not result in improvement in mental health at 12-week follow-up, according to a study in the Nov. 6 issue of JAMA. (2013-11-05)

Learned safety cheers depressed mice: An animal model of behavioral intervention for depression
A new animal model has provided insight into the cellular and molecular mechanisms associated with behavioral therapy for depression. The study, published by Cell Press in the Oct. 9 issue of Neuron, may provide a good model system for testing cellular and molecular interactions between antidepressive medications and behavioral treatments for depression. (2008-10-08)

Antidepressant use increasing in the United States
A marked and broad expansion in antidepressant treatment occurred among Americans older than 6 years between 1996 and 2005, although treatment rates remain low among racial and ethnic minorities, according to a report in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals. (2009-08-03)

Worrying rise in use of antidepressants in children
The use of antidepressant drugs in children is increasing, although evidence for their effectiveness and safety in children and adolescents is scant and widely debated, particularly for selective serotonin reuptake inhibitors (SSRIs) argue researchers in a letter to this week's BMJ. (2004-03-18)

Are older antidepressants better for depression in Parkinson's disease?
A new study shows that antidepressant drugs which only affect serotonin, often used as first choice treatments, may not be best for depression in people with Parkinson's disease. The new research is published in the Dec. 17, 2008, online issue of Neurology, the medical journal of the American Academy of Neurology. Depression affects up to 50 percent of people with Parkinson's disease. (2008-12-17)

Does the brain 'remember' antidepressants?
Using a placebo pill identical to the real thing, UCLA researchers have found that how the brain responds to antidepressant medication may be influenced by its remembering past antidepressant exposure. (2012-03-26)

Suicide risk does not increase when adults start using antidepressants, study finds
The risk of serious suicide attempts or death by suicide generally decreases in the weeks after patients start taking antidepressant medication, according to a study led by Group Health Cooperative researchers and published in the January issue of the American Journal of Psychiatry. The study also found that the risk of suicidal behavior after starting 10 newer antidepressant medications is less than the risk posed by older medications. These findings challenge a 2004 FDA advisory. (2006-01-01)

Antidepressant drugs may protect brain from damage due to depression
Studying women with histories of clinical depression, investigators at Washington University School of Medicine in St. Louis found that the use of antidepressant drugs appears to protect a key brain structure often damaged by depression. (2003-08-01)

Researchers link age, general health and antidepressant use with eye disorders
Abnormal binocular vision, which involves the way eyes work together as a team, increases dramatically as we age, according to research from the University of Waterloo. The study also found a correlation between this condition, general health and antidepressant use. (2014-05-01)

New research: Ketamine activates opioid system to treat depression
A new study appearing online today from the American Journal of Psychiatry finds that ketamine's acute antidepressant effect requires opioid system activation, the first time that a receptor site has been shown in humans to be necessary for any antidepressant's mechanism of action. While opioids have been used historically to treat depression, they are known to carry a high risk of dependence. (2018-08-29)

Substance present in ayahuasca brew stimulates generation of human neural cells
Human neural progenitors exposed to harmine, an alkaloid presented at the psychotropic plant decoction ayahuasca, led to a 70 percent increase in proliferation of these cells. The effect of generating new human neural cells involves the inhibition of DYRK1A, a gene that is over activated in patients with Down syndrome and Alzheimer's Disease. Thus harmine could have a potential neurogenesis role and possibly a therapeutic one over cognitive deficits. (2016-12-07)

Effectiveness of certain antidepressants may be influenced by gene variations of individuals
Whether specific types of antidepressants are effective for patients with late-life major depression may depend if they have certain genetic variations, according to a study in the Oct. 4 issue of JAMA. (2006-10-03)

Newer antidepressants not necessarily safest for older people
New generation antidepressants, known as selective serotonin reuptake inhibitors are associated with an increased risk of several severe adverse outcomes in older people compared with older tricyclic antidepressants, finds a study published online today. (2011-08-02)

