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Heart Muscle Current Events, Heart Muscle News Articles.
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Yale lead test site for detecting heart disease in diabetics
Yale will be the lead test site for a $3.2 million national study aimed at earlier diagnosis of the leading silent killer of persons with diabetes -- heart disease. (2000-08-21)

Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
By studying chickens' hearts, a University of Missouri researcher has identified certain proteins within the heart muscle that play an important regulatory role in embryonic heartbeat control. Understanding these components and how they interact will give researchers a better understanding of heart development and abnormalities in humans. (2009-01-21)

Collective action
Genetic switches called enhancers and the molecules that activate them can be used to draw a cell's family tree, EMBL scientists have found. (2012-02-03)

UCSF study shows that drug administered during heart procedures preserves blood flow into the heart muscle
A drug commonly used during invasive heart procedures not only helps maintain blood flow through the large blood vessels that have been enlarged during the procedure by balloons and metal tubes, but also preserves blood flow through the smaller blood vessels downstream that may become blocked by debris. (2000-11-13)

Special cells contribute to regenerate the heart in Zebrafish
It is already known that zebrafish can flexibly regenerate their hearts after injury. An international research group led by Prof. Nadia Mercader of the University of Bern now shows that certain heart muscle cells play a central role in this process. The insights gained could be used to initiate a similar repair process in the human heart. (2019-10-23)

The benefits of reperfusion therapy
The wider use of reperfusion therapy in patients with heart attack can save millions of lives in Europe. Effective reperfusion therapy in an AMI patient can cut the individual risk of dying by half. AMI is caused by a sudden blockage of a coronary artery, one of the vessels supplying the heart muscle with oxygen and nutrients. Effective reperfusion therapy provides a timely and sustainable reopening of the blockage. (2009-09-01)

MicroRNAs, alternative splicing and the muscle proteome
As reported in the January 1 issue of G&D, a UCLA research team led by Dr. Douglas Black has shown how microRNAs regulate alternative splicing during muscle development. (2006-12-31)

Cells make costume changes for cardiac regeneration
If the heart following a heart attack is not sufficiently supplied with blood, heart tissue dies. In adult humans, the ability to heal itself is hardly developed. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim, together with US colleagues, have now observed in the embryo of the zebrafish that muscle cells migrate from the undamaged atrium into the ventricle and thus significantly contribute to regeneration. (2013-07-11)

More sensitive blood test better at identifying heart attacks
A highly sensitive blood test could help identify heart attacks in thousands of patients who would otherwise have gone undiagnosed, a study suggests. The test, which identifies heart muscle damage, detected heart attacks in a third more patients who were admitted to hospital with chest pain than previous tests. (2011-03-22)

Targeting leg fatigue in heart failure
Doctors should not only treat the heart muscle in chronic heart failure patients, but also their leg muscles through exercise, say researchers in a study published today in the Journal of Applied Physiology. (2011-10-31)

Breakthrough in adult heart repair
Cardiovascular disease (CVD) is responsible for approximately one-third of all deaths. A major problem with CVD is that adult hearts do not repair well after injury. Now, researchers have discovered a way to change that. By identifying and manipulating the normal signals that block heart repair, they were able to show complete functional heart recovery in adult mice after myocardial infarction, which mimics a human heart attack. This breakthrough brings new hope for treating CVD. (2013-11-19)

Compound improves cardiac function in mice with genetic heart defect, MU study finds
Congenital heart disease is the most common form of birth defect. Researchers from the University of Missouri recently found success using a drug to treat laboratory mice with one form of congenital heart disease, hypertrophic cardiomyopathy -- a weakening of the heart caused by abnormally thick muscle. By suppressing a faulty protein, the researchers reduced the thickness of the mice's heart muscles and improved their cardiac functioning. (2014-02-20)

Children's Hospital scientists achieve repair of injured heart muscle in lab tests of stem cells
Researchers at Children's Hospital of Pittsburgh of UPMC have been able to effectively repair damaged heart muscle in an animal model using a novel population of stem cells they discovered that is derived from human skeletal muscle tissue. (2008-11-25)

Could humans ever regenerate a heart? A new study suggests the answer is 'yes'
A new study's findings point to potential for tweaking communication between human genes and advancing our ability to treat heart conditions and stimulate regenerative healing. (2017-06-26)

