Hepatocytes Current Events | Page 2

Hepatocytes Current Events, Hepatocytes News Articles.
Sort By: Most Viewed | Most Recent
Page 2 of 6 | 232 Results
Newly discovered cells restore liver damage in mice without cancer risk
The liver is unique among organs in its ability to regenerate after being damaged. Exactly how it repairs itself remained a mystery until recently, when researchers supported by the National Institutes of Health discovered a type of cell in mice essential to the process. The researchers also found similar cells in humans. (2015-08-14)

Evolutionary conservation of a mechanism of longevity from worms to mammals
Though the study of aging in the nematode model organism C. elegans has provided much insight into this complex process, it is not yet clear whether genes involved in aging in the worm have a similar role in mammals. In a recent study, Dr. Hekimi and colleagues of McGill University (Canada) report that inactivation of the gene mclk1, the murine ortholog of the C. elegans gene clk-1, results in increased cellular fitness and prolonged lifespan in mice. (2005-10-03)

Liver tissue model accurately replicates hepatocyte metabolism, response to toxins
A team of researchers from the Massachusetts General Hospital Center for Engineering in Medicine have created a 'liver on a chip,' a model of liver tissue that replicates the metabolic variations found throughout the organ and more accurately reflects the distinctive patterns of liver damage caused by exposure to environmental toxins, including pharmaceutical overdose. (2016-07-18)

New progress toward finding best cells for liver therapy
In an important step toward using transplanted cells to treat liver failure, researchers demonstrate successful transplantation of fetal rat liver cells to an injured adult rat liver. (2017-04-26)

Japanese researchers report on liver transplantation studies using animal and iPS cells
Japanese researchers have made breakthroughs in liver cell transplantation, finding that induced pluripotent stem cells derived from mouse somatic cells used in in vitro experiments might help overcome transplant immunological rejection and that the cells can proliferate without limits to become hepatocyte-like. Successful experiments with the transplantation of porcine liver cells into mice with acute liver failure point to possible similar successes in humans, to counter the shortage of human livers for transplant. (2010-10-18)

Beyond liver transplants: Acutely damaged livers may be repaired via transplanted hepatocytes
Alternatives to liver transplantation are needed because of the shortage of liver donors. A research team in Taiwan has evaluated the transplantation of liver cells in animal models to assess efficacy. They found that enhanced proliferation of even small numbers of liver cells could reverse liver failure. Additionally, they found prolonged hepatic stellate cell activation, that is crucial for liver repair and plays a role in hepatocyte engraftment, which declined after four weeks. (2010-02-01)

Cell transplantation procedure may one day replace liver transplants
In an effort to find therapeutic alternatives to whole liver transplantation and improve the outcomes of hepatocyte transplantation, researchers tested the efficacy and feasibility of transplanting multi-layered sheets of hepatocytes and fibroblasts into the subcutaneous cavity of laboratory rats modeled with end stage liver failure. The cells in the multi-layered hepatocyte sheets survived better than cells transplanted by traditional methods and the cells proliferated, maintaining liver function in the animals for at least two months. (2015-08-26)

Can Taurine be a potent antioxidant drug in the future?
In hepatotoxin induced liver fibrısis, taurine alleviates ultrastructural injury and organelle based transmission electron microscopy findings can successfully reflect the histological results as well as tissue healing in hepatocytes. (2008-09-19)

Molecule's role in maintaining liver size and function revealed
Researchers at TMDU found that the YAP molecule is a key mediator in the identification and clearance of damaged cells from the liver. They showed that, in the absence of injury, YAP activation led to hepatocyte proliferation. However, when injury was induced to mouse liver, it instead induced hepatocytes to migrate to the hepatic sinusoids, undergo cell death, and be degraded by the immune system. (2017-08-01)

Researchers identify human protein that aids development of malaria parasite
Researchers in Japan have discovered that the Plasmodium parasites responsible for malaria rely on a human liver cell protein for their development into a form capable of infecting red blood cells and causing disease. The study, which will be published June 12 in the Journal of Experimental Medicine, suggests that targeting this human protein, known as CXCR4, could be a way to block the parasite's life cycle and prevent the development of malaria. (2019-06-12)

It is important to demonstrate the influence of the microenvironment in the process of metastasis
In the work defended at the University of the Basque Country, an in vitro culture model of human colon cancer was created in order to reproduce the gene regulation that is expressed in these cancer cells during their growth as metastasis in the liver of patients. (2007-12-20)

How hepatitis B and delta viruses establish infection of liver cells
Princeton University researchers have developed a new, scalable cell culture system that allows for detailed investigation of how host cells respond to infection with hepatitis B (HBV) and delta virus (HDV). The paper describing their findings was published online on June 18, 2019 in the journal Hepatology. (2019-06-18)

