Cystic Fibrosis Current Events

Cystic Fibrosis Current Events, Cystic Fibrosis News Articles.
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Successful Specialist Care For Cystic Fibrosis Patients From Childhood To Adulthood
It is the clinical responsibility of all physicians to ensure that specialist care of patients with cystic fibrosis begins in childhood and is continued throughout adult life, says Dr Ravi Mahadeva et al from Papworth Hospital in Cambridge. (1998-06-12)

Mucus retained in cystic fibrosis patients' cells leads to potentially deadly infections
Researchers at the University of Missouri recently found that cystic fibrosis mucus actually gets stuck inside some of the cells that create it, rather than simply becoming stuck on the outside linings of organs. (2015-02-18)

Mini-guts predict cystic fibrosis patients' response to therapy
Mini-guts grown in the lab using cystic fibrosis patients' cells can help pinpoint those who are most likely to benefit from new drugs, according to a new study. (2016-06-22)

Dramatic rise expected in adults living with cystic fibrosis
The number of people living with cystic fibrosis into adulthood is expected to increase dramatically by 2025, prompting calls for the development of adult cystic fibrosis services to meet the demand. (2015-03-18)

Cystic Fibrosis Foundation announces $5 million initiative to enhance care for adults with CF
The Cystic Fibrosis Foundation today announced the launch of a new $5 million initiative to enhance care for the growing adult CF population. The initiative, called the Program for Adult Care Excellence, will expand the scope of adult care programs for people with cystic fibrosis. (2008-03-18)

Cystic Fibrosis Foundation hosts 19th Annual Worldwide Cystic Fibrosis Conference
The Cystic Fibrosis Foundation will host its 19th Annual North American Cystic Fibrosis Conference in Baltimore, Md., from Oct. 20-23. Open to the media. Any members of the media wishing to attend must RSVP in advance to Carolyn Habbersett. News announcements issued by the CF Foundation will be made available on the CF Foundation's Web site at (2005-10-17)

Protein opens hope of treatment for cystic fibrosis patients
Scientists have finally identified a direct role for the missing protein that leaves cystic fibrosis patients open to attack from lung-damaging bacteria, the main reason most of them die before their 35th birthday, scientists heard today at the Society for General Microbiology's Autumn meeting being held this week at Trinity College, Dublin. (2008-09-10)

Mizzou, Iowa researchers take first step to create cystic fibrosis model using pigs
The median lifespan for those with cystic fibrosis is 36 years, and lung disease is the major cause of mortality. For years, scientists have studied cystic fibrosis using mice in which the cystic fibrosis gene was altered. However, mice do not develop lung disease like humans with cystic fibrosis. Now, researchers at the University of Missouri and the University of Iowa have taken the first step in developing a porcine cystic fibrosis model that may more faithfully mimic the disease in humans. (2008-03-06)

Cystic fibrosis and diabetes link explained
Many people with cystic fibrosis develop diabetes. The reasons for this have been largely unknown, but now researchers at Lund University in Sweden and Karolinska institutet have identified a molecular mechanism that contributes to the raised diabetes risk. (2014-06-02)

1 step closer to a drug treatment for cystic fibrosis, MU professor says
A University of Missouri researcher believes his latest work moves scientists closer to a cure for cystic fibrosis, one of the world's most common fatal genetic diseases. (2010-10-12)

Antibiotic could offer promise for treatment of cystic fibrosis
The antibiotic azithromycin could offer some benefit to people with cystic fibrosis if they do not respond to conventional treatment, suggest authors of a study in this week's issue of The Lancet. (2002-09-26)

Cystic Fibrosis Foundation launches $175 million fundraising campaign
The Cystic Fibrosis Foundation today announced the launch of a $175 million major gifts fundraising campaign to support research into better treatments and an ultimate cure for the life-threatening disease. This is the largest major gifts campaign in the Foundation's 50-year history. (2005-10-19)

Cystic fibrosis treatments may have unseen long-term benefits
Cystic fibrosis medicines that help to break down mucus in the lungs may carry an unexpected long-term benefit, a study suggests. The treatments not only help breathing in the short term -- they may also make lung infections develop to be less harmful in the long run, research from the University of Edinburgh shows. (2009-07-16)

