Immune Cells Current Events

Immune Cells Current Events, Immune Cells News Articles.
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Making cancer-fighting cells in the lab
Scientists reprogram human invariant natural killer T cells to induced pluripotent stem cells, which were then differentiated back to iNKT cells that showed stronger activity than the original iNKT cells. This study shows iPS cell technology can be used to recover immune cells that have weakened immune activity. (2016-02-14)

Harnessing immune cells' adaptability to design an effective HIV vaccine
In infected individuals, HIV mutates rapidly to escape recognition by immune cells. This process of evolution is the main obstacle to natural immunity and the development of an effective vaccine. A new study published by in the journal Immunity reveals that the immune system has the capacity to adapt such that it can recognize mutations in HIV. (2013-03-21)

Not such a 'simple' sugar -- glucose may help fight cancer and inflammatory disease
Scientists have just discovered that glucose, the most important fuel used in our bodies, also plays a vital role in the immune response. Targeting glucose-controlled systems in the body thus offers an exciting new option for regulating this response. (2017-05-30)

How breast cancer cells sneak past local immune defenses
Breast cancer cells grow locally, then metastasize throughout the body. They succeed in establishing tumors by sabotaging local immune cells embedded in tissues, thus evading detection and destruction by the body's roving immune defenses. (2020-07-15)

New Zealand researchers makes 'natural born killer' cell discovery
An unexpected role for a white blood cell called the Natural Killer (NK) cell -- a critical cell for ridding the body of infection and cancer, has been discovered by researchers t New Zealand's University of Otago. The NK cell is a 'vigilante' killer -- a white blood cell that destroys invaders and cancer cells through a process of 'identity card' checking. The researchers' new work shows that violent vigilante NK cells act as helper cells to start up the immune response. (2017-08-31)

Study reveals that chemotherapy works in an unexpected way
New research published in the journal Immunity shows that effective chemotherapies actually work by mobilizing the body's own immune cells to fight cancer. Researchers found that chemo-treated dying tumors secrete a factor that attracts certain immune cells, which then ingest tumor proteins and present them on their surfaces as alert signals that an invader is present. This new understanding of how chemotherapy works with our immune systems could prompt new tactics for treating cancer. (2013-04-04)

Exhausted B cells fail to fight HIV
HIV tires out the cells that produce virus-fighting proteins known as antibodies, according to a human study that will be published online July 14 in the Journal of Experimental Medicine. (2008-07-14)

Tumor-trained T cells go on patrol
In cancer, immune cells infiltrate tumors -- but it hasn't been known which immune cells exit the tumor or where they go next. Garvan researchers have shown that activated T cells are the main immune cell to leave tumors, and that these T cells move to other tumors and to draining lymph nodes The findings will inform the development of T-cell-based immunotherapies for metastatic cancer. (2017-05-15)

Nuclear DNA gets cut and activates immune system to attack cancer cells
The enzyme MUS81 cuts DNA in the nucleus of cancer cells, causing the cut DNA to move to the cytoplasm instead of becoming degraded. The out-of-place DNA triggers an immune response against cancer cells. Discovering this new means of enhancing anti-cancer immune responses could lead to more effective cancer therapies using a combination of a MUS81-stimulating drug and an immunotherapy. (2016-05-10)

How self-reactive immune cells are allowed to develop
A research team at Lund University in Sweden has found the mechanism that controls the growth of B1-cells in mice. The findings, which may lead to a deeper understanding of certain forms of cancer and autoimmune diseases, was recently published in the journal Science Immunology. (2019-11-13)

The search for the origin of mast cells
A team of researchers from CNRS, INSERM and Aix-Marseille Université (AMU) at the Centre of immunology Marseille-Luminy, together with the Singapore Immunology Network, has proven that not all of the immune system's important mast cells are produced in bone marrow, as was previously thought. Scientists found embryonic mast cells in mice with functions that are likely to be different than the mast cells found in adults. The study appears in the June 2018 edition of Immunity. (2018-06-04)

Ultraviolet B exposure expands proenkephalin+ regulatory T cells with a healing function
Skin exposure to ultraviolet B (UVB) induces expansion of regulatory T (Treg) cells with immunosuppressive activity. Here researchers found that UVB-expanded skin Treg (UVB-skin Treg) cells had a tissue repair function. UVB-skin Treg cells expressed proenkephalin (PENK) and amphiregulin (AREG), which promoted keratinocyte outgrowth and skin wound healing. Their results provide a new implication in developing a therapy using UVB-skin Treg cells. (2020-09-01)

