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OHSU Researchers Find Estrogen/Progestin Therapy More Beneficial Than Estrogen Alone
Researchers at Oregon Health Sciences University have discovered that a new hormonal drug combination allows post-menopausal women to get the benefits of estrogen without experiencing the side effects of menses-like bleeding. Their findings appear in the Nov. 6, 1996 issue of the Journal of the American Medical Association (1996-11-01)

Estrogen improves Parkinson's disease symptoms
Brain-selective estrogen treatment improves the symptoms of Parkinson's disease in male mice, according to new research published in JNeurosci. These findings may help explain the sex differences in Parkinson's disease and could lead to estrogen-based treatments. (2019-08-12)

Estrogen found to play key role in male birds' ability to sing
Why do male but not female zebra finches sing? Scientists for 20 years have known that males develop the correct brain pathway but researchers didn't know why. Mystery solved: Male brains produce enough of the so-called female hormone estrogen at exactly the right time. (2001-02-28)

Researchers discover effects of exercise in women taking hormone replacement therapy
Researchers have found that women who take hormone replacement therapy (HRT) through a skin patch have higher estrogen levels during exercise than women who exercise and take HRT orally. These study findings,published in the June issue of Fertility and Sterility, should help doctors advise their patients about HRT options on a more individualized basis. There are concerns about a possible connection between elevated estrogen levels and the development of certain kinds of cancers. (2002-06-07)

Mayo Clinic finds estrogen may prevent younger menopausal women from strokes
Estrogen may prevent strokes in premature or early menopausal women, Mayo Clinic researchers say. Their findings challenge the conventional wisdom that estrogen is a risk factor for stroke at all ages. The study was published in the journal Menopause. (2011-10-12)

Protective Effect Of Progestin In Hormone Replacement Therapy Appears To Be Dose-Related
To help protect against endometrial cancer, women who take estrogen replacement therapy should also take progestin at least 10 days a month, say researchers at the University of Washington. Progestins are hormones that oppose the effects of estrogen on the endometrial cells that line the uterus. (1997-02-14)

Oral contraceptive use associated with increased risk of breast cancer
Investigators from the Slone Epidemiology Center at Boston University School of Medicine have reported that African-American women who use oral contraceptives have a greater likelihood of developing breast cancer than nonusers. The study results, recently published on-line in Cancer Epidemiology Biomarkers and Prevention, were based on data from the Black Women's Health Study, a large follow-up study of 59,000 African-American women from across the US conducted by investigators at the Slone Epidemiology Center since 1995. (2010-08-03)

Tamoxifen stimulates breast cancer growth following alteration of estrogen receptor
Scientists have discovered that resistance to tamoxifen treatment can be mediated by a modification of the estrogen receptor. These results enhance the understanding of what underlies tamoxifen resistance in breast cancer and may eventually allow for earlier identification of resistant tumors, providing critical time to choose an alternative therapeutic strategy that is more likely to be effective. (2004-06-03)

Anti-estrogen medication reduces risk of dying from lung cancer
A new study has found that tamoxifen, an anti-estrogen breast cancer medication, may reduce an individual's risk of death from lung cancer. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study supports the hypothesis that there is a hormonal influence on lung cancer and that estrogen levels play a role in lung cancer patients' prognosis. (2011-01-24)

Stress could increase risk of heart disease in women
Reduced estrogen levels due to stress may put some young women on a high-risk course for heart disease, reported researchers from Wake Forest University Baptist Medical Center today at a meeting of the North American Menopause Society. (2000-09-08)

Targeting estrogen receptors prevents binge eating in mice
A new study in the Journal of Clinical Investigation suggests that estrogen replacement may limit binge-eating behaviors. (2014-08-26)

BPA exposure in pregnant mice changes gene expression of female offspring
Prenatal exposure to bisphenol A, or BPA, a chemical found in many common plastic household items, can cause numerous genes in the uterus to respond differently to estrogen in adulthood, according to a study using a mouse model. The results will be presented Tuesday at the Endocrine Society's 94th Annual Meeting in Houston. (2012-06-26)

New link between estrogen and breast cancer
The female sex hormone estrogen turns on a gene linked to breast cancer, according to new research by Brisbane scientists. (2007-08-24)

