Enzyme Current Events

Enzyme Current Events, Enzyme News Articles.
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USC Scientists Identify Enzyme Important In Short-term Memory
An enzyme that fails to get activated in patients with Alzheimer's disease may play a broader role in normal memory, USC scientists report. The new finding may explain why Alzheimer's patients suffer from memory loss. (1998-11-11)

Enzyme may get key role in drug design for breast cancer and brain condition
In recent years, researchers have focused on the enzyme TLK2 suspecting it of playing a main role in several diseases. A new study conducted at the University of Copenhagen now reveals that the enzyme displays lower levels of activity in intellectual disability and that it is possible to inhibit it in breast cancer, where it is overactive. The study thus suggests that the enzyme may be a target for potential therapies. (2018-06-29)

A fat-regulating enzyme could hold the key to obesity, diabetes, cancer, other diseases
It had already been known that the enzyme known as phosphatidic acid phosphatase plays a crucial role in regulating the amount of fat in the human body. Controlling it is therefore of interest in the fight against obesity. But scientists at Rutgers University-New Brunswick have now found that getting rid of the enzyme entirely can increase the risk of cancer, inflammation and other ills. Their findings were published online in the Journal of Biological Chemistry last month. (2017-09-18)

Researchers closer to being able to change blood types
What do you do when a patient needs a blood transfusion but you don't have their blood type in the blood bank? It's a problem that scientists have been trying to solve for years but haven't been able to find an economic solution -- until now. (2015-04-29)

Enzyme Engineering XIX
The Enzyme Engineering Conferences started in 1971 and has become the leading international forum for new developments in enzyme technology and biocatalysis, including both fundamental and practical aspects of emerging technologies. The Enzyme Engineering Conference series has been instrumental in bringing together the leaders in applied chemistry, biology and engineering throughout the world. (2007-02-04)

Enzyme discovery paves way to tackling deadly parasite diseases
An enzyme found in all living things could hold the key to combating deadly diseases such as sleeping sickness, a study suggests. (2014-09-24)

Discovery could lead to new treatment strategy against TB
By uncovering the 3-dimensional structure of an enzyme that is critical for the survival of the bacterium that cause tuberculosis, researchers may be one step closer to developing a new strategy to combat TB infections. (2016-02-16)

Virus might fight brain tumors better if armed with bacterial enzyme, study shows
New research shows that oncolytic viruses, which are engineered to destroy cancer cells, might be more effective in treating deadly brain tumors if equipped with an enzyme that helps them penetrate the tumor. The enzyme removes sugar chains that branch from proteins that fill the narrow spaces between cells. By cutting away these branches, the enzyme clears a path that enables the virus to spread through the tumor. (2011-01-13)

Missing link in plant immunity identified
An enzyme critical to plant immunity is found to be activated in a previously unknown way. (2014-03-12)

Williams Biology Prof. Receives NSF Grant For Work On dUTPase
The National Science Foundation has awarded a grant of $266,191 to nancy Roseman, assistant professor of biology, for her work on deoxyuridine triphosphatase (dUTPase), an enzyme involved in DNA metabolism. (1998-02-12)

A defense mechanism to kill intestinal worms
Researchers have discovered a mechanism that kills intestinal worms, which affect nearly a third of the world's population as well as livestock. (2017-10-11)

Move over Michaelis-Menten!
Researchers from Aarhus University challenge one of the cornerstones of biochemistry, the Michaelis-Menten equation. They show that many enzymes in signalling pathways are independent of substrate concentration, because the substrate is physically connected to the enzyme. With these results, it may one day be possible to develop drugs that not only target the enzyme, but also affect how it is connected to its substrate. (2020-08-20)

Quality control is vital for the energy production of cells
Researchers have uncovered a mitochondrial error-correction mechanism, which is vital for the construction of the mitochondrial respiratory chain and the energy production of cells. (2017-12-11)

Pharmacogenetics of angiotensin-converting enzyme inhibitors for Alzheimer's disease
The researchers aimed to investigate whether ACE gene polymorphisms rs1800764 and rs4291 are associated with cognitive and functional change in patients with Alzheimer's disease. (2018-04-09)

