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New interferon shows promise against hepatitis B in cell culture, and animal model
Hepatitis B is notoriously difficult to eradicate with currently available agents. Now, in a new study, a novel form of 'pegylated' interferon-β has reduced hepatitis B virus (HBV) infections in experimental human-derived cells and in mice more effectively than the conventional pegylated interferon-α2a, suggesting that it could lead to improved treatment for hepatitis B infection in humans. (2017-04-03)

Discovery of a protein that protects against fatty liver
A team co-headed by scientists at the Institute for Research in Biomedicine and the IDIBAPS Biomedical Research Institute (part of the Hospital Clínic de Barcelona) has revealed the capacity of the CPEB4 protein to prevent fatty liver disease. (2017-01-17)

Elevated lymphotoxin expression in liver leads to chronic hepatitis and causes HCC
A recent study maps the pathway that leads from infection with hepatitis B and C virus to chronic hepatitis and liver cancer and proposes a new therapeutic strategy for treating liver diseases with chronic inflammation. The research, published by Cell Press in the October issue of the journal Cancer Cell, describes a signaling pathway that can be beneficial during liver regeneration, but can lead to chronic hepatitis and severe liver damage when chronically activated. (2009-10-05)

A potential breakthrough in obesity medicine with the help of gold nanoparticles
A team of researchers in Korea believes to have discovered a synthetic gold-based compound which may help patients with obesity. The nanoparticles were tested in both 3T3-L1 and HepG2 cell lines, which are two known candidates for studying obesity and related disease models. (2020-04-14)

Cincinnati surgeon's pediatric laparoscopic liver surgery a world first
A University of Cincinnati surgeon recently performed what is believed to be the world's first pediatric laparoscopic liver surgery, a specialized procedure for removing cancerous liver tumors without the need for a major incision. (2006-08-07)

Erasing a genetic mutation
An MIT team reverses a liver disorder in mice by correcting a mutated gene. (2014-03-30)

First successful organ donation from newborn carried out in UK
The very first successful organ donation from a newborn carried out in the UK is reported in the Fetal & Neonatal Edition of Archives of Disease in Childhood. (2015-01-19)

Merlin protein found to control liver stem cells, prevent tumor development
A protein known to be involved in a rare hereditary cancer syndrome may have a role in the regulation of liver stem cells and the development of liver cancer. In the Aug. 15 issue of Genes & Development, a Massachusetts General Hospital research team describes finding that the protein called merlin, encoded by the NF2 gene, controls the activity of adult stem cells that give rise to the two major types of liver cells. (2010-08-12)

A potential targeting gene therapy for developing HCV
An HCV-specific promoter is required to restrict transgene expression only in HCV infected cells. A research group in China demonstrated that HCV-core protein activates the 2'-5'oligoadenylate synthetase (OAS) gene promoter specifically and effectively. Since HCV-core protein plays an important role in persistent infection and hepatocellular carcinogenesis, and amino acid sequence of core protein is relatively conserved, utilization of OAS promoter to drive therapeutic gene expression would be an ideal strategy for HCV targeting gene therapy. (2009-07-16)

Reprogramming a patient's eye cells may herald new treatments against degenerative disease
Scientists have overcome a key barrier to the clinical use of stem cells with a technique which transforms regular body cells into artificial stem cells without the need for introducing foreign genetic materials, which could be potentially harmful. The research, published in Stem Cells, suggests that cells taken from a patient's eye can be (2009-10-22)

A human liver cell atlas
The cellular composition of the liver is incompletely understood. Researchers at the Max Planck Institute for Immunobiology and Epigenetics have created a comprehensive map of all cell types in the healthy human liver using a method named single-cell RNA sequencing. They discovered new subpopulations of liver cell types and demonstrated the usefulness of their human liver cell atlas as a resource to reveal how cells change in liver cancer. The study was published in Nature. (2019-07-10)

Gene therapy useful in treating major complication of cirrhosis of the liver in animal studies
Duke University Medical Center researchers, using a modified cold virus, have delivered a nitric oxide-producing gene to key liver cells in rats, reversing the major complication of cirrhosis of the liver. (2000-03-13)