Antidepressant use during pregnancy not associated with increased risk of autism, ADHD in children
Two studies published by JAMA examine the risk of autism and other adverse birth outcomes among women who use antidepressants during pregnancy. (2017-04-18)

Children and teens taking antidepressants might be more likely to attempt, complete suicide
Antidepressant medications may be associated with suicide attempts and death in severely depressed children and adolescents but not in adults, according to an article in the August issue of Archives of General Psychiatry, one of the JAMA/Archives journals. (2006-08-07)

Can treatment for depression after a heart attack reduce the long-term risk of another cardiac event
Depression has been associated with poorer medical outcomes for patients with acute coronary syndrome (ACS), including heart attack and unstable angina. This randomized clinical trial of 300 patients in South Korea examined whether antidepressant treatment after ACS improved long-term cardiac outcomes. (2018-07-24)

Antidepressant drug alleviates hot flashes in men undergoing prostate cancer treatment
Venlafaxine, an antidepressant drug, helps reduce the incidence of hot flashes in men undergoing androgen- deprivation therapy for prostate cancer, according to a recent Mayo Clinic report published in the Journal of Urology (1999-09-03)

Costs of antidepressants could have funded effective alternatives
Some of the costs of prescribing antidepressant drugs over the last decade could have been used to deliver psychological treatments of proven effectiveness, finds a study published online by the BMJ today. (2005-03-17)

Suicidality test being brought to market
The new test, based on research carried out at the Max Planck Institute of Psychiatry, should help doctors to decrease the risk of suicidality in patients treated with antidepressants who show certain gene markers. (2013-12-12)

Taking antidepressants during pregnancy not associated with neonatal problems at 2-4 weeks
Babies exposed to an antidepressant or a mood disorder during fetal life did not have any more signs of irritability, difficulty feeding, sleep disturbances and respiratory problems two to four weeks after birth than babies who were not exposed. Instead, the major factor associated with newborn problems was preterm birth, according to a new Northwestern Medicine study. (2017-06-01)

Women with major depression at risk of relapse during pregnancy
Contrary to a common belief that the hormonal changes associated with pregnancy provide a protective effect against depression, women with major depression who discontinue antidepressant medication during pregnancy are at risk of relapse, according to a study in the February 1 issue of JAMA. (2006-01-31)

Insights into depression could aid development of new treatments
Fresh insights into changes in the brain linked to depression could pave the way for new therapies. The University of Edinburgh study also sheds light on why a certain category of antidepressant drugs stop working in some people. (2018-02-26)

Prenatal exposure to certain antidepressants may modestly increase risk of autism spectrum disorders
Prenatal exposure to selective serotonin reuptake inhibitors, especially during the first trimester, is associated with a modest increase the risk of developing an autism spectrum disorder, according to a report published Online First in the Archives of General Psychiatry, one of the JAMA/Archives journals. (2011-07-04)

Nursing home residents at heightened risk of falling in the days following
Nursing home residents taking certain antidepressant medications are at an increased risk of falling in the days following the start of a new prescription or a dose increase of their current drug, according to a new study by the Institute for Aging Research of Hebrew SeniorLife, an affiliate of Harvard Medical School. (2011-07-15)

Inflammation, depression and antidepressant response: Common mechanisms
In findings published electronically in Molecular Psychiatry, researchers from University of Miami found polymorphisms in inflammation-related genes that are associated with susceptibility to major depression and antidepressant response. Two genes critical for T cell function in the immune system have been associated with susceptibility for major depressive disorder and antidepressant treatment response: PSMB4 (proteasome beta 4 subunit) and TBX21 (T-bet). (2008-05-29)

Induction of adult cortical neurogenesis by an antidepressant
The production of new neurons in the adult normal cortex in response to the antidepressant, fluoxetine, is reported in a study published online this week in Neuropsychopharmacology. (2013-01-04)

