Cocaine Current Events

Cocaine Current Events, Cocaine News Articles.
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Alcohol makes rats more vulnerable to compulsive cocaine use
Rats given alcohol for 10 days prior to cocaine exhibited enhanced cocaine-addiction behavior, including continuing to seek cocaine despite receiving a brief electric shock when they did so, a new study reports. (2017-11-01)

Cocaine use linked to poor adherence to antiretroviral therapy in HIV patients
Researchers from the Montefiore Medical Center in New York City found that active cocaine use was the strongest predictor of poor adherence to antiretroviral drug regimens HIV-infected current and former cocaine users. (2002-06-27)

Behavioral treatment may reverse brain changes that occur with cocaine use and help prevent relapse
The findings from this study indicate that behavioral-based treatment approaches have the potential to reverse or lessen the harmful neurobiological and behavioral consequences of chronic drug use. (2003-05-23)

Neuronal differences in certain brain regions observed in chronic users of cocaine
Differences in the areas of the brain involved in decision making, behavioral inhibition, and emotional reaction to the environment were found in chronic cocaine users. (2002-05-28)

Medication for multiple sclerosis may help in treating cocaine addiction
Results of a NIDA-funded study show that a combination of substance abuse counseling and baclofen--a medication often used to treat muscle spasms in people with multiple sclerosis--can reduce cocaine use. (2004-05-03)

Research helps explain why perception of pleasure decreases with chronic cocaine use
Repeated starting and stopping of cocaine use decreases the brain's reward function and reduces the pleasurable effects of the drug. (2002-07-31)

Cocaine-related deaths, drug-related emergency visits drastically increasing, UT Southwestern researchers report
Physicians should consider the possibility of cocaine use as a culprit when young adults are brought to emergency rooms for nontraumatic chest pains, according to researchers at the UT Southwestern Medical Center at Dallas. (2001-08-02)

A single cocaine dose lowers perceptions of sadness and anger
A single dose of cocaine can interfere with the ability to recognize negative emotions such as anger and sadness, according to new research presented at the ECNP conference in Amsterdam. (2015-08-29)

New research indicates that a common heart drug
Researchers from Boston University School of Medicine and Harvard Medical School have found that diltiazem, a drug used in the treatment of high blood pressure, reduces cocaine cravings in a rat model. These findings will appear in the March issue of the leading medical journal Nature Neuroscience. (2008-02-27)

Study finds cocaine use in rats affects adolescents differently than adults
Many people who use drugs start during adolescence, a time when the brain is undergoing many neural changes. Now, researchers from the University of Miami School of Medicine have demonstrated in rats that repeated exposure to cocaine during adolescence may cause different neurochemical and behavioral effects than when exposure occurs during adulthood. (2003-01-13)

Cocaine use may alter brain cells, play role in depression
Chronic cocaine use may cause damage to brain cells that help produce feelings of pleasure, which may contribute, in part, to the high rates of depression reported among cocaine abusers. (2003-03-05)

Sons of cocaine-using fathers may resist addiction to drug, Penn Medicine study suggests
A father's cocaine use may make his sons less sensitive to the drug and thereby more likely to resist addictive behaviors, suggests new findings from an animal study presented by Penn Medicine researchers at Neuroscience 2013, the annual meeting of the Society for Neuroscience. (2013-11-11)

Sleep-deprived mice find cocaine more rewarding
Sleep deprivation may pave the way to cocaine addiction. Too-little sleep can increase the rewarding properties of cocaine, according to new research in mice published in eNeuro. (2020-11-02)

Cocaine use may cause increase in coronary calcium, an indicator of atherosclerosis
Researchers have found a significant association between cocaine use and the presence of calicium in the coronary arteries. (2002-11-04)

Cocaine use decreases ability to respond to stimulation, Yale researchers find
Using an innovative method called transcranial magnetic stimulation (TMS) to measure brain responsiveness, Yale researchers have found that a cocaine addict's response to stimulation is decreased, indicating possible evidence that cocaine causes permanent brain damage. (2001-02-21)

