Hypoglycemia Current Events

Hypoglycemia Current Events, Hypoglycemia News Articles.
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Risk of low blood sugar differs among similar diabetes drugs
Adding sulphonylureas (SUs) to metformin remains a commonly used strategy for treating type 2 diabetes, but individual SUs differ and may confer different risks of abnormally low blood sugar, or hypoglycemia. SUs -- which include newer generation agents such as gliclazide, glipizide, glimepiride, and glibenclamide -- stimulate the production of insulin in the pancreas and increase the effectiveness of insulin in the body. (2016-07-19)

Tramadol associated with increased risk of hospitalization for hypoglycemia
The opioid pain-reliever tramadol appears to be associated with an increased risk of hospitalization for hypoglycemia, a potentially fatal condition caused by low blood sugar, according to a report published online by JAMA Internal Medicine. (2014-12-08)

Alternative fuel for your brain
In this issue of the Journal of Clinical Investigation, Raimund Herzog and colleagues at Yale University used magnetic resonance spectroscopy to measure the concentrations and enrichment of different energy substrates and their metabolites in a rat model of recurrent hypoglycemia. (2013-04-01)

Yale to launch new Center for the Study of Hypoglycemia with $5 million JDRF award for research
Yale School of Medicine recently opened the Juvenile Diabetes Research Foundation (JDRF) Center for the Study of Hypoglycemia at Yale University with a five-year, $5 million JDRF grant. The funds will be used to advance multidisciplinary research into the effects of hypoglycemia--low blood sugar--on the brain and how to prevent it. (2000-11-13)

Insulin degludec lowers risk of recurrent low blood sugar or has similar risk to insulin glargine
Insulin degludec, a new ultra-long-acting insulin, has a similar or reduced risk of recurrent hypoglycemia -- low blood sugar -- compared with the commercially available insulin glargine, a new meta-analysis study finds. Results of the combined analysis, of five completed clinical trials, will be presented Tuesday at The Endocrine Society's 95th Annual Meeting in San Francisco. (2013-06-18)

Sensor-augmented insulin pump therapy reduces rate of severe hypoglycemic events
Use of an insulin pump with a sensor that suspends insulin delivery when blood glucose falls below a set threshold reduced the rate of severe and moderate hypoglycemia among patients with type 1 diabetes and impaired awareness of hypoglycemia, according to a study in the Sept. 25 issue of JAMA. (2013-09-24)

Severe hypoglycemia linked with higher risk of dementia for older adults with diabetes
Having hypoglycemic (low blood sugar level) episodes that are severe enough to require hospitalization are associated with a greater risk of dementia for older adults with type 2 diabetes, according to a study in the April 15 issue of JAMA, a theme issue on diabetes. (2009-04-14)

How sweet it isn't: Repeat episodes of low blood sugar spell diabetic disaster
For diabetics, single or repeated episodes of low blood sugar (hypoglycemia) can impair the body's ability to detect and react to low blood sugar in the future, resulting in severe hypoglycemia that can be fatal. Yale University researchers now show in rats that urocortin I activity in the brain, which activates corticotrophin-releasing factor receptor 2 (CRFR2), impairs the sensitivity of glucose-sensing neurons and is responsible for suppressing the body's counterregulatory response to hypoglycemia. (2006-06-01)

Reactive hypoglycemia symptoms improve with sitagliptin
The diabetes drug sitagliptin appears to reduce the severity of reactive hypoglycemia, a form of low blood sugar that occurs after a meal, a preliminary study finds. The results will be presented Sunday at the Endocrine Society's 94th Annual Meeting in Houston. (2012-06-24)

Studies compare types of insulin for reducing episodes of low blood sugar for patients with Type 1 or 2 diabetes
Treatment with the insulin degludec compared to glargine U100 for 32 weeks resulted in a reduced rate of hypoglycemic (low blood sugar) episodes among patients with type 1 or 2 diabetes and at least one risk factor for hypoglycemia, according to two studies published by JAMA. (2017-07-03)

Hypoglycemia link to HbA1c has declined in type 1 diabetes
The link between low average glucose blood levels and greater risk for severe hypoglycemia and hypoglycemic coma substantially declined between 1995 and 2012 in young Germans and Austrians with type 1 diabetes, according to a study published by Beate Karges and colleagues from the RWTH Aachen University, Germany in this week's PLOS Medicine. (2014-10-07)

Low blood sugar: A killer for kidney disease patients?
Low blood sugar, or hypoglycemia, poses a serious health threat for patients with chronic kidney disease, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology. The findings indicate that hypoglycemia may account for some portion of the excess heart-related deaths seen in CKD patients. (2009-05-07)

