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Cholesterol-reducing drugs may lessen brain function, says ISU researcher
An Iowa State University study shows that drugs that inhibit the liver from making cholesterol may also keep the brain from making cholesterol, which is vital to efficient brain function. (2009-02-23)

Researchers identify a cell type that limits stroke damage
A research team including Serge Rivest of University Laval's Faculty of Medicine has demonstrated the existence of a type of cells that limits brain damage after a stroke. The study was recently published in the online version of Nature Medicine. (2009-01-27)

Increasingly complex mini-brains
Scientists improved the initial steps of a standard protocol and produced organoids displaying regionalized brain structures, including retinal pigmented cells. The announcement was published today in BMC Developmental Biology by the D'Or Institute for Research and Education's team. (2019-03-07)

'Housekeepers' of the brain renew themselves more quickly than first thought
Cells in the brain responsible for detecting and fixing minor damage renew themselves more quickly than previously thought, new research has shown. (2017-01-10)

Local inflammatory cells are characteristic for advanced multiple sclerosis
In the brains of people that suffer from long-term multiple sclerosis (MS), inflammatory cells are not entering the brain via the bloodstream anymore. Instead, the cells arise from local memory cells in the brain. Nina Fransen and her colleagues of the Netherlands Institute for Neuroscience show this in a recently published article in the scientific journal Brain. (2020-05-14)

Post brain injury: New nerve cells originate from neural stem cells
In the study group of Dr. Magdalena Goetz in the Institute of Stem Cell Research of the Helmholtz Zentrum Muenchen and Ludwig Maximilians-University Munich, another step has been taken towards the understanding of processes to be able to substitute for injured brain cells after accidents. Stem cells that originate from supporting cells can evolve again into new nerve cells. (2008-03-11)

Anti-cancer drug damages brain vessels
New research may help explain why an anti-cancer drug causes potentially fatal brain inflammation in certain patients. Scientists at Harvard Medical School mimicked the drug's activity in mice and found that it damaged the cell lining that prevents fluid from leaking from the spinal cord into the brain. The results will be published online on Feb. 11 in the Journal of Experimental Medicine. (2008-02-11)

Memory decline after head injury may be prevented by slowing brain cell growth
Rutgers scientists say a new study indicates that the excessive burst of new brain cells after a traumatic head injury that researchers have traditionally believed helped in recovery could instead lead to epileptic seizures and long-term cognitive decline. (2017-09-15)

Prion protein hints at role in aiding learning and memory
Scientists from the University of Leeds have found that the protein called prion helps our brains to absorb zinc, which is believed to be crucial to our ability to learn and the well-being of our memory. (2012-10-16)

Adult stem cells shown to develop into all brain cell types
Researchers at the University of Minnesota provide evidence for the first time that stem cells derived from adult bone marrow and injected into the blastocyst of a mouse can differentiate into all major types of cells found in the brain. (2003-04-25)

CD38 gene is identified to be important in postnatal development of the cerebral cortex
The brain consists of neurons and glial cells. Recent research uncovers the importance of glial cells; their developmental abnormality causes various diseases and aberrant cerebral cortex development. Herein, C38 gene knocking-out is shown to cause aberrant development of glial cells, especially, those called astrocytes and oligodendrocytes. CD38 gene is known to be involved in the cerebral cortex development. The present study suggests the importance of glial cells for the cerebral cortex development. (2017-04-07)

Anti-inflammatory drug blocks brain plaques
An anti-inflammatory drug may help restore brain function in patients with Alzheimer's disease, according to an animal study published today in the Journal of Experimental Medicine. (2008-06-23)

New methods identify and manipulate 'newborn' cells in animal model of Parkinson's disease
A research team from Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute and Lund University in Sweden used an engineered virus to deliver a protein that glows green when exposed to blue light (green fluorescent protein) into newborn cells of the striatum in an animal model of Parkinson's disease. (2008-09-03)

U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
Researchers at the University of Minnesota Medical School and the Brain Sciences Center at the Minneapolis VA Medical Center have discovered a new way to assess how brain networks act together. (2006-02-09)

