Gene Regulation Current Events

Gene Regulation Current Events, Gene Regulation News Articles.
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How life generates new forms
A new study identifies the kind of gene regulation most likely to generate evolutionary change. (2018-04-11)

DNA's twisted communication
Gene expression needs to be finely controlled during embryo development. Fgf8 is one of these regulation factors that control how the limbs, the head and the brain grow. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of interdependent regulatory elements. (2013-02-28)

Wired for change
A study of gene expression led by scientists at the EMBL-European Bioinformatics Institute and the University of Cambridge has revealed the first steps of evolution in gene regulation in mice. Published in the journal Cell, the research has implications for the study of differences in gene regulation between people. (2013-08-02)

FASEB Science Research Conference: Mechanism and Regulation of Prokaryotic Transcription
This SRC will focus on the process of transcription in prokaryotes, from structure/function investigations to transcription networks and system level regulation. In all organisms, controlling the process of transcription is fundamental to gene expression, gene regulation, and development. (2017-02-28)

Humans and sponges share gene regulation
Humans have a lot in common with the humble sea sponge, according to research that changes the way we think about animal evolution. University of Queensland School of Biological Sciences researcher Dr Milos Tanurdzic said a collaborative study found sponges use a complex gene regulation toolkit similar to much more complex organisms such as humans. (2017-04-10)

'Epigenetics:' The new comprehensive guide from Cold Spring Harbor Laboratory Press
In this new edition of 'Epigenetics' from CSHL Press, 36 chapters by experts in the field introduce and explain epigenetic effects from many perspectives. These include the varied molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of model organisms in which epigenetic effects have been most studied. The book is a benchmark text for advanced undergraduate and graduate courses on gene regulation, and an essential resource for scientists interested in this rapidly moving field. (2015-04-10)

NYU, Rockefeller researchers find complexity of regulation by microRNA genes
Collaborating researchers at New York University and Rockefeller University have discovered that microRNA genes, which have recently been shown to have key roles in gene regulation, can team up and regulate target genes in mammals. The paper, published in the latest issue of the journal Nature Genetics, found that a microRNA gene regulates, on average, 200 different human gene transcripts and that many microRNAs can coordinate their activities to regulate specific target genes. (2005-04-04)

Specific gene region in hypertension revealed
The renin-angiotensin system plays an essential role in blood pressure homeostasis. To address the molecular mechanisms controlling hypertension-responsive mouse renin (mRen) gene regulation, University of Tsukuba researchers deleted specific regions of the endogenous mRen gene and placed the animals in a hypertensive environment. The mRen gene bearing the 5? deletion lost hypertension responsiveness. The team proposes that in a hypertensive environment, the activity of this novel enhancer is attenuated and mRen gene transcription is suppressed to maintain blood pressure. (2018-03-20)

Global crosstalk limits gene regulation
Scientists at the interface of biophysics, evolutionary biology and systems biology develop new framework to analyze effects of global crosstalk on gene regulation. An interdisciplinary collaboration between three IST Austria research groups leads to publication in Nature Communications. (2016-08-12)

CRISPR editing in pancreatic cells reduced cell death and increased insulin secretion
With the help of the CRISPR/Cas9 gene scissors, researchers at Lund University Diabetes Centre in Sweden have managed to 'turn off' an enzyme that proved to play a key role in the regulation of the diabetes-associated TXNIP gene. The results are decreased cell death and increased insulin production in the genetically modified pancreatic beta cells. (2016-12-01)

Genomatix wins BioChance grant worth $1.6 million
Genomatix Software GmbH of Munich, Germany, has won a (2006-09-14)

New research initiative investigates gene regulation in evolution and development
Johannes Gutenberg University Mainz has received EUR 900,000 for three years to investigate, jointly with the Institute of Molecular Biology, how gene regulation affects evolution and development. (2014-04-02)

A splice of the action: Translational role for WT1 isoform
In the June 15th issue of G&D, Dr. Marie-Louise Hammarskjold (UVA) and colleagues lend new insight into the function of the Wilms' Tumor 1 tumor suppressor. (2006-06-01)

