Dopamine Current Events

Dopamine Current Events, Dopamine News Articles.
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Sleep attacks from Parkinson's drugs do exist
Car crashes in patients with Parkinson's disease have been associated with sudden sleep attacks caused by dopamine drugs, but the concept of sleep attacks, and their connection with dopamine drugs, has been disputed. (2002-06-20)

News tips from the Journal of Neuroscience
Story ideas include managing cellular stress in worm dopamine neurons. (2005-04-12)

Researchers uncover how dopamine transports within the brain
Researchers at University of Florida Health have discovered the mechanics of how dopamine transports into and out of brain cells, a finding that could someday lead to more effective treatment of drug addictions and neurological disorders such as Parkinson's disease. (2016-01-25)

Real-time monitoring of brain activity helps explain how cues contribute to drug relapse
Real-time monitoring of dopamine activity in the brain shows that in rats the mere anticipation of receiving cocaine may cause significant increases in dopamine levels. This finding may help explain why, in humans recovering from cocaine addiction, cocaine paraphernalia, surroundings, and other factors associated with drug use can elicit an intense craving for the drug, often resulting in relapse to use. (2003-05-02)

Transformative technology
UC Davis neuroscientists have developed fluorescence sensors that are opening a new era for the optical recording of dopamine activity in the living brain. (2018-06-01)

Striatal dopamine transporter binding correlates with body composition and visual attention bias for food cues in healthy young men
Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior, the foremost society for research into all aspects of eating and drinking behavior, describes a way that brain chemistry may make some people notice food more easily, which can tempt overeating even in people who are not overweight. (2014-07-29)

Appetite accomplice: Ghrelin receptor alters dopamine signaling
New research reveals a fascinating and unexpected molecular partnership within the brain neurons that regulate appetite. The study, published by Cell Press in the Jan. 26 issue of the journal Neuron, resolves a paradox regarding a receptor without its hormone and may lead to more specific therapeutic interventions for obesity and disorders of dopamine signaling. (2012-01-25)

Boost for dopamine packaging protects brain in Parkinson's model
An increase in the protein that helps store dopamine, a critical brain chemical, led to enhanced dopamine neurotransmission and protection from a Parkinson's disease-related neurotoxin in mice. (2014-06-17)

New target for Parkinson's disease identified by Emory researchers
Emory investigators have discovered a novel link between a protein called SV2C and Parkinson's disease (PD). Prior work had suggested that the SV2C gene was associated with the curious ability of cigarette smoking to reduce PD risk. (2017-02-28)

PET provides insight into schizophrenic brain function
Schizophrenia is a devastating disease that affects some 2.5 million Americans. Doctors and researchers are striving to better understand this disease; most believe the neurotransmitter dopamine (DA) plays a crucial role in the disease - particularly the dopamine regulated by D2 receptors (D2R). A recent study using PET scans backs the theory that irregular transmission of dopamine is present in schizophrenics. (2003-06-23)

Flies on speed offer insight into the roles of dopamine in sleep and arousal
Methamphetamine, the drug of choice for long-distance truckers and college students pulling all-nighters, appears to do a similar trick for fruit flies, too. This finding is one of several in a new study that demonstrates a critical role for the neurotransmitter dopamine in the modulation of sleep, wake, and arousal states. (2005-07-11)

A high-fat diet alters crucial aspects of brain dopamine signaling
Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior, the foremost society for research into all aspects of eating and drinking behavior, finds that prolonged exposure to a high fat diet is correlated with changes in the brain chemical dopamine within the striatum, a critical component of the brain's reward system. (2010-07-13)

Neurons transplanted into Parkinson's-affected brains appear healthy after 14 years
When transplanted into the midbrains of adult patients with Parkinson's disease, dopamine neurons derived from fetal tissue can remain healthy for many years. The findings reported in the Cell Press journal Cell Reports on June 5 suggest that transplanted neurons don't degenerate over time as some had suggested and feared they would, which provides further rationale for pursuing stem cells as a source for transplant-ready dopamine neurons, according to the researchers. (2014-06-05)

How amphetamine affects the dopamine transporter
It is thought that abnormal concentrations of dopamine in synapses initiate a series of events that cause the behavioral effects of many psychostimulants, including amphetamine. Jonathan Javitch and colleagues have identified a chemical modification of the dopamine transporter (DAT) that is essential for DAT-mediated dopamine release in the presence of amphetamine. Since this modification does not inhibit the ability of DAT to accumulate dopamine, it may suggest a molecular target for treating drug addiction. (2004-03-16)

