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The blood-brain barrier: A misunderstood key to finding life-saving cures to brain disease
A team of international scientists, including a Saint Louis University researcher, demystifies the blood-brain barrier in an article in the Lancet Neurology. (2007-12-17)

Scientists create new map of brain's immune system
A team of researchers under the direction of the Medical Center -- University of Freiburg has created an entirely new map of the brain's own immune system in humans and mice. (2019-02-19)

Dementia study sheds light on how damage spreads through brain
Insights into how a key chemical disrupts brain cells in a common type of dementia have been revealed by scientists led by the University of Edinburgh. (2017-11-20)

Protein involved in nerve-cell migration implicated in spread of brain cancer
The invasion of brain-tumor cells into surrounding tissue requires the same protein molecule that neurons need to migrate into position as they differentiate and mature, according to new research from the University of Illinois at Chicago College of Medicine and published Aug. 7 in the online journal PLOS ONE. (2013-08-07)

Research suggests molecular approaches to brain tumor treatment
Researchers at Wake Forest University Baptist Medical Center have found promising new molecular targets and treatment approaches for some of the most malignant brain tumors. (2005-05-07)

Lieber Institute for Brain Development shares grant to study origins of schizophrenia
Daniel R. Weinberger, M.D., CEO at LIBD explains that 'this type of collaborative research support is fundamental... We must bring together the best minds to bear on the incredibly complex questions in psychiatric illness -- how they come to be and how we get people better. I am particularly grateful for the opportunity to work again with friends Drs. Fred Gage and John Moran, and look forward to the important work our teams will carry out.' (2015-04-29)

Georgia State researchers shed light on fat burning
Researchers at Georgia State University have found that fat cells give feedback to the brain in order to regulate fat burning much the same way a thermostat regulates temperature inside a house. (2009-02-05)

Scientists learn more about how star-shaped brain cells help us learn
A molecule that enables strong communication between our brain and muscles appears to also aid essential communication between our neurons, scientists report. (2016-06-23)

How toxic protein spreads in Alzheimer's disease
Toxic versions of the protein tau are believed to cause death of neurons of the brain in Alzheimer's disease. A new study published in Nature Communications shows that the spread of toxic tau in the human brain in elderly individuals may occur via connected neurons. The researchers could see that beta-amyloid facilitates the spread of toxic tau. (2020-05-29)

Researchers find reduced levels of an important neurotransmitter in MS
Researchers at the University of Illinois at Chicago show for the first time that damage to a particular area of the brain and a consequent reduction in noradrenaline are associated with multiple sclerosis. (2011-02-11)

Rejuvenating the brain's disposal system
A characteristic feature of Alzheimer's disease is the presence of so called amyloid plaques in the patient's brain -- aggregates of misfolded proteins that clump together and damage nerve cells. Researchers from the German Center for Neurodegenerative Diseases (DZNE), Munich and the Ludwig Maximilians University (LMU) Munich have now discovered a strategy to help the brain remove amyloid plaques. The work is published today in The EMBO Journal. (2016-12-21)

OHSU researchers discover new synapses in brain
Oregon Health Sciences University researchers have discovered a new type of synapse taking place in the brain between oligodendrocyte cells and neurons. It is believed that this communication is involved in the development of multiple sclerosis. (2000-05-14)

Promising gene therapy could rejuvenate aging brain networks
Age-related deterioration in critical brain networks may be restored by gene therapy, according to a study in monkeys presented at the American Academy of Neurology's 52nd Annual Meeting in San Diego, CA, April 29 - May 6, 2000. This finding lends support to a study just underway to treat Alzheimer's disease using a similar gene therapy approach, say the study's authors. (2000-04-29)

Blood clotting protein triggers immune attack on the brain
A new study from the Gladstone Institutes shows that a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis. This is the first demonstration that introduction of blood in the healthy brain is sufficient to cause peripheral immune cells to enter the brain, which then go on to cause brain damage. (2015-10-09)

