Ketamine Current Events

Ketamine Current Events, Ketamine News Articles.
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First ever large-scale study of ketamine users published
The first ever large-scale, longitudinal study of ketamine users has been published online today in the journal Addiction. With Ketamine (K, Special K) use increasing faster than any other drug in the UK (British Crime Survey, 2008) this research showing the consequences of repeated ketamine use provides valuable information for users and addiction professionals alike. (2009-11-16)

FSU research: Ketamine could help men suffering from alcohol use disorder
Research from Florida State University is giving physicians a better understanding of ketamine, a potentially useful tool in treating depression that still has unanswered questions. A team of researchers working in the laboratory of Mohamed Kabbaj, a professor of Biomedical Sciences and Neuroscience in the College of Medicine, showed that ketamine can decrease alcohol consumption in male rats that previously had consumed high amounts of alcohol when given unrestricted access several times a week. (2019-11-19)

Low-dose ketamine may be an effective alternative to opioids
Opioids are commonly prescribed in the emergency department (ED) for the treatment of acute pain, but due to the epidemic of opioid misuse, analgesic alternatives are being explored. A new Academic Emergency Medicine analysis of relevant studies found that low-dose ketamine is as effective as opioids for the control of acute pain in the ED. (2018-07-18)

Antidepressant effects of ketamine
New preclinical evidence was put forward by investigators in a series of presentations at the recent meeting of the American College of Neuropsychopharmacology suggest that the a metabolite of ketamine can produce antidepressant-like effects in a mouse model of depression. The metabolite is produced when ketamine is broken down in the body. This finding may lead to further research to better understand ketamine's efficacy in depression and its potential side effects. (2016-12-08)

How ketamine defeats chronic depression
Many chronically depressed and treatment-resistant patients experience immediate relief from symptoms after taking small amounts of the drug ketamine. For a decade, scientists have been trying to explain the observation first made at Yale University. (2012-10-04)

Ketamine reduces drinking in male, but not female, rats
The drug ketamine decreases alcohol consumption in male, but not female, rats, according to new research published in eNeuro. The findings suggest that ketamine may be a viable treatment option for male patients with an alcohol use disorder. (2019-11-18)

Researcher awarded $1.8 million grant to study gender differences in antidepressant effects
A Florida State University College of Medicine researcher is investigating why ketamine, used as an antidepressant for the last decade, requires a higher dosage to improve depression in males. (2013-08-15)

New effects of ketamine abuse uncovered
Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder. (2016-03-18)

Study reveals superior sedation method for children
Procedural sedation and analgesia is an essential element of care for children requiring painful procedures in the emergency department. Research led by Drs. Amit Shah, Gregory Mosdossy and Michael Rieder of the University of Western Ontario and Lawson Health Research Institute provides evidence that when compared to ketamine alone, patients who receive a combination of ketamine and propofol have a slightly faster recovery time and suffer from less severe side effects. (2010-10-19)

Ketamine, a painkiller used by the army, does not impair tolerance to blood loss
A low dose of ketamine, administered intravenously, does not alter a healthy human's tolerance to blood loss. In other words, if someone was given ketamine to kill pain associated with a battlefield injury, they would be able to tolerate blood loss just as well as someone who did not received this pain killer. (2020-10-21)

New meta-analysis shows ketamine effective against persistent post-surgical pain and could provide major cost-savings globally
A new meta-analysis showing the effectiveness of ketamine for dealing with persistent post-surgical pain (PPSP) is to be presented at Euroanaesthesia 2016. Ketamine, a cheap and safe drug, may have the potential to save health systems billions of dollars globally by being used in place of other drugs to prevent PPSP. (2016-05-26)

Study casts doubt on ketamine nasal sprays for depression
Researchers from UNSW Sydney and the Black Dog Institute have questioned the efficacy and safety of intranasal ketamine for depression, with their pilot trial stopped early due to poor side effects in patients. (2018-03-16)

Ketamine for the difficult-to-sedate ER patient
For the small segment of the emergency population whose acute behavioral disturbance does not respond to traditional sedation, ketamine appears to be effective and safe, according to an Australian study published online last Thursday in Annals of Emergency Medicine. (2016-02-24)