Vollum scientists find new form of dopamine transmission
An Oregon Health & Science University research team has uncovered a novel form of transmission between neurons in the brain that is mediated by dopamine. The neurons are found in parts of the brain associated with movement, substance abuse and mental disorders. Scientists reported in a study published in the journal Neuron that the neurotransmitter dopamine is released from midbrain nerve cells in a much more precise, targeted manner than previously thought. (2004-07-14)

Neurotrophic factor GDNF is an important regulator of dopamine neurons in the brain
New research results are expanding our understanding of the physiological role of the glial cell line-derived neurotrophic factor GDNF in the function of the brain's dopamine systems. In an article recently published in the Journal of Neuroscience, University of Helsinki researchers establish that GDNF is an important physiological regulator of the functioning of the brain's dopamine neurons. (2017-02-15)

U of T researcher links schizophrenia, gene mutations
The supersensitivity to dopamine that is characteristic of schizophrenia can be caused by mutations to a wide variety of genes, rather than alterations to just two or three specific genes, says a University of Toronto researcher. (2005-02-14)

Dopamine conducts prefrontal cortex ensembles
New research in rodents reveals for the first time how dopamine changes the function of the brain's prefrontal cortex. In a study published today in the journal Cell Reports, researchers found that dopamine has little effect on individual cells. Instead, it generates sustained activity in the ensemble of cells in the prefrontal cortex that lasts for up to 20 minutes. (2019-04-02)

Brain scans show dopamine levels fall during migraine attacks
Using PET scans of the brain, University of Michigan researchers showed that dopamine falls and fluctuates at different times during a migraine headache. (2017-03-29)

Study examines cannabis' effects on brain neurochemistry
A new Addiction Biology study provides the first evidence of a blunted response to stress-induced dopamine signaling in the brain's prefrontal cortex in individuals at high risk for psychosis who regularly used cannabis. (2019-08-07)

Danish researchers 1 step closer towards a cocaine antidote
Researchers at the University of Copenhagen have gained new insight into the mechanism behind a protein dopamine transporter that could help in the development of future medical treatment against cocaine addiction. (2015-01-13)

Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinson's symptoms
New evidence indicates that the loss of two types of brain cells -- not just one as previously thought -- may trigger the onset of symptoms associated with Parkinson's disease. The evidence, based on mouse models, shows a link between the loss of both norepinephrine and dopamine neurons and the delayed onset of symptoms associated with Parkinson's disease. It was originally thought that the loss of only dopamine neurons triggered symptoms. Dopamine is a neurotransmitter critical for coordinating movement. (2007-08-13)

Pitt researchers find 'switch' for brain's pleasure pathway
In the current issue of Proceedings of the National Academy of Sciences, Pitt professor of neuroscience, psychiatry, and psychology Anthony Grace and Pitt neuroscience research associate Daniel Lodge suggest a new mechanism for how the brain's reward system works. (2006-03-22)

Kidney dopamine regulates blood pressure, life span
The neurotransmitter dopamine is best known for its roles in the brain -- in signaling pathways that control movement, motivation, reward, learning and memory. Now, Vanderbilt University investigators report in the July Journal of Clinical Investigation that dopamine produced outside the brain -- in the kidneys -- is important for renal function, blood pressure regulation and life span. Their studies suggest that the kidney-specific dopamine system may be a therapeutic target for treating hypertension and kidney diseases. (2011-07-19)

New data suggests nicotine while pregnant alters genes
A University of Houston biomedical research team is reporting that a possible cure for addiction may be found by following the pathways of significantly altered dopamine neurons in newborns who were chronically exposed to nicotine in utero. (2019-02-05)

Study finds gaba cells help fight alcoholism
Scientists of the Higher School of Economics, Indiana University, and École normale supérieure clarified how alcohol influences the dopamine and inhibitory cells in the midbrain that are involved in the reward system and the formation of dependency on addictive drugs. The results of the study were published in the article 'Dynamical ventral tegmental area circuit mechanisms of alcohol-dependent dopamine release'. (2018-12-19)

Brain parasite directly alters brain chemistry
A research group from the University of Leeds has shown that infection by the brain parasite Toxoplasma gondii, found in 10-20 percent of the UK's population, directly affects the production of dopamine, a key chemical messenger in the brain. (2011-11-04)

Dopamine model could play role in treating schizophrenia and drug addiction
Researchers at the University of Copenhagen have succeeded in creating a model of the way the brain releases dopamine, an important chemical involved in transmitting signals between nerve cells. The model will be an important tool in helping scientists understand how we learn and how the brain perceives reward and punishment. It is hoped that the model can be used to understand drug addiction and in the treatment of schizophrenia. (2010-10-20)

