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Fish shed light on human melanoma
Zebrafish, a transparent member of the minnow family, are providing insight into human melanoma - a form of skin cancer - that may lead to new or repurposed drug treatments, for skin and other cancers. This will be reported by researchers from the Weill Cornell Medical College in New York City at the Genetics Society of America's (2012-06-18)

UCLA study pinpoints new function for histones
Refuting earlier theories, scientists discovered that histones act as an enzyme that converts copper into a form that can be used by the cells. (2020-07-02)

How 'pioneer' protein turns stem cells into organs
Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The discovery, published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs. (2020-03-18)

Chromosome organization emerges from 1-D patterns
Researchers at Rice University and Baylor College of Medicine have developed a method to predict how a human chromosome folds based solely on the epigenetic marks that decorate chromatin inside cells. (2017-10-31)

UMMS scientists lead effort to annotate human genome
UMass Medical School scientists Jill Moore, PhD, Zhiping Weng, PhD, and MD/PhD students Michael Purcaro and Henry Pratt are lead authors on the latest publication of data from the ambitious ENCODE project to annotate the human genome. (2020-07-29)

'Oncometabolite' linked with widespread alterations in gene expression
New research enhances the understanding of the link between metabolic deregulation and cancer and may help to guide development of new targeted cancer therapies. The new study finds that a metabolite commonly elevated in brain cancer and leukemia may promote tumorigenesis by altering the expression of a large number of genes. (2011-01-17)

Cell cycle proteins help immune cells trap microbes with nets made of DNA
In your bloodstream, there are immune cells called neutrophils that, when faced with a pathogenic threat, will expel their DNA like a net to contain it. These DNA snares are called neutrophil extracellular traps or NETs. Researchers from Germany and the United States describe an important step in how these NETs are released and how they stop a fungus from establishing an infection in mice and human cells in the journal Developmental Cell. (2017-11-20)

Scientists discover new mechanism regulating the immune response
Scientists at an Academy of Finland Centre of Excellence have discovered a new mechanism regulating the immune response that can leave a person susceptible to autoimmune diseases. (2013-06-28)

Genetic risk factors of disparate diseases share similar biological underpinnings
The discovery of shared biological properties among independent variants of DNA sequences offers the opportunity to broaden understanding of the biological basis of disease and identify new therapeutic targets. (2016-04-28)

International scientists present the latest advances in RNAi and its clinical impact
On December 11-13, the Institute for Research in Biomedicine (IRB Barcelona) will welcome more than sixty scientists to its site at the Barcelona Science Park to discuss the latests advances regarding the mechanisms of gene regulation mediated by ribonucleic acid molecules. The conference, (2006-12-04)

Progress in understanding the malarial parasite
In a new study publishing in PLoS Computational Biology on Sept. 14, 2007, Dr. Tatu and colleagues from the Indian Institute of Science have constructed a chaperone interaction network for the parasite which provides, for the first time, a rational basis for the antimalarial effect of known drugs and highlights new proteins that can potentially be used in the fight against malaria. (2007-09-13)

Protein complex plays role in suppressing pancreatic tumors, Stanford study shows
A well-known protein complex responsible for controlling how DNA is expressed plays a previously unsuspected role in preventing pancreatic cancer, according to researchers at the Stanford University School of Medicine. (2012-01-09)

'Metal' drugs to fight cancer
What is the mechanism of action of metal-based chemotherapy drugs (the most widely used for treating common cancers like testicular or ovarian cancer)? How can we improve their effect and reduce their toxicity? A new study combining experiments and theory has broadened our knowledge of the molecular mechanisms of these active drugs to help experimentalists devising increasingly effective drugs with fewer side effects. The study, just published in the journal ChemMedChem, was conducted with SISSA of Trieste. (2015-12-21)

Skeletal muscle satellite cells and stem cells
The overall scientific objective of this conference is to provide a forum for cutting-edge work in muscle satellite and stem cells, including regulatory mechanisms controlling normal and abnormal functions of muscle stem cells in regeneration, homeostasis, hypertrophy, aging and disease. (2016-01-28)

