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Daclatasvir-sofosbuvir combination highly effective and well tolerated in patients with hepatitis C
Phase III results revealed today at the International Liver Congress 2015 show that once-daily treatment with daclatasvir plus sofosbuvir resulted in an overall 97 percent sustained virologic response at 12 weeks post-treatment in patients with hepatitis C virus and HIV co-infection, including cirrhotic patients. (2015-04-23)

Understanding HIV's persistence
Study sheds new light on the mechanism underlying the persistence of HIV-1 infected cells despite antiviral treatment. (2017-06-19)

Study confirms early elevated HIV infection risk in some Step Study participants
A long-term follow-up analysis of participants in the Step Study, an international HIV-vaccine trial, has confirmed that certain subgroups of male study participants were at higher risk of becoming infected after receiving the experimental vaccine compared to those who received a placebo. (2012-05-07)

Infant formula blocks HIV transmission via breastfeeding
A team of researchers from Lavax and the University of Illinois at Chicago, reporting today during the 86th General Session of the International Association for Dental Research, is developing a new technology that prevents the infection of HIV by breastfeeding. (2008-07-03)

Pitt Public Health analysis challenges assumptions about bisexual men and HIV transmission
The number of HIV positive men who have sex with both men and women is likely no higher than the number of HIV positive heterosexual men, according to a US-based analysis by University of Pittsburgh Graduate School of Public Health researchers. The finding challenges a popular assumption that bisexual men are responsible for significant HIV transmission to their female partners. (2013-11-06)

Nanotechnology based gene editing to eradicate HIV brain reservoir in drug abusers
The study will use nanotechnology with magneto electric nanoparticles (MENPs) to deliver drugs across the blood brain barrier in conjunction with the Cas9/gRNA gene editing strategy that has shown great promise in finding and destroying copies of HIV that have burrowed into the host's genome. (2017-02-15)

Researchers unveil new monkey model for HIV
By altering just one gene in HIV-1, scientists have succeeded in infecting pig-tailed macaque monkeys with a human version of the virus that has until now been impossible to study directly in animals. (2009-03-02)

MS drug Tysabri shows promise in efforts to combat HIV's 'viral reservoirs'
A drug now used to treat Crohn's disease and multiple sclerosis has shown effectiveness in lab experiments in blocking viral reservoirs, which have been tied to illnesses that afflict people living with HIV, Boston College biologists and colleagues reported in the journal PLOS Pathogens. (2015-02-18)

New research shows promise for possible HIV cure
Researchers have used radioimmunotherapy to destroy remaining human immunodeficiency virus (HIV)-infected cells in the blood samples of patients treated with antiretroviral therapy, offering the promise of a strategy for curing HIV infection. (2013-12-03)

UCSF researchers call for shift in HIV prevention priorities
HIV prevention resources are not allocated in the most cost- effective fashion say UCSF researchers. Funding is disproportionately allocated towards preventing heterosexual transmission although HIV infection among heterosexuals appears to be falling, and rates of HIV infection for men who have sex with men have remain stable and may be increasing. (2000-10-26)

Friendly bacteria in humans may protect against HIV
Scientists have identified good bacteria already living in some humans that target and trap HIV and may protect against infection. They report their findings today at the 2005 American Society for Microbiology Beneficial Microbes Conference. (2005-04-18)

African children with HIV would benefit from daily doses of cheap antibiotic
Results of a randomised trial in this week's issue of The Lancet highlight how the low-cost antibiotic co-trimoxazole should be given to all children with HIV in developing countries to help reduce illness and death from opportunistic infections such as pneumonia. The trial was stopped early when it became obvious that co-trimoxazole treatment nearly halved the mortality rate compared with placebo. (2004-11-18)

Researchers look for culprit behind oral health problems in HIV-positive patients
Researchers want to help HIV-positive patients live better by understanding why their essentially dormant infection is still wreaking havoc in their mouths. (2014-02-20)

Case Western Reserve researchers identify HIV-inhibiting mechanism
Researchers at Case Western Reserve University School of Medicine have discovered a long-sought cellular factor that works to inhibit HIV infection of myeloid cells, a subset of white blood cells that display antigens and hence are important for the body's immune response against viruses and other pathogens. The factor, a protein called SAMHD1, is part of the nucleic acid sensing machinery within the body's own immune system. (2011-06-29)

MDR1 gene variation predicts immune recovery after HIV treatment
A study in this week's issue of THE LANCET suggests that the ability of the immune response to recover after antiretroviral treatment for HIV-1 infection may be dependent on the composition of the MDR1gene, which encodes the P-glycoprotein. (2002-01-03)