Enzyme controlling cell death paves way for treatment of brain damage in newborns
Brain damage due to birth asphyxia -- where the brain is starved of oxygen around the time of delivery -- is normally treated by cooling the infant, but this only helps one baby in nine. New research from the Sahlgrenska Academy at the University of Gothenburg, Sweden, could now pave the way for new ways of treating brain damage in newborns. (2011-10-25)

Transplanted nerve cells survive a quarter of a century in a Parkinson's disease patient
In the late 1980s and over the 1990s, researchers at Lund University in Sweden pioneered the transplantation of new nerve cells into the brains of patients with Parkinson's disease. The outcomes proved for the first time that transplanted nerve cells can survive and function in the diseased human brain. Some patients showed marked improvement after the transplantation while others showed moderate or no relief of symptoms. A small number of patients suffered unwanted side-effects in the form of involuntary movements. (2016-05-03)

Sex differences in brain activity alter pain therapies
A female brain's resident immune cells are more active in regions involved in pain processing relative to males, according to a recent study by Georgia State University researchers. (2017-03-02)

Toxins from diseased brain cells make diseases of the brain even worse
Sometimes our immune defense attacks our own cells. When this happens in the brain we see neurodegenerative diseases such as dementia, Alzheimer's and Parkinson's disease. But if the the immune defense is inhibited, the results could be disastrous. Researchers at the University of Copenhagen have now discovered one of the molecular combat mechanisms in the brain that gets out of control in these diseases. In time this may enable targeted therapies to slow down the disease without harming the patient. (2012-02-22)

Knowing where the center of a space is helps inform spatial awareness
As you enter a new environment such as visiting a classroom for the first time, your brain takes in information about your surroundings to help inform where you are and what direction you are facing. Knowing where the center of the room is located helps provide a reference point for processing space. A Dartmouth study published in Science provides new insight into navigation and spatial learning by examining how the rat brain processes spatial information. (2019-08-02)

Map of a billion brain links reveals clues about how we think
Scientists have created an elaborate map of more than a billion brain cell connections, helping to shed light on how memories are formed and recalled. (2018-08-02)

Unexpected associations found between drug response and cell changes in brain cancer
Therapies for treating glioblastoma brain cancer can be delivered with greater precision and existing drugs can be used in new ways. These are the conclusions from a study from Uppsala University investigating a large number of cell samples from patients with brain tumours. The researchers have characterised how changes in glioblastoma cells influence the effect of different drugs. Their findings are published in the journal Cell Reports. (2020-07-14)

Using human brain cells to make mice smarter
What happens when human brain cells that surround and support neurons are implanted into the brains of newborn mice? Researchers reporting in the March 7th issue of the Cell Press journal Cell Stem Cell recently found that such mice had enhanced learning and memory when compared with normal mice that hadn't received the transplanted human cells. The findings indicate that these supportive cells, called glia, play an important role in human cognition. (2013-03-07)

Brain size may depend upon how neural cells are cleaved
Howard Hughes Medical Institute researchers have discovered a novel way in which the brain size of developing mammals may be regulated. They have identified a signaling pathway that controls the orientation in which dividing neural progenitor cells are cleaved during development. The researchers speculate that this type of regulatory decision point may play a powerful role in determining the ultimate size of the mammalian brain. (2005-07-14)

SLU research implicates natural toxin as triggering Parkinson's disease
In new research from Saint Louis University, investigators have found evidence that a toxin produced by the brain is responsible for the series of cellular events that lead to Parkinson's disease. (2011-02-10)

Treating dementia with the healing waves of sound
Ultrasound applied to the brain could help treat patients with dementia. (2018-07-19)

New discovery for how the brain 'tangles' in Alzheimer's Disease
University of Queensland researchers have discovered a new 'seeding' process in brain cells that could be a cause of dementia and Alzheimer's disease. (2021-02-01)

Human umbilical cord blood cells found to enhance survival and maturation of key brain cells
In vitro studies examining the activity of human umbilical cord blood cells (HUCB) on experimental animal models of central nervous system aging, injury and disease, have shown that HUCBs provide a (2010-12-14)