Yale researchers create topical estrogen that alleviates sexual dysfunction in menopausal women and eliminates side effects of conventional estrogen
To alleviate vaginal dyspareunia or dryness, a painful symptom of menopause that causes sexual dysfunction, Yale researchers have created a topical estrogen that eliminates side effects of conventional estrogen and that in the future could also alleviate some symptoms of aging skin. (2001-05-09)

Estrogen can reduce stroke damage by inactivating protein
Estrogen can halt stroke damage by inactivating a tumor-suppressing protein known to prevent many cancers, Medical College of Georgia researchers say. (2009-07-16)

Researchers say estrogen can kill breast cancer cells once fueled by the hormone
Fox Chase Cancer Center researchers say some breast cancer cells once fueled by estrogen can be killed by the same hormone. This raises the possibility that estrogen therapy after estrogen deprivation may overcome the cells' eventual resistance to hormone therapy. (2005-12-06)

New biomarker predicts effectiveness of breast cancer drugs
University of Cincinnati researchers have identified a new way to predict when anti-estrogen drug therapies are inappropriate for patients with hormone-dependent breast cancer. Scientists say these findings could help physicians more accurately predict which tumors will respond to anti-estrogen therapy and improve long-term survival for breast cancer patients. (2006-12-07)

Long-term estrogen therapy linked to breast cancer risk
Long-term estrogen therapy may be related to a higher risk of breast cancer among postmenopausal women who have had a hysterectomy, according to an article in the May 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. (2006-05-08)

Osteoporosis drug may help treat advanced hormone-sensitive breast cancer
A new osteoporosis drug hinders the growth of estrogen-sensitive cancer that has become resistant to treatment with tamoxifen, a study in mice shows. (2013-06-15)

Estrogen found to increase growth of the most common childhood brain tumor
University of Cincinnati researchers have discovered that estrogen receptors are present in medulloblastoma -- the most common type of pediatric brain tumor--leading them to believe that anti-estrogen drug treatments may be beneficial in limiting tumor progression and improving patients' overall outcome. (2009-02-16)

Estrogen may dictate what problem-solving strategy brain uses
Deciding on hormone-replacement therapy - weighing the far-reaching benefits and risks - can give a woman a headache. Now researchers say estrogen may dictate what problem-solving strategies the brain uses to solve problems. (2002-05-15)

UCLA study shows loss of key estrogen regulator may lead to metabolic syndrome and atherosclerosis
UCLA researchers demonstrated that loss of a key protein that regulates estrogen and immune activity in the body could lead to aspects of metabolic syndrome, a combination of conditions that can cause Type 2 diabetes, atherosclerosis and cancer. (2011-09-06)

Src inhibitors may prove beneficial in breast cancer therapy
Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha. These ER-alpha-negative cancers are more aggressive and have a worse prognosis than do ER-alpha-positive breast cancers, and have been thought to be estrogen independent. In a new JCI study, University of Miami researchers shed further light on the mechanisms regulating ER-alpha expression levels during breast cancer. (2007-07-12)

Estrogen, soy boost recovery in hearts after surgery, studies show
Extensive damage to cells, reduced nitric oxide production and too much calcium buildup. These negative consequences followed open-heart surgery in mice and rats in the absence of estrogen. With estrogen or a soy-based equivalent, post-operative damage is much less. (2001-08-01)

Low estrogen levels in men linked to increased risk for hip fracture
A new study has found that men with low estrogen levels have an increased risk for future hip fracture, and those with both low estrogen and low testosterone levels have the greatest risk. (2006-05-01)

Study of early estrogen's effect on heart disease similar to WHI findings
Researchers in The Department of Obstetrics, Gynecology & Reproductive Sciences at Yale have launched the Kronos Early Estrogen Prevention Study (KEEPS), which will further understanding of the possible beneficial effects on the heart and arteries and/or quality of life in recently menopausal women. (2006-02-28)

Estrogen's role in the sex differences of alcohol abuse
Fluctuating estrogen levels may make alcohol more rewarding to female mice, according to new research in JNeurosci. Untangling the involved signaling pathways could unveil sex-based treatments for alcohol use disorders. (2020-06-01)

