Hepatocytes Current Events

Hepatocytes Current Events, Hepatocytes News Articles.
Sort By: Most Viewed | Most Recent
Page 1 of 6 | 232 Results
Different sources, same result
Induced pluripotent stem cells from fetal skin cells and embryonic stem cells display comparable potential for derivation of hepatocytes. (2011-01-05)

Progress toward the clinical application of autologous induced pluripotent stem cells and gene repair therapy for treatment of familial hypercholesterolemia
Study shows, for the first time, the successful reprogramming of diseased human hepatocytes into induced pluripotent stem cells. (2011-04-01)

Simple method rescues stressed liver cells
Isolated human hepatocytes are essential tools in preclinical and clinical liver research, but cell quality is highly variable. Now, researchers from Uppsala University have devised a simple protocol that improves hepatocyte quality and enables cells from a wider quality spectrum to be used in standard and advanced cell culture. The findings are published in Archives of Toxicology. (2018-12-21)

Liver progenitor cells are involved in the development of hepatic tumors
The malignant transformation of hepatocytes is the origin of most hepatocellular carcinomas, an aggressive type of liver cancer with high mortality rates. But these cells do not act alone. Research conducted by scientists at the Spanish National Cancer Research Centre (CNIO) reveals how hepatocytes 'recruit' and 'instruct' liver progenitor cells to contribute to the hepatic lesions. (2017-04-18)

The Liver's Secret Of Regeneration
The key to the liver's amazing powers of regeneration could be stem cells migrating from bone marrow, say biologists in Pennsylvania. They hope that bone marrow stem cells could be used to grow new liver tissue for patients with cirrhosis. (1999-04-28)

Cell division typically associated with cancer may also protect the liver from injury
Oregon Health & Science University researchers have found that the liver, which is known to have a tremendous capacity for regeneration, also has an amazing degree of diversity. A better understanding of this process may reveal why some individuals are more susceptible to different forms of liver injury than others, which could lead to new therapies for the treatment of liver disease. (2010-09-22)

Targeting metastatic disease with gene therapy
Because hepatocytes are constantly exposed to portal blood, the liver can be readily transduced with injected transgenes. Noting that this organ is also particularly prone to taking up metastatic colorectal tumor cells, Tada and colleagues have proposed to use gene therapy to render the liver a less hospitable environment for exogenous tumors. (2001-06-26)

Scientists develop novel method to generate functional hepatocytes for drug testing
Scientists have for the first time produced liver cells from adult skin cells using the induced pluripotent stem cell technology. The study, led by the University of Edinburgh's MRC Centre for Regenerative Medicine, paves the way for the creation of a stem cell library that can be used for in vitro hepatic disease models. (2009-10-20)

Is liver damage down the TRAIL for a promising cancer therapy?
Although TRAIL is a protein that is considered a promising cancer therapeutic because it can kill tumor cells, controversy surrounds whether or not it affects nontumor cells. A new study now shows that TRAIL alone does not kill mouse liver cells in vitro, but it does enhance both in vitro and in vivo liver cell death induced by signaling through another liver cell protein, indicating that TRAIL-based therapeutics might cause liver damage. (2006-09-01)

Transplanted bone marrow stromal cells lead to hepatocellular carcinoma?
The safety and efficacy of hepatic stem cells derived from bone marrow stromal cells should be adequately confirmed before any therapies are tested in humans. Hepatocarcinogenesis was induced with diethylnitrosamine. The liver was evaluated by immunohistochemistry and fluorescence in situ hybridisation. The results demonstrate that bone marrow stromal cells could differentiate into hepatocytes and hepatic stem cells derived from bone marrow stromal cells are not cellular origin of hepatocellular carcinoma. (2008-05-21)

Source of liver stem cells identified
Howard Hughes Medical Institute scientists have identified stem cells in the liver that give rise to functional liver cells. The work solves a long-standing mystery about the origin of new cells in the liver, which must constantly be replenished as cells die off, even in a healthy organ. (2015-08-05)

Study shows main cell type in the liver has key role in defending against some viruses
Scientists at Scripps Research have uncovered an important disease-fighting role for cells called hepatocytes, which constitute most of the liver. The discovery could potentially be harnessed to develop new medicines for viral illnesses. (2020-10-16)

Mature liver cells may be better than stem cells for liver cell transplantation therapy
Stem or progenitor cells have shown they can be cryopreserved for a long time and expanded in vitro. However, a comparison between the repopulation efficiency of immature hepatic stem/progenitor cells and mature hepatocytes transplanted into liver-injured rats concluded that mature hepatocytes offered better repopulation efficiency than stem/progenitor cells. The growth of the stem/progenitor cells was faster than the mature hepatocytes, but most of the stem/progenitor cells soon died while mature hepatocytes survived and proliferated. (2012-06-04)