Researchers uncover previously unstudied cancer enzyme
In a new study published in the scientific journal of repute Nature Communications researchers from the University of Copenhagen have discovered how an enzyme that plays a key role in cancer development functions. The researchers hope the new knowledge will lead to the design of more precise drugs. (2018-09-12)

Clemson researchers collect and reuse enzymes while maintaining bioactivity
Clemson University researchers are collecting and harvesting enzymes while maintaining the enzyme's bioactivity. Their work, a new model system that may impact cancer research, is published in the journal Small. (2012-08-08)

New technology for enzyme design
Scientists at the University of Würzburg have chemically modified the enzyme levansucrase using a new method. The enzyme can now produce sugar polymers that are exciting for applications in the food industry and medicine. (2018-06-01)

Unexpected discovery about essential enzyme
The enzyme that produces DNA building blocks plays an important role when cells divide. In a new study, researchers have discovered for the first time that the so-called master switch of the enzyme can change locations -- while still performing the same task. (2018-02-21)

Scientists find donut-shaped structure of enzyme involved in energy metabolism
Using advanced X-radiation techniques, University of Missouri researchers were able to visualize one of these terminals inside of an enzyme that degrades proline, which is an amino acid that has a central role in metabolism. In humans, proline is important for suppression of cancer, cell death and oxidation. Understanding the structure of this enzyme will help scientists better understand how it functions and develop drugs that may inhibit its catalytic function. (2010-02-15)

Researchers inhibit ebola virus
The incurable Ebola virus has long been feared due to its high mortality rate and danger of infection. Now researchers from the University of Copenhagen and Phillips Universität Marburg have succeeded in inhibiting the virus in cell cultures. The researchers hope to be able to continue doing animal testing and developing an actual drug. (2017-12-29)

X-ray diffraction may play key role in stopping 'kissing bug,' fungus
If finding the cure for a fungus and parasite that affects millions of people were the subject of a detective show, University of Missouri Chemistry Professor John Tanner would be the forensic expert in the lab, using high-tech equipment to make a model that could eventually solve the crime. (2010-10-19)

Exploring the evolutionary history of the immune system
Researchers from Charité - Universitätsmedizin Berlin have found that human ALOX15 appears to have developed a much higher capacity to stimulate the production of these lipid mediators than the enzyme variant found in lower primates. (2016-12-09)

UVa researchers seek to unlock broccoli's cancer fighting secret
Janet V. Cross, assistant professor of pathology at the University of Virginia School of Medicine, and her colleague Dennis J. Templeton, M.D., Ph.D., chairman of the UVa Department of Pathology, have received a $1.3 million grant from the National Cancer Institute to study how specific nutrients in healthy vegetables like broccoli work to prevent cancer. (2006-10-16)

TSRI chemists report nicotine-chomping bacteria may hold key to anti-smoking therapy
A new study from scientists at The Scripps Research Institute explores a bacterial enzyme that might be used as a drug candidate to help people quit smoking. The research shows that this enzyme can be recreated in lab settings and possesses a number of promising characteristics for drug development. (2015-08-06)

Minimal changes alter an enzyme dramatically
A new study by a research team at Uppsala University shows how new functions can develop in an enzyme. This can explain, for example, how resistance to toxins can occur so simply. The findings are now being published in the Journal of Biological Chemistry. (2010-01-19)

New knowledge about the building blocks of life
A study of an enzyme that helps build and repair DNA in living organisms increases our understanding of how these processes are controlled and how we can use this to combat infections. (2016-09-02)

Parasite study paves way for therapies to tackle deadly infections
New understanding of a parasite that causes a million cases of disease each year could point towards effective drug treatments. (2017-10-10)

New MS research shows remarkable findings
New research findings from the Research Institute of the McGill University Health Center (MUHC) provide hope for patients with multiple sclerosis (MS), one of the most common and devastating diseases of the nervous system. This study identifies a key enzyme that triggers MS-like disease in an animal model. The findings also show that blocking this enzyme has a remarkable effect in preventing disease and relapses. (2004-02-05)