Transplanted liver cells function in older animals but do not proliferate as much as in younger ones
Hepatocyte transplantation has been successful in a number of animal models, raising hopes that use of cells could overcome the shortage of donor livers and the problems of surgery, but the procedure has not been as successful in humans. Was the problem related to the age of the donor? Scientists at the Martin Luther University Hale-Wittenberg, Germany, believe they know the answer. Age of the donor makes no difference, but age of the recipient makes a big one. (2009-04-19)

Human stem cell-derived hepatocytes regenerate liver function
Researchers have generated functional hepatocytes from human stem cells, transplanted them into mice with acute liver injury, and shown the ability of these stem-cell derived human liver cells to function normally and increase survival of the treated animals. (2013-07-26)

What is the pathogenesis of liver damage induced by ethanol?
They investigated the effects of ethanol on the IGF-I system with the involvement of JNK1/2 activity and ADH by using each chemical inhibitor in primary cultured rat hepatocytes. The results indicate that ethanol inducedp-JNK1/2 activation is associated with the IGF-I system and cell viability in hepatocytes. Furthermore, alcohol dehydrogenase is involved in the relationship between ethanol-induced inactivation of p-JNK1/2 and the changes of the IGF-I system and cell viability. (2008-10-07)

Cell reprogramming during liver regeneration
Researchers have been able to reprogram cells experimentally, but few have shown that cells can change their identities under normal physiological conditions in the body, particularly in mammals. Penn researchers did just that in the liver of a mouse. (2013-03-28)

A gene that fights cancer, but causes it too
An international team of researchers, led by scientists at the University of California, San Diego School of Medicine, and the Eastern Hepatobiliary Surgery Hospital in China, say a human gene implicated in the development of leukemia also acts to prevent cancer of the liver. (2011-05-16)

Stem cell, artificial liver research receives Coulter Foundation funding at NJIT
Two NJIT biomedical researchers have received the prestigious Coulter Foundation Translational Awards for promising patent applications that may some day extend peoples' lives. (2010-08-10)

Pigs grow new liver in lymph nodes, study shows
Hepatocytes -- the chief functional cells of the liver - are natural regenerators, and the lymph nodes serve as a nurturing place where they can multiply. Researchers demonstrated that large animals with ailing livers can grow a new organ in their lymph nodes from their own hepatocytes. (2020-08-24)

Functional human tissue-engineered liver generated from stem and progenitor cells
A research team led by investigators at The Saban Research Institute of Children's Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver (TELi) was found to contain normal structural components such as hepatocytes, bile ducts and blood vessels. The study has been published online in the journal Stem Cells Translational Medicine. (2016-08-30)

New study questions the safety of caspase inhibitors for the treatment of liver disease
Many acute and chronic liver diseases, including alcoholic hepatitis, result from apoptotic (programmed) cell death mediated by the enzyme caspase. Caspase inhibitors have therapeutic potential to treat and prevent apoptosis-mediated liver injury, and some are currently in clinical trials. However, a new study published in The American Journal of Pathology raises serious safety concerns regarding the clinical use of caspase inhibitors by demonstrating the occurrence of delayed-onset necrotic, non-caspase-dependent liver cell injury. (2016-10-20)

How viable is your liver after you die?
In a paper to be published in a forthcoming issue of TECHNOLOGY, a group of researchers from Harvard Medical School have done a study on the viability of donated livers and its correlation with donor demographics. The results of this study could reduce the number of livers that are discarded and facilitate development of novel therapeutics and bioengineering for clinical research applications. (2019-05-13)

Regeneration mechanism discovered in mice could provide target for drugs to combat chronic liver disease
Researchers at the University of Cambridge have uncovered a novel molecular mechanism that allows damaged adult liver cells to regenerate, paving the way for design of drugs to boost regeneration in conditions such as cirrhosis or other chronic liver diseases where regeneration is impaired. (2019-11-04)

Bone Marrow Gives Rise To Functioning Liver Cells, University Of Pittsburgh Scientists Discover
Bone marrow-derived cells give rise to fully functional liver cells, states a University of Pittsburgh study published May 14 in Science, yielding the first report that bone marrow- derived cells provide a lineage for cells of solid organs and suggesting that they could eventually repair or replace injured or diseased livers. (1999-05-14)

Cycles of cell death, proliferation key to liver cancer
School of Medicine shows that liver cancer is likely caused by cycles of liver cell death and renewal. The research, appearing online the week of June 19 in advance of publication in the journal Proceedings of the National Academy of Sciences (2006-06-22)

Duke study: Cold needed to preserve livers for transplant also can kill certain cells
A team of Duke University Medical Center researchers has figured out why donated livers can suffer a mysterious injury that damages their ability to perform well once transplanted. (1999-12-29)