New chimeric mouse model for human liver diseases, drug testing
Cells cultured in the lab are like a fish out of water. Often, their behavior does not reflect their biological function within an entire organ or organism, which, for example, turns studying human liver cells into a big challenge. (2007-12-03)

Newly discovered cells regenerate liver tissue without forming tumors
The mechanisms that allow the liver to repair and regenerate itself have long been a matter of debate. Now researchers at University of California, San Diego School of Medicine have discovered a population of liver cells that are better at regenerating liver tissue than ordinary liver cells, or hepatocytes. The study is the first to identify these so-called 'hybrid hepatocytes,' and show that they are able to regenerate liver tissue without giving rise to cancer. (2015-08-13)

In vitro infection and replication of hepatitis E virus in human hepatocytes
Groundbreaking data presented today demonstrate, for the first time, in vitro infection and replication of swine hepatitis E virus (HEV) in human hepatocytes. (2011-04-02)

Ribosome biogenesis gene DEF/UTP25 is essential for liver homeostasis and regeneration
Digestive-organ-expansion-factor (Def) is a nucleolar factor. Depletion of Def causes hypoplastic digestive organs in zebrafish. Mechanistically, Def recruits cysteine proteinase Calpain3 (Capn3) to the nucleolus to cleave target proteins including p53 and Mpp10 during organogenesis. Here researchers demonstrate that Def is also essential for liver homeostasis and regeneration in mouse, a mammalian model. Their results reveal a novel feature of nucleolus, also called the 'nucleus of a nucleus', a subcellular organelle known for ribosome biogenesis. (2020-04-28)

Japanese scientists show 'new' liver generation using hepatocyte cell transplantation
Hepatocyte cells, comprising the main tissues of the liver and involved in protein synthesis and storage, can be retrieved and propagated for the purposes of creating a new liver system. This study demonstrates the feasibility of propagating mouse hepatocytes by creating a vascularized platform using a growth factor releasing device, and by creating uniform hepatocyte (2012-06-11)

Neonatal livers better source for hepatocytes than adult livers
The source of liver cells for transplantation is primarily from adult livers found unsuitable for organ transplantation. Neonatal livers are an alternative source because they are too small for organ transplantation, yet have good quality cells. A high-yield preparation of viable liver cells, isolated for transplantation from frozen, banked 1- to 23-day-old neonatal livers, were assessed for quality and function and found to have better thawing recovery than hepatocytes from adult livers. (2013-09-17)

A novel molecular link between cholesterol, inflammation and liver cancer
Hepatocellular carcinoma (HCC) is a deadly disease with no effective cure that develops in the context of liver diseases associated with chronic inflammation. New paper describes how important is the protein c-Fos for HCC development, because it affects cholesterol homeostasis in hepatocytes. Using genetically modified mouse models, researchers at the Spanish National Cancer Research Centre (CNIO) experimentally document how c-Fos modulates premalignant hepatocyte transformation and how this is linked to cholesterol and inflammation. (2017-03-29)

Liver cells benefit from mesenchymal stem cell co-culture prior to transplantation
Hepatocyte transplantation is an accepted therapy for acute liver failure for liver regeneration or as a bridge to liver transplantation. However, maintaining the viability and functional aspects of hepatocytes has been a concern even with successful cryopreservation. To improve the viability and function of cryopreserved hepatocytes prior to transplantation, researchers co-cultured hepatocytes with human mesenchymal stem cells derived from umbilical cord or fat tissues and found that the co-culturing confers improved hepatocyte survival and function. (2013-12-18)

Functional human liver cells grown in the lab
In new research appearing in the prestigious journal Nature Biotechnology, an international research team led by The Hebrew University of Jerusalem describes a new technique for growing human hepatocytes in the laboratory. This groundbreaking development could help advance a variety of liver-related research and applications, from studying drug toxicity to creating bio-artificial liver support for patients awaiting transplantations. (2015-11-26)

Model of viral lifecycle could help in finding a cure for hepatitis B
MIT researchers find that a new technique sustains hepatitis B in liver cells, allowing the study of immune response and drug treatments. (2014-08-04)

Liver fully recovers from a low protein diet
Damage caused to the liver by a low protein diet can be repaired, a new study just published in the prestigious journal Nutrition has found. (2017-03-27)

New culture method for hepatitis C virus uses primary hepatocytes and patient serum
Researchers open the way for improved study of hepatitis C virus by devising a novel virus culture system that allows replication of patient-isolated virus in nontransformed hepatocytes, instead of culture-adapted virus strains in transformed cell lines. The related report by Lázaro et al, (2007-01-23)

Is hepatic differentiation of embryonic stem cells induced by valproic acid and cytokines?
A research team from China developed a protocol for direct hepatic lineage differentiation from early developmental progenitors to a population of mature hepatocytes. Their study showed that hepatic cells of different developmental stages from early progenitors to matured hepatocytes can be acquired in the appropriate order based on sequential induction with valproic acid and cytokines. (2009-11-18)

