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Transplantation of sperm stem cells restores fertility after chemotherapy
Chemotherapy for leukemia can cause infertility in males. In a JCI study, researchers separated healthy germ cells, including spermatogonial stem cells, from leukemic cells in mice. These cells were transplanted into the gonads of healthy recipient mice previously exposed to chemotherapeutic agents, and resulted in healthy progeny. Birth of healthy offspring without the transmission of leukemia to the recipient, suggests the potential of autotransplantation of germ cells in order to treat infertility resulting from chemotherapy. (2005-06-16)

Anti-psychotic drug pushes cancer stem cells over the edge
An anti-psychotic drug used to treat schizophrenia appears to get rid of cancer stem cells by helping them differentiate into less threatening cell types. The discovery reported in the Cell Press journal Cell on May 24 comes after researchers screened hundreds of compounds in search of those that would selectively inhibit human cancer stem cells, and it may lead rather swiftly to a clinical trial. (2012-05-24)

Leukemia drug shows promise for skin, breast and other cancers
A leukemia drug called dasatinib shows promise for treating skin, breast and several other cancers, according to researchers at Loyola University Chicago Stritch School of Medicine. (2014-08-18)

Potential seen for tailoring treatment for acute myeloid leukemia
Rapid screening of leukemia cells for drug susceptibility and resistance are bringing scientists closer to patient-tailored treatment for acute myeloid leukemia. Research on the differing drug response patterns of leukemia stem cells and blasts may show why some attempts to treat are not successful and why some patients relapse. (2018-12-07)

FASEB Science Research Conference: Hematologic Malignancies
This SRC focuses on bringing together biochemists, geneticists, molecular biologists and clinicians interested in the pathophysiology of the leukemias and lymphomas, and the development of novel therapies for these diseases. (2017-02-28)

Bone marrow transplant patients may benefit from new immune research
Bone marrow transplant researchers at the Medical College of Wisconsin Cancer Center in Milwaukee may have found a mechanism that could preserve the leukemia-killing effects of a transplant graft, while limiting the damage donor immune cells might do to the recipient host's vital organs. (2009-02-11)

Cancer scientists create 'human' leukemia process to map how disease begins, progresses
Cancer researchers led by Dr. John Dick at Ontario Cancer Institute (OCI) have developed a method to convert normal human blood cells into (2007-04-26)

Scientists awarded $1.4 million to develop new therapeutic approaches to chronic leukemia
Scientists from the Florida campus of The Scripps Research Institute have been awarded more than $1.4 million from the National Cancer Institute of the National Institutes of Health to create a potential new drug to attack the malignant cells that cause chronic lymphocytic leukemia, the most common leukemia in the Western world. (2013-06-19)

U of MN researchers find regular use of aspirin may lower risk of adult leukemia
Researchers from the Cancer Center at the University of Minnesota have found that adult women taking aspirin two or more times a week may lower their risk of adult leukemia by more than 50 percent. (2003-06-13)

New tools for prediction of disease progression in acute childhood leukemia
Researchers at Uppsala University and University Children's Hospital in Uppsala have devised powerful new tools for typing cells from children with acute lymphatic leukemia and for prediction of how children with leukemia will respond to chemotherapy. The study was recently published in electronic form by the prestigious hematological journal Blood. (2009-11-27)

CML found to wield 'death factor' that kills normal blood marrow cells
Based on surprising results from animal experiments, researchers at The University of Texas M. D. Anderson Cancer Center have revamped common beliefs about how chronic myeloid leukemia (CML) functions within bone marrow - a discovery they hope may some day lead to additional therapeutic strategies. (2005-04-19)

Syracuse University research team discovers switch that causes the body to produce cancerous cells
A team of Syracuse University researchers discovered a second molecular switch within the Mixed Lineage Leukemia protein complex that they believe could be exploited to prevent the overproduction of abnormal cells that are found in several types of cancer, including leukemia. (2009-09-04)

Reversing t cells' misunderstood rep in responding to a pediatric leukemia
A study of pediatric patients with leukemia demonstrates that they were able to generate T cells against tumor-associated mutations, contradicting previous assumptions that T cells cannot be effectively unleashed on pediatric tumors. (2019-06-26)

Discovery of a gene associated with a leukemia mostly affecting children
Researchers from Universty of Quebec in Montreal made a major breakthrough in research on B-cell acute lymphocytic leukemia, a disease that occurs most commonly in children. She has successfully identified a gene that may facilitate the diagnosis of this cancer, which is characterized by an abnormal proliferation of B-cells, antibody-producing cells that defend the body against infection. Her findings were recently published in the prestigious scientific journal Blood. (2011-01-18)

