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Repairing DNA damage: Researchers discover critical process in cancer treatment
According to a new study published in the early online edition of Proceedings of the National Academy of Sciences, scientists from the Universite de Montreal and the Maisonneuve-Rosemont Hospital Research Centre have identified a new biochemical pathway which controls DNA repair. (2008-11-06)

Basis created for directing and filming blood vessels
A new method of filming blood-vessel cells that move in accordance with targeted signals has been developed by researchers at Uppsala University in collaboration with researchers at the University of California. The method can also be used to study how migration of cancer cells and nerves can be controlled. These interesting findings have now been published in the Journal of Biological Chemistry. (2008-03-26)

New chemical weapon to combat cancer
Patients often suffer from side effects due to the doses used in the treatments for fighting cancer. How can this two-fold problem be managed? Scientists (UNIGE) analysed 200 combinations of different anti-tumour drugs. They employed a new technique to test the impact of a combination on a cancer cell and healthy cell simultaneously. They discovered a highly promising mix of four components that can kill tumour cells while leaving healthy cells undamaged. (2019-10-23)

Gene expression to distinguish metastasizing from non-metastasizing head and neck cancers
The validation of a test, based on gene expression and predicting the tumors that will metastasize in lymph nodes of head and neck cancers, was presented today at the 3rd International Conference on innovative approaches in Head and Neck Oncology, in Barcelona. (2011-02-24)

New treatment hope for women with BRCA1 breast cancers
Researchers have found a new way to use immunotherapy, a breakthrough mode of cancer treatment which harnesses the patient's immune system, to treat an aggressive form of breast cancer. The researchers at Melbourne's Walter and Eliza Hall Institute and Peter MacCallum Cancer Centre have shown, for the first time, that combining two immunotherapy drugs could be effective in treating triple negative breast cancers arising in women with BRCA1 mutations. (2017-06-07)

New statistical method offers automatic mitotic cell detection for cancer diagnosis
Scientists have developed a statistical image analysis method which can assist in the grading of breast cancer by automatically segmenting tumour regions and detecting dividing cells in tissue samples. (2012-11-12)

Bile duct cancer study sheds light on triggers that cause disease
Scientists at the University of Edinburgh have identified a molecule that drives the development of bile duct cancer. The research in mice sheds new light on what triggers the disease and how the illness progresses. (2016-10-10)

New tumour sampling method significantly improves genetic testing for cancer treatment
A wholistic tumour sampling method that more accurately detects genetic alterations in tumours, which are critical in allowing treatment to be personalised to each and every patient, has been developed by researchers from the Crick, Roche and The Royal Marsden NHS Foundation Trust. (2020-05-05)

Tumor chromosomal translocations reproduced for the first time in human cells
Scientists from the Spanish National Cancer Research Centre and the Spanish National Cardiovascular Research Centre have been able to reproduce, for the first time in human cells, chromosomal translocations associated with two types of cancer: acute myeloid leukemia and Ewing's sarcoma. The discovery, published today in the journal Nature Communications, opens the door to the development of new therapeutic targets to fight these types of cancer. (2014-06-03)

Case study published in The Lancet documents development of malignant tumor 7 years after radiosurgery to treat benign tumor
Seven years after undergoing radiosurgery to treat a benign tumor, a 70-year-old woman developed a malignant brain tumor called a glioblastoma, according to a case report prepared by researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute. It is published in the November 2000 issue of the British medical journal, The Lancet. (2000-11-25)

Unexpected associations found between drug response and cell changes in brain cancer
Therapies for treating glioblastoma brain cancer can be delivered with greater precision and existing drugs can be used in new ways. These are the conclusions from a study from Uppsala University investigating a large number of cell samples from patients with brain tumours. The researchers have characterised how changes in glioblastoma cells influence the effect of different drugs. Their findings are published in the journal Cell Reports. (2020-07-14)

Study examines drowning-induced brain injury in children
A new study indicates that children who develop brain injury due to non-fatal drowning often experience severe motor deficits but maintain relatively intact perceptual and cognitive capabilities. (2017-08-01)

International study shows efficacy of new gastric cancer drug
The phase III study, published in the prestigious scientific journal, The Lancet, in which researchers at the Vall d'Hebron University Hospital and the Vall d'Hebron Institute of Oncology have participated, shows that an antibody (ramucirumab) inhibits the action of various proteins involved in tumor growth, prolonging survival of patients with advanced gastric cancer. (2013-10-02)