Stress could increase risk of heart disease in women
Reduced estrogen levels during women's pre-menopausal years may set the stage for heart disease later in life, reports Jay Kaplan, Ph.D., from Wake Forest University Baptist Medical Center in the March issue of The Green Journal, a publication of the American College of Obstetricians and Gynecologists. (2002-02-28)

Female Hormone, Estrogen, May Be Weapon Against Stroke
For the first time researchers have shown that estrogen -- a hormone that may protect women from heart disease -- also may be a weapon for both men and women against stroke. Researchers say the results of the study, conducted in rats, support the possibility that estrogen given shortly after a stroke may help reduce brain damage in both men and women. (1998-08-06)

UCLA study identifies 'designer estrogen' as potential MS drug
While people with multiple sclerosis have many choices for anti-inflammatory drugs to help prevent flare-ups of their physical symptoms, no medication exists to stop MS from causing degeneration of the brain and spinal cord. Now a UCLA study finds that a new form of estrogen protects the brain without increasing the risk of hormone-induced cancers of the breast and uterus. (2007-08-27)

Hormone replacement therapy (HRT) may protect against cognitive decline in women 65 and older who have a certain genetic make-up
Researchers led by a UC San Francisco scientist are reporting that hormone replacement therapy (HRT) using estrogen may protect against cognitive decline in women 65 and older. (2000-05-22)

Osteoporosis drug stops growth of breast cancer cells, even in resistant tumors
A drug approved in Europe to treat osteoporosis has now been shown to stop the growth of breast cancer cells, even in cancers that have become resistant to current targeted therapies, according to a Duke Cancer Institute study. (2013-06-15)

Estrobolome disparities may lead to developing biomarkers that could mitigate cancer risk
Investigating disparities in the composition of the estrobolome, the gut bacterial genes capable of metabolizing estrogens in both healthy individuals and in women diagnosed with estrogen-driven breast cancer may lead to the development of microbiome-based biomarkers that could help mitigate the risk of certain cancers, according to a review paper published April 22 in the JNCI: Journal of the National Cancer Institute. (2016-04-22)

Future hope for patients with breast cancers resistant to tamoxifen
Researchers have found a new family of therapeutic agents that interferes with the ability of estrogen to stimulate the growth of breast cancer cells. The results of the new study will be presented by Nicole Patterson at the Endocrine Society's 90th Annual Meeting in San Francisco. (2008-06-16)

How does estrogen protect bones? Unraveling a pathway to menopausal bone loss
Women who have reached menopause are at a greater risk of developing osteoporosis, which can lead to bone fractures and long-term impairment of mobility. Studies have suggested a link between reduced bone density and low estrogen levels due to menopause, but the basis for this link is unclear. Researchers at Tokyo Medical and Dental University found that the protein Sema3A plays a key role in maintaining healthy bones, suggesting a new therapeutic avenue to treat osteoporosis. (2019-03-22)

Clue to unusual drug-resistant breast cancers found
Researchers at the University of Illinois at Chicago College of Medicine have found how gene expression that may contribute to drug resistance is ramped up in unusual types of breast cancer tumors. Their findings may offer new therapy targets. (2010-10-08)

Novel technique switches triple-negative breast cancer cells to hormone-receptor positive cells
Within many hormone-receptor positive breast cancers lives a subpopulation of receptor-negative cells - knock down the hormone-receptor positive cells with anti-estrogen drugs and you may inadvertently promote tumor takeover by more dangerous, receptor-negative cells. A study recently published in the Proceedings of the National Academy of Sciences describes how to switch these receptor-negative cells back to a state that can be targeted by existing hormone therapies. (2011-11-01)

Estrogen therapy may help prevent memory decline in elderly women
Normal aging in women affects their capacity for learning - coding, consolidating, and retrieving new information. A McGill researcher has shown that hormone replacement therapy may help prevent some of the decline in explicit memory that occurs with normal aging (2000-10-10)

Does estrogen influence alcohol use disorder?
A new study from researchers at the University of Illinois at Chicago shows that high estrogen levels may make alcohol more rewarding to female mice. (2020-06-01)

Discovery Could Help Understand Breast-Cancer Therapies
Breast-cancer researchers at the University of Illinois have identified four amino acids viewed as leading actors in the binding of estrogen and anti-estrogen hormones to receptor proteins in the female reproductive system. (1996-10-03)

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