Embryonic gene regulation through mechanical forces
During embryonic development genetic cascades control gene activity and cell differentiation. In a new publication of the journal PNAS, the team of Ulrich Technau of the Department of Molecular Evolution and Development at the University of Vienna reported that besides the genetic program, also mechanical cues can contribute to the regulation of gene expression during development. Comparisons with other animals suggests that this regulatory principle is ancient. (2018-05-22)

Technique finds gene regulatory sites without knowledge of regulators
A new statistical technique developed by researchers at the University of Illinois allows scientists to scan a genome for specific gene-regulatory regions without requiring prior knowledge of the relevant transcription factors. The technique has been experimentally validated in both the mouse genome and the fruit fly genome. (2009-11-19)

Research effort seeks A's to gene expression Q's
The National Institute of Standards and Technology (NIST) has launched a new $6.25 million, five-year program to explore and address challenges in measurement, validation and quality control for the rapidly growing field of gene expression profiling.Gene expression measurements impact everything from basic bioresearch to drug development and clinical diagnostics. (2004-11-10)

Rewiring of gene regulation across 300 million years of evolution
As published today in Science, researchers from Cambridge, Glasgow and Greece have discovered a remarkable amount of plasticity in how transcription factors, the proteins that bind to DNA to control the activation of genes, maintain their function over large evolutionary distances. (2010-04-09)

The 80th CSH Symposium Proceedings addresses 21st Century Genetics: Genes at Work
'21st Century Genetics: Genes at Work,' the 80th Cold Spring Harbor Symposium Proceedings, provides a current synthesis of genetic mechanisms and genome/chromosome biology. This volume spans a broad range of topics that reflect our current understanding of genetic mechanisms in humans and other organisms. Themes include chromosome biology and nuclear structure, topologically associating domains, gene-enhancer interactions, chromatin and epigenetics, gene regulation and control, developmental regulation, RNA controlling elements, maintenance of genome stability, nuclear receptors, circadian clocks and aging, and genome editing. (2016-07-19)

Mechanism sheds light on how the brain adapts to stress
Scientists now have a better understanding of the way that stress impacts the brain. New research, published by Cell Press in the Jan. 26 issue of the journal Neuron, reveals pioneering evidence for a new mechanism of stress adaptation and may eventually lead to a better understanding of why prolonged and repeated exposure to stress can lead to anxiety disorders and depression. (2012-01-25)

Understanding lens development
As published in G&D, scientists have discovered the key molecular event behind vertebrate lens induction.This finding reveals a novel cooperation between two distinct classes of transcription factors. (2001-05-14)

New genetic region responsible for testicle development found
New research presented today at the European Society for Pediatric Endocrinology meeting has found a genetic region, which may control testicle development in the fetus. (2011-09-26)

Study reveals key role of mRNA's 'fifth nucleotide' in determining sex in fruit flies
A team of scientists led by the University of Birmingham has shown how a common mRNA modification, N6-methyladenosine (m6A), regulates gene expression to determine the sex of fruit flies. (2016-11-30)

How organ functions were shaped over the course of evolution
A large-scale study conducted by molecular biologists from Heidelberg University has yielded groundbreaking new insights into the evolution and regulation of gene expression in mammalian organs. The scientists investigated RNA synthesis and subsequent protein synthesis in the organs of humans and other representative mammals. They were able to demonstrate that the interplay of the two synthesis processes during evolution was crucial for shaping organ functions. (2020-11-11)

A new light shed on genetic regulation's role in the predisposition to common diseases
An international team with people from King's College, Oxford University, Wellcome Trust Sanger Institute and Faculty of Medicine of University of Geneva, has discovered several thousands new genetic variants impacting gene expression some of which are responsible for predisposition to common diseases, bringing closer to the biological interpretation of personal genomes. (2012-09-02)

Researchers find a key to growth differences between species
The tiny, little-noticed jewel wasp may provide some answers as to how different species differ in size and shape. And that could lead to a better understanding of cell growth regulation, as well as the underlying causes of some diseases. (2012-02-23)

Error correction strategies of cells
Professor Gasper Tkačik and graduate students Sarah Cepeda-Humerez and Georg Rieckh examine error correction of cells in their paper published on Dec. 4, 2015, in the Physical Review Letters. They investigate the importance of crosstalk and its effects, and propose an alternative model that suppresses erroneous initiation. (2015-12-04)