Various miRNAs predict the effect of anti-angiogenic agents on renal cancer
CNIO researchers have come across various potential predictive biomarkers of tyrosine kinase inhibitors (TKI) -- a type of anti-angiogenic agent widely used -- response in metastatic renal cancer. In their study, published in JCI Insight, the researchers identify various miRNAs that define a group of patients with the poorest response to TKI treatment and with the worst prognosis. The study, conducted on 139 patient samples, is the most robust to date in renal cell carcinoma. (2016-07-07)

Benign or cancerous?
Findings from a new University of Leicester investigation into benign moles and malignant melanoma will be announced at a public lecture on Nov. 12. (2008-11-11)

Researchers at the CNIO discover a gene that is essential for the DNA-replication process
Millions of cells in our body are constantly dividing to repair tissue damage and ensure our continuity. This is one of the most complex processes that cells go through and, in order for it to be successful, they must, among other things, produce a copy of their DNA. Researchers at the CNIO have discovered the critical role of the POLD3 protein in this DNA-replication process; without POLD3 cells do not divide, they die. (2016-09-06)

UEA research could help fine-tune cancer treatment
Cancer therapies that cut off blood supply to a tumour could be more effective in combination with existing chemotherapeutic drugs -- according to new research from the University of East Anglia. New research published today in the journal EMBO Reports reveals that tumour growth is better-reduced in mice when the expression of a particular protein called Beta3-integrin is targeted in combination with drugs that are already used in cancer patients. (2018-05-25)

No link between early child cancers and living near mobile phone masts
There is no association between risk of early childhood cancers and a mother's exposure to a mobile phone base station during pregnancy, concludes a new study published on bmj.com today. (2010-06-22)

50 years after the release of the film 'Fantastic Voyage,' science upstages fiction
Fifty years to the day after the film 'Fantastic Voyage' was first shown in theaters, the Polytechnique Montréal Nanorobotics Laboratory is unveiling a unique medical interventional infrastructure devoted to the fight against cancer. The outcome of 15 years of research conducted by Professor Sylvain Martel and his team, it enables microscopic nanorobotic agents to be guided through the vascular systems of living bodies, delivering drugs to targeted areas. (2016-08-24)

Cancer quest boosted by renewal
The value of WEHI's research into devastating blood malignancies has been resoundingly affirmed with the renewal of a five-year US$6.25 million grant from the US-based Leukemia and Lymphoma Society. (2005-07-28)

A new strategy induces the regression of advanced lung tumors in mice
A study conducted by researchers at the Spanish National Cancer Research Centre (CNIO) shows how the elimination of the c-Raf kinase by genetic manipulation causes the regression of Kras oncogene-driven advanced lung tumors in a genetically designed mouse model. It has also been shown that the elimination of the c-Raf protein produces very tolerable toxic effects. This opens a new possibility for the development of new therapies. (2018-01-25)

Rectal cancer patients who "watch and wait" may only need few years of stringent follow-up
The growing consensus among experts is that surgery should no longer be the only therapeutic option for rectal cancer. A non-invasive approach, the Watch-and-Wait protocol - which drastically reduces the toll on patients' quality of life - has increasingly shown promising results for the treatment of such tumours. A new study now explores the next logical step: should these patients be submitted for life or just for a certain time to the required stringent follow-up? (2020-12-11)

Blocking copper uptake in tumor cells may be clue to boosting immune system
Australian researchers have discovered that removing copper from the blood can destroy some of the deadliest cancers that are resistant to immunotherapy using models of the disease. (2020-08-18)

Researchers turn to machines to identify breast cancer type
Team from University of Alberta and Alberta Health Services develop new technique to determine if tumours fed by estrogen. (2013-12-02)

It is important to demonstrate the influence of the microenvironment in the process of metastasis
In the work defended at the University of the Basque Country, an in vitro culture model of human colon cancer was created in order to reproduce the gene regulation that is expressed in these cancer cells during their growth as metastasis in the liver of patients. (2007-12-20)

Researchers discover new immunotherapy combination effective at killing cancer cells
Researchers at the University of Calgary recently discovered an immunotherapy that uses existing cancer drugs in a whole new way. 'What we found is a combination of cancer therapies that complement each other in helping the immune system clear the cancer,' says Doug Mahoney, PhD. 'Our results suggest that we've been looking at these cancer drugs the wrong way -- as tumour-targeting drugs -- instead of what we now feel is their most important biological role: as immune stimulating therapy.' (2017-08-29)

