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Infectious Diseases Current Events, Infectious Diseases News Articles.
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NIH-funded researchers identify target for chikungunya treatment
Scientists have identified a molecule found on human cells and some animal cells that could be a target for drugs against chikungunya virus infection and related diseases, according to new research published in the journal Nature. A team led by scientists at Washington University School of Medicine in St. Louis conducted the research, which was funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (2018-05-21)

West African Ebola virus strain less virulent than prototype 1976 strain
The Makona strain of Ebola virus circulating in West Africa for the past year takes roughly two days longer to cause terminal disease in an animal model compared to the original 1976 Mayinga strain isolated in Central Africa, according to a new NIH report. The new study suggests the current virus has a decreased ability to cause disease in their animal model compared to the 1976 strain. (2015-06-09)

Single-use N95 respirators can be decontaminated and used again, study finds
N95 respirators, which are widely worn by health care workers treating patients with COVID-19 and are designed to be used only once, can be decontaminated effectively and used up to three times, UCLA scientists and colleagues report. (2020-08-27)

Study finds young Africans suffering advanced HIV disease from delayed diagnosis
A new study suggests the effects of long-standing, undiagnosed HIV infection are hanging over a generation of adolescents in Zimbabwe, causing organ damage, chronic ill health, stunted growth, and other problems. The research demonstrates the need to reduce barriers to early testing and admission to care for these adolescents. It appears in the March 15 issue of Clinical Infectious Diseases, currently available online. (2007-02-08)

Hurricane aftermath: Infectious disease threats from common, not exotic, diseases
In the wake of Katrina, the public health threats from infectious diseases in hurricane-devastated areas are more likely to come from milder, more common infections rather than exotic diseases. These common infections can often be prevented using simple hygiene measures and a little common sense. (2005-09-13)

Gastric acid suppressants linked to hospitalization
New research has found a link between popular heartburn drugs and an increase in the risk of infectious gastroenteritis -- an illness that results in 13.1 million lost days of work in Australia a year. (2017-01-11)

Soldiers acquired drug-resistant infections in field hospitals
An outbreak of drug-resistant wound infections among soldiers in Iraq likely came from the hospitals where they were treated, not the battlefield, according to a new study in the June 15 issue of Clinical Infectious Diseases, currently available online. (2007-05-21)

Researchers identify mechanism that helps bacteria avoid destruction in cells
Infectious diseases currently cause about one-third of all human deaths worldwide, more than all forms of cancer combined. Advances in cell biology and microbial genetics have greatly enhanced understanding of the cause and mechanisms of infectious diseases. Researchers from Thomas Jefferson University, the Pasteur Institute in Paris, and Yale University reported in PLoS ONE, a way in which intracellular pathogens exploit the biological attributes of their hosts in order to escape destruction. (2009-10-09)

NIH study of Ebola patient traces disease progression and recovery
Analysis of daily gene activation in a patient with severe Ebola virus disease cared for at NIH in 2015 found changes in antiviral and immune response genes that pinpointed key transition points in the response to infection. The changes included a marked decline in antiviral responses that correlated with clearance of virus from white blood cells. NIAID researchers led the study. (2017-04-12)

HIV is spread most by people with medium levels of HIV in blood, says study
People with medium levels of HIV in their blood are likely to contribute most to the spread of the virus, according to new research published today in the journal Proceedings of the National Academy of Sciences. The study found that those with a high viral load are the most infectious group, but have only limited time to infect others, because they generally progress to AIDS quite quickly. (2007-10-22)

'Asexual' Chagas parasite found to sexually reproduce
The parasite that causes Chagas disease, which had largely been thought to be asexual, has been shown to reproduce sexually after scientists uncovered clues hidden in its genomic code. (2019-09-10)

NIH-funded researchers find signs TB can persist in lungs despite treatment
It has been known that the microbe that causes TB, Mycobacterium tuberculosis, can persist in the lungs even after patient tissue samples test negative for the bacteria. In new research appearing in Nature Medicine, intramural researchers at the NIAID its grantees found through the use of positron emission tomography/computerized tomography scanning that TB lesions can remain in the lungs long after treatment with antibiotics has been completed. (2016-09-06)

Specially-bred mice help target an annual outbreak: the flu
Oregon Health & Science University researchers are studying specially bred mice that are more like humans than ever before when it comes to genetic variation. Through these mice, the researchers hope to better understand and treat an infectious disease that plagues us year in and year out: the flu. (2012-02-21)

NIH funds new Boston College-Boston University study of B-1a cell associated with leukemia
Boston College Biology Professor Thomas Chiles and colleagues at Boston University Medical Center have been awarded approximately $4.5-million by NIH to study the small subset of white blood cells called B-1a lymphocytes. The new project will seek to better understand the molecular mechanisms that control when B-1a cells enter the cell cycle and proliferate. Insights gained from this research could shed light on the molecular basis of a number of disorders, including chronic lymphocytic leukemia. (2004-05-13)