Studies focus on vascular spasm as a common cause of cardiomyopathy
Even though many cardiologists ignore it, vascular spasm happens. During spasm, constricted vessels cut off the blood supply to parts of the heart, causing further damage, reduced cardiac function, irregular heart rhythms and death. Here, researchers show that substances released by damaged heart muscle cells can trigger vascular spasm. They argue that spasm is an under-recognized source of cardiac damage and the time has come to get aggressive about treating it. (2004-03-01)

Growing new blood vessels could provide new treatment for recovering movement
New research published today in The Journal of Physiology highlights the link between loss of the smallest blood vessels in muscle and difficulties moving and exercising. (2020-02-06)

Just a few cell clones can make heart muscle
Just a handful of cells in the embryo are all that's needed to form the outer layer of pumping heart muscle in an adult zebrafish. Researchers at Duke University Medical Center used zebrafish embryos and careful employment of a new technique that allows for up to 90 color labels on different cells to track individual cells and cell lines as the heart formed. (2012-04-25)

Brain research to help in fight against cardiovascular disease
Scientists at the University of Liverpool, supported by the British Heart Foundation, are studying blood flow in the brain to further medical understanding of cardiovascular disease. (2005-03-21)

Molecular defect found that may cause heart failure
A new study has identified a molecular defect in cardiac cells that may be a fundamental cause of heart failure, a progressive weakening of the heart that leaves the organ unable to pump blood through the body. The findings show that specialized proteins called ryanodine receptors malfunction in the failing heart. They form channels that become leaky, leading to calcium imbalances that prevent the heart from contracting effectively and relaxing adequately. (2005-09-19)

Novel compound may lessen heart attack damage
A novel drug designed to lessen muscle damage from a heart attack has passed initial safety tests at the Duke Clinical Research Institute. Results of the study, available online and to be published in the Feb. 19 issue of the journal Circulation, reflect the first time the drug has been tested in humans. (2008-02-07)

First ever transplantation of skeletal muscle cells into patient's heart to test whether the cells can repair damaged heart muscle
To test whether it will improve cardiac function, Temple University Hospital physicians have transplanted a patient's own skeletal muscle cells (autologous myoblasts) directly into a damaged area of his heart. The hope is that the transplanted skeletal muscle cells will help repair the damaged heart muscle and strengthen the patient's heart contractions. (2000-09-24)

Extreme makeover of the heart: Matrix therapy is first FDA-approved procedure of its kind
A cardiovascular team at University of Utah Hospital has successfully performed a first-in-the-world heart procedure on a 72-year-old attorney after suffering a large heart attack. Amit N. Patel, M.D. M.S., was the first physician to perform an emerging heart procedure where cardiac matrix is directly injected into a damaged heart. This is the first clinical trial to be approved by the US Food and Drug Administration (FDA) for matrix therapy of the heart. (2015-09-17)

Rejuvenating hormone found to reverse symptoms of heart failure
Heart failure is one of the most debilitating conditions linked to old age. A study published in Cell reveals that a blood hormone known as growth differentiation factor 11 declines with age, and old mice injected with this hormone experience a reversal in signs of cardiac aging. The findings shed light on the underlying causes of age-related heart failure and may offer a much-needed strategy for treating this condition in humans. (2013-05-09)

Researchers identify the link between heart failure and weight loss
Congestive heart failure is associated with elevated levels of angiotensin II in the blood (which causes vessel contraction and high blood pressure) in addition to muscle wasting. The mechanisms underlying the association between heart failure and weight loss are poorly understood. Tulane University researchers now demonstrate in the Journal of Clinical Investigation that angiotensin II inhibits insulin-like growth factor-1 (IGF-1) signaling in skeletal muscle and that this effect is causally related to skeletal muscle loss. (2005-01-13)

Gene therapy may aid failing hearts
In an animal study, researchers at the University of Washington show that it was possible to use gene therapy to boost heart muscle function. The finding suggests that it might be possible to use this approach to treat patients whose hearts have been weakened by heart attacks and other heart conditions. (2013-03-25)

Middle-aged muscle mass linked to future heart disease risk
The amount of lean muscle a healthy person has in middle age is linked to their future risk of heart disease, suggests research in the Journal of Epidemiology & Community Health. (2019-11-11)

Revealed:Protein's role in preventing heart muscle growth leading to heart failure
Hebrew University Faculty of Medicine researchers showed for the first time that the protein Erbin is an important brake that helps prevent pathological cardiac hypertrophy. They showed that damage to this protein leads to excess growth of heart muscle, a decrease in function, and severe pathological growth of heart muscle. Their research has implications for breast cancer treatment, as Erbin interacts with the receptor Her2/ErBb2, which is overexpressed in approximately 30 percent of breast cancers. (2014-05-11)

