Cleft Palate Current Events

Cleft Palate Current Events, Cleft Palate News Articles.
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Can cleft palate be healed before birth?
In a study newly published in the journal Development, investigators at the USC School of Dentistry describe how to nonsurgically reverse the onset of cleft palate in fetal mice -- potentially one step in the journey to a better understanding of similar defects in humans. (2009-12-01)

MRI more accurate for prenatal cleft lip and palate than sonography
Fetal MRI allows more detailed and conclusive prenatal evaluation of the upper lip than sonography alone, allowing for better diagnosis of cleft lip and palate in fetuses, according to researchers from Harvard Medical School and Beth Israel Deaconess Medical Center and Children's Hospital in Boston, MA. (2004-07-01)

Scientists identify mutation associated with cleft palate in humans and dogs
Scientists studying birth defects in humans and purebred dogs have identified an association between cleft lip and cleft palate -- conditions that occur when the lip and mouth fail to form properly during pregnancy -- and a mutation in the ADAMTS20 gene. Their findings were presented today at the American Society of Human Genetics 2014 Annual Meeting in San Diego. (2014-10-19)

Cleft palate research receives £200,000 award
Pioneering research that could lead to a breakthrough in understanding the causes of cleft palate in newborn babies has begun in Manchester. (2005-01-10)

Folic acid cuts risk of cleft lip
Taking folic acid supplements in early pregnancy seems to substantially reduce the risk of cleft lip, finds a new study published online. (2007-01-25)

Children born with a cleft lip unlikely to be genetically inclined to do poorly at school
New research has found that children born with a cleft lip, either with or without a cleft palate, are not likely to be genetically predisposed to do less well at school than their peers. The study by the Cleft Collective research team at the University of Bristol is published today in the International Journal of Epidemiology. (2020-05-06)

Novel genes associated with risk for oral cleft malformation identified
An international consortium of scientists has identified two genes that when altered are closely associated with cleft lip and/or cleft palate. Cleft lip and cleft palate are among the world's most common congenital malformations and occur in one in every 700 births. The study identified four different regions of the human genome likely to contain genes controlling risk for cleft lip and/or cleft palate. (2010-05-03)

Wider cleft width appears associated with hypernasal speech, nasal air escape
Patients with wider cleft palates appear more likely to postoperatively develop velopharyngeal insufficiency, a condition characterized by hypernasal speech and nasal air escape when speaking, according to a study published Online First by Archives of Facial Plastic Surgery, a JAMA Network publication. (2012-04-16)

New method to fix cleft palate shows promise in Mayo Clinic lab study
Results from a Mayo Clinic laboratory study in animals suggest that using distraction osteogenesis, a procedure that uses the mechanical force of an appliance to lengthen soft tissue and bone, may be a feasible and effective method to repair cleft palate in the future. (2005-01-22)

Researchers Discover Mechanism Of Cleft Palate Development
Researchers led by a team of UC San Francisco scientists have identified the mechanism by which cleft palate develops. The most common craniofacial birth defect in humans occurs when the palate does not properly fuse during fetal development, leaving an opening or cleft in the roof of the mouth. (1999-05-01)

Research shows timing improves cleft palate surgery
Research by Dr. Damir Matic, a scientist with Lawson Health Research Institute in London, Ontario, is changing the way cleft palate surgeries are performed throughout North America and around the world. Matic has been conducting research to determine the optimal time to close the gum tissue of cleft palate patients. His research suggests that it is best to wait until the child is older. (2008-05-12)

Cleft palate discovery in dogs to aid in understanding human birth defect
Discovery of a genetic mutation that causes a form of cleft palate in a retriever breed provides the first dog model for this craniofacial defect and offers a tool for better understanding cleft palate in humans. (2014-04-05)

First trimester smoking linked to oral clefts
Smoking during the first trimester of pregnancy is clearly linked with an increased risk of cleft lip in newborns. Genes that play a role in detoxification of cigarette smoke do not appear to be involved. This is shown in a new study published in the journal Epidemiology. (2008-12-18)

