Cytokines Current Events

Cytokines Current Events, Cytokines News Articles.
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Rethinking new therapies for Crohn's disease at U.Va.
In a Perspective article in the Nov. 11 issue of the New England Journal of Medicine, Dr. Fabio Cominelli, chief of the division of gastroenterology and hepatology at the University of Virginia Health System reports that a dysregulated response by the innate immune system- the body's initial, non-specific response to infection- may have more to do with the development of Crohn's than acquired immunity, currently thought by many to be the most likely suspect. (2004-11-11)

Blood inflammation plays role in Alzheimer's disease
People whose blood shows signs of inflammation are more likely to later develop Alzheimer's disease than people with no signs of inflammation, according to a study published in the May 29, 2007, issue of Neurology, the scientific journal of the American Academy of Neurology. (2007-05-28)

Protection against Malaria: A matter of balance
A balanced production of pro and anti-inflammatory cytokines at two years of age protects against clinical malaria in early childhood, according to a study led by ISGlobal, an institution supported by ''la Caixa'' Foundation. The results also indicated that early exposure to the parasite does not affect the risk of developing the disease, although it could affect the parasite-specific immune response later in life. (2018-11-14)

iNOS expression may links chronic biliary inflammation to malignant transformation
A study by Dr. Kitasato and colleagues demonstrated that cytokine stimulation induced iNOS expression and NO generation, which was sufficient to cause DNA damage in normal hamster gallbladder epithelial cells. These findings suggest that NO-mediated oxidative DNA damage produced by inflammatory cytokines through iNOS expression is involved in an initiation process that links chronic biliary inflammation to malignant transformation. (2007-12-19)

Does the COVID-19 cytokine storm exist?
Cytokines play a crucial role in the immune response. If this immune response is too strong, also known as ''cytokine storm'', it can cause harm to the patient. Following the measurement of several important cytokines in patients with COVID-19 and various other severe diseases, researchers at Radboud university medical center show that COVID-19 is not characterized by a cytokine storm. This may have consequences for the treatment of these patients, the researchers write in JAMA. (2020-09-04)

Missing signals lead to diabetic nerve injury
Molecules that help cells communicate with each other--called cytokines--might be the key to repairing diabetic nerve damage, according to a new study published in Experimental Neurology. Diabetes devastates nerve cells, which can lead to poor circulation, muscle weakness, blindness, and other painful side effects. The new study showed diabetic mice can't repair nerve cells after damage due to low levels of specific cytokines. (2017-08-01)

Add nature, art and religion to life's best anti-inflammatories
Taking in such spine-tingling wonders as the Grand Canyon, Sistine Chapel ceiling or Schubert's 'Ave Maria' may give a boost to the body's defense system. UC Berkeley researchers have linked positive emotions - especially the awe we feel when touched by the beauty of nature, art and spirituality - with lower levels of pro-inflammatory cytokines. (2015-02-03)

Lower levels of anti-inflammatory proteins may contribute to chronic widespread pain
A new study examined cytokine profiles in patients with chronic widespread pain and found that they had significantly lower levels of the anti-inflammatory cytokines IL-4 and IL-10. (2006-07-26)

Closer to the source of the itch
Scientists at Hokkaido University are getting closer to understanding the underlying mechanisms that lead to psoriasis. (2016-05-25)

St18 is a negative regulator of VEGF
A research team led by Kenta Maruyama M.D., Ph.D. from National Institute for Physiological Sciences explored the role of St18 in the regulation of VEGF expression. Mice lacking St18 in myeloid lineages are highly susceptible to septic shock. These mice also exhibit increased retinal vasculature with enhanced serum VEGF concentrations, and pharmacological inhibition of VEGF signaling rescues the high mortality rate of septic shock. These findings suggest that St18 is a negative regulator of VEGF. (2020-07-14)

Slacker or sick?
Early nerve damage caused by repetitive strain injuries can trigger (2005-10-24)

The RANKL cytokine at 2.6 Å
The tumor necrosis factor (TNF) superfamily represents a large, loosely related, and versatile group of homotrimeric cytokines. Here, Lamn et al. report a high-resolution crystal structure of the RANK ligand (RANKL), a TNF relative that acts through its receptor (RANK) to promote the differentiation and bone-resorptive activity of osteoclasts in osteoporosis. (2001-09-26)