Stem cells from teeth can make brain-like cells
University of Adelaide researchers have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting they could one day be used in the brain as a therapy for stroke. (2014-04-30)

Scientists surprised to discover lymphatic 'scavenger' brain cells
The brain has its own inbuilt processes for mopping up damaging cellular waste -- and these processes may provide protection from stroke and dementia. University of Queensland scientists discovered a new type of lymphatic brain 'scavenger' cell by studying tropical freshwater zebrafish -- which share many of the same cell types and organs as humans. (2017-05-01)

Discovery of the cell fate switch from neurons to astrocytes in the developing brain
During mammalian brain development, neural precursor cells first generate neurons and later astrocytes. This cell fate change is a key process generating proper numbers of neurons and astrocytes. Here we discovered that FGF regulates the cell fate switch from neurons to astrocytes in the developing cerebral cortex using mice. FGF is a critical extracellular regulator of the cell fate switch, necessary and sufficient, in the mammalian cerebral cortex. (2019-06-21)

Blood flow command center discovered in the brain
An international team of researchers has discovered a group of cells in the brain that may function as a 'master-controller' for the cardiovascular system, orchestrating the control of blood flow to different parts of the body. (2019-05-15)

Barrow scientists identify new stem cell activity in human brain
Researchers at Barrow Neurological Institute at St. Joseph's Hospital and Medical Center have identified a new pathway of stem cell activity in the brain that represents potential targets of brain injuries affecting newborns. The recent study, which raises new questions of how the brain evolves, is published in the current issue of Nature, one of the world's most cited scientific journals. (2011-09-28)

Do viruses make us smarter?
A new study from Lund University in Sweden indicates that inherited viruses that are millions of years old play an important role in building up the complex networks that characterize the human brain. (2015-01-12)

Brain teaser: 3-D printed 'tissue' to help combat disease
A bench-top brain that accurately reflects actual brain tissue would be significant for researching not only the effect of drugs, but brain disorders like schizophrenia, and degenerative brain disease. Our researchers at the ARC Centre of Excellence for Electromaterials Science have made progress in this area, 3-D printing a six-layered structure like brain tissue, in which cells are accurately placed and remain in their designated layer. (2015-08-02)

Astrocytes affect brain's information signaling
Astrocytes are the most common type of cell in the brain and play an important role in the function of neurons -- nerve cells. New research from the University of Gothenburg, Sweden, shows that they are also directly involved in the regulation of signaling between neurons. (2010-06-14)

Moderate alcohol consumption enhances the formation of new nerve cells
Moderate alcohol consumption over a relatively long period of time can enhance the formation of new nerve cells in the adult brain. The new cells could prove important in the development of alcohol dependency and other long-term effects of alcohol on the brain. The findings are published by Karolinska Institutet. (2005-04-26)

Brain metastases cause severe brain damage that can be inhibited by treatment
By using a specific treatment to override this activation, the researchers were able to return cerebrovascular flow to healthy levels. This improvement in blood flow around the metastases can limit the neurological deterioration associated with the progression of this disease and improve the otherwise poor life expectancy of these patients. (2020-11-12)

Rutgers neuroscientist says protein could prevent secondary damage after stroke
Rutgers University neuroscientist Bonnie Firestein says a protein that regulates nerve cells and assists in overall brain function may be key to preventing the long-term damage of stroke and hopes her work leads to the development of an effective therapeutic intervention. (2011-11-02)

'Sleeping' stem cells could aid brain repair
Scientists at the Wellcome Trust/ Cancer Research UK Gurdon Institute, University of Cambridge, have identified a new type of stem cell in the brain which they say has a high potential for repair following brain injury or disease. (2018-04-05)

Scientists discover a new type of brain cell that could help detect distance
A new kind of brain cell has been discovered which will help to understand how we remember where we left objects, such as car keys and mobile phones. (2020-12-21)