Epilepsy drug may not increase risk of birth defects
Babies born to pregnant women taking the epilepsy drug lamotrigine may not be at an increased risk of birth defects, such as cleft lip, cleft palate or clubfoot, according to a study published in the April 6, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2016-04-06)

Speech impairment in five-year-old international adoptees with cleft palate
In a group of internationally adopted children with cleft lip and/or palate, speech at age five is impaired compared to a corresponding group of children born in Sweden, a study shows. The adopted children also need more extensive surgery, which may be due to their surgical interventions taking place later in life. (2019-09-06)

Gene linked to cleft lip and palate identified
A gene variant that is a major contributor to oral clefts and triples the risk of recurrence in affected families has been identified by an international team of scientists supported in part by the March of Dimes. (2004-08-18)

Nasoalveolar molding use for cleft lip and palate reduces number of surgeries, cost of care
Patients with complete unilateral and bilateral cleft lip and palate (U/BCLP) who were treated with nasoalveolar molding (NAM) required fewer surgeries and a reduction in overall healthcare costs compared to similar patients who did not have NAM treatment, according to a study in The Journal of Craniofacial Surgery, authored by Parit A. Patel, MD. (2016-02-08)

Genetic "Short Circuit" Leads To Cleft Palate
Scientists have identified not just a single gene but a genetic circuit, that when broken, causes cleft palate in newborn mice. The findings may help define the genetic components of cleft palate in humans, and explain the link between clefting and risk factors that raise the level of steroids in the body. (1997-12-22)

Insights into genetics of cleft lip
Scientists at EMBL Heidelberg have identified how a specific stretch of DNA controls far-off genes to influence the formation of the face. The study, published today in Nature Genetics, helps understand the genetic causes of cleft lip and cleft palate, which are among the most common congenital malformations in humans. (2014-05-26)

Researchers report new gene test for isolated cleft lip and palate
Researchers have developed a new genetic test that can help predict whether parents who have one child with the (2004-09-10)

USC researchers identify alternate pathway that leads to palate development
Researchers at the University of Southern California School of Dentistry have uncovered another clue behind the causes of cleft palate and the process that leads to palate formation. (2008-08-11)

UTHeath study: Children with specific birth defects at increased risk for abuse
Children born with cleft lip or palate and spina bifida are at an increased risk for abuse before the age of 2, according to researchers from The University of Texas Health Science Center at Houston (UTHealth). (2015-12-10)

Novel genome-wide association study risk loci for nonsyndromic orofacial clefts
At the 96th General Session of the International Association for Dental Research (IADR), held in conjunction with the IADR Pan European Regional (PER) Congress, Azeez Butali, University of Iowa, Iowa City, USA, gave an oral presentation titled 'Novel Genome-wide Association Study Risk Loci for Nonsyndromic Orofacial Clefts.' (2018-07-27)

Corticosteroid use during pregnancy not linked to facial clefts in infants
The use of corticosteroids during pregnancy does not appear to be associated with an increased risk of orofacial clefts in infants, according to an article in Canadian Medical Association Journal. (2011-04-11)

Does dosing of drug for mom make a difference for baby's risk of cleft lip, palate?
Taking a higher dose of topiramate during the first three months of pregnancy may increase a baby's risk of cleft lip or cleft palate more than when taking a lower dose, according to a study published in the Dec. 27, 2017, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2017-12-27)

Understanding genetic synergy in cleft palate
Like mechanics fixing a faulty engine, Youssef A. Kousa, M.S., D.O., Ph.D., says researchers will not be able to remedy problems related to IRF6, a gene implicated in cleft palate, until they better understand how the gene works. (2017-07-19)

Research could lead to new treatments for birth defects
Pioneering new research into cleft lip and palate could open the door to babies with certain craniofacial disorders being successfully treated in the womb. (2006-10-15)

New gene responsible for cleft lip and palate syndrome identified
An international team led by researchers from Karolinska Institutet in Sweden has identified a new gene related to the Van der Woude syndrome, the most common syndrome with cleft lip and palate. The study is published in the scientific periodical American Journal of Human Genetics and can lead the way to improved genetic diagnostic of individuals and families with orofacial clefts. (2013-12-19)