Real-time monitoring of brain activity helps explain how cues contribute to drug relapse
Real-time monitoring of dopamine activity in the brain shows that in rats the mere anticipation of receiving cocaine may cause significant increases in dopamine levels. This finding may help explain why, in humans recovering from cocaine addiction, cocaine paraphernalia, surroundings, and other factors associated with drug use can elicit an intense craving for the drug, often resulting in relapse to use. (2003-05-02)

Sigma receptors play role in mediating the behavioral and toxic effects of cocaine
Cocaine is traditionally thought to exert its effects on behavior by interacting with dopamine transporters. However, recent research, co-funded by NIDA, has shown that other mechanisms may also mediate the behavioral effects of the drug. The research team led by Dr. Rae Matsumoto from the University of Oklahoma Health Sciences Center has demonstrated that interfering with cocaine's access to sigma receptors can block the behavioral and toxic effects of the drug. (2003-01-13)

Genetically modified mice provide information on treatments for cocaine dependence
Cocaine's rewarding effects were still apparent in mice that were lacking both the dopamine and the norepinephrine transporter. Indeed, cocaine was just as rewarding in mice lacking these targets as in control mice that had been raised under identical conditions, but did not have genetic deletions of both the dopamine and the norephinephrine transporter gene. (2003-04-12)

Anti-cocaine vaccine produces antibodies and is shown to be safe in Phase 1 study conducted by Yale researcher
A therapeutic cocaine vaccine designed to suppress the high addicts get from taking cocaine is safe and produced cocaine antibodies in humans, a Yale study finds. The vaccine, TA-CD, is designed to generate drug-specific antibodies, which bind to cocaine and prevent it from travelling to the brain from the bloodstream. This neutralizes its psychoactive effect. (2000-03-06)

Treatment for cocaine addiction may reduce HIV risk
Research indicates that treatment for cocaine addiction, including HIV-risk reduction counseling, may be an effective strategy for preventing HIV infection. (2003-05-23)

Sigma receptors play role in cocaine-induced suppression of immune system
Cocaine use is known to have negative effects on the immune system but how the drug exerts this effect is poorly understood. Now researchers have demonstrated that some of cocaine's effects on the immune system may be mediated by sigma receptors. These receptors are unique proteins found in the brain and other areas of the body and have been shown to play a role in some of the toxic and behavioral effects of the drug. (2003-05-02)

Non-cocaine, topical anaesthetics can kill pain when repairing skin wounds
While some pain killers need to be injected into the damaged tissue in order to work, topical anesthetics only need to be spread on the surface. The earliest examples of (2011-07-27)

Heart problems caused by continued cocaine abuse highlighted
The heart problems caused by sustained cocaine abuse are highlighted in a case report published in this week's edition of the Lancet. (2007-05-03)

Researchers reveal new test for cocaine in urine and oral fluid
Chemistry researchers develop a simple diagnostic test which can identify the level of cocaine in a person's urine or oral fluid. New test offers a low cost, quick method which could be used for testing at the roadside, in the workplace or in prisons Current commercially available portable testing kits can give false positive results and cannot tell how much cocaine a person has ingested. (2016-11-21)

Study using animal model provides clues to why cocaine is so addictive
Scientists at Wake Forest Baptist Medical Center are one step closer to understanding what causes cocaine to be so addictive. (2016-08-01)

How the brain puts the brakes on the negative impact of cocaine
Research published by Cell Press in the Jan. 12 issue of the journal Neuron provides fascinating insight into a newly discovered brain mechanism that limits the rewarding impact of cocaine. The study describes protective delayed mechanism that turns off the genes that support the development of addiction-related behaviors. The findings may lead to a better understanding of vulnerability to addiction and as well as new strategies for treatment. (2012-01-11)

Cocaine use related to level of education achieved
According to a study by researchers at the Johns Hopkins Bloomberg School of Public Health, the decreased use of cocaine in the United States over the last 20 years mostly occurred among the highly educated, while cocaine use among non-high school graduates remained constant. (2007-08-29)

