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GW professor awarded grant to study new methods of early breast cancer detection
Sidney Fu, M.D., professor of medicine at the George Washington University School of Medicine and Health Sciences, received a two-year, $362,060 grant from the National Cancer Institute to research a way to use novel biomarkers to determine whether or not a patient carries cells that will eventually turn into breast cancer. (2012-10-04)

Diseased cell fragments burst from pockets in immune cells to activate response
Researchers at the Francis Crick Institute have uncovered an important process in how our immune system detects signs of disease and activates a protective response. This understanding could improve efforts to find new and effective immunotherapy treatments for diseases like cancer. (2020-12-21)

Lung cancer: Scientists find answer to resistance
Scientists at the University of Southern Denmark have found a new strategy for overcoming the resistance, which many lung cancer patients develop towards a recent drug, which can arrest the growth of tumors. (2017-09-08)

Experts to share how research is tackling cancer
Cancer touches many people, but few have the chance to meet the researchers who have dedicated their lives to tackling the disease. (2008-09-01)

BPA stimulates growth of breast cancer cells, diminishes effect of treatment
Bisphenol A, a chemical commonly used in plastics, appears to increase the proliferation of breast cancer cells, according to Duke Medicine researchers presenting at an annual meeting of endocrine scientists. (2014-06-23)

Aspirin inhibits ovarian cancer growth, lab study finds
Aspirin may inhibit ovarian tumor growth, according to a new laboratory study by the University of South Florida College of Medicine. (2002-11-06)

Lab study: Daily aspirin could block growth of breast, other cancers
A Veterans Affairs lab study found that a daily dose of aspirin was effective at blocking breast tumor growth. Previous studies have already shown a similar effect on colon, gastrointestinal, prostate, and other cancers. (2015-06-11)

Blood test can help some bowel cancer patients avoid unnecessary drug side-effects
Manchester researchers have provided early evidence to suggest that a blood test could be used to identify bowel cancer patients that may benefit from more intensive chemotherapy. (2015-03-25)

Tasmanian devil research could help tackle immunotherapy resistance
A cluster of interacting proteins that are active in both human cancers and Tasmanian devil facial tumours, may give clues to how cancers evade the immune system, according to a study part-funded by Cancer Research UK and published in Cancer Cell today (Thursday). (2019-09-26)

Irradiating stem cell niche doubles survival in brain cancer patients
Patients with deadly glioblastomas who received high doses of radiation that hit a portion of the brain that harbors neural stem cells had double the progression-free survival time as patients who had lower doses or no radiation targeting the area, a study from the Radiation Oncology Department at UCLA's Jonsson Comprehensive Cancer Center has found. (2010-07-22)

Researchers discover that a protein in grape skins can kill cancer cells
It's well known that drinking red wine in moderation can have some health benefits, mainly attributed to a compound called resveratrol. Now, scientists at the University of Virginia Health System have discovered how. (2004-05-25)

Normal cells in tumors may aid cancer growth
Normal cells that live among the cancer cells in a tumor may not be the innocent bystanders they are usually assumed to be. A study here has found that the normal cells in tumors, known collectively as the tumor stroma, may lose more regions of DNA than do the cancer cells in the course of tumor development. (2004-10-15)

BVES butts heads with colorectal cancer
Once a cancer gains the ability to invade local tissues and spread to a distant site it becomes much harder to treat. Researchers have now identified the protein BVES as a suppressor of colorectal cancer progression to this dangerous state, leading them to suggest that BVES could be a therapeutic or preventative target in colorectal cancer. (2011-09-12)

Ovarian cancer: Quick steps to widespread disease
Ovarian cancer cells that interact with cancer-associated fibroblasts can mobilize glycogen as an energy source, leading to proliferation, invasion and metastasis. Blocking glycogen mobilization in cancer cells might reduce tumor spread. (2018-09-06)

Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
Patients who survive an initial diagnosis of breast cancer often succumb to the disease years later when the cancer shows up in a different part of the body. Now, scientists have identified key signals that support the long term survival of breast cancer cells after they have spread to the bone marrow. (2009-07-06)

Nanoparticles can overcome drug resistance in breast cancer cells
Nanoparticles filled with chemotherapeutic drugs can kill drug-resistant breast cancer cells, according to a study published in the scientific journal Biomaterials. (2013-11-07)

Residual fetal cells in women may provide protection against breast cancer
Fetal cells that persist in a woman's body long after pregnancy -- a common occurrence known in scientific circles as fetal microchimerism -- in some cases may reduce the woman's risk of breast cancer, according to researchers at Fred Hutchinson Cancer Research Center. (2007-10-01)

Heating targeted cancer drugs increases uptake in tumor cells
Manchester scientists have found that gentle heating of targeted nano-sized drug parcels more effectively in deliver them to tumor cells -- resulting in an improvement in survival rates. (2015-02-11)

Researchers Demonstrate That COX-2 Inhibits Angiogenisis In Tumor Cells
Aspirin's preventive effects on colon cancer may result from its influence on the development of blood vessels needed for tumor growth. (1998-05-29)

Tumor-associated neutrophils boost anti-tumor immune responses
A new study in the Journal of Clinical Investigation suggests that tumor-associated neutraphils help bolster the immune response against lung tumors. (2014-11-10)

Engineered killer T cells could provide long-lasting immunity against cancer
In experiments with mice, UCLA researchers have shown they can harness the power of iNKT cells to attack tumor cells and treat cancer. The new method, described in the journal Cell Stem Cell, suppressed the growth of multiple types of human tumors that had been transplanted into the animals. (2019-09-23)

An Achilles heel in cancer cells
A protein that shields tumor cells from cell death and exerts resistance to chemotherapy has an Achilles heel, a vulnerability that can be exploited to target and kill the very tumor cells it usually protects, researchers from the University of Illinois at Chicago show in a new study published in the Dec. 9 issue of Cancer Cell. (2008-12-08)

Healthy blood stem cells have as many DNA mutations as leukemic cells
Researchers from the Princess Máxima Center for Pediatric Oncology have shown that the number of mutations in healthy and leukemic blood stem cells does not differ. Rather the location of the mutations in the DNA is relevant. Using the mutation patterns in the hematopoietic stem and progenitor cells (HSPCs) the team was able to trace the developmental lineage tree of the cells. (2018-11-28)

Children's brain tumors more diverse than previously believed
Paediatric brain tumors preserve specific characteristics of the normal cells from which they originate - a previously unknown circumstance with ramifications for how tumor cells respond to treatment. This has been shown by Uppsala researcher Fredrik Swartling together with colleagues in the US, Canada and England in a study that was published today in the distinguished journal Cancer Cell. (2012-05-14)

Researchers identify new stem cell population important in the growth of colon cancer
Researchers at Lawson Health Research Institute have identified a previously unknown, long-lived radiation-resistant stem cell population in the colon. Most importantly, they also found that these stem cells can give rise to colonic tumors and sustain their growth. The findings, which are published in the prominent journal Cell Stem Cell, will significantly change the way we study and treat colon cancer. (2015-06-16)

Researchers identify how to switch off cancer cell genes
A new study led by researchers at the University of Southern California identifies how genes are silenced in cancer cells through distinct changes in the density of nucleosomes within the cells. (2007-11-12)

Cancer cells 'remove blindfold' to spread
Cells are effectively 'blindfolded' as they lose sensitivity to their surroundings early in cancer progression, but scientists used a new method to find some cancer cells are able to switch this sense back on in order to move and spread. In future, these cells could potentially be targeted by treatments before cancer spreads to give patients a better chance of recovery. (2020-12-01)

UCSD team demonstrates potential for widely effective cancer vaccine
Vaccination against an enzyme common to a variety of human tumors might effectively mobilize the body's own immune system to attack and kill cancer cells, scientists from the UCSD School of Medicine and Cancer Center report in the April 4 issue of the Proceedings of the National Academy of Science. (2000-04-03)