The role of stem cells in developing new drugs
DefiniGEN, a new spin-out company from the University of Cambridge, has been formed to supply hIPSC-derived cells to the drug discovery and regenerative medicine sectors. The company is based on the research of Dr. Ludovic Vallier, Dr. Tamir Rashid and Professor Roger Pedersen of the Anne McLaren Laboratory of Regenerative Medicine. (2012-10-31)

CRISPR-HOT: A new tool to 'color' specific genes and cells
Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs. They used this new method, called CRISPR-HOT, to investigate how hepatocytes divide and how abnormal cells with too much DNA appear. By disabling the cancer gene TP53, they showed that unstructured divisions of abnormal hepatocytes were more frequent, which may contribute to cancer development. (2020-03-02)

Improved culture system for hepatitis C virus infection
A University of California, San Diego School of Medicine researcher has developed the first tissue culture of normal, human liver cells that can model infection with the hepatitis C virus and provide a realistic environment to evaluate possible treatments. The novel cell line will allow pharmaceutical companies to effectively test new drug candidates or possible vaccines for the HCV infection, which afflicts about 170 million people worldwide. (2008-07-15)

The mouse with a human liver: A new model for the treatment of liver disease
How do you study -- and try to cure in the laboratory -- an infection that only humans can get? A team led by Salk Institute researchers does it by generating a mouse with an almost completely human liver. This (2010-02-22)

What is the role of reactive oxygen species in ethanol-mediated cell death of polarized hepatic cells?
The clinical progression of alcoholic liver disease is associated with an increase in hepatocellular damage that may involve the promotion and execution of apoptotic death mechanisms. A liver research group in Nebraska has reported that the signaling and selection of apoptotic over necrotic cell death mechanisms involves particular factors such as the level of oxidative stress in the hepatocyte as well as the ability antioxidant defenses of the cell have in coping with oxidative damage. (2009-06-12)

A human liver microphysiology platform for studying physiology, drug safety, and disease
Currently available animal and human liver models provide limited predictions of human drug efficacy and toxicity, primarily due to metabolic differences and the limited ability of simple 2-D models to recapitulate the complex cellular interactions that lead to toxicity. To fill this gap we have developed a novel 4 cell type, 3-D, microfluidic, human liver model with the ability to monitor multiple cellular toxicity and human disease related functions over at least 28 days. (2016-02-29)

Boosting cell production could help treat liver disease
Scientists have shed light on how the liver repairs itself with research that could help develop drugs to treat liver disease. (2012-03-04)

UC San Diego and Samsara Sciences team up to advance liver tissue models
Researchers at University of California, San Diego School of Medicine and Samsara Sciences, Inc., a wholly-owned subsidiary of Organovo Holdings, Inc., have entered into an agreement focused on the development of techniques and methods for the isolation and characterization of liver cells that will help drive new research on liver biology, drug safety and efficacy, and the treatment of liver diseases. (2016-01-14)

Gout medications might be useful in treating alcohol-induced liver disease
New research in mice shows that two commonly used gout medications, which target uric acid and adenosine triphosphate, may offer protection from alcohol-induced liver disease and inflammation. These findings suggest that clinical trials in humans with alcoholic liver disease should be considered. The report appears in the August 2015 issue of the Journal of Leukocyte Biology. (2015-07-31)

Novel therapeutic approaches to cure chronic HBV infection
Exciting new data presented today at the International Liver Congress™ 2013 include results from early in vitro and in vivo studies targeting covalently closed circular DNA, which may form the basis of a cure for chronic hepatitis B virus infection. (2013-04-25)

Are bone marrow mononuclear cells effective in reducing hepatic lesions?
In this study, they used an experimental model of hepatic fibrogenesis caused by chronic infection with S.mansoni in order to evaluate the contribution of cellular therapy in hepatic diseases. They investigated the potential of syngeneic bone marrow mononuclear cells in the modulation of fibrosis, albumin expression and cellular alterations. They found that transplanted BMCs migrate to and reduce the damage of chronic fibrotic liver lesions caused by S.mansoni. (2008-10-23)

Critical link in cell death pathway revealed
The role of a protein called XIAP in the regulation of cell death has been identified by Walter and Eliza Hall Institute researchers and has led them to recommend caution when drugs called IAP inhibitors are used to treat cancer patients with underlying liver conditions. (2009-07-22)

In vivo RNAi screening identifies new regulators of liver regeneration
This study establishes a unique system to perform in vivo RNAi screens for genetically dissecting the cellular signaling networks that regulate hepatocyte proliferation during chronic liver damage. (2011-04-01)

Duke Researchers Show That Anti-Cancer Agents Protect Donor Livers Awaiting Transplantation
After noticing -- almost entirely by chance -- the striking cellular similarities between the damage that occurs to donor livers awaiting transplantation and the very early stages of tumor growth, Duke University Medical Center researchers believe they have found a novel way of extending the amount of time livers can remain safely. (1997-10-31)

Page 2 of 6 | 232 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.