Portable breast scanner allows cancer detection in the blink of an eye
Women could have a fast test for breast cancer and instantly identify the presence of a tumor in the comfort of their own home thanks to groundbreaking new research from the University of Manchester. (2010-10-27)

Antifungal drug eliminates sleeping bowel cancer cells in mice
An antifungal medication, commonly prescribed for toenail infections, could help eliminate dormant cells within bowel tumors, according to new research funded by Cancer Research UK and published in the Journal of Experimental Medicine today. (2018-05-31)

Arthritis drug could help beat melanoma skin cancer
A breakthrough discovery by the University of East Anglia and Children's Hospital Boston promises an effective new treatment for one of the deadliest forms of cancer. (2011-03-23)

New targets for melanoma treatment
A collaborative study led by Monash University's Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute (ONJCRI) has uncovered new markers (HLA-associated peptides) that are uniquely present on melanoma tumours and could pave the way for therapeutic vaccines to be developed in the fight against melanoma. (2020-09-16)

Helicobacter-pylori status might predict prognosis after surgery for gastric cancer
Patients who test negative for the bacterium Helicobacter pylori might have a worse prognosis after curative surgery for gastric cancer than those who are positive, according to researchers reporting in the March issue of The Lancet Oncology. (2006-02-27)

Major differences between male and female breast cancers uncovered but male patients still disadvantaged by lack of research, say investigators
Male breast cancer has important biological differences from female breast cancer, according to results from a study of 1203 tumor samples from male patients. Until now it has been assumed that male patients should be treated in the same way as females, but these results mean that this is not the case, and should help doctors make better treatment choices, say the research team. (2016-03-10)

NUS scientists discover that modifications to protein RUNX3 may promote cancer growth
Scientists from the Cancer Science Institute of Singapore at the National University of Singapore have discovered that a modification called phosphorylation made to a protein called RUNX3 may promote cancer progression by allowing cell division. The phosphorylation, or the addition of a phosphate group to a molecule, is carried out by an enzyme called Aurora Kinase, which has been observed to be present in unusually high levels in some cancers. (2016-07-14)

Researchers 'drug the undruggable' through unique collaboration
A new study published in Nature, conducted by an alliance between industry and academia involving the University of Liverpool, highlights a new approach to targeting key cancer-linked proteins, thought to be 'undruggable'. (2017-10-19)

Researchers form new nerve cells – directly in the brain
The field of cell therapy, which aims to form new cells in the body in order to cure disease, has taken another important step in the development towards new treatments. A new report from researchers at Lund University in Sweden shows that it is possible to re-program other cells to become nerve cells, directly in the brain. (2013-03-26)

Good indicator of cancer prognosis turned on its head by new research
A molecule which, for the last 20 years has been believed to be an indicator of good prognosis in tumors has been shown to have a dark side by new research from The Universities of Manchester, Athens and collaborators, recently published in Nature Cell Biology. (2016-07-07)

Identification of 'fingerprint' of rare tumor leads to development of cheap and reliable new test
Researchers at the University of Oxford have developed a cheap and reliable diagnostic test for a rare form of cancer. The test involves screening tumor samples for a particular molecular fingerprint unique to this type of cancer. (2011-05-19)

Breakthrough in understanding how cancer cells metastasize
A protein commonly found in human cells could be an important switch that activates cancer cell metastasis, according to a new study by researchers at the Montreal Neurological Institute and Hospital -- The Neuro at McGill University and the MUHC. The finding focuses attention on a biological mechanism that until now was largely overlooked. The discovery of the protein's effect significantly expands our understanding of epithelial cancers such as breast and lung cancer. (2015-02-27)

New research helps explain how tumors go undetected by the body
Scientists studying how immune cells are regulated in healthy individuals, have made a key discovery in understanding why tumors may go undetected by the immune system and remain untreated by the body's own natural defences. The findings, published online this week (November 19-23) by the Proceedings of the National Academy of Sciences, could lead to new treatments for tumors. (2007-11-19)

International Agency for Research on Cancer classifies radiofrequency electromagnetic fields (including those caused by mobile phones) as possibly carcinogenic to humans
The Lancet Oncology today publishes a summary from a meeting of the International Agency for Research on Cancer (IARC), that classifies radiofrequency electromagnetic fields (RF-EMF) (including those caused by mobile phones) as possibly carcinogenic to humans (division 2B in the IARC classification). (2011-06-22)

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