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Pitt team searches for genetic roots of cleft lip, palate
An $11.8 million grant from the National Institutes of Health will help University of Pittsburgh researchers explore the genetic roots of craniofacial disorders, including cleft lip and palate, and expand these efforts to populations in Colombia, Nigeria, the Philippines and Pennsylvania. (2014-09-30)

Genetic cause of cleft palates
Some children are born with cleft palates and, of those children, some have an asymmetrical face and a malformed ear. A team of scientists led by Berlin-based researcher Enno Klußmann of the Max Delbrück Center for Molecular Medicine has taken an important step towards discovering the genetic causes of this condition, known as Goldenhar syndrome. (2015-11-26)

Folic acid may prevent cleft lip and palate
A new study finds that women who take folic acid supplements early in their pregnancy can substantially reduce their baby's chances of being born with a facial cleft. (2007-01-26)

USC team tracks down cause of birth defect
A USC research team has pinpointed the source of a genetic disorder that causes life-threatening birth defects, which may allow doctors to quickly diagnose and better treat the disease. (2012-02-13)

Oregon researchers discover a mechanism leading to cleft palate
By creating a genetic mutation in zebrafish, University of Oregon scientists say they've discovered a previously unknown mechanism for cleft palate, a common birth defect in humans that has challenged medical professionals for centuries. (2008-02-11)

New genetic mutations found that may cause cleft lip/palate
University of Iowa researchers and collaborators have identified new genetic mutations that likely cause the common form of cleft lip and palate. The results could eventually help clinicians predict a family's risk of having more children with the condition. The findings appear in the week of March 5 online Early Edition of the Proceedings of the National Academy of Sciences. (2007-03-05)

Scientists from Penn and CHOP confirm link between missing DNA and birth defects
A team from the University of Pennsylvania and the Children's Hospital of Philadelphia has identified the genetic basis for a particular human syndrome that involves cleft palate, epilepsy and respiratory difficulties. (2014-03-11)

Researchers discover gene for branchio-oculo-facial syndrome
In a collaborative effort, researchers from Boston University School of Medicine have discovered that deletions or mutations within the TFAP2A gene result in the distinctive clefting disorder Branchio-Oculo-Facial syndrome. This rare disorder is characterized by specific skin anomalies involving the neck and behind the ear, eye abnormalities, a typical facial appearance, and frequently cleft lip and palate. (2008-04-23)

Solving the mystery of the dancer mice, and cleft lip too
By watching mice (2004-04-30)

Birth defect gene identified
USC craniofacial researchers identify gene involved in skull malformation and rescue defects in animal embryos with over-expression of signaling protein. (2005-12-22)

Topiramate in early pregnancy increases risk of oral clefts
A new study by investigators from Brigham and Women's Hospital and the Harvard T.H. Chan School of Public Health suggest that using topiramate in early pregnancy, particularly at the high doses used for epilepsy, increases the risk of oral clefts. Their results are published in Neurology. (2017-12-28)

Mutations responsible for cleft palate and related birth defects identified
Researchers located a novel gene mutation causing cleft lip and cleft palate defects, which slows the turnover of hyaluronan, an important component of the hard palate. Martina Muggenthaler working with Professor Andrew Crosby, Dr. Emma Baple and colleagues at the University of Exeter, and Biswajit Chowdhury working with Professor Barb Triggs-Raine of the University of Manitoba, report these findings Jan. 12, 2017, in PLOS Genetics. (2017-01-12)

NIH taps Hopkins craniofacial program as 'center of discovery', awards $7.5million grant
What is the likelihood that a baby will be born with a cleft palate? How will smoking or a glass of wine consumed during pregnancy affect a fetus's skull development? Johns Hopkins researchers will use a $7.5 million research grant from the National Institute of Dental and Craniofacial Research (a division of the National Institutes of Health) to answer these questions and others. (1999-08-27)

Breakthrough for babies born with severe cleft palates after experiments at ISIS
Scientists working on a treatment for babies born with cleft palates have made a promising breakthrough and the first clinical trials are planned for early next year. Clefts are the most common birth defect in Britain, with one in every 700 babies affected; currently in severe cases radical surgery is required to correct the problem, and in addition future complications can occur as the child grows into an adult. (2010-03-18)