Study finds HIV 'superinfection' boosts immune response
Women who have been infected by two different strains of HIV from two different sexual partners - a condition known as HIV superinfection - have more potent antibody responses that block the replication of the virus compared to women who've only been infected once. These findings, by researchers at Fred Hutchinson Cancer Research Center in Seattle, are published online March 29 in PLoS Pathogens. (2012-03-29)

Pneumococcal conjugate vaccines can improve the lives of HIV-infected children
An international team of experts has published the first comprehensive review of evidence on pneumococcal conjugate vaccination for children with HIV infection. Now available in the online edition of the journal Lancet Infectious Diseases, the review shows that HIV increases the risk of pneumococcal infection by up to 40 fold, that the disease is usually due to serotypes in the PCV, and that the vaccine can protect HIV-infected infants. (2007-11-28)

Clergy can fight HIV on faith-friendly terms
In the United States, where blacks bear a disproportionate burden of the HIV/AIDS epidemic, black religious institutions could help turn the tide. In a new study in PLoS ONE based on dozens of interviews and focus groups with 38 of Philadelphia's most influential black religious leaders, physicians and public health researchers find that traditional barriers to preaching about HIV prevention could give way to faith-friendly messages about getting tested and staying on treatment. (2012-05-16)

People living with HIV diagnosed with COPD 12 years younger than HIV-negative people
Researchers analyzed incidences of chronic obstructive pulmonary disease (COPD) among adults 35 years and older who were living with and without HIV between 1996 and 2015 in Ontario - where over 40 per cent of Canadians living with HIV reside. People in Ontario living with HIV had a 34 per cent higher incidence rate of COPD and were diagnosed with the disease about 12 years younger than HIV-negative individuals. (2020-02-18)

HVTN 505 vaccine induced antibodies nonspecific for HIV
A study by researchers at the National Institute of Allergy and Infectious Diseases and Duke University helps explain why the candidate vaccine used in the HVTN 505 clinical trial was not protective against HIV infection despite robustly inducing anti-HIV antibodies: the vaccine stimulated antibodies that recognized HIV as well as microbes commonly found in the intestinal tract, part of the body's microbiome. (2015-07-30)

RV144 vaccine efficacy increased against certain HIV viruses
Scientists used genetic sequencing to discover new evidence that the first vaccine shown to prevent HIV infection in people also affected the viruses in those who did become infected. Viruses with two genetic (2012-09-10)

Alcoholism and HIV infection have different effects on visuomotor procedural memory processes
Visuomotor procedural memory processes include driving a car, riding a bike, and using a computer mouse. This study examined the separate and combined injurious effects of chronic alcoholism and HIV infection upon visuomotor procedural memory processes. Results indicate the two conditions differently affect the processes involved in procedural learning and memory of visuomotor information. (2012-07-23)

Timely antiretroviral therapy essential for best prognosis in people with HIV-1 infection
Authors of an international study in this week's issue of THE LANCET highlight how timely treatment with highly-active antiretroviral therapy (HAART) can substantially improve the three-year prognosis for people with HIV-1 infection. (2002-07-11)

HIV/AIDS linked to extensively drug resistant TB
A highly drug-resistant form of tuberculosis (TB) has been linked to HIV/AIDS in a study conducted in rural South Africa by researchers at Yale School of Medicine. (2006-11-10)

Major gaps in HIV programs in Africa
HIV management in developing countries varies with socioeconomic and structural circumstances, with two Flinders University studies finding examples of key ways to close the gap for those worst affected in developing countries. The studies, just published in PLoS ONE journal, call for reforms to nutritional programs and for better treatment of HIV affected prisoners - providing guidance for several sub-Saharan regions as well as other low and middle-income countries. (2020-05-31)

Mother-to-child HIV transmission in Gipuzkoa has fallen from 25 percent to 2 percent over the last 25 years
Miren Apilánez, researcher in the Department of Paediatrics of the UPV/EHU-University of the Basque Country, has studied the evolution that took place between 1984 and 2011 in paediatric HIV infection in Gipuzkoa. The development of methods to diagnose the disease coupled with increasingly more effective treatments have made it possible to reduce mother-to-child transmission (vertical transmission) from 23.9 percent to 2.4 percent, thus virtually eradicating infection in children. (2013-11-29)