Researchers find test to ID children at higher risk for cystic fibrosis liver disease
A major multi-center investigation of children with cystic fibrosis has identified a test that allows earlier identification of those at risk for cystic fibrosis liver disease. The study, which includes 11 clinical sites in North America, was led by Michael Narkewicz, MD, professor of pediatrics from the University of Colorado School of Medicine and Children's Hospital Colorado. The findings of the study are published today ahead of print in The Journal of Pediatrics. (2020-02-12)

Study recommends universal newborn screening for cystic fibrosis
Newborn screening for cystic fibrosis saves on treatment costs and would offset the actual costs of the screening program. This new economic evidence suggests that universal newborn screening programs for cystic fibrosis should be adopted internationally, according to an article in this week's issue of the Lancet. (2007-04-05)

Groundbreaking treatment for patients with cystic fibrosis
Groundbreaking treatment that uses two medications that target the most common genetic cause of cystic fibrosis shows lung function improvement and lowers the rate of pulmonary exacerbations. (2015-05-17)

Key found to kill cystic fibrosis superbug
Researchers from the Schulich School of Medicine & Dentistry at the University of Western Ontario, working with a group from Edinburgh, have discovered a way to kill the cystic fibrosis superbug, Burkholderia cenocepacia. These investigators, under the leadership of Dr. Miguel Valvano, Department of Microbiology and Immunology, have had their research published in the May issue of the Journal of Bacteriology, and highlighted in Nature Reviews/Microbiology. (2007-04-24)

$2.8 million grant boosts cystic fibrosis research at Queen's
Scientists at Queen's University Belfast have begun work into improving the lives of thousands of cystic fibrosis sufferers thanks to the award of a £1.74 ($2.8) million US-Ireland Research and Development Partnership grant. (2011-02-04)

Gene therapy: A promising candidate for cystic fibrosis treatment
An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular Virology and Gene Therapy at KU Leuven, Belgium. (2015-11-16)

Cibio knocks out cystic fibrosis
The fight against cystic fibrosis continues, targeting in particular some of the mutations that cause it. This time, scientists relied on genome editing. A research team of the Cibio Department of the University of Trento was able to prove the efficacy of Crispr-Cas, the molecular scissors it has been working on for some time, in solving once and for all the problem that causes the disease. (2019-08-07)

Women with cystic fibrosis "too embarrassed" to seek help for incontinence
A study in this week's BMJ finds that over two-thirds of women with the chest disease cystic fibrosis suffer urinary incontinence, yet are reluctant to seek help. (2001-06-21)

Gene variant heightens risk of severe liver disease in cystic fibrosis
A UNC study, which appears in the Sept. 9 issue of the Journal of the American Medical Association, could lead to earlier detection and diagnosis of cystic fibrosis liver disease and better treatment options for the patients affected by the disease. (2009-09-08)

Researchers show cystic fibrosis defect in mice corrected with turmeric extract
Researchers at Yale University and the Hospital for Sick Children in Toronto report that curcumin, a compound in the spice turmeric, corrects the Delta-F508 defect of cystic fibrosis (CF) in mice. This mutation, present in ~90 percent of people with CF, causes a mis-folded chloride channel (CFTR) that fails to reach the cell surface and function. In curcumin treated cultured cells, CFTR protein moved to the surface, and in CFTR mice, the epithtlia regained nearly normal function. (2004-04-23)

UI study advances understanding of antimicrobials and cystic fibrosis-related infection
Human airway secretions include antimicrobial agents that normally protect the lungs from infection caused by inhaled bacteria and other microorganisms. A recent University of Iowa Health Care study suggests that high salt concentrations in the airways of people with cystic fibrosis prevent these antimicrobial factors from working effectively. (1999-09-08)

An 'unconventional' path to correcting cystic fibrosis
Researchers have identified an unconventional path that may correct the defect underlying cystic fibrosis, according to a report in the Sept. 2 issue of the journal Cell, a Cell Press publication. This new treatment dramatically extends the lives of mice carrying the disease-associated mutation. (2011-09-01)

New research finds novel method for generating airway cells from stem cells
Researchers have developed a new approach for growing and studying cells they hope one day will lead to curing lung diseases such as cystic fibrosis through 'personalized medicine.' (2017-03-30)