Gene involved in common birth defect also regulates skin biology
Following up on an earlier discovery that a gene called IRF6 is involved in the common birth defect cleft lip and palate, University of Iowa researchers and their colleagues have identified the function of the gene. Their latest findings, published online Oct. 15 in Nature Genetics, reveal an unexpected role for IRF6 in the growth and development of skin cells, a discovery that may have implications for wound healing and cancer research. (2006-10-15)

New technique uses umbilical cord stem cells for early repair of cleft palate
A technique using umbilical cord blood stem cells could be a promising new approach for repair of cleft palate in infants, reports a paper in The Journal of Craniofacial Surgery, published in the Lippincott portfolio by Wolters Kluwer. (2018-10-02)

Researchers identify gene causing rare form of cleft palate
The identification of a gene that causes a rare form of the congenital defect, cleft palate, may offer an important insight into human development and the mechanisms involved in the condition. Researchers led by Dr Philip Stanier from Imperial College have found that the sex-linked form of cleft palate (CPX) and an associated form of the disorder known as tongue-tie are caused by mutations in a gene called T-box 22. The study is published online today in the journal Nature Genetics. (2001-09-16)

Study shows variation in rates of secondary cleft lip and palate surgery
For children with cleft lip and palate, the chances of undergoing secondary surgery vary depending on the center where they're treated, reports a study in Plastic and Reconstructive Surgery -- Global Open®, the official open-access medical journal of the American Society of Plastic Surgeons. (2015-07-10)

In low- to middle-income countries, barriers to cleft lip and palate surgery persist
Charitable organizations perform more than 80 percent of cleft lip and cleft palate surgeries in Vietnam -- reflecting the complex and persistent barriers to surgical care in low- to middle-income countries, according to a study in the November issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons. (2016-10-28)

Alcohol binges early in pregnancy increase risk of infant oral clefts
A new study by researchers at the National Institute of Environmental Health Sciences, part of the National Institutes of Health, shows that pregnant women who binge drink early in their pregnancy increase the likelihood that their babies will be born with oral clefts. (2008-07-31)

WHO centre calls for global action on cleft palate
A global research network is needed if scientists are ever going to understand and prevent cleft palate, say experts at the first World Health Organization Collaborating Centre set up to develop such a structure. (2005-05-11)

Surprise cell death discovery provides birth defect clues
Researchers have made a surprise discovery that could rewrite our understanding of the role programmed cell death plays in embryonic development and congenital birth defects. The team showed that, while programmed cell death -- or apoptosis -- is essential for healthy development overall, many organs and tissues do not require apoptosis to develop normally. The study also suggested that abnormalities in cell death processes are likely to contribute to some common birth defects in humans, such as spina bifida, heart vessel defects and cleft palate. (2018-05-17)

Educating local physicians key to care of children with cleft deformities in Zimbabwe
A surgical team that traveled to Zimbabwe successfully treated 39 children with cleft lip or palate, and an ongoing relationship with physicians there will help meet the needs of local patients, according to an article that will appear in the November/December 2007 print issue of Archives of Facial Plastic Surgery, one of the JAMA/Archives journals. (2007-10-22)

Variation in the shape of speech organs influences language evolution
Why do speech sounds vary across languages? Does the shape of our speech organs play a role? In a computer modelling study reported in Nature Human Behaviour, researchers from the Max Planck Institute for Psycholinguistics show that variation in the hard palate -- the roof of the mouth -- leads to subtle differences in pronunciation. As newly learned vowels were passed on to next generations, these differences were amplified, showing that our anatomy can influence language evolution. (2019-08-19)

Estimating unmet need for cleft lip and palate surgery in India
An estimated more than 72,000 cases of unrepaired cleft lip and/or palate exist in 28 of India's 29 states and poor states with less health infrastructure had higher rates, according to an article published online by JAMA Facial Plastic Surgery. (2016-06-09)

Mount Sinai researchers find mechanism behind cleft palate development
Researchers from Mount Sinai School of Medicine have found a new mechanism that explains why a certain gene mutation causes craniofrontonasal syndrome, a disorder that causes cleft palate and other malformations in the face, brain and skeleton. Cleft palate affects one of every 1,000 newborns. The research is published in the Sept. 15 issue of Genes & Development. (2010-09-14)