A new model to trial preventative treatments for schizophrenia
Neuroscientists at The University of Queensland have developed a new animal model of schizophrenia that will enable researchers around the world to better understand the disease and develop new treatments. Schizophrenia, which affects around seven people in 1,000, is a poorly understood group of mental disorders that disrupt cognition and behavior. The precise neurological cause of schizophrenia is unknown and the development of better treatments are urgently needed. This research will provide a model to begin to address some of the underlying fundamental mechanisms involved. (2019-03-29)

Dopamine receptors implicated in obesity
A deficiency of dopamine in the brain may explain why some individuals engage in pathological overeating, resulting in severe obesity, according to a study published in this week's Lancet. Based on their findings, the researchers believe that individuals deficient in dopamine may need to eat more than people with higher dopamine levels to induce feelings of satisfaction and gratification. (2001-01-31)

McGill team offers new hopes in cures for Parkinson's disease, schizophrenia, depression, drug addiction and severe pain
Dopamine and somatostatin are two major neurotransmitter systems that share a number of structural and functional characteristics. It is generally accepted that there is a physiologically relevant interaction between the two systems. However, the molecular basis for such interaction is unclear. In today's issue of Science, a team of scientists led by McGill Professor Dr. Yogesh Patel, shows how this direct intra-membrane association works. (2000-04-06)

Scientific discovery may change treatment of Parkinsons
When monitoring Parkinson's disease, SPECT imaging of the brain is used for acquiring information on the dopamine activity. A new study conducted in Turku, Finland, shows that the dopamine activity observed in SPECT imaging does not reflect the number of dopamine neurons in the substantia nigra, as previously assumed. (2017-03-22)

UTSA neuroscientist receives $1.8 million grant to support dopamine research
Carlos Paladini, UTSA associate professor of neuroscience, has received a $1.8 million grant from the National Institutes of Health to take a closer look at dopamine bursts in the brain. Paladini, who has done extensive research on methods to treat drug addiction by manipulating dopamine levels, hopes that this new undertaking could help people afflicted by clinical depression, drug addiction, schizophrenia or Parkinson's disease. (2016-01-25)

Brain chemicals can thwart desire to smoke cigarettes
Giving smokers medication to mimic an increase in their brain's level of a substance called dopamine could help squelch their desire for cigarettes, according to a new study. (2002-09-03)

Cocaine use may alter brain cells, play role in depression
Chronic cocaine use may cause damage to brain cells that help produce feelings of pleasure, which may contribute, in part, to the high rates of depression reported among cocaine abusers. (2003-03-05)

New finding in studying dopamine transporter
Yale researchers observed an altered availability of the dopamine transporter in healthy persons with a genetic variation linked to substance abuse and attention deficit hyperactivity disorder. (2005-06-06)

Dopamine agonists reduce motor complications in Parkinson's disease, but increase other side effects
Dopamine agonists are increasingly used to treat people with Parkinson's disease, but there is a debate about how well they work. A review of current data indicates that there is less risk of developing motor complications with these drugs. (2008-04-15)

1 sleepless night increases dopamine in the human brain
Just one night without sleep can increase the amount of the chemical dopamine in the human brain, according to new imaging research in the August 20 issue of the Journal of Neuroscience. Because drugs that increase dopamine, like amphetamines, promote wakefulness, the findings offer a potential mechanism explaining how the brain helps people stay awake despite the urge to sleep. However, the study also shows that the increase in dopamine cannot compensate for the cognitive deficits caused by sleep deprivation. (2008-08-19)

Feeding hormone ghrelin modulates ability of rewarding food to evoke dopamine release
New research findings to be presented at the upcoming annual meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, finds that ghrelin, a natural gut hormone that stimulates feeding, also modulates the ability of tasty food and food-related cues to alter dopamine levels within the striatum, a critical component of the brain's reward system. (2011-07-12)

A new study suggests that a neurotransmitter might improve the treatment of cancer
A new study found that injections of the neurotransmitter dopamine can improve blood flow to tumors and delivery of an anticancer drug, doubling the amount of drug reaching tumors and increasing its effectiveness. Dopamine also raised tumor oxygen levels, which typically improves the effectiveness of both chemotherapy and radiation therapy. The study suggests a use for dopamine in treating cancer and perhaps other disorders in which normalizing abnormal blood vessels might improve therapeutic responses. (2011-12-05)

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