Growth factor gene shown to be a key to cleft palate
Cleft palate has been linked to dozens of genes. During their investigation of one of these genes, researchers at Washington University School of Medicine in St. Louis were surprised to find that cleft palate occurs both when the gene is more active and when it is less active than normal. (2010-02-02)

USC researchers close to identifying crucial gene for human cleft lip and palate
A group of researchers has found that three siblings born with cleft lip and palate share a common gene mutation associated with the birth defect. The study -- a collaborative effort between the Ostrow School of Dentistry, the Keck School of Medicine of USC, Children's Hospital Los Angeles and the nonprofit Operation Smile -- was published in the journal Human Molecular Genetics. (2017-03-21)

Experts make breakthrough in cleft lip and palate research
Leading scientists have identified an important gene that is associated with cleft lip and palate. (2016-03-24)

In-utero treatment reverses cleft palate in mice
Researchers at University of Utah Health clarified a molecular pathway responsible for the formation of cleft palate and identified a new treatment to reverse this defect in mouse pups in utero. (2017-09-13)

The tale of the bats, dark matter and a plastic surgeon
What happens when a plastic surgeon meets a bat expert zoologist and a paleobiologist? No, it's not a strange Halloween story about spooky bat dinosaurs but rather, a story about a new discovery about bats which may unlock vital clues about the causes of cleft palate in humans. (2016-10-24)

Study finds genetic variant plays role in cleft lip
Researchers have found, in a previously identified gene, a variation that likely contributes to one in five cases of isolated cleft lip. It's the first time a genetic variant has been associated with cleft lip alone, rather than both cleft lip and palate. The study provides insight on a previously unknown genetic mechanism and could eventually help with diagnosis, prevention and treatment of cleft lip, which affects more than five million people worldwide. (2008-10-06)

Genetic profile reveals susceptibility to cleft palate
For the first time, researchers from the University of Pittsburgh School of Dental Medicine have identified a series of genetic mutations that appear to be linked to significant risk for cleft palate and other dental abnormalities. These are devastating conditions that cause tremendous social isolation, and also are associated with decreased lifespan, a higher risk of cancer and increased susceptibility to psychiatric disorders, even after surgical repair. (2008-09-15)

Cleft lip and palate: Genes more important than thought?
Comparing 500,000 snippets of human DNA put scientists from the University of Bonn on the right track. A genetic variant on chromosome 8 occurs with significantly higher frequency in people with cleft lip and palate than in the control group. The results are to be published in the forthcoming issue of the journal Nature Genetics. (2009-03-08)

Smoking during pregnancy found to increase risk of cleft lip and palate
Women who smoke while pregnant are 50 to 70 percent more likely than nonsmokers to give birth to a baby with a cleft lip or palate, according to a new study at the University of Michigan. The risk of the disfiguring facial defect rises with the number of cigarettes smoked each day. (2000-03-27)

Study: Birth Defects Decrease Survival, Childbirth, Boost Risk Of Similar Defects
A new study of nearly a half million girls and women shows that those born with birth defects are less likely to survive, especially during the first years of life, than others born without them. Survival is lowest for such catastrophic conditions as anencephaly, hydrocephalus, other syndromes and central nervous system irregularities and highest for cleft palate and lip, clubfoot and malformations of skin, hair, nails and genitals. (1999-04-08)

Cleft lip/palate cause much more than cosmetic problems
Children born with cleft lip, cleft palate and other craniofacial disorders face numerous medical challenges beyond appearance. Patients can face serious airway, feeding, speech and hearing problems, as well as social and psychological challenges. (2012-05-22)

Prdm16: A novel gene important for craniofacial development
In the United States, a baby is born with a facial cleft every hour, of every day of the year. Such birth defects result from both gene mutations and environmental assaults. PRDM16 is a transcription factor originally described as being aberrantly activated in specific types of leukemia, and more recently as a master regulator of brown adipose tissue differentiation. (2012-05-02)

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