Blueprint for the skull
Once upon a time in Europe, pregnant women avoided rabbits to prevent their babies from being born with a 'harelip.' But, that isn't the only misconception about the condition now known as cleft lip. In the May 1 issue of Cell Reports, UConn Health researchers report the popular modern belief that the condition is caused by a gene is wrong. Their research could transform how we understand the formation of the face. (2018-05-01)

Cleft lip corrected genetically in mouse model
Scientists at Weill Cornell Medical College used genetic methods to successfully repair cleft lips in mice embryos specially engineered for the study of cleft lip and cleft palate. The research breakthrough may show the way to prevent or treat the conditions in humans. (2011-11-28)

Researchers report new gene test for isolated cleft lip and palate
Researchers report they now can predict whether some parents are more likely than others to have a second child with the (2004-08-18)

Small molecule replacement therapy to rescue craniofacial defects
Today at the 45th Annual Meeting & Exhibition of the American Association for Dental Research, researcher Shihai Jia, University of Utah, Salt Lake City, USA, will present a study titled 'Small Molecule Replacement Therapy to Rescue Craniofacial Defects.' (2016-03-19)

SWAT team of immune cells helps reduce infection rates in babies after cleft lip surgery
The mouth is widely considered the dirtiest part of the human body, yet babies have surprisingly low infection rates following cleft lip and palate surgery. (2016-10-17)

Gene offers new lead in cleft lip and palate research
Researchers report that a much-studied gene called SUMO1, when under expressed, can cause cleft lip and palate, one of the world's most common birth defects. (2006-09-21)

Muscle-building therapy may reduce overly nasal speech, says study
For people with hypernasal speech, many of them with repaired cleft palates, there have been few remedies other than surgery, and the surgery comes with risks. Some of these people, however, may find help in a kind of weight-lifting for the soft palate, says a professor of speech and hearing science at the University of Illinois. (2000-03-30)

Scientists identify new gene responsible for puberty disorders
A new gene responsible for some puberty disorders has been identified by Medical College of Georgia researchers. (2008-10-27)

Overall quality of pregnant woman's diet affects risk for two birth defects, Stanford study shows
The overall quality of a pregnant woman's diet is linked with risk for two types of serious birth defects, a new study from the Stanford University School of Medicine has shown. In the study, women who ate better before and during pregnancy gave birth to fewer infants with malformations of the brain and spinal cord, or orofacial clefts, such as cleft lip and cleft palate. (2011-10-03)

Researchers use mouse model to study craniofacial disorders
Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model. The methodology could expand research into the genetic aspects of this craniofacial abnormality. (2016-02-25)

Scientists discover why teeth form in a single row
A system of opposing genetic forces determines why mammals develop a single row of teeth, while sharks sport several, according to a study published today in the journal Science. When completely understood, the genetic program described in the study may help guide efforts to re-grow missing teeth and prevent cleft palate, one of the most common birth defects. (2009-02-26)

National statistics for 18 major birth defects released
Among 18 major birth defects included in this study, cleft lip and/or palate had the highest prevalence, followed by Down Syndrome, according to research that for the first time provides population-based estimates for the prevalence of specific birth defects nationwide. Previous estimates had indicated that 3 percent of all births are affected by a birth defect. However, this is the first time national estimates for specific defects, other than neural tube defects, have been calculated. (2006-01-05)

Obesity during pregnancy associated with increased risk of birth defects
For women who are obese during pregnancy, there is an associated increased risk of certain birth defects, such as spina bifida and neural tube defects, although the absolute increase in risk is likely to be small, according to an analysis of previous studies, reported in the Feb. 11 issue of JAMA. (2009-02-10)

In the gaping mouth of ancient crocodiles
A new study by a team of international experts, led by University of Witwatersrand PhD candidate Kathleen Dollman and Professor Jonah Choiniere published today in the American Museum Novitates, endeavoured to further explore the mouth of one of the earliest occurring and least understood groups of crocodilians, the shartegosuchids. (2018-06-18)

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