New glucagon delivery system reduces episodes of post-bariatric surgery hypoglycemia
The number of bariatric surgeries is increasing, as is the incidence of post-bariatric hypoglycemia (PBH). Physicians do not have adequate tools to treat this condition. A smart glucagon device developed by Joslin Diabetes Center and the Harvard School of Engineering and Applied Sciences has been shown to reduce episodes of PBH. (2018-02-08)

Dual-hormone artificial pancreas is a step closer for patients with Type 1 diabetes
For patients with Type 1 diabetes, a dual-hormone artificial pancreas system (also known as a closed-loop delivery system) improved the control of glucose levels and reduced the risk of hypoglycemia compared with conventional pump treatment in a trial published in CMAJ. (2013-01-28)

Wearable heart rate monitor could signal low blood sugar in type 1 diabetes
A wearable medical patch measuring the beat-to-beat variation in heart rate is a promising device for the early detection of hypoglycemia, or low blood sugar, in type 1 diabetes, according to the researchers who tested the new monitor. Results of their preliminary study will be presented Saturday at ENDO 2018, the Endocrine Society's 100th annual meeting in Chicago. (2018-03-19)

Unsuspected brain region involved in side effects of diabetes drugs
A brain region involved in emotional and intellectual processes appears to also play an unsuspected role in the body's visceral response to dangerously low blood sugar levels, according to research at Washington University School of Medicine in St Louis. Low blood sugar, called hypoglycemia, is a common and dangerous side effect of drugs that control insulin levels in people with diabetes. (2004-03-15)

Low blood glucose levels in hospitalized patients linked to increased mortality risk
In hospitalized patients, low blood sugar -- also known as hypoglycemia -- is associated with increased short- and long-term mortality risk, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. (2016-11-17)

Researchers reveal link between hunger and mood, new study
The study used rats to examine the impact on emotional behavior of a sudden drop in blood sugar. When the rats were given a glucose blocker, researchers found they had higher levels of cortisol. They also showed signs of stress and sluggish behavior similar to a poor mood. To prove the behavior wasn't just a lack of glucose to the muscles, researchers then gave them a common antidepressant and the behavior disappeared. (2018-09-25)

Older adults with type 1 diabetes often not aware of hypoglycemia
Older adults with type 1 diabetes typically have low blood sugar, or hypoglycemia, for more than an hour a day, suggests research to be presented Monday, March 25, at ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La. (2019-03-23)

Popular pain medication associated with greater risk of hypoglycemia
As the opioid tramadol has grown in popularity so too have documented cases of adverse effects. In a new study, researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego show that patients who take tramadol are at greater risk for hypoglycemia, abnormally low blood sugar. (2019-08-28)

Patients with type 1 diabetes don't wake in response to hypoglycemia
A study of 16 patients with type 1 diabetes mellitus (T1DM) and 16 normal individuals shows that only one of the 16 T1DM patients, as compared to ten healthy control participants, awakened upon hypoglycemia. (2007-02-26)

Low blood sugar poses unaddressed threat to people with type 2 diabetes
New research from the Endocrine Society and Avalere Health finds that clinicians lack the resources to identify, assess and manage patients who are at a high risk of developing hypoglycemia, or episodes of dangerously low blood sugar. (2018-03-05)

Elderly diabetics have fewer bouts of hypoglycemia at night with new insulin
A new variety of long-lasting insulin, called insulin degludec, lowers the risk of nighttime low blood sugar in elderly diabetic adults compared with insulin glargine, a systematic review of diabetes studies has found. The meta-analysis of phase 3 clinical trials will be presented Monday at the Endocrine Society's 94th Annual Meeting in Houston. (2012-06-25)

Common diabetes treatment could extend hypoglycemia
Researchers at the University of Adelaide have discovered that a common treatment for people with type 2 diabetes could cause longer-than-normal periods of the low blood sugar reaction hypoglycemia, which may result in increased health risks to people with diabetes. (2014-04-08)

Severe hypoglycemia linked to increased risk of death in people with diabetes
A single instance of blood sugar falling so low as to require an emergency department visit was associated with nearly double the risk of cardiovascular disease or death, finds a new Johns Hopkins Bloomberg School of Public Health study of older adults with type 2 diabetes. (2017-03-10)

Glucose monitoring helps prevent hypoglycemia in hospitalized heart disease patients
Hospitalized patients with stable coronary artery disease (CAD) may need frequent glucose monitoring to prevent hypoglycemia and death, new research reports. The results will be presented in a poster on Saturday, March 17, at ENDO 2018, the annual 100th meeting of the Endocrine Society in Chicago, Ill. (2018-03-17)