Kinetochores prefer the 'silent' DNA sections of the chromosome
The protein complex responsible for the distribution of chromosomes during cell division is assembled in the transition regions between heterochromatin and euchromatin. (2011-07-05)

Potential new way to suppress tumor growth discovered
Researchers at the University of California, San Diego School of Medicine, with colleagues at the University of Rochester Medical Center, have identified a new mechanism that appears to suppress tumor growth, opening the possibility of developing a new class of anti-cancer drugs. (2013-06-03)

Stem cells know how to open up and unwind
Research has revealed a new understanding of how an open genome structure supports the long-term and unrestricted developmental potential in embryonic stem cells. This insight provides new avenues for improving the quality and stability of embryonic stem cells -- an essential requirement to fulfill their promise in regenerative medicine. (2016-04-28)

Shilatifard Lab sheds light on molecular machinery required for translation of histone crosstalk
The Stowers Institute's Shilatifard Lab has published findings that shed light on the molecular machinery required for the translation of histone crosstalk, or communication between histones. (2007-12-14)

A promising new approach for treating leukemia discovered
A group of researchers at the Institute for Research in Immunology and Cancer (IRIC) of Université de Montréal discovered a promising new approach to treating leukemia by disarming a gene that is responsible for tumor progression. (2014-02-13)

DNA imprinting defects associated with childhood osteosarcoma development and progression
Children diagnosed with osteosarcoma may be impacted by a DNA imprinting defect also found in parents, according to new research from the Masonic Cancer Center, University of Minnesota. DNA imprinting is a phenomenon in which just one of the two inherited genes is active while the other is present but inactive. The study is published now in the journal Oncotarget. (2016-01-26)

Unique centromere type discovered in the European dodder
Commonly, the presence of histone variant CENH3 epigenetically determines the positioning of centromeres. In monocentric chromosomes, CENH3 occurs in a single region, whilst in holocentrics, CENH3 is distributed along the entire chromosome. Scientists have discovered a new type of centromere in the plant Cuscuta europae. Centromere activity is distributed in holocentric fashion, despite CENH3 only occurring on 1 to 3 distinct regions on the chromosome. The findings were published in Frontiers in Plant Sciences. (2020-01-27)

Researchers from IMIM describe a new function of 2 molecules involved in metastasis
Researchers from Hospital del Mar Medical Research Institute lead by Dr. Sandra Peiró have described a new function for two key molecules involved in tumor progression. Transcription factor SNAIL1 and enzyme LOXL2 are essential to Epithelial-Mesenchymal Transition, meaning the process by which tumor cells are able to move and reach other tissues. The study places LOXL2 as a possible therapeutic target to treat cancers such as breast, lung or skin cancer. (2013-11-14)

New image of a cancer-related enzyme in action helps explain gene regulation
New images of an enzyme in action as it interacts with the chromosome could provide important insight into how cells--including cancer cells -- regulate their gene (2020-06-04)

Research implicates causative genes in osteoporosis, suggesting new targets for future therapy
Scientists have harnessed powerful data analysis tools and three-dimensional studies of genomic geography to implicate new risk genes for osteoporosis, the chronic bone-weakening condition that affects millions of people. Knowing the causative genes may later open the door to more effective treatments. (2019-03-21)

Forgotten by evolution?
For a fairly long time, adult stem cells have been a point of scientific interest. Besides the question of how to use them therapeutically, researchers have been investigating what exactly their physiological function could be. (2005-11-02)

Cancer is a stem cell issue
There is an urgent reason to study stem cells: stem cells are at the heart of some, if not all, cancers. Mounting evidence implicates a clutch of rogue stem cells brandishing 'epigenetic' marks as the main culprits in cancer. Wiping out tumours for good, some biologists believe, depends on uprooting these wayward stem cells. (2007-02-19)

How the wrong genes are repressed: New finding from UCL
The mechanism by which (2010-06-11)