Peptic ulcer bacterium alters the body's defense system
Helicobacter pylori survives in the body by manipulating important immune system cells. This is shown in a thesis from the Sahlgrenska Academy at the University of Gothenburg, Sweden. The discovery may lead to new treatments against the common peptic ulcer bacterium. (2009-06-29)

McMaster University researchers discover drug destroys human cancer stem cells but not healthy ones
A team of scientists at McMaster University has discovered a drug, thioridazine, successfully kills cancer stem cells in the human while avoiding the toxic side-effects of conventional cancer treatments. To test more than a dozen different compounds, McMaster researchers pioneered a fully automated robotic system to identify several drugs, including thioridazine. (2012-05-24)

New bowel cancer drug target discovered
Researchers at the Francis Crick Institute have discovered a new drug target for bowel cancer that is specific to tumour cells and therefore less toxic than conventional therapies. (2017-10-17)

Redundancies in T cells
Researchers at ETH Zurich have discovered redundancies in the biochemical signalling pathways of immune cells. This finding has important implications for advances in cancer immunotherapy, among other areas. (2019-06-18)

Can a virus fight cancer?
Two Ottawa researchers are taking innovative approaches to improving virus-based cancer therapy with new funding from the Canadian Cancer Society. (2012-07-25)

UTA study says zinc can halt the growth of cancer cells
Zinc supplements can significantly inhibit the proliferation of esophageal cancer cells, according to a new study co-authored by a University of Texas at Arlington researcher. (2017-09-28)

UIC conducts phase I drug study for advanced pancreatic cancer
UIC researchers are conducting a clinical trial to evaluate a new, three-drug combination therapy for advanced pancreatic cancer. (2014-06-03)

New type of immunotherapy may pave the way for better cancer treatments
Immunotherapy for cancer has made great advances and many patients can now receive effective treatments that were not available ten years ago. However, there are certain types of cancer that do not respond to existing immunotherapy. A study from Karolinska Institutet in Sweden published in Proceedings of the National Academy of Sciences (PNAS) reports on a new kind of immunotherapy that gives hope of more treatment options for cancer in the future. (2020-11-23)

Spice it up or just veg out, either way you may be helping to defend against cancer
Two new studies suggest that broccoli and red chili pepper may slow or prevent the growth of cancerous tumor cells. The findings, being presented by the University of Pittsburgh at the American Association for Cancer Research's annual meeting, April 16 to 20, at the Anaheim Convention Center in Anaheim, Ca., looked at the effect of these dietary agents on ovarian and pancreatic cancers and found that both were effective inhibitors of the cancer process. (2005-04-19)

Serendipity points to new potential target and therapy for melanoma
A University of Colorado Cancer Center study in this month's edition of the Journal of Investigative Dermatology describes a new target and potential treatment for melanoma, the most dangerous form of skin cancer. MicroRNA can decide which genes in a cell's DNA are expressed and which stay silent. Melanoma tends to lack microRNA-26a, which makes the gene SODD go silent. (2012-12-20)

Jefferson researchers uncover new evidence of prolactin's possible role in breast cancer
Scientists at the Kimmel Cancer Center at Jefferson in Philadelphia have discovered new molecular evidence of the role of the hormone prolactin in breast cancer. They have found that prolactin, a pituitary hormone that normally stimulates breast development and milk production, initiates a new (2007-09-28)

Proteins that deliver leucine to prostate cancer cells are therapeutic targets
Like normal cells, cancer cells require amino acids for growth, maintenance, and cell signaling, and L-type amino acid transporters (LATs) are the delivery vehicles that supply them. Metastatic, castration-resistant prostate cancer cells are highly dependent on LATs to deliver the amino acid leucine that the cells need for growth and proliferation, according to a study published Sept. 19 in the Journal of the National Cancer Institute. (2013-09-19)

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