How does insulin-like growth factor I protect liver function?
A team led by Dra. Castilla de Cortázar Larrea from the University San Pablo-CEU has characterized some beneficial effects promoted by Insulin-like Growth Factor I (IGF-I) therapy on mitochondrial dysfunction associated to experimental cirrhosis, increasing the membrane potential and ATPase activity and reducing the intramitochondrial free radicals production and caspase-3 activity. (2008-05-07)

How does radial flow bioreactor system apply in the fields of bioartificial liver?
A team led by Dr. Yuji Ishii from the Jikei University School of Medicine has reported the hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor. The authors evidenced that cells organized in organoids with the presence bile duct like structure. They also showed that hepatocytes growth factor favored differentiation and survival of cells in the bioreactor. (2008-05-07)

New genetic screen paves the way for long-sought treatments for liver disease
Chronic liver failure is a major health problem that causes about one million deaths each year. A study published in Cell reveals a new type of screen for identifying genes that promote liver repair in mouse models of liver disease. The study shows that the MKK4 gene could be a promising therapeutic target to enhance liver regeneration and provides a blueprint for future studies aimed at discovering new therapies for liver disease. (2013-04-11)

New therapeutic avenue in the fight against chronic liver disease
A recent study, affiliated with South Korea's Ulsan National Institute of Science and Technology (UNIST) has introduced a novel targeted drug delivery system in the fight against cancer. (2019-01-18)

When malaria parasites trick liver cells to let themselves in
A new study led by Maria Manuel Mota, group leader at Instituto de Medicina Molecular, now shows that malaria parasites secrete the protein EXP2 that is required for their entry into hepatocytes. These findings, published today in the scientific journal Nature Communications, open a new avenue for prophylactic anti-malarial strategies, since blocking or decreasing the infection of the liver can prevent the disease. (2020-11-06)

Hepatitis therapy: Kupffer cells adjust the balance between pathogen control and hepatocyte regenera
Scientists from TWINCORE have now published new insights on the processes involved in liver inflammation in the Journal of Hepatology: Type I interferons, on the one hand, limit viral replication and thereby help the immune cells to control the viral pathogen. On the other hand, type I interferons delay the regeneration of immune cells, which are important to adjust and maintain the immune balance within the liver during acute inflammation. (2018-01-17)

Anti-cancer compound could cause serious liver damage, report University of Pittsburgh scientists
An anti-cancer compound initially slated to enter clinical trials within months could harm patients, according to a University of Pittsburgh report in the May issue of Nature Medicine. The Pittsburgh scientists found that TNF-related apoptosis inducing ligand (TRAIL) causes catastrophic damage to human liver cells. (2000-04-30)

Applying stem cell technology to liver diseases
Great excitement greeted the discovery a few years ago that certain cells from mice and humans could be reprogrammed to become inducible pluripotent stem cells (iPS cells) as they hold promise for cell replacement therapy and modeling human disease. Two independent research groups have now shown that both possibilities are true for iPS cell-derived liver cells known as hepatocytes. (2010-08-25)

University Of Pittsburgh Researchers Identify Immune System Process That Could Halt Progress Of Cirrhosis In Humans
Results of animal studies conducted at the University of Pittsburgh and being reported at Experimental Biology '99 dispel the notion that interleukin-6 causes liver fibrosis or cirrhosis and instead suggest that it is important to the liver's recovery. Patient studies will determine if IL-6 can slow liver disease progression. (1999-04-18)

Deadly liver cancer may be triggered by cells changing identity, UCSF study shows
A rare type of cancer thought to derive from cells in the bile ducts of the liver may actually develop when one type of liver cell morphs into a totally different type, a process scientists used to consider all but impossible. UCSF researchers triggered this kind of cellular transformation -- and caused tumors to form in mice -- by activating just two genes. Their discovery suggests that drugs that are able to target those genes may provide a way to treat the deadly cancer, known as cholangiocarcinoma. (2012-07-16)

Princeton researchers report new system to study chronic hepatitis B
Scientists from Princeton University have successfully tested a cell-culture system that will allow researchers to perform laboratory-based studies of long-term hepatitis B virus (HBV) infections with the goal of testing new therapies. (2017-07-25)

Swine cells could power artificial liver
Scientists are examining a line of (2013-02-27)

Cancer most frequently spreads to the liver; here's why
When cancer spreads to another organ, it most commonly moves to the liver, and now researchers at the Abramson Cancer Center of the University of Pennsylvania say they know why. (2019-03-06)

Researchers find molecular switch turning on self-renewal of liver damage
The liver is one of the few organs in our body that can regenerate itself, but how it occurs is a biological mystery. New research from BRIC, University of Copenhagen has identified a protein complex that act to switch on a self-regeneration program in the liver. (2013-03-07)

Page 1 of 6 | 232 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.