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BUSM study shows potential of differentiated iPS cells in cell therapy without immune rejection
A new study from Boston University School of Medicine shows that tissues derived from induced pluripotent stem (iPS) cells in an experimental model were not rejected when transplanted back into genetically identical recipients. (2013-01-25)

The liver increases by half during the day
In mammals, the liver reaches its maximum efficiency when they are active and feed. Biologists from the University of Geneva (UNIGE), Switzerland, showed in mice that the size of the liver increases by almost half before returning to its initial dimensions, according to the phases of activity and rest. This fluctuation disappears when the normal biological rhythm is reversed. The disruption of our circadian clock probably has important repercussions on our liver functions. (2017-05-04)

New tool aids stem cell engineering for medical research
A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform that uses network biology methods to aid stem cell engineering. Details of CellNet and its application to stem cell engineering are described in two back-to-back papers in the journal Cell. (2014-08-28)

Transplanted cells may hold the key to curing hemophilia A, Einstein scientists report
Scientists at the Albert Einstein College of Medicine have shown for the first time that transplanted cells can cure hemophilia A (the most common form of the disease) in an animal model. To do so, the researchers transplanted healthy liver endothelial cells from donor mice into a mouse model of the disease. Their findings also overturned conventional wisdom regarding which cells produce factor VIII, the crucial clotting protein that people with type A hemophilia lack. (2008-02-14)

Peptide improves glucose and insulin sensitivity, lowers weight in mice
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School of Medicine researchers. (2018-02-08)

Specialized blood vessels jumpstart and sustain liver regeneration
The liver's unique ability among organs to regenerate itself has been little understood. Now Weill Cornell Medical College scientists have shed light on how the liver restores itself by demonstrating that endothelial cells -- the cells that form the lining of blood vessels -- play a key role. (2010-11-11)

A new model of liver regeneration
Harvard Stem Cell Institute scientists at Boston Children's Hospital have new evidence in mice that it may be possible to repair a chronically diseased liver by forcing mature liver cells to revert back to a stem cell-like state. (2014-06-05)

How did glycine significantly decrease liver injury?
Chronic cholestasic liver diseases lead to liver injury and ultimately progress to portal fibrosis, cirrhosis, and end-stage liver disease requiring liver transplantation. A research group in the US and Germany investigated the effects of (dietary) glycine against oxidant-induced injury caused by bile duct ligation in rats. The study demonstrate that hepatic injury due to BDL is significantly reduced by dietary glycine and glycine decreases liver injury thru a direct effect on hepatocytes. (2008-10-31)

First successful delivery of mitochondria to liver cells in animals
This experiment marks the first time researchers have ever successfully introduced mitochondria into specific cells in living animals. The study lays the groundwork to address a serious gap in treatment for liver diseases and may even eventually be used to treat other maladies throughout the body affected by mitochondrial malfunction or damage. (2020-06-25)

Possible new treatment strategy for fatty liver disease
Researchers at Karolinska Institutet in Sweden have identified a molecular pathway that when silenced could restore the normal function of immune cells in people with fatty liver disease. The findings could lead to new strategies for treating the condition, which is a major health risk for people with obesity. The study is published in the scientific journal Science Translational Medicine. (2020-02-26)

Rockefeller University's Center for Clinical and Translational Science funds pilot studies
The Rockefeller University Center for Clinical and Translational Science has announced the recipients of its 2008 Pilot Project grants. Eight Rockefeller researchers will each receive $25,000 from the center to fund early studies in translational science that, if successful, might lead to clinical trials. (2008-01-07)

Your fat may help you heal
A person's own fat cells may be the source of matrix material to grow new cells and, ultimately, new tissue for humans without risk of rejection. (2010-03-25)

New biomarker to identify hepatitis B-infected patients at risk for liver cancer
Hepatitis B-infected patients with significantly longer telomeres -- the caps on the end of chromosomes that protect our genetic data -- were found to have an increased risk of getting liver cancer compared to those with shorter ones, according to findings presented by researchers at Jefferson's Kimmel Cancer Center at the American Association for Cancer Research Annual Meeting 2012. (2012-04-03)

3D liver tissue implants made from human stem cells support liver function in mice
Stem cells transformed into 3D human liver tissue show promising support of liver function when implanted into mice with a liver disease. The scientists say that in addition to being early-stage progress towards developing human liver tissue implants, it could also reduce the need for animals in research by providing a better platform to study human liver disease and test drugs in the lab. (2018-08-27)

New lights on the pathogenic mechanisms of liver cirrhosis with ascites
The concept of altered intestinal permeability is important and has been implicated in a number of pathological situations. A research group in Korea investigated the relation between intestinal permeability in compensated and decompensated cirrhosis and urine nitrite oxide levels. The main results of the study are that the increased permeability and nitrite oxide is of importance in the pathophysiology of decompensated cirrhosis. (2008-09-23)

Is it pancreatitis in acute abdominal pain in acute viral hepatitis?
Acute viral hepatitis is prevalent worldwide. A three-year study led by Dr. Pankaj Jain and Dr. Sandeep Nijhawan from Sawai Man Singh Hospital on acute abdominal pain in acute viral hepatitis revealed acute pancreatitis in 5.65 percent, which was mild and recovered with conservative treatment. Remaining patients had stretching of the glissons capsule as a cause of abdominal pain. (2007-10-30)