Mayo Clinic Proceedings study finds link between hypoglycemia and mortality rates in critically ill
In a study published in the March issue of Mayo Clinic Proceedings, researchers report that they have found a link between mild to moderate hypoglycemia (low blood sugar) and mortality in critically ill patients. (2010-03-15)

Continuous glucose monitoring reduces hypoglycemia in older adults with type 1 diabetes
Laura Young, MD, PhD, associate professor of medicine, was UNC's principal investigator for this six-month clinical trial that shows the use of continuous glucose monitoring (CGM) reduces serious levels of hypoglycemia compared with standard monitoring by daily use of blood glucose finger-stick test strips. (2020-06-16)

Association between hypoglycemia, dementia in older adults with diabetes
A study of older adults with diabetes mellitus suggests a bidirectional association between hypoglycemic (low blood glucose) events and dementia, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication. (2013-06-10)

Is there such a thing as too much sugar?
Treatment with insulin can cause hypoglycemia (low levels of glucose in the blood), which, if prolonged, can lead to neuronal death, brain injury and coma. In a new study, researchers found that in hypoglycemic mice, neuronal death is triggered by treatment with glucose rather than by the hypoglycemia. This suggests that it might be best to treat individuals in hypoglycemic coma by gradually increasing their blood glucose levels rather than by restoring glucose levels rapidly. (2007-04-02)

Drivers with type-1 diabetes report increased incidence of car crashes
Drivers with type-1 diabetes reported higher numbers of driving mishaps according to a multi-center study led by researchers at the University of Virginia Health System. The study investigated whether or not diabetes treatments to control blood sugar level are associated with increased risks for driving mishaps. The results will be published in the August edition of Diabetes Care. (2003-07-25)

Association between transient newborn hypoglycemia, 4th grade achievement
A study matching newborn glucose concentration screening results with fourth-grade achievement test scores suggests that early transient newborn hypoglycemia (low blood sugar) was associated with lower test scores at age 10, according to an article published online by JAMA Pediatrics. (2015-08-24)

Fasting for lab tests isn't good for patients with diabetes
Fasting before getting your blood drawn for cholesterol tests is common practice, but new research from Michigan State University shows it is a contributing factor of low blood sugar, or hypoglycemia, in patients who take diabetes medications. (2018-12-04)

Chemical in brain acts like a fuel gauge
The neurotransmitter norepinephrine can alert the brain to dangerously low blood sugar levels, according to a new study. Finding has implications for diabetes research. (2007-07-05)

Tramadol associated with increased risk of hospitalization for hypoglycemia
The opioid pain-reliever tramadol appears to be associated with an increased risk of hospitalization for hypoglycemia, a potentially fatal condition caused by low blood sugar, according to a report published online by JAMA Internal Medicine. (2014-12-08)

Is there a benefit to switching from flash monitoring to RT-CGM for hypoglycemia?
In follow-up to the I HART CGM study, which showed the benefit of real-time continuous glucose monitoring (RT-CGM) compared to flash monitoring for time spent in hypoglycemia among adults with type 1 diabetes at high hypoglycemia risk, researchers conducted an extension trial that assessed the effects of continuing RT-CGM or switching from flash to RT-CGM of the subsequent 8 weeks. (2018-10-12)

Hypoglycemia may affect newborn's brain cell function, says Hopkins researcher
Hypoglycemia, or low blood sugar, may have a significant effect on activity patterns in a newborn's brain, say researchers at Johns Hopkins Children's Center and St. Christopher's Hospital for Children in Philadelphia. Their study of piglet brains, which are metabolically and structurally close to that of humans, is reported in this month's Brain Research. (2002-02-14)

Researchers create model to predict risk of low blood sugar in people with diabetes
A new study by researchers from Regenstrief Institute and Merck identifies the risk factors that could help healthcare providers recognize patients being treated for diabetes who are most likely to have low blood sugar. Many patients with diabetes, especially those with recurring episodes of low blood sugar, are unaware when it occurs, despite the risk of serious adverse events including cognitive impairment, coma and death. (2019-07-25)

Continuous glucose monitors warn of low blood sugar threat
Continuous glucose monitors (CGM) can protect individuals who have had type 1 diabetes for years and are at risk of experiencing dangerously low blood sugar by increasing their awareness of the symptoms, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism. (2017-11-28)

Study suggests potential connection between low blood sugar and cardiovascular problems
Studies have shown an association between strict control of blood sugar and increased mortality. They have also suggested that a consequence of this control is low blood sugar (hypoglycemia), which may have adverse effects on the heart. In a new study, published by Diabetes, researchers examined the effects of hypoglycemia on cardiovascular autonomic control. They found that in their experimental model of hypoglycemia, there was a clear change in the body's responses to cardiovascular stress. (2015-11-03)

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