Confining cell-killing treatments to tumors
Researchers at the Koch Institute for Integrative Cancer Research at MIT have developed a technique to prevent cytokines escaping once they have been injected into the tumor, by adding a Velcro-like protein that attaches itself to the tissue. (2019-06-26)

Combined effect of proteins saves lives in cases of pneumonia
An effective host defence to the most prevalent form of pneumonia is only obtained if two proteins combine their forces. Dutch researcher Anita Rijneveld made this discovery during her PhD research at the Academic Medical Centre, University of Amsterdam. (2003-05-16)

Scientists identify a septic shock susceptibility gene
In the November 15 issue of G&D, Dr. Robert Schneider and colleagues at NYU School of Medicine report that the AUF1 gene underlies susceptibility to septic shock. (2006-11-02)

University of Montreal researchers discover how drug prevents aging and cancer progression
University of Montreal researchers have discovered a novel molecular mechanism that can potentially slows the aging process and may prevent the progression of some cancers. (2013-03-26)

Gene therapy promising for rheumatoid arthritis
Northwestern University researchers have reported the first successful use of interleukin-13 (IL-13) cytokine gene therapy to treat and prevent rheumatoid arthritis in an animal model (2002-02-11)

Will blocking IL-17A help treat kidney disease?
Animal studies of diseases damaging glomeruli suggest that IL-17A/F and Th17 cells are involved in the initial inflammatory response within the kidney. (2016-01-22)

Test method provides biocompatibility 'barometer'
A new method for quantitatively measuring the compatibility of materials with living tissue has been developed by NIST researchers. Described in a Dec. 11 technical presentation, the technique should provide a more sensitive and reliable means to evaluate the biocompatibility of new materials for a wide range of applications from contact lenses to dental coatings to bone implants. (2003-12-19)

Danish-American research presents new ways of developing treatment of chronic inflammation
Researchers from Aarhus University Hospital and Aarhus University in Denmark in collaboration with researchers from Colorado in the United States have found a new way to treat the inflammation involved in chronic diseases such as psoriasis, asthma and HIV. A group of transmitter substances (cytokines) in the immune system, the so-called IL-1 family, has been shown to play an important role in many of these diseases by regulating the body's immune responses. (2019-08-30)

Research shows some people predisposed for recurrent C. difficile infection
University of Cincinnati (UC) researchers have found that some patients appear to be more predisposed for recurrent infection from the bacterium Clostridium difficile, or C. diff, and that it may advance to a more serious inflammatory condition in those individuals. (2012-05-21)

Univ. of Kentucky Sanders-Brown Center on Aging awarded Alzheimer's drug discovery research grant
Linda J. Van Eldik, director of the University of Kentucky Sanders-Brown Center on Aging, has been awarded a $750,000 grant to further her research into a possible treatment for Alzheimer's disease. (2011-01-24)

Study finds unique form of chronic sinusitis in older patients
Older patients with a diagnosis of chronic sinusitis -- a disease of the nasal cavity and paranasal sinuses that often persists over many years -- have a unique inflammatory signature that may render them less responsive to steroid treatment, according to a new study published by Vanderbilt researchers. (2019-01-23)

Obesity and diabetes: Immune cells in fat tissue explain the link
Inflammation-causing cells in fat tissue may explain the link between obesity and diabetes, a team of Walter and Eliza Hall Institute researchers in Melbourne, Australia, has shown. (2010-08-14)

Breath may help diagnose infection
Researchers from Johns Hopkins University are developing a novel method of testing exhaled breath to detect infection rapidly after potential exposure to a biological warfare agent. They report their findings today at the 2005 ASM Biodefense Research Meeting. (2005-03-21)

Scientists favor needles over tablets for global vaccinations
According to the World Health Organization, 2 billion people around the globe suffer from chronic parasitic worm infections, which, in addition to causing illness and developmental delay, are also suspected to interfere with the effectiveness of ordinary vaccines, making their victims more vulnerable to life-threatening diseases. A recent discovery by researchers at the Trudeau Institute promises to bypass these obstacles and help deliver more effective vaccines to these people, boosting their protection against common childhood diseases. (2010-04-26)

Researchers discover new signaling pathway linked to inflammatory disease
Scientists at the University of California, San Diego School of Medicine have described for the first time a key inhibitory role for the IL-1 signaling pathway in the human innate immune system, providing novel insights into human inflammatory bowel disease (IBD) and potential new treatments. (2010-12-14)