Scientists find new path in brain to ease depression
Scientists have discovered a new pathway in the brain that can be manipulated to alleviate depression. The pathway offers a promising new target for developing a drug that could be effective in individuals for whom other antidepressants have failed. New antidepressant options are important because a significant number of patients don't adequately improve with currently available antidepressant drugs. (2016-10-05)

A potential new class of fast-acting antidepressant
More than one in 10 Americans take antidepressants, but these medications can take weeks -- and for some patients, months -- before they begin to alleviate symptoms. Now, scientists from the University of Chicago have discovered that selectively blocking a serotonin receptor subtype induces fast-acting antidepressant effects in mice, indicating a potential new class of therapeutics for depression. The work was published Oct. 29 in Molecular Psychiatry. (2013-10-29)

Are antidepressants overused?
Antidepressant prescriptions in the UK have increased by 9.6 percent in 2011, to 46 million prescriptions. Does this reflect overmedicalisation or appropriate treatment? Two experts debate the issue on today. (2013-01-22)

Mouse study identifies new method for treating depression
Standard antidepressant medications don't work for everyone, and even when they do they are slow to kick in. In an effort to find better depression treatments, researchers at University of California San Diego School of Medicine discovered that inhibiting an enzyme called Glyoxalase 1 (GLO1) relieves signs of depression in mice. Moreover, inhibiting GLO1 worked much faster than the conventional antidepressant Prozac. (2017-03-21)

Brain activity prior to treatment flags vulnerability to antidepressant side effects
In a finding that opens new doors to determining susceptibility to antidepressant side effects, researchers at the UCLA Neuropsychiatric Institute report that changes in brain activity prior to treatment with antidepressants can flag patient vulnerability. The study is the first to link brain function and medication side effects, and to show a relationship between brain function changes during brief placebo treatment and later side effects during treatment with medication. (2005-03-30)

Antidepressant use in pregnant women linked to small increase in autism
Antidepressant use in pregnant women was linked to increased cases of autism in their children, though the absolute risk appeared to be small. (2017-07-24)

Adult stem cell study shows fish oil may help with depression
A study published in Molecular Psychiatry shows that patient-derived adult stem cells can be used to model major depressive disorder and test how a patient may respond to medication and that fish oil, when tested in the model, created an antidepressant response. (2020-06-11)

Antidepressant medications appear to be generally safe
Antidepressants are generally safe, according to a new study by an international team of researchers. By assessing evidence from 45 meta-analyses, which combined the results from many studies, the researchers did not find strong evidence of adverse health outcomes associated with antidepressant use. The findings have been published in JAMA Psychiatry. (2019-10-02)

Antidepressants enhance neuronal plasticity in the visual system
In the April 18 issue of Science, scientists from the Scuola Normale Superiore in Pisa, Italy and the Neuroscience Centre at the University of Helsinki, Finland, provide new information about the mechanism of action of antidepressant drugs. In addition, the study suggests that antidepressants could also be used for the treatment of amblyopia. However, to produce a functional effect, antidepressant treatment also seems to require environmental stimuli, such as rehabilitation or therapy. (2008-04-17)

Algorithm identifies patients best suited for antidepressants
Results of a new study bring us closer to identifying individuals likely to benefit from antidepressants. (2018-07-17)

Depressed patients should be allowed to choose their treatment
Generic counselling appears to be as effective as antidepressant drugs for major depression, although patients given drugs may recover more quickly, according to a study in this week's BMJ. (2001-03-29)

Anti-inflammatory agents can effectively and safely curb major depressive symptoms
Anti-inflammatory agents, such as aspirin/paracetamol, statins, and antibiotics, can safely and effectively curb the symptoms of major depression, finds a pooled analysis of the available evidence, published online in the Journal of Neurology Neurosurgery & Psychiatry. (2019-10-28)

When physical and mental health problems co-occur and money gets tight, which prescriptions go unfilled?
A new study from CAMH points to a troubling connection between out-of-pocket expenses for people contending with both physical illnesses and depression, affecting access to antidepressant treatment. (2009-04-07)

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