Skin patch could replace the syringe for disease diagnosis
Drawing blood and testing it is standard practice for many medical diagnostics. As a less painful alternative, scientists are developing skin patches that could one day replace the syringe. In the ACS journal Analytical Chemistry, one team reports they have designed and successfully tested, for the first time, a small skin patch that detected malaria proteins in live mice. It could someday be adapted for use in humans to diagnose other diseases, too. (2014-10-22)

New hypothesis links habitat loss and the global emergence of infectious diseases
Auburn University researchers have published a new hypothesis that could provide the foundation for new scientific studies looking into the association of habitat loss and the global emergence of infectious diseases. The research was recently presented in the paper, 'The Coevolution Effect as a Driver of Spillover,' in the latest issue of the scientific journal, Trends in Parasitology. (2019-06-24)

NIH researchers make progress toward Epstein-Barr virus vaccine
A research team led by scientists from NIH's National Institute of Allergy and Infectious Diseases (NIAID) has determined how several antibodies induced by Epstein-Barr virus (EBV), a herpesvirus that causes infectious mononucleosis and is associated with certain cancers, block infection of cells grown in the laboratory. They then used this information to develop novel vaccine candidates that, in animals, elicited potent anti-EBV antibody responses that blocked infection of cell types involved in EBV-associated cancers. (2019-04-09)

Less virulent strains of avian influenza can infect humans
In findings with implications for pandemic influenza, a new study reports for the first time that a less-virulent strain of avian influenza virus can spread from poultry to humans. The research appears in the October 1 issue of The Journal of Infectious Diseases, now available online. (2005-09-13)

Lab tests key to identifying, treating infectious diseases
A new guide developed by the Infectious Diseases Society of America and the American Society for Microbiology will help physicians appropriately and accurately use laboratory tests for the diagnosis of infectious diseases. Laboratory test results drive approximately two-thirds of physicians' medical decisions. (2013-07-11)

CHOP experts describe types of rashes associated with MIS-C
In a study published in Open Forum Infectious Diseases, researchers at Children's Hospital of Philadelphia (CHOP) describe the array of rashes seen in MIS-C patients at their hospital through late July 2020, providing photos and information that could help doctors diagnose future cases. (2021-02-22)

Prevention experts urge modification to 2009 H1N1 guidance for health care workers
Three leading scientific organizations specializing in infectious diseases prevention issued a letter to President Obama today expressing their significant concern with current federal guidance concerning the use of personal protective equipment by health care workers in treating suspected or confirmed cases of 2009 H1N1 influenza. (2009-11-06)

Researchers take an important step toward an HIV vaccine
Researchers from the University of Copenhagen have developed a strategy that can revolutionize vaccine design. The new strategy is used to develop vaccines that can prevent HIV infection and the development of AIDS. (2017-05-17)

PrEP can reduce new HIV cases by a third among MSM over next 10 years
A daily pill to prevent HIV infection can reduce new cases among men who have sex with men (MSM) by a third in the US over the next 10 years, according to a new modeling study published in The Journal of Infectious Diseases and available online. The expected significant drop in HIV incidence, however, will depend on clinicians prescribing the medication according to federal guidelines and on patients using it as directed. (2016-07-14)

New tick-borne disease threatens primarily immune suppressed persons
A newly discovered tick-borne bacterium known as 'Candidatus Neoehrlichia mikurensis' has been implicated in six cases of disease in Sweden. A new international study led by the Sahlgrenska Academy has shown that this bacterium is primarily a risk for people who are already sick and who are receiving immunosuppressive drugs. (2014-05-27)

Northwestern exposing most deadly infectious diseases in 3-D
The unearthly creature looks like something out of a sci-fi flick, but the horror is real. This 3-D image that seems to leap out of the computer screen into the lab is a protein from the deadly antrax bacteria. Northwestern University is directing a $31 national project to map proteins in 3-D from the most deadly infectious diseases. This fresh view will help scientists design new drugs to disable these diseases. (2007-10-31)

Could preserving biodiversity reduce disease?
EPA has funded three interdisciplinary teams to explore the links between biodiversity and human health. The grants, totaling $2.25 million, support research programs working to better understand and characterize the mechanisms that link environmental stressors, such as deforestation and climate change, to the loss of biodiversity and the transmission of infections diseases to people. (2008-07-23)

NIH-developed Epstein-Barr virus vaccine elicits potent neutralizing antibodies in animals
NIAID researchers and their collaborators have developed an experimental, nanoparticle-based vaccine against Epstein-Barr virus (EBV) that can induce potent neutralizing antibodies in vaccinated mice and nonhuman primates. Microscopic particles, known as nanoparticles, are being investigated as potential delivery vehicles for vaccines. The scientists' findings suggest that using a structure-based vaccine design and self-assembling nanoparticles to deliver a viral protein that prompts an immune response could be a promising approach for developing an EBV vaccine for humans. (2015-08-13)