Cocaine adulterant may cause brain damage
People who regularly take cocaine cut with the animal anti-worming agent levamisole demonstrate impaired cognitive performance and a thinned prefrontal cortex. These findings from two recent studies at the University of Zurich indicate that levamisole could have a toxic effect on the brain. Drug-checking programs should therefore be expanded, argue the researchers. (2018-10-31)

Researchers discover key link between mitochondria and cocaine addiction
Scientists at the University of Maryland School of Medicine identified significant mitochondrial changes that take place in cocaine addiction, and they have been able to block them. (2017-12-20)

Study finds link between inflammatory protein and heart disease among cocaine users
This study found that many chronic cocaine users have elevated levels of serum CRP, a protein associated with inflammation, and a possible marker for future cardiovascular events. (2003-05-23)

Abnormal brain structure linked to chronic cocaine abuse
Researchers at the University of Cambridge have identified abnormal brain structures in the frontal lobe of cocaine users' brains which are linked to their compulsive cocaine-using behavior. (2011-06-20)

One in every hundred Londoners could be crack cocaine users, claim researchers
Researchers believe there could be 46,000 crack cocaine users aged 15-44 in London, suggesting one in every hundred young adult Londoners could be a user. (2005-09-19)

Early escalation of cocaine intake is a predictor of addiction
New users of cocaine who quickly escalate the amount they are taking is a good predictor of who is likely to become addicted, a Yale study shows. The study, using an animal model, showed the animals with the highest craving responses in abstinence showed a dramatic escalation of cocaine intake prior to abstinence. (2000-05-29)

Some positive findings in new study on cocaine exposed children
A study suggests that prenatal cocaine exposure was not associated with lower full scale IQ scores, or verbal or performance IQ scores at age 4 years. However, the study also found that prenatal cocaine exposure was associated with specific cognitive impairments and a lower likelihood of an above average IQ, but that home environments could make a difference for better outcomes for some children. (2004-05-26)

Methamphetamine, cocaine abusers have different patterns of use
Studies show that methamphetamine abusers follow a pattern of usage that more closely resembles taking a medication rather than using a drug for pleasure whereas cocaine abusers are more likely to exhibit a (2002-07-31)

Dosage appears to be a critical factor in cocaine vaccine
Dosage appears to be a critical factor in the effectiveness of a cocaine vaccine being tested by Yale researchers that is designed to block the euphoria drug abusers experience. (2002-01-28)

Genes may be central to cocaine addiction
Two related genes that help control signaling between brain cells may be central components of the biological machinery that causes cocaine addiction, researchers have found. Peter Kalivas and his colleagues found that deleting either of two genes in the Homer family in mice produced the same symptoms seen in withdrawal from cocaine. The researchers said that their findings could open a new research pathway to understanding how genetic susceptibility to addiction interacts with environmental factors to cause addiction. (2004-08-04)

UK awarded $6 million to further develop treatment for cocaine abuse
University of Kentucky College of Pharmacy Professor Chang-Guo Zhan, along with fellow UK Professors Fang Zheng and Sharon Walsh, and Professor Mei-Chuan Ko from Wake Forest University, recently received $6 million in funding over five years to further develop a potential treatment for cocaine abuse. (2015-11-20)

Progress toward a vaccine to fight cocaine addiction is reported
A potential vaccine against the addictive effects of cocaine was described here today at the national meeting of the American Chemical Society, the world's largest scientific society. (1999-08-23)

Researchers Discover How Cocaine Use May Cause Heart Attacks
It's well documented that cocaine can over-stimulate the heart and cause a heart attack. Researchers say they may have found one reason why this happens, offering new hope for treatment. German scientists say cocaine attacks cells in the endothelium, a layer of cells that lines the inside of blood vessels, and causes the cells to release endothelin, a chemical which signals blood vessels to contract. (1998-08-03)

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