Protein regulation linked to intellectual disability
Genetics researchers at the University of Adelaide have solved a 40-year mystery for a family beset by a rare intellectual disability - and they've discovered something new about the causes of intellectual disability in the process. (2012-10-25)

Evolution is driven by gene regulation
It is not just what's in your genes, it's how you turn them on that accounts for the difference between species -- at least in yeast -- according to a report by Yale researchers in this week's issue of Science. (2007-08-09)

Molecular regulation of hypoxic-ischemic brain damage
Dr. Lijun Yang and co-workers from Beijing Friendship Hospital, Capital Medical University in China prepared whole brain slices from a rat model of oxygen-glucose deprivation and explored dynamic expression pattern of Olig1 during hypoxic-ischemic brain damage and after miRNA-9 transfection. (2014-08-25)

Gene regulation: Can we stomach it?
A breakthrough in decoding gene regulation of Helicobacter pylori has been made by an international research team led by Jorg Vogel of the Max Planck Institute for Infection Biology in Berlin. Using a newly developed sequencing technique, the researchers discovered 60 small ribonucleic acids -- tiny RNA-particles which can regulate genes -- in the genome of this human pathogen. These findings could facilitate the development of new therapeutic strategies against this widespread pathogen. (2010-02-23)

Molecular regulation of hypoxic-ischemic brain damage
Dr. Lijun Yang and co-workers from Beijing Friendship Hospital, Capital Medical University in China prepared whole brain slices from a rat model of oxygen-glucose deprivation and explored dynamic expression pattern of Olig1 during hypoxic-ischemic brain damage and after miRNA-9 transfection. (2014-05-12)

What makes us unique? Not only our genes
Scientists at EMBL Heidelberg and Yale and Stanford Universities have found that we differ from each other mainly because of differences not in our genes, but in how they're regulated -- turned on or off, for instance. (2010-03-18)

Doctors must embrace regulation changes
Doctors should accept the main proposals to change regulation of the medical profession as the best way of restoring public confidence, according to an editorial in this week's BMJ by a leading member of the GMC. (2006-07-20)

Gene regulation: Risk-free gene reactivation
Chemical modification of DNA subunits contribute to the regulation of gene expression. Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich have now deciphered a new pathway can reactivate genes that have been silenced in this way, while avoiding the risk of damaging the DNA. (2017-12-01)

The informant: a jumping gene
Scientists at EMBL Heidelberg have developed a new method for studying gene regulation, by employing a jumping gene as an informant. Called GROMIT, it allows scientists to also create mouse models for human diseases caused by chromosomal rearrangements, such as Down syndrome. (2011-03-21)

Naturopaths support tougher regulation of complementary medicine
Naturopaths are strongly in favor of regulation of their industry, a University of Queensland researcher has found. (2008-07-10)

Copy/paste and delete -- or how to thrive without gene regulation
Turning genes on and off as needed allows an organism to adapt to changes in the environment -- provided the organism has a specific regulatory design in place. Scientists from the Institute of Science and Technology Austria (IST Austria) have shown that under rare or rapidly changing conditions, the fitness of a population of bacteria can increase simply by producing a higher number of copies of one and the same gene. The results are highly relevant in resistance to antibiotics treatment. (2020-03-09)

Scientists model gene regulation with chromatin accessibility
Researchers from the Academy of Mathematics and Systems Science (AMSS) of the Chinese Academy of Sciences have teamed up with Stanford University and Tsinghua University scientists to successfully model data on gene regulation with paired expression and chromatin accessibility (PECA) and have developed new tools to infer context-specific regulatory networks. (2017-06-06)

Gene suppression helps form memories
A new study has identified a number of genes that are repressed at various time points after memory formation, providing important clues as to how long-term memories are formed. (2015-10-01)

Regulation of cancer-causing protein could lead to new therapeutic targets
Researchers with the Cincinnati Cancer Center and the University of Cincinnati Cancer Institute have discovered a new regulation for the cancer-causing protein KRas which may help with the development of targeted therapies for patients with a KRas mutation. (2013-12-16)

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