Altered microbiome linked to liver disease in adolescents with cystic fibrosis
Michael Narkewicz, MD, professor of pediatrics at the University of Colorado School of Medicine, and colleagues potential found targets for therapy for some adolescents with cystic fibrosis who develop advanced liver disease. (2015-02-18)

A newly discovered disease may lead to better treatment of cystic fibrosis
Cystic fibrosis is the most frequent severe inherited disorder worldwide. Researchers have now discovered a novel disease that might lead to a better understanding of cystic fibrosis and new treatment options in the future. The results have been published in the scientific journal ''Journal of Medical Genetics''. (2020-06-05)

Inhaled antibiotic for treatment of early lung infection in patients with cystic fibrosis
Inhalation of the antibiotic tobramycin could have an important future role in reducing lung infection of patients with cystic fibrosis, suggest authors of a research letter in this week's issue of THE LANCET. (2001-09-20)

Trial reveals safer and simpler approach to treating children with cystic fibrosis
Treating chest infections in young cystic fibrosis patients with an antibiotic once instead of three times daily is as effective and less toxic, conclude the results of a randomised trial published in this week's issue of The Lancet. (2005-02-10)

Breathing for better lung health
While working to find novel ways to treat the life-threatening disease of cystic fibrosis, researchers at the University of North Carolina have discovered that the rhythmic motion of the lungs during normal breathing is a critical regulator of the clearance of bacteria and other noxious materials. Their research, funded by the Cystic Fibrosis Foundation and the National Institutes of Health, is published in the latest issue of The Journal of Physiology. (2007-04-14)

Cystic fibrosis gene typo is a double whammy
Researchers at the University of North Carolina at Chapel Hill School of Medicine have demonstrated that the gene mutated in cystic fibrosis not only controls traffic on the chloride highway, but also keeps the sodium highway from being overused. (2010-11-12)

New X-ray imaging developed by scientists
Scientists have developed an X-ray imaging system that enables researchers to see 'live' how effective treatments are for cystic fibrosis. (2014-08-15)

Cystic fibrosis gene undetected in screening of infertile men
A new study at the University of Toronto shows a significant number of infertile men have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and many of these genetic defects go undetected in routine screening for cystic fibrosis. (1999-06-10)

Insights into a new therapy for a rare form of cystic fibrosis
Scientists at the Hospital for Sick Children in Toronto have established that a drug recently approved by the US Food and Drug Administration to treat a rare form of cystic fibrosis works in an unconventional way. Their results reveal new possibilities for treating various forms of cystic fibrosis. (2012-10-29)

Wayne State receives $1.9 million from NIH to create novel cystic fibrosis treatments
Cystic fibrosis is caused by a defective gene encoding the cystic fibrosis transmembrane conductance regulator. The most common mutation is the deletion of the phenylalanine amino acid residue that leads to a defect in the protein transport to the cell surface, resulting in premature digestion of the protein. Researchers at Wayne State University recently received nearly $1.9 million from the National Heart, Lung and Blood Institute of the NIH to better understand this problem. (2011-11-21)

Common virus linked to faster disease progression in cystic fibrosis
A new study has found that cystic fibrosis patients who have a common virus may experience faster disease progression than patients who do not have the virus. Signs of faster cystic fibrosis disease progression included earlier times to lung transplant referral and reaching the final stages of the disease. (2019-04-07)

Study of international cystic fibrosis centers highlights spread of aggressive bacteria
A bacterium damaging to the lungs and once thought to be acquired from the environment is actually spread -- at least in cystic fibrosis clinics -- through human transmission, a new study reveals. (2016-11-10)

Cystic fibrosis patients' self-assessment of health can predict prognosis
Adult cystic fibrosis patients can provide important information that helps to predict their prognosis, according to research that asked 223 adult CF patients to assess their own health and well-being. (2008-12-29)

Blood test could lead to cystic fibrosis treatment tailored to each patient
Researchers at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago, and colleagues, used a blood test and microarray technology to identify distinct molecular signatures in children with cystic fibrosis. These patterns of gene expression ultimately could help predict disease severity and treatment response, and lead to therapies tailored to each patient's precise biology. (2018-12-12)

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