Lobachevsky University scientists create a neurochip for replacing damaged areas of the brain
Lobachevsky University researchers are working to create a neurochip capable of transmitting a signal to healthy brain cells. The neurochip can be used in devices intended to replace damaged parts of the brain. First experiments have been conducted to transmit signals from an artificial neuron to living cells of the brain slice, demonstrating the possibility of interfacing between them. (2017-12-05)

Diabetes drug makes brain cells grow
The widely used diabetes drug metformin comes with a rather unexpected and alluring side effect: it encourages the growth of new neurons in the brain. The study reported in the July 6th issue of Cell Stem Cell, a Cell Press publication, also finds that those neural effects of the drug also make mice smarter. (2012-07-05)

Neural stem cells steered by electric fields in rat brain
Electric fields can be used to guide neural stem cells transplanted into the brain towards a specific location. The research, published July 11 in the journal Stem Cell Reports, opens possibilities for effectively guiding stem cells to repair brain damage. (2017-07-11)

How to read brain activity?
Scientists at the Max Planck Institute for Biological Cybernetics in Tuebingen, Germany, have found a crucial link between the activity generated within the brain to that measured with EEG. This finding will provide a better understanding of the waveforms measured with EEG, and thus potentially allow for a better diagnosis and subsequent treatment of patients. (2009-12-07)

Getting cancer drugs to the brain is difficult -- but a new 'road map' might make it easie
Purdue University scientists have provided the first comprehensive characterization of both the blood-brain and blood-tumor barriers in brain metastases of lung cancer, which will serve as a road map for treatment development. The work was recently published in Oncotarget. (2019-11-12)

Researchers visualize the development of Parkinson's cells
In the US alone, at least 500,000 people suffer from Parkinson's disease, a neurological disorder that affects a person's ability to control his or her movement. New technology from the University of Bonn in Germany lets researchers observe the development of the brain cells responsible for the disease. (2012-01-31)

Stem cells from human peripheral blood protect against acute stroke in rats
Enriched stem cells from the circulating blood of human donors improved functional recovery when transplanted into the brains of rats with strokes, report researchers from the University of South Florida and Medical College of Georgia. The researchers conclude the findings support investigating these human peripheral cells for neurotransplantation therapy in stroke patients. (2003-11-12)

Researchers develop new technique for modeling neuronal connectivity using stem cells
Human stem cells can be differentiated to produce other cell types, such as organ cells, skin cells, or brain cells. While organ cells, for example, can function in isolation, brain cells require synapses, or connectors, between cells and between regions of the brain. In a new study published in Restorative Neurology and Neuroscience, researchers report successfully growing multiple brain structures and forming connections between them in vitro, in a single culture vessel, for the first time. (2015-06-15)

Breast cancer cells disguise themselves as neurons to cause brain tumors
Too often, breast cancer cells are discovered growing as new tumors within the brain. Now City of Hope researchers have found how this happens. (2014-01-14)

Brain cancer discovery reveals clues in quest for new therapies
Researchers at the University of Edinburgh have pinpointed two key molecules that drive the growth of an aggressive type of adult brain cancer. The findings shed light on the mechanisms that underpin brain cancer progression and could eventually reveal targets for the development of much-needed therapies, researchers say. (2017-05-10)

Study Illuminates Brain's Ability To "Rewire" Itself After Strokes Or Injuries
The adult brain appears to have a surprisingly strong built- in capacity for change, a study by Vanderbilt University researchers suggests in a paper published in recent issue of Science. (1998-11-17)

Gelatin accelerates healing of the blood brain barrier in acute brain injury
Researchers already know that gelatin-covered electrode implants cause less damage to brain tissue than electrodes with no gelatin coating. Researchers at the Neuronano Research Centre (NRC) at Lund University in Sweden have now shown that microglia, the brain's cleansing cells, and the enzymes that the cells use in the cleaning process, change in the presence of gelatin. (2017-11-06)

Gene study points towards therapies for common brain disorders
University of Edinburgh scientists have pinpointed the cells that are likely to trigger common brain disorders, including Alzheimer's disease, Multiple Sclerosis and intellectual disabilities. The findings offer a roadmap for the development of new therapies to target the conditions. (2016-01-27)

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