Researchers reveal the clearest new pictures of immune cells
Scientists from The University of Manchester have revealed new images which provide the clearest picture yet of how white blood immune cells attack viral infections and tumors. They show how the cells, which are responsible for fighting infections and cancer in the human body, change the organization of their surface molecules, when activated by a type of protein found on viral-infected or tumor cells. (2013-07-23)

Research reveals how lymph nodes expand during disease
Cancer Research UK and UCL scientists have discovered that the same specialized immune cells that patrol the body and spot infections also trigger the expansion of immune organs called lymph nodes, according to a study published in Nature on Wednesday, Oct. 22, 2014. (2014-10-22)

Researchers reveal new mechanism to 'activate' the immune system against cancer
A new mechanism for activating the immune system against cancer cells allows immune cells to detect and destroy cancer cells better than before, and most effectively in lung cancer and melanoma. (2019-01-04)

Researchers work on vaccine to improve immune system in newborns
As soon as babies are born, they are susceptible to diseases and infections, such as jaundice and E. coli. For up to a month, their immune systems aren't adequately developed to fight diseases. Although these infections are often minor, they can lead to serious problems if left untreated. To help strengthen newborns' immune systems, University of Missouri researchers have pinpointed a group of depleted white blood cells, which might lead to an immune-strengthening vaccine. (2009-12-15)

iPS cells to regulate immune rejection upon transplantation
Scientists suggest a new strategy that uses induced pluripotent stem cells (iPSCs) to regulate immune reaction to transplanted tissues. (2020-02-06)

Key to immune system disease could lie inside the cheek
Cardiff University scientists have produced powerful new cells which can suppress the body's immune system. The cells are obtained by cloning tissue lining the human cheek, a less invasive process than obtaining adult stem cells from bone marrow. The breakthrough offers long term hope for dealing with immune system disorders. (2012-03-21)

Immune system maintains a memory of past infections by priming genes for future encounters
Our ability to fight off recurrent infections, such as colds or flu, may lie in the 'immunological memory' found in a newly discovered class of gene regulatory elements, according to research from the University of Birmingham, supported by the BBSRC and Bloodwise. (2016-01-21)

Study finds therapies using induced pluripotent stem cells could encounter immune rejection problems
Biologists at UC San Diego have discovered that an important class of stem cells known as (2011-05-13)

Study finds therapies using induced pluripotent stem cells could encounter immune rejection problems
Biologists at UC San Diego have discovered that an important class of stem cells known as (2011-05-13)

Fighting cancer with the help of someone else's immune cells
A new step in cancer immunotherapy: researchers from the Netherlands Cancer Institute and University of Oslo/Oslo University Hospital show that even if one's own immune cells cannot recognize and fight their tumors, someone else's immune cells might. Their proof of principle study is published in the journal Science on May 19. (2016-05-19)

In fighting gut infections, nervous system is key, Yale-Harvard team finds
The peaceful and delicate co-existence of friendly gut bacteria and the immune system relies on highly coordinated information exchange between immune system cells and certain cells lining the intestine. Scaientists at Yale and Harvard medical schools have discovered that, in response to bacterial invaders, nerve cells within the intestine -- and not immune cells or cells lining the intestinal wall -- release infection-fighting cytokines. (2020-01-09)

Stress related responses regulate immune function
The immune system is composed of a wide range of different immune cells each with dedicated functions. Natural killer T cells form a specialized immune cell that protects against a variety of diseases such as cancer, autoimmunity, metabolic disease or certain infections such as Lyme disease (2018-12-19)

Protein proves influential to healthy immune system
Researchers have discovered that the protein Myb plays a vital role in keeping our immune system healthy, and preventing the development of immune and inflammatory diseases. Preclinical findings revealed that Myb gives immune cells called regulatory T (Treg) cells the 'authority' to control the strength of the immune response depending on the level of 'threat,' from minor infections to aggressive diseases. (2017-03-13)

'Educating' patients' immune cells may help combat diabetes
New research reveals that a treatment called Stem Cell Educator therapy is safe and effective for treating type 1 and type 2 diabetes. (2017-07-07)

Why recovery from flu may increase odds of bacterial infection
Successfully fighting off the flu can leave you more vulnerable than usual to other lung infections. A new study shows that flu infection in mice causes immune cells to ignore later infections. The study will appear in the Feb. 18 issue of the Journal of Experimental Medicine. (2008-02-18)