Quantum chemical computations provide insight into liver toxicity
By systematic computational studies on 55 hydrocarbons Balasubramanian and Basak have ranked the toxicity of halocarbons on the basis of the electron affinity and proton-extraction propensity from the lipid membrane of the liver. (2016-05-06)

Fatty liver disease research set to benefit from stem cell advance
Scientists have developed a lab-based system for studying the most common type of liver disease, paving the way for research into new therapies. The team at the University of Edinburgh has devised a way to probe Non-Alcoholic Fatty Liver Disease, which affects up to one in three people, using cells in a dish. (2018-05-23)

One more piece in the puzzle of liver cancer identified
Manuela Baccarini and her team at the Max F. Perutz Laboratories (MFPL) of the University of Vienna and Medical University of Vienna are one step closer to unraveling the mechanisms behind liver cancer. The researchers discovered that RAF1, a protein known as an oncogene in other systems, unexpectedly acts as a tumor suppressor in hepatocellular carcinoma. The study is published in the renowned journal Nature Communications. (2016-12-21)

Embryonic stem cells treated with growth factor reverse hemophilia in mice
Embryonic stem cells treated in culture with a growth factor and then injected into the liver reverse a form of hemophilia in mice analogous to hemophilia B in humans, a study from the University of North Carolina at Chapel Hill shows. (2005-02-15)

Entry inhibitors show promise as drugs with new MOA for treatment of HBV and HDV infection
Promising new viral hepatitis data presented today at the International Liver Congress show that entry inhibitors a new mechanism of action for drugs to treat viral hepatitis could provide the first new hepatitis B and hepatitis D treatments for many years. (2011-04-02)

Towards the goal of precision therapy in hepatocellular carcinoma
Hepatocellular carcinoma is a highly lethal disease, therefore effective and tolerable treatment is urgently needed. (2016-03-07)

Study shows proof of concept of BioIVT HEPATOPAC cultures with targeted assay to evaluate bioactivation potential and drug-induced liver injury (DILI) risk
New in vitro Bioactivation Liver Response Assay used HEPATOPAC model to demonstrate utility of in vitro transcriptomic signature-based strategy in preclinical DILI risk assessment. (2020-10-12)

Liver transplants could be redundant with discovery of new liver cell
Researchers at King's College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the need for transplants. (2019-07-26)

BUSM researchers uncover liver's role in preventing dissemination of lung infection
Researchers at Boston University School of Medicine have discovered the regulation and functional significance of the acute phase response during a lung infection. (2012-04-02)

A step closer to artificial livers
Researchers identify compounds that help liver cells grow outside the body. (2013-06-02)

CRISPR-carrying nanoparticles edit the genome
MIT researchers have developed nanoparticles that allow for CRISPR genome-editing in adult animals. Using a new nanoparticle-based, nonviral delivery technique, the researchers were able to cut out a disease-causing gene in about 80 percent of liver cells, and permanently lower cholesterol in mice. (2017-11-13)

New source of cells for modeling malaria
MIT researchers have discovered a way to grow liver-like cells from induced pluripotent stem cells. (2015-02-05)

Development of new cell models that report circadian clock function
Researchers at the University of Memphis and University of Pennsylvania report the development of robust new liver and fat cell models that report circadian clock function. (2014-04-11)

Supply and demand
In a study published today in Cell Metabolism, scientists at the European Molecular Biology Laboratory in Heidelberg, Germany, have discovered that a group of proteins called IRPs ensure that iron balance is kept and as such are essential for cell survival. More specifically, they found that IRPs are required for the functioning of mitochondria, the cell's energy factories. (2010-08-04)

What's the clonality status and allelotype of focal nodular hyperplasia?
Focal nodular hyperplasia (FNH) is considered a hyperplastic lesion found in an otherwise normal liver, its clonality status has not been elucidated and the development of hepatocyte nodules within the involved parenchyma needs to be explained. A research group from China demonstrates that classical FNH is polyclonal in cell composition. However, the formation of multiple nodules of altered hepatocytes (NAH), showing monoclonality and genetic alterations, was found within all the FNH lesions. (2009-10-18)