RUDN immunologists developed method for assessing inflammation in respiratory tract diseases
A team of immunologists from RUDN University suggested a new tool to control inflammation levels in asthma patients with accompanying diseases. To obtain information about disease flow and risks of complications, they used different types of cytokines found in the patients' nasal swabs. (2020-12-05)

Biological link established between tumors and depression
In a study that could help explain the connections between depression and cancer, researchers have used an animal model to find, for the first time, a biological link between tumors and negative mood changes. The team determined that substances associated with depression are produced in increased quantities by tumors and are transmitted to the brain. Additionally, pathways that normally moderate the impact of depression-causing substances are disrupted when a tumor develops. (2009-05-18)

Protein found that may provide relief from neuropathic pain
Research in rodents by scientists from the UC-San Diego School of Medicine has provided evidence that a protein called LRP1 may help to ease neuropathic pain by blocking the response of glial cells that support and protect sensory neurons in the peripheral nervous system. Neuropathic pain is caused by injury to the peripheral nerves in diseases such as HIV/AIDS, shingles, and cancer or in repetitive motion disorders and trauma, and does not respond well to conventional pain-relieving drugs. (2007-12-04)

Cytokine resistance contributes to pathology of type 2 diabetes
In a study appearing this month in the Journal of Immunology, researchers at the University of Illinois describe how an impaired anti-inflammatory response plays a role in the pathology of type 2 diabetes. (2007-06-14)

A bifidobacterial protein that can reduce inflammation in COVID-19 found by a RUDN geneticist
A geneticist from RUDN University studied the effect of Bifidobacterium (intestinal bacteria) on the inflammatory process and discovered that their surface protein is capable of stopping excessive or uncontrollable inflammation, like the one observed in COVID-19 patients. A fragment of this protein can be used as an anti-inflammatory medication when treating coronavirus and other diseases. (2020-09-14)

Cancer: The immune system attacks tumors remotely
How does the immune system act to limit tumor development? Using in vivo imaging tools, scientists from the Institut Pasteur and Inserm described the spatiotemporal activity of tumor-infiltrating T lymphocytes, both locally and remotely. (2020-03-12)

Interleukin-12 indicates survival prospects for melanoma patients
Higher blood levels of an immune system protein predict poor survival prospects for melanoma patients with advanced disease, researchers at the University of Texas M. D. Anderson Cancer Center report today at the annual meeting of the American Association for Cancer Research. (2008-04-16)

Bird flu virus triggers worse inflammation in human lung cells than human flu viruses
Scientists might have identified one of the reasons why the bird flu virus H5N1 is so deadly to humans. A study published today in the open access journal Respiratory Research reveals that, in human cells, the virus can trigger levels of inflammatory proteins more than 10 times higher than the common human flu virus H1N1. (2005-11-10)

Emory Researchers Advance Gene Therapy Studies For Metastatic Melanoma Treatment
Melanoma reseachers at Emory University are uncovering new information about a vital cellular ingredient which they believe may direct the body's immune system to kill malignant melanoma tumor cells. (1997-04-24)

Amgen introduces new rheumatoid arthritis book and first online resource for access to interleukin-1 (IL-1) research
Amgen announced the introduction of and Proinflammatory and Anti-Inflammatory Cytokines in Rheumatoid Arthritis: A Primer for Clinicians, two new resources designed to provide health care professionals with updated, reliable and comprehensive information about the role of cytokines, specifically interleukin-1 (IL-1), in rheumatoid arthritis. Interleukin- is the first Web site with the latest scientifically rigorous clinical data regarding IL-1 in RA. (2000-10-28)

Researchers Identify New Mechanism Underlying Pain
New research on neuropathic pain -- the kind of burning, shooting pain for which standard analgesics provide little relief -- is producing evidence that the immune system is intimately involved in the initiation and maintenance of pain, through production of proteins called cytokines. (1998-02-13)

Immunity's Nervous Supervisor
As reported in PNAS, direct communication between the nervous and immune systems, discovered by Weizmann Institute scientists, may help understand and eventually treat autoimmune disorders. (1998-11-30)

Research reveals control of potent immune regulator
A new study reveals how the production of a potent immune regulator called interferon gamma (IFNg) is controlled in natural killer (NK) cells, immune cells that typically defend the body against cancer and infections. IFNg, produced by NK cells and other cell types, plays a critical role in killing pathogen-infected cells and in defending against tumor cells. (2006-05-23)

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