12 scientists named ASBMB award winners
The American Society for Biochemistry and Molecular Biology in July named 12 scientists the winners of its annual awards. The newly announced recipients and one winner from 2011 will give talks at the society's annual meeting April 21-25 in San Diego. (2011-07-28)

Breakthrough in knowledge of how some sarcomas arise
The origin of certain cancers in the sarcoma group is associated with a hitherto unknown interaction among different proteins. Findings now being presented create the opportunity to test new treatments of these forms of sarcoma. (2019-04-08)

Based on earlier successes, NIH awards new study in cancer research to Virginia Tech's Chang Lu
Preliminary results showing an ultrahigh sensitivity using a new technology for studying protein-DNA interactions has led to the National Institutes of Health's National Cancer Initiative award of $710,000 to Virginia Tech's Chang Lu of chemical engineering. (2013-06-10)

Scientists identify a key molecule that blocks abnormal blood vessel growth in tumors
A new and better understanding of blood vessel growth and vascular development (angiogenesis) in cancer has been made possible by research carried out by a team of scientists from Moffitt Cancer Center, the University of Florida, Harvard University, Yale University and the Children's Hospital of Los Angeles. (2011-09-21)

Minority researchers receive AACR awards
Each year, the American Association for Cancer Research (AACR) presents awards to minority scholars who have made an impact in cancer research, and show potential to continue to do so in the future. (2004-12-30)

Temple scientists ID new targets to treat fibrosis -- a feature of many chronic diseases
When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. Fibroblasts give rise to healing cells called myofibroblasts, which generally is good in the short term -- but bad when myofibroblast activation gets out of hand. Now, Lewis Katz School of Medicine at Temple University researchers show how fibroblast activation and myofibroblast formation occurs, providing clues for how to target fibrosis -- which impacts several chronic diseases. (2019-10-04)

Biologists pioneer first method to decode gene expression
Biologists have developed the first system for determining gene expression based on machine learning. Considered a type of genetic Rosetta Stone for biologists, the new method leverages algorithms trained on a set of known plant genes to determine a species-wide set of transcribed genes, or 'expressome,' then creates an atlas of expressible genes. The method carries implications across biology, from drug discovery to plant breeding to evolution. (2019-08-12)

Your immune system holds the line against repeat invaders, thanks to this molecule
his new insight may allow researchers to design drugs that improve immune responses to vaccines. (2018-04-17)

Gene-chip studies provide new leads in treating lung disease of premature newborns
Some 20 to 40 percent of extremely premature infants suffer abnormal lung development leading to bronchopulmonary dysplasia, a chronic lung disease that can cause long-term breathing problems. Little is known about how to predict whether a premature infant will develop BPD in the weeks after birth, much less how to prevent or treat it. Now, gene-chip studies of these tiny babies' umbilical cords provide unexpected, much-needed leads into predicting and treating this debilitating condition. (2007-10-03)

Intraepithelial neoplasia may be a leading risk factor for prostate and ovarian cancers
Intraepithelial neoplasia is a precancerous, noninvasive lesion that may signal the onset of tumor development in both the prostate and ovary, according to research presented today at the American Association for Cancer Research (AACR) Second Annual International Conference on Frontiers in Cancer Prevention Research. Both prostate and ovarian cancers are common and deadly, and novel preventive or early detection techniques are extremely important. (2003-10-27)

Stowers study hints that stem cells prepare for maturity much earlier than anticipated
Unlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility (2012-12-27)

Tight DNA packaging protects against 'jumping genes,' potential cellular destruction
Scientists discovered that the major developmental function of heterochromatin -- a form of tight DNA packaging found in chromosomes -- is likely the suppression of virus-like DNA elements known as transposons or 'jumping genes,' which can otherwise copy and paste themselves throughout the genome, potentially destroying important genes, and causing cancers and other diseases. (2016-09-01)

New method to boost supply of life-saving stem cells
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City have found a new method for growing a large quantity of life-saving blood stem cells. The scarcity of these cells is one of the greatest limitations for their use in a variety of medical procedures, from treatment of blood cancers to inherited blood disorders that require a bone marrow transplantation. (2020-12-08)

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