Artificial liver for drug tests
The liver is one of the most important metabolizing organs in humans. Fraunhofer researchers have developed a model of the liver, which is viable outside the body and which is suitable for testing drugs. (2009-06-25)

Tissue model reveals how RNA will act on the liver
MIT researchers have shown an engineered model of human liver tissue can be used to investigate nucleic acid-based therapies, such as RNA interference, before testing them in patients. (2019-03-05)

Licorice is a hot trend in hot flashes, but could interact with medications
Licorice roots have a flavorful history, having been used in ancient Egyptian teas and in traditional Chinese medicines, all the way to today as a flavoring agent and candy. And some women now take licorice extracts as supplements to treat menopausal symptoms. But scientists caution that licorice could pose a health risk by interacting with medications. The researchers are presenting their results today at the 254th National Meeting & Exposition of the American Chemical Society. (2017-08-21)

A new method for bone-marrow-derived liver stem cells isolation and proliferation
Bone-marrow-derived liver stem cells were once a hot topic in the field of stem cell research because of their important therapeutic implications, but little progress has been made in recent years because of the difficulty of isolation and proliferation of this special cell population. A research group in China has provided a new method for BDLSC isolation and proliferation, which brings new hope to the clinical use of bone-marrow-derived stem cells. (2009-04-15)

Researchers discover adult stem cell that can transform itself into nearly any organ in the body
Adult stem cells that can create new liver, lung, gastrointestinal and skin cells, and possibly any other organ in the body, have been discovered in bone marrow, according to a newly-published study by a Yale researcher and collaborators. (2001-05-02)

A valuable lesson in gene therapy
A year after 18-year-old Jesse Gelsinger died after experimental gene therapy, US researchers are beginning to understand what went wrong. Their work may help to make gene therapy safer and prevent similar tragedies in the future. (2001-01-16)

How liver cancer develops
Researchers at the University of Zurich and the University Hospital Zurich have discovered a major mechanism in the development of liver cancer. In chronic liver diseases, damaged cells die off and are replaced by new ones over a period of years. As time goes on, DNA damage accumulates, furthering the development of cancer. The caspase-8 enzyme plays an important dual role in this process. (2017-09-11)

Percentage of African ancestry affects gene expression
The percentage of African ancestry in a person's genome determines the level that certain genes are expressed, called mRNA, according to a new Northwestern Medicine study. The discovery could offer insight into the different risk of diseases as well as a different response to medications in African Americans. This is the first study to compare gene production between African Americans. Previous studies compared only black and white individuals. (2019-12-02)

Understanding immune reaction to the hepatitis B virus
A collaboration of researchers from Japan and Malaysia has further clarified the immune response to hepatitis B virus through in vivo experimentation. (2016-11-24)

New ways to ease liver disease
Many liver diseases are driven by immune-mediated mechanisms and therapies that can inhibit these immune-based triggers and block liver damage are needed. A study in the JCI identifies new targets in liver diseases using models of liver damage that causes hepatitis and involve T cells. Mechanisms involved in mediating IL-6 -- dependent protection -- included expression of two proteins in hepatocytes, KC and SAA2. KC and SAA2 may be of interest in developing therapies to treat immune-mediated liver disease in humans. (2005-03-03)

CeMM PR -- Immunity -- Master regulator of liver metabolism identified during infection
Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection. (2019-11-26)

Cells derived from pluripotent stem cells are developmentally immature
Stem cell researchers at UCLA have discovered that three types of cells derived from human embryonic stem cells and induced pluripotent stem cells are similar to each other, but are much more developmentally immature than previously thought when compared to those same cell types taken directly from human tissue. (2011-08-16)

Active component from wine-processed Fructus corni inhibits hippocampal neuron apoptosis
This finding, published in the Neural Regeneration Research, provides theoretical evidence for the treatment of neurodegenerative disease with 5-hydroxymethylfurfural extracted from wine-processed Fructus corni and lays the foundations for clinical prevention and treatment of oxidative injury-related diseases in the brain. (2013-11-27)

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