The 'Berlin patient,' first and only person cured of HIV, speaks out
Timothy Ray Brown, long known only as the 'Berlin Patient' had HIV for 12 years before he became the first person in the world to be cured of the infection following a stem cell transplant in 2007. He recalls his many years of illness, a series of difficult decisions, and his long road to recovery in the first-person account, 'I Am the Berlin Patient: A Personal Reflection,' published in AIDS Research and Human Retroviruses. (2015-01-06)

More than 2 million people co-infected with HIV and hepatitis C
An estimated 2.3 million people living with HIV are co-infected with hepatitis C virus (HCV) globally, a new study by the University of Bristol and the London School of Hygiene & Tropical Medicine has found. (2016-03-08)

WHO guidelines for treatment of pneumonia infected children under 1 need revision
The World Health Organization's guidelines for treatment of pneumonia in children under one year in Africa are inadequate and need revision, conclude authors of an article published in this week's edition of the Lancet. (2007-04-26)

AIDS epidemic should be treated as a disaster
In September, the World Health Organization (WHO) declared the HIV/AIDS epidemic a global health emergency requiring a rapid scaled-up treatment response, but researchers in this week's BMJ argue that governments should go one step further and treat it as a disaster. (2003-11-06)

SLU researchers uncover direct evidence on how HIV invades healthy cells
New insight into how HIV infects healthy cells could lead to new drug therapies, according to new research at Saint Louis University's Institute for Molecular Virology. (2005-12-21)

Miriam Hospital receives renewal of NIH grant for AIDS Clinical Trials Group
A $2.4 million grant renewal will support the Miriam Hospital's continued efforts in research and new treatments for HIV and AIDS. The Miriam Hospital is the largest HIV/AIDS care provider in the state. (2014-03-19)

Amount of AIDS virus in genital secretions predicts risk of heterosexual transmission
In a study that took place in seven African countries, higher concentrations of the AIDS virus in genital secretions were linked to a greater risk of virus transmission between opposite-sex couples. The effect is independent of blood levels of the virus. The findings point to research strategies to make HIV positive people less infectious to their partners. The genital HIV levels may be a marker of effectiveness in testing preventive strategies. (2011-04-06)

Involving partners of pregnant women in Africa to improve AIDS prevention
In the Ivory Coast, an IRD team conducted a two-year follow-up of a group of women after the offer of an HIV test during pregnancy. Such monitoring showed the importance for them of communication with their partner about this test opportunity. The results should pave the way to provision of psychosocial counseling for pregnant women at key moments during or after their pregnancy, in order better to control HIV infection and its consequences for their couple. (2008-04-28)

Immune Response To HIV Predicts Disease Progression
Certain patterns of immune responses to the human immunodeficiency virus (HIV) during the first weeks of infection are highly predictive of an individual's subsequent rate of disease progression, according to investigators at the National Institute of Allergy and Infectious Diseases (NIAID) and their colleagues. (1997-01-09)

Trial finds more support for universal HIV screening in emergency departments
Screening everyone for HIV in the emergency department may be superior to testing only those with apparent risk, when trying to identify patients with undiagnosed HIV infection, according to a new results by researchers at the University of Cincinnati and published in the Journal of Acquired Immune Deficiency Syndromes. (2013-08-05)

Deciphering how CD4 T cells die during HIV infection
Gladstone scientists have solved a long-standing mystery about HIV infection -- how HIV promotes the death of CD4 T cells. Loss of these critical immune cells that leads to the development of AIDS. Most immune cells that die during HIV infection are seemingly not infected, a phenomenon formerly described as (2010-11-24)

We have a lot more to learn before we can halt the AIDS pandemic
Basic ignorance about how vaccines like polio and measles actually work is stalling the urgent quest for an AIDS vaccine, say leading HIV researchers. The assumption that successful vaccines work by simply producing antibodies is almost certainly wrong. (2000-05-23)

On HIV Testing Day, HIVMA calls for health care reform to make testing routine every day
This Saturday, June 27, HIV Testing Day, the HIV Medicine Association urges everyone to get tested for HIV, a vital step in linking people to lifesaving care and reducing the spread of new infections. (2009-06-22)

NIH funds research to detect tuberculosis progression in people with HIV
Tuberculosis (TB) is the leading cause of death worldwide among people infected with HIV. But as yet, no test can reliably show when latent (inactive) TB infections in people with HIV starts progressing to active -- and potentially fatal -- TB disease. Now, a researcher at Albert Einstein College of Medicine has received a five-year, $3.7 million National Institutes of Health grant to identify biomarkers that signal an increase in activity by Mycobacterium tuberculosis, the bacterium that causes TB, in people with HIV. (2016-08-29)

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