New research: Ketamine activates opioid system to treat depression
A new study appearing online today from the American Journal of Psychiatry finds that ketamine's acute antidepressant effect requires opioid system activation, the first time that a receptor site has been shown in humans to be necessary for any antidepressant's mechanism of action. While opioids have been used historically to treat depression, they are known to carry a high risk of dependence. (2018-08-29)

ER docs can treat pediatric pain without a needle
Children in emergency departments can safely be treated for pain from limb injuries using intranasal ketamine, a drug more typically used for sedation, according to the results of the first randomized, controlled trial comparing intranasal analgesics in children in the emergency department. The study was published online last month in Annals of Emergency Medicine. (2014-12-04)

Researchers identify potentially revolutionary antidepressant compound
Ketamine can treat depression rapidly. But it has major side effects, including hallucinations. Now, researchers have identified a metabolite of ketamine that quickly reverses depression in mice, without ketamine's side effects. (2016-05-04)

Researchers discover a critical receptor involved in response to antidepressants like ketamine
Effective treatment of clinical depression remains a major mental health issue, with roughly 30 percent of patients who do not respond to any of the available treatments. Researchers at the University of Maryland School of Medicine (UMSOM) have discovered a crucial receptor called mGlu2 that is critical to the mechanism of fast-acting antidepressants such as ketamine when used to treat depression. (2019-03-28)

Ketamine can be a wonder drug for ER patients and their physicians
For critically ill patients arriving at the emergency department, the drug ketamine can safely provide analgesia, sedation and amnesia for rapid, life-saving intubation, despite decades-old studies that suggested it raised intracranial pressure. The results of a systematic review of 10 recent studies of what many emergency physicians regard as a 'wonder drug' are published online in Annals of Emergency Medicine. (2014-07-23)

One in three pain patients suffer side effects after ketamine infusion therapy
As the opioid epidemic continues to devastate the United States, ketamine use has grown as a pain management alternative, yet more than one in three patients may experience side effects such as hallucinations and visual disturbances, suggests new research presented at the ANESTHESIOLOGY® 2019 annual meeting. (2019-10-21)

Overeating and depressed? Yale team finds connection -- and maybe a solution
Chronic overeating and stress are tied to an increased risk of depression and anxiety, and in a new study, Yale researchers explain why that happens and suggest a possible solution. The researchers report that the anesthetic ketamine reverses depression-like symptoms in rats fed a high-fat diet in a similar way it combats depression and synaptic damage of chronic stress in people. (2015-12-21)

Why is ketamine an antidepressant?
Delving deep inside the neural circuitry of 'depressed' mice, researchers have revealed how ketamine works in cells to achieve its fast-acting antidepressant effect. (2019-04-11)

Ketamine acts fast to treat depression and its effects last -- but how?
Researchers led by Mark Rasenick in the University of Illinois at Chicago College of Medicine, describe the molecular mechanisms behind ketamine's ability to squash depression and keep it at bay. They report their findings in the journal Molecular Psychiatry. (2018-06-21)

World-first ketamine trial shows promise for geriatric depression
Australian researchers have completed the world's first randomised control trial (RCT) assessing the efficacy and safety of ketamine as a treatment for depression in elderly patients. (2017-07-22)

Common genetic link between autism and Tourette's impairs brain communication
Scientists have discovered how a genetic alteration that increases the risk of developing Autism and Tourette's impacts on the brain. Their research also suggests that ketamine, or related drugs, may be a useful treatment for both of these disorders. Deletion of the Neurexin1 gene affects brain areas involved in Autism and Tourette's including the thalamus, a collection of brain regions that play a key role in helping other brain areas communicate with each other. (2019-12-09)

Yale team describes secrets of 'magic' antidepressant
Yale researchers have discovered how a novel antidepressant can take effect in hours, rather than the weeks or months usually required for most drugs currently on the market. The findings, described in the Aug. 20 issue of the journal Science, should speed development of a safe and easy-to-administer form of the antidepressant ketamine, which has already proven remarkably effective in treating severely depressed patients. (2010-08-19)

Ketamine works for female rats, too
A first of its kind study in female rats finds that a single, low dose of ketamine promotes resilience to future adverse events as it does in male rats. Published in eNeuro, the research addresses a critical gap in understanding and developing treatments for stress-related disorders, which disproportionately afflict females. (2018-02-26)