ISU researcher develops green, bio-based process for producing fuel additive
A new green, bio-based method for producing a much-used fuel additive and industrial chemical that is currently made from petroleum products has been developed by Iowa State University researcher Thomas Bobik. (2010-06-24)

Enzyme may drive breast cancer growth
A recently discovered enzyme drives the production of a potent form of estrogen in human breast cancer tissue, according to researchers from the University of Illinois at Chicago College of Medicine. (2011-05-18)

Enzyme promotes fat formation
The enzyme TPPII may contribute to obesity by stimulating the formation of fat cells, suggests a study in EMBO reports this week. The enzyme, TPPII, has previously been linked to making people feel hungry, but Jonathan Graff and colleagues now show that it may be even more deeply involved in causing obesity. (2007-10-11)

New therapy for heart failure
During heart failure the body reacts to the production of the hormone aldosterone. Too much aldosterone can stiffen and damage the muscles of the heart. Dutch researcher Luc Roumen has optimized compounds that inhibit the production of this hormone and looked at their optimum dosage. The compounds were manufactured by the companies Schering-Plough and SyMO-Chem BV and a drug patent has been applied for. (2008-10-15)

Unlocking the function of enzymes
Fitting a key into a lock may seem like a simple task, but researchers at Texas A&M University are using a method that involves testing thousands of keys to unlock the functions of enzymes, and their findings could open the door for new targets for drug designs. (2007-11-06)

A near-universal way to measure enzyme inhibition
Researchers at McGill University have invented a new technique for measuring how quickly drugs interact with their molecular targets. The discovery provides scientists with a new way to investigate the effectiveness of drug candidates that might otherwise have been overlooked. (2018-03-01)

Alcohol-breakdown molecule may play a role in breast cancer development
Scientists from The University of Manchester -- part of the Manchester Cancer Research Centre -- and the University of Salford looked at a particular enzyme, a biological molecule that accelerates chemical reactions -- known as CYP2E1. Their findings offer a possible target to improve outcomes for patients in the later stages of the disease. (2014-02-11)

Bioremediation to keep atrazine from waterways
Farmers around the world are expected to benefit from the successful trial of an enzyme that breaks down the herbicide, atrazine, in run-off water. (2009-02-17)

Japanese researchers make breakthrough in antioxidant enzyme linked to jaundice
A Japanese research team involving Osaka University investigated biliverdin reductase, the enzyme producing bilirubin -- a substance linked with jaundice -- from biliverdin (BV). Two BV molecules were found at the enzyme reaction site, in an unusual stacked arrangement. Mutation experiments confirmed which enzyme amino acid was necessary for bilirubin production. In the proposed mechanism, this amino acid transfers hydrogen to one BV molecule, using the other BV as a conduit. This aids the search for anti-jaundice drugs. (2017-03-29)

Novel strategies for healthy aging
Protein degradation is a major cause of ageing and can be the result of attacks on proteins by other molecules. One of these processes, glycation, involves the attack by sugars on proteins. Protection against glycation declines with age leading to increasing damage with increasing age. A critical enzyme involved in protection against glycation is (2007-03-31)

Research proves new soybean meal sources are good fish meal alternatives
Two new sources of soybean meal are capturing attention throughout the country. University of Illinois research indicates that fermented soybean meal and enzyme-treated soybean meal may replace fish meal in weanling pig diets. (2011-02-07)

Research reveals how succinate dehydrogenase is linked to both tumor and neurodegeneration
Sarah Fendt (VIB-KU Leuven): 'In this project we studied mutations in enzyme succinate dehydrogenase, which are associated with tumors, but also neurodegeneration. This is interesting, because tumors are defined by cells that show sustained proliferation and in this sense sustained fitness, while neurodegeration is defined by cells of impaired fitness. It is surprising that mutations in one and the same enzyme, which all lead to loss of enzyme expression result in two distinct disease phenotypes.' (2016-11-15)

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