A braking system for immune responses
For the first time, researchers have identified a receptor on human cells that specifically recognizes crystals. It is found on immune cells and binds uric acid crystals, which trigger gout but also control immune responses. The team, led by researchers from Technische Universitaet Muenchen's Klinikum rechts der Isar hospital have published their findings in the Immunity journal. (2014-03-20)

Cellular mechanism for severe viral hepatitis identified
KAIST medical scientists identified a cellular mechanism causing inflammatory changes in regulatory T cells that can lead to severe viral hepatitis. Research on this mechanism will help further understand the nature of various inflammatory diseases and lead to the development of relevant clinical treatments. (2018-01-18)

How cellular structure orchestrates immunologic memory
With every infection or vaccination, memory cells form that the body uses to remember the pathogen. This has been known for decades -- but the structure of this cellular immunologic memory has previously proven impossible to pin down. Researchers from the University of Basel and University Hospital Basel have now identified a microanatomical region in memory cells that enables them to work rapidly in the first few hours of an immune response, as they report in the journal Immunity. (2018-03-08)

UT Southwestern researchers engineer cells that may hold key to treating inflammatory diseases
Researchers at UT Southwestern Medical Center at Dallas have converted specialized cells that normally trigger an immune response into cells that trigger cell death. (1999-08-04)

How Toxoplasma gondii gets noticed
Researchers provide insight into how Toxoplasma gondii, a common parasite of people and other animals, triggers an immune response in its host. The report will appear online on Jan. 19 in the Journal of Experimental Medicine. (2009-01-19)

For aggressive breast cancer in the brain, researchers clarify immune response
In a preliminary study presented at the American Association for Cancer Research Annual Meeting 2018 in Chicago, researchers from the UNC Lineberger Comprehensive Cancer Center revealed findings for what kind of immune response the body is staging against triple negative breast cancer that has spread to the brain. They hope they can use these findings to improve patient responses to drugs that work by unleashing the immune system against cancer. (2018-04-17)

New insight into immune tolerance furthers understanding of autoimmune disease
The mechanisms that underlie immune activation and tolerance are not completely understood. Now, a new research study published by Cell Press in the journal Immunity and available online on Sept. 15 provides intriguing insight into the complex immune regulatory mechanisms that underlie immune tolerance. (2011-09-15)

Vitamin D study sheds light on immune system effects
Scientists at the University of Edinburgh have uncovered fresh insights into how vitamin D affects the immune system and might influence susceptibility to diseases such as multiple sclerosis. (2019-04-17)

Modified immune cells seek and destroy melanoma
In this issue of the Journal of Clinical Investigation, researchers led by Scott Pruitt at Duke University and Merck Research Laboratories report on a human clinical trial in which modified dendritic cells, a component of the immune system, were tested in patients with melanoma. (2013-06-24)

Zika-related nerve damage caused by immune response to the virus
The immune system's response to the Zika virus, rather than the virus itself, may be responsible for nerve-related complications of infection, according to a Yale study. This insight could lead to new ways of treating patients with Zika-related complications, such as Guillain-Barré syndrome, the researchers said. (2017-11-20)

Cancer under pressure: Visualizing the activity of the immune system on tumor development
As tumors develop, they evolve genetically. How does the immune system act when faced with tumor cells? How does it exert pressure on the genetic diversity of cancer cells? Scientists from the Institut Pasteur and Inserm used in vivo video techniques and cell-specific staining to visualize the action of immune cells in response to the proliferation of cancer cells. The findings have been published in the journal Science Immunology on Nov. 23, 2018. (2018-11-27)

Precise decoding of breast cancer cells creates new option for treatment
Researchers at the University of Zurich and from IBM Research have investigated the vary-ing composition of cancer and immune cells in over one hundred breast tumors. They've found that aggressive tumors are often dominated by a single type of tumor cell. If certain immune cells are present as well, an immune therapy could be successful for a specific group of breast cancer patients. (2019-04-15)

Finnish research group discovers a new immune system regulator
Academy Professor Riitta Lahesmaa's research group from Turku Centre for Biotechnology of the University of Turku and Åbo Akademi University, Finland, has discovered a new regulator of the immune system, a key factor that controls development of regulatory T cells. The discovery provides basis for new strategies for the treatment of both cancer and immune-mediated diseases. (2018-02-22)

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