New study shows how ketamine combats depression
The anaesthetic drug ketamine has been shown, in low doses, to have a rapid effect on difficult-to-treat depression. Researchers at Karolinska Institutet now report that they have identified a key target for the drug: specific serotonin receptors in the brain. Their findings, which are published in Translational Psychiatry, give hope of new, effective antidepressants. (2020-05-31)

A 'communication breakdown' during general anesthesia
When ketamine is used for general anesthesia, two connected parts of the cortex turn to 'isolated cognitive islands.' (2016-05-11)

Ketofol an alternative deep sedative for emergency departments
Researchers have shown in a large clinical trial that 'ketofol'- - a combination of ketamine and propofol -- can be used safely and effectively to sedate adults in the emergency department. Knowing that ketofol is a viable alternative to propofol will give clinicians more options, especially as ketamine has pain relieving properties, which may reduce the need for other opiates. The trial also debunked the widely-held idea that ketamine caused frequent adverse psychological reactions in adults. (2016-11-08)

Anesthetic for depression? Mayo Clinic study finds low-dose ketamine effective
Low-dose intravenous infusions of ketamine, a general anesthetic used in minor surgeries, given over a long period are an effective treatment for depression, Mayo Clinic researchers found. The study is published in the Journal of Psychopharmacology. (2013-06-04)

Ketamine for depression encouraging, but questions remain around long-term use
A world-first systematic review into the safety of ketamine as a treatment for depression, published in the prestigious Lancet Psychiatry, shows the risks of long-term ketamine treatment remain unclear. (2017-07-27)

Psychedelic drugs, ketamine change structure of neurons
In a paper published on June 12 in the journal Cell Reports, UC Davis researchers show that a wide range of psychedelic drugs, including LSD and MDMA, impact the structure and function of neurons, potentially leading to new treatments for depression, anxiety, and related disorders. (2018-06-12)

Ketamine as anesthetics can damage children's learning and memory ability
Recent studies have found that anesthesia drugs have neurotoxicity on the developing neurons, causing learning and memory disorders and behavioral abnormalities. Ketamine is commonly used in pediatric anesthesia. A clinical retrospective study found that children below 3 years old who receive a long time surgery, or because of surgery require ketamine repeatedly will exhibit the performance of school-age learning and memory disorders and behavioral abnormalities. (2013-07-18)

High doses of ketamine can temporarily switch off the brain, say researchers
Researchers have identified two brain phenomena that may explain some of the side-effects of ketamine. Their measurements of the brain waves of sheep sedated by the drug may explain the out-of-body experience and state of complete oblivion it can cause. (2020-06-11)

Ketamine isn't an opioid and treats depression in a unique way
Ketamine has gotten a bad rap as an opioid when there's plenty of evidence suggesting it isn't one, Johns Hopkins experts say. They believe this reputation may hamper patients from getting necessary treatment for the kinds of depression that don't respond to typical antidepressants. In a new paper, the researchers clarify the mechanism behind ketamine's mechanism of action in hopes of restoring the therapy's standing among health care professionals and the public. (2019-07-31)

Researchers identify new compound to treat depression
Researchers have identified a compound, hydroxynorketamine, that may treat symptoms of depression just as effectively and rapidly as ketamine, without the unwanted side effects associated with the psychoactive drug, according to a study in the July issue of Anesthesiology, the official medical journal of the American Society of Anesthesiologists. Interestingly, use of HNK may also serve as a future therapeutic approach for treating neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, the authors note. (2014-06-17)

Yale study reconciles two models of schizophrenia
Study shows interplay of two brain signaling systems, glutamate and dopamine, in psychosis and cognitive function. (2005-09-12)

First large-scale population analysis reinforces ketamine's reputation as antidepressant
Researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego mined the FDA Adverse Effect Reporting System (FAERS) database for depression symptoms in patients taking ketamine for pain. They found that depression was reported half as often among the more than 41,000 patients who took ketamine, as compared to patients who took any other drug or drug combination for pain. (2017-05-03)

Ketamine is a safe, effective alternative to opioids in treating acute pain in the ED
Intravenous, low-dose ketamine (LDK) is as effective as intravenous morphine in the control of acute pain in adults in the emergency department (ED). (2018-10-15)

Researchers uncover new information on the effects of antidepressants
The findings of a new study challenge the prevailing thinking on the primary role of serotonin and other neurotransmitters in the effects of antidepressants. (2021-02-18)

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