NIH scientists find real-time imaging in mice a promising influenza study tool
Real-time imaging of influenza infection in mice is a promising new method to quickly monitor disease progression and to evaluate whether candidate vaccines and treatments are effective in this animal model, according to scientists from NIAID. They evaluated the live imaging system as a potential alternative to traditional methods of assessing investigative influenza vaccines and treatment in mice, which can be time consuming and require more study animals for valid statistical comparison. (2017-05-30)

Species barrier may protect macaques from chronic wasting disease
Data from an ongoing study suggest that people who consume deer and elk with chronic wasting disease (CWD) may be protected from infection by an inability of the CWD infectious agent to spread to people. The study appears online in the journal Emerging Infectious Diseases. (2009-07-30)

OHSU scientists look for methods to improve vaccinations for smallpox and other infectious diseases
Researchers at Oregon Health & Science University are looking for ways to improve the smallpox vaccine and other vaccines that a large portion of the public cannot receive. The researchers are using immunosuppressed mice to look for ways to increase the number of people who can be protected. (2003-05-19)

Cell cultures can sort out CJD and scrapie infectious agents
Research at Yale University School of Medicine shows that infection with a weak strain of Creutzfeldt-Jacob Disease (CJD) prevents infection by more virulent strains and that the protection requires persistent replication by the infectious agent, but not misfolded prions. Protection with a weak animal agent may account for the low incidence of CJD linked to Mad Cow Disease in people. (2005-10-20)

Maternal HIV-1 treatment protects against transmission to newborns
Mothers receiving highly active antiretroviral therapy to treat HIV-1 infection are less likely than untreated mothers to transmit the virus to their newborns through breastfeeding, according to a new study. The findings, now available online in the Nov. 15 issue of the Journal of Infectious Diseases, suggest HAART regimens should be initiated as early as possible in eligible mothers in areas with limited resources, such as Africa, where most infant HIV-1 infections occur, and breastfeeding is common. (2009-10-16)

Weekly cycles of once-daily anti-HIV drugs could reduce cost of HIV treatment
In a small study conducted at the U.S. National Institutes of Health (NIH), researchers have shown that it may be feasible to treat HIV-infected patients with a simple, once-daily regimen of anti-HIV drugs given in pre-planned, 7-day-on, 7-day-off cycles. This approach is known formally as (2004-05-20)

NIAID rotavirus vaccine licensed for commercialization
NIAID announced today a new license agreement aimed at helping to prevent hundreds of thousands of deaths annually from rotavirus diarrhea in children living in developing countries. An effective oral rotavirus vaccine--created by NIAID scientists in the mid- to late 1980s and developed further through a Cooperative Research and Development Agreement with an industry partner--has now been licensed by the NIH Office of Technology Transfer to BIOVIRx, Inc. BIOVIRx plans global commercialization of the oral vaccine (RotaShield®). (2004-05-04)

Correct treatment of common diabetic foot infections can reduce amputations
Diabetic foot infections are an increasingly common problem, but proper care can save limbs and, ultimately, lives, suggest new guidelines released by the Infectious Diseases Society of America. (2012-05-22)

Study shows suppressing herpes virus may reduce infectiousness of HIV
A recent study of men co-infected with herpes simplex virus type 2 (HSV-2) and HIV revealed that drugs used to suppress HSV decrease the levels of HIV in the blood and rectal secretions, which may make patients less likely to transmit the virus. This study is published in the Nov. 15 issue of the Journal of Infectious Diseases, now available online. (2007-11-15)

Seasonal influenza vaccination during pregnancy may reduce risk of stillbirth
Seasonal influenza vaccination may guard against stillbirth, a new study published in Clinical Infectious Diseases and available online suggests. Researchers in Western Australia analyzed data from nearly 60,000 births that occurred during the southern hemisphere's 2012 and 2013 seasonal influenza epidemics, and found that women who received the trivalent influenza vaccine during pregnancy were 51 percent less likely to experience a stillbirth than unvaccinated mothers. (2016-03-31)

Parasitic worms may help treat diseases associated with obesity
On the list of undesirable medical conditions, a parasitic worm infection surely ranks fairly high. Although modern pharmaceuticals have made them less of a threat in some areas, these organisms are still a major cause of disease and disability throughout much of the developing world. (2013-01-08)

Viral load a major factor affecting risk of sexually transmitting HIV
The level of HIV-1 in the blood of an HIV-infected partner is the single most important factor influencing risk of sexual transmission to an uninfected partner, according to a multinational study of heterosexual couples in sub-Saharan Africa. The study, published in the Journal of Infectious Diseases and available online, calculated the risk of HIV-1 transmission per act of sexual intercourse and found the average rate of infection to be about 1 per 900 coital acts. (2012-01-12)

Prime-boost H7N9 influenza vaccine concept promising in clinical trial
With hopes of making one dose of an inactivated H7N9 vaccine fully protective, NIAID scientists successfully tested a prime-boost concept in a small clinical trial. The 'primer' vaccine introduces the immune system to H7N9 influenza virus, and subsequent vaccination with the 'booster' inactivated virus vaccine promotes a better immune response. (2015-12-10)

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