Study may improve survival of transplanted livers
New research at the University of North Carolina at Chapel Hill School of Medicine shows that treatment with nitric oxide after storage may dramatically improve the viability of transplanted livers. (2004-05-24)

New studies examine elimination of hepatitis B and C
Two new studies in the April issue of Hepatology explore the ways that hepatitis B virus and hepatitis C virus can be cleared from patients' bodies. Hepatology is a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases. The articles are also available online at Wiley Interscience. (2009-04-01)

A promising new approach to cadmium induced hepatoxicity: Cytoprotective effect of midkine
Cadmium is a very toxic substance which causes serious damage in the kidney, liver, heart and testes. At present, there is no effective treatment for cadmium intoxication, and patients are given supportive treatment according to their symptoms. A research group in Turkey has found that midkine has a curative effect in cadmium induced toxicity in hepatocytes. (2008-01-16)

Researchers find promising therapy to fight epidemic of liver disease
In an effort to combat a growing worldwide epidemic of Nonalcoholic Fatty Liver Disease (NAFLD), scientists have discovered a new target and a new therapy that has shown promising results in preclinical mouse models, according to researchers at the University of Colorado Anschutz Medical Campus. (2020-07-08)

New study identifies targets to lessen the effects of alcoholic liver disease
Chronic alcohol consumption causes abnormal fat accumulation in liver cells (steatosis) and liver fibrosis, which can lead to hepatitis, cirrhosis, and sometimes liver cancer. A new study in The American Journal of Pathology offers insights into the cellular aging that may trigger excessive fibrosis formation in the liver as well as possible means to inhibit these changes, which may lead to new therapeutic approaches for patients with ALD. (2017-11-08)

JCI table of contents: April 2, 2007
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published April 2, 2007, in the JCI, including: Is there such a thing as too much sugar?; Heart grafts avoid rejection; New gene defect causes heavy bones; Pancreatic cells show variable plasticity; We've got drinking water on our minds; and HIF-2 boosts red blood cell numbers. (2007-04-02)

Type 2 diabetes, it all starts in the liver
Among the detrimental effects of obesity is the risk of developing type 2 diabetes. If the strong links between obesity and type 2 diabetes are well known, the cellular and molecular mechanisms were so far poorly understood. Scientists from the University of Geneva unravel the factors linking obesity and insulin resistance. By deciphering how the protein PTPR-γ inhibits insulin receptors located at the surface of liver cells, they open door to potential news therapeutic strategies. (2017-11-28)

Liver cancer: Lipid synthesis promotes tumor formation
Lipid, also known as fat, is an optimal energy source and an important cell component. Much is required for the rapid and uncontrolled growth of cancer cells. Researchers from the Biozentrum of the University of Basel and from the University of Geneva have now discovered that the protein mTOR stimulates the production of lipids in liver tumors to satisfy the increased nutrient turnover and energy needs of cancer cells among other functions. (2017-12-11)

Long-term L-carnitine supplementation prevents development of liver cancer
Liver cancer is one of the most common malignancies worldwide, especially in Asia and Africa. Although there are many strategies for the treatment of liver cancer, the therapeutic outcome of this cancer remains very poor. Therefore, prevention seems to be the best strategy for lowering the incidence of this disease. (2009-03-24)

BioIVT publishes new research on the mechanisms underlying the C-DILI assay
BioIVT, a leading provider of research models and services for drug development, today announced its research into the mechanisms involved in cholestatic drug-induced liver injury (DILI) has been published in Applied In Vitro Toxicology. DILI is one of the primary causes of drug development failures. As a result, sponsors endeavor to identify new drug candidates with a high DILI risk early in the development process. (2018-09-10)

Hepatitis B: Natural controllers shed light on immunity mechanisms
To improve our understanding of the antibody response conferring protection against HBV infection, scientists from the Institut Pasteur and Inserm, in collaboration with the Roche Innovation Center in Switzerland, produced and characterized human monoclonal antibodies specific to viral envelope antigens, referred as HBsAg, from blood memory B cells isolated from HBV vaccinees and natural controllers. (2020-08-13)

A new way to model cancer
New gene-editing technique from researchers at MIT allows scientists to more rapidly study the role of mutations in tumor development. (2014-08-06)

JCI online early table of contents: June 15, 2009
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, June 15, 2009, in the JCI: (2009-06-15)

Stopping liver cancer in its tracks
A University of Tokyo research group has discovered that AIM (apoptosis inhibitor of macrophage), a protein that plays a preventive role in obesity progression, can also prevent tumor development in mice liver cells. This discovery may lead to a therapy for hepatocellular carcinoma, the most common type of liver cancer and the third most common cause of cancer deaths. (2014-10-02)

Microexons: Small fragments of genes, essential for neurone maturation
Study led by researchers from the University of Toronto and involving the Centre for Genomic Regulation in Barcelona has described a group of small DNA fragments that are key in neurone regulation and maturity. The discovery reveals the importance of these small fragments and their relationship with autism. CRG Researcher and first author of the work Manuel Irimia has just received a 1.5 million euro grant from the European Research Council to continue studying this phenomenon. (2014-12-18)

UCLA scientists receive $2 million grant to improve quality of donor livers for transplant
A team of scientists from UCLA have been awarded a three-year, $2 million grant from the W.M. Keck Foundation to fund research aimed at increasing the quality of donor livers. (2013-08-27)

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