Researchers characterize important regulators of tissue inflammation, fibrosis and regeneration
Although macrophages (cells involved in the detection and destruction of bacteria and other harmful organisms as well as dead cells) are classified as immune cells functioning in the activation and resolution of tissue inflammation, it is now clear that they are critically involved in a variety of disease processes, such as chronic inflammatory diseases, tumor growth and metastasis and tissue fibrosis. (2020-08-10)

Tracking the formation of the early heart, cell by cell
Richard Tyser and colleagues have mapped the origins of the embryonic mouse heart at single-cell resolution, helping to define the cell types that make up the heart in the earliest days of development. (2021-01-07)

Theory Supporting Radical Heart Surgery Proposed By Penn Surgeon
A mathematical model that explains the scientific basis of the Batista procedure -- a radical heart reduction surgery -- has been developed at the University of Pennsylvania Medical Center. This theory could help to better select appropriate candidates for the controversial procedure. It may also provide insights into heart-failure mechanics. (1997-07-15)

While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
Based on a striking similarity between heart disease and Duchenne muscular dystrophy, researchers at Columbia University Medical Center have discovered that a new class of experimental drugs for heart failure may also help treat the fatal muscular disorder. (2009-02-08)

Diseased hearts to heal themselves in future
Oncostatin M regulates the reversion of heart muscle cells into precursor cells and is vitally important for the self-healing powers of the heart. (2011-11-11)

Scientist clears hurdles for muscular dystrophy therapy
Boys with Duchenne Muscular Dystrophy will lose the ability to walk by their teens and typically die before the age of 30. For years, scientists have studied the use of gene therapy as a possible way to correct the muscle deterioration, but hurdles such as the need to treat all muscles in the body, including both skeletal muscle and heart muscle, have challenged researchers looking for an effective therapy until now. (2008-10-28)

Exercise before menopause is important to optimise health in later years
The small blood vessels in muscles of women after menopause are less able to grow compared to young women, according to new research published today in the Journal of Physiology. This means exercising before menopause is all the more important for women in order to develop blood vessels in muscles, and thus the ability to develop muscle strength. (2020-09-22)

Giant Thai insect reveals clues to human heart disease
A Florida State University professor used an electron microscope to capture the first three-dimensional image of a tiny filament, or strand, of an essential muscle that the palm-sized water bug Lethocerus indicus uses to fly. This filament is made of chains of a protein called myosin, which produce the power needed to contract muscles. This image shows for the first time the individual molecules in the filament in a relaxed state, which is necessary to re-extend muscles. (2016-10-03)

MS drug shows promise for preventing heart failure
A drug already approved to treat multiple sclerosis may also hold promise for treating cardiac hypertrophy, or thickening of the cardiac muscle -- a disorder that often leads to heart failure, researchers at the University of Illinois at Chicago College of Medicine report. (2013-07-16)

Exercise slows muscle wasting from age and heart failure
A four-week exercise program for heart-failure patients slowed muscle-wasting and improved their exercise capacity, regardless of age. The study confirms that exercise can reduce inflammation in skeletal muscle. Findings offer a possible avenue for future drug therapy to treat muscle-wasting in heart failure patients. (2012-05-07)

Researchers gain detailed insight into failing heart cells using new nano technique
Researchers have been able to see how heart failure affects the surface of an individual heart muscle cell in minute detail, using a new nanoscale scanning technique developed at Imperial College London. The findings may lead to better design of beta-blockers, the drugs that can slow the development of heart failure, and to improvements in current therapeutic approaches to treating heart failure and abnormal heart rhythms. (2010-02-25)

Study provides new insights into structure of heart muscle fibers
A study led by researchers from McGill University provides new insights into the structure of muscle tissue in the heart -- a finding that promises to contribute to the study of heart diseases and to the engineering of artificial heart tissue. (2012-05-28)

Heart transplant recipients can improve fitness and perform high intensity workouts
Heart transplant recipients' cardio-respiratory fitness is around 30 to 50 percent lower than age-matched healthy sedentary individuals. As a result, exercise rehabilitation should be very important to these patients, and a University of Alberta study shows they can improve their overall physical fitness. (2009-07-02)

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