Researchers apply brainpower to understanding neural stem cell differentiation
How do humans and other mammals get so brainy? In a paper that will be published in Cell Reports on October 24, USC researcher Wange Lu, Ph.D., and his colleagues explained how neural stem and progenitor cells differentiate into neurons and related cells called glia. Neural stem and progenitor cells offer tremendous promise as a future treatment for neurodegenerative disorders, and understanding their differentiation is the first step towards harnessing this therapeutic potential. (2013-10-24)

Study details how cocaine works in the brain, offers possibility of drug to treat addiction
A research team led by the University of Colorado Boulder has discovered a mechanism in the brain that is key to making cocaine seem pleasurable, a finding that could lead to a drug treatment for fighting addiction. (2015-02-03)

Cell of origin affects malignancy and drug sensitivity of brain tumors
Patients with glioblastoma have very poor prognosis since there are no effective therapies. In a study published in Cell Reports, researchers at Uppsala University have discovered a correlation between the cell type from which the tumor originates and the growth and drug sensitivity of the tumor. More knowledge about the mechanisms behind this correlation could be important for developing more effective drugs against subgroups of glioblastoma. (2017-01-24)

New nanocarrier drug delivery technology crosses the blood-brain barrier
The blood-brain barrier (BBB) makes it more difficult for substances to be delivered from the blood to the brain compared to peripheral organs. Japanese researchers have developed a cyclic peptide that enhances BBB penetration. By putting drugs into nanoparticles that have the cyclic peptide on their surface, new drug nanocarriers may be developed for the delivery to the brain. (2020-04-16)

First report of stem cell signal of intention to become specific neuron
Scientists at Rush-Presbyterian-St. Luke's Medical Center in Chicago have discovered an important shortcut to creating a more efficient, more reliable, and safer source of stem cells with the ability to turn into specific neurons or brain cells. Paul Carvey, PhD, chairman of pharmacology at Rush, used his team's discovery to clone several generations of stem cells that, when grafted into the brains of rats with a Parkinson's like disease, developed into healthy dopamine neurons. (2002-05-09)

The Lancet Neurology press release
Although rabies kills more people every year (50 000 worldwide) than dengue virus, yellow fever, and Japanese encephalitis combined, it receives little attention and is at the bottom of the WHO's (2002-05-15)

Brain stem cells age faster in MS patients
Brain stem cells in people with the most severe form of multiple sclerosis look much older than they really are, according to a study led by UConn Health and published in the Proceedings of the National Academy of Sciences (PNAS). The prematurely old cells act differently in the brain than normal ones, and could be the key to new treatments for the disease. (2019-03-25)

Better brain wiring linked to family genes
How well our brains function is largely based on our family's genetic makeup, according to a University of Melbourne-led study. (2011-03-03)

Gut cells are gatekeepers of infectious brain diseases, study finds
Fresh insights into infectious brain conditions help to explain why some people -- and animals -- are more at risk than others. (2016-12-14)

Alleviating the burden of Multiple Sclerosis
Depression, coordination and speech problems, muscle weakness and disability are just a few of the symptoms of Multiple Sclerosis (MS). Researchers from the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy and the Department of Neuropathology at the Faculty of Medicine, University of Göttingen, Germany, have now discovered that these symptoms are aggravated by a specific signal in cells in the nervous system. (2006-08-06)

Ingredients for lasting memories
Scientists at the RIKEN-MIT Center for Neural Circuit Genetics (CNCG) have found evidence that helps explain how long lasting cortical engrams are formed in the brain. (2017-04-06)

How the brain senses nutrient balance
Now, a research study discovers intriguing new information about how dietary nutrients influence brain cells that are key regulators of energy balance in the body. The study, published by Cell Press in the Nov. 17 issue of the journal Neuron, suggests a cellular mechanism that may allow brain cells to translate different diets into different patterns of activity. (2011-11-17)

MIT research finds 'noisiest' neurons persist in the adult brain
MIT neuroscientists have discovered that when it comes to new neurons in the adult brain, the squeakiest wheels get the grease. (2010-01-13)

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