Novel discoveries on aggressive NK-cell leukemia pave the way for new treatments
International research consortium led by researchers from the University of Helsinki, Finland, discovered new information related to a rare form of leukemia called aggressive NK-cell leukemia. Potential new treatment options were found which are highly warranted as currently this disease usually leads to rapid death of patients. (2018-04-19)

New treatment for specific type of leukemia
Chronic Eosinophilic Leukemia (CEL), a specific form of leukemia, is currently treated with Glivec. However, recent research has shown that prolonged usage can cause resistance to Glivec, rendering this chronic form of leukemia untreatable. Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the Catholic University of Leuven have now discovered that another drug, Sorafenib (Nexavar), works on patients that have developed this resistance. (2006-05-10)

Universal CAR T cell therapy helps beat a hard-to-treat pediatric cancer
Two infants diagnosed with a relapsed form of childhood cancer who had previously exhausted all other treatment options remain disease-free after receiving a first-in-human experimental therapy that uses genetically engineered T cells, a new analysis reports. (2017-01-25)

Cancer stem cells in 'robbers cave' may explain poor prognosis for obese patients
University of Colorado Cancer Center study published in the journal Cell Stem Cell offers a compelling hypothesis explaining poor prognosis for obese cancer patients: researchers found that leukemia stem cells (2016-07-20)

JAK-STAT signaling keeps leukemia cells alive
Large granular lymphocyte (LGL) leukemia is characterized by the clonal expansion of a T-cell population sharing many similarities with antigen-activated cytotoxic T lymphocytes (CTLs). Unlike normal CTLs, which are readily targeted for destruction by Fas ligand (FasL) binding to the Fas receptor, leukemic LGLs resist Fas-mediated apoptosis. Here, Epling- Burnette and co-workers present data on abnormalities underlying LGL leukemia. (2001-01-31)

How 'sleeper cell' cancer stem cells are maintained in chronic myelogenous leukemia
Even when chronic myelogenous leukemia is in remission, 'sleeper cell,' quiescent leukemic stem cells are maintained in microenvironments in the bone marrow. This maintenance is poorly understood. Researchers now describe how niche-specific expression of a particular chemokine by a particular type of bone marrow cell controls quiescence of these treatment-resistant leukemic stem cells. The chemokine is CXCL12, and the particular bone marrow cells expressing it are mesenchymal stromal cells. (2019-03-21)

Wake Forest Baptist researcher pieces together AML prognosis puzzle
Timothy S. Pardee, M.D., Ph.D., an assistant professor of hematology and oncology at Wake Forest Baptist, said that previous studies of AML have shown that when patients express high levels of the MN1 gene, chemotherapy doesn't help as much and they die sooner from the disease. (2012-10-15)

New insights into why people with down syndrome are at higher risk for leukemia
Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago were the first to examine endothelial cells - one of the main sources of blood production - for clues as to why people with Down syndrome have higher prevalence of leukemia. They identified a new set of genes that are overexpressed in endothelial cells of patients with Down syndrome. (2020-09-08)

Without 'yoga and chardonnay' leukemia stem cells are stressed to death
University of Colorado Cancer Center researchers nix leukemia stem cell (LSC) stress-relief pathway to kill LSCs without harming healthy blood stem cells, paving the way for new therapies targeting these most dangerous cancer cells. (2018-06-14)

Cardiovascular drug may offer new treatment for some difficult types of leukemia
A drug now prescribed for cardiovascular problems could become a new tool in physicians' arsenals to attack certain types of leukemia that so far have evaded effective treatments, researchers say. (2011-09-12)

2-faced leukemia?
One kind of leukemia sometimes masquerades as another, according to a study published online this week in the Journal of Experimental Medicine. (2011-12-12)

The HLF-gene controls the generation of our long-term immune system
A research group at Lund University in Sweden has found that when the HLF (hepatic leukemia factor) gene -- which is expressed in immature blood cells -- does not shut down on time, we are unable to develop a functional long-term immune system. This could be a very early stage of leukemia. (2017-11-22)

Novel drug preventing protein recycling shows potential for treating leukemia
Researchers from the Children's Cancer Hospital at the University of Texas M. D. Anderson Cancer Center have found that a novel targeted therapy effectively treats acute leukemia in animal models by preventing cancer cells from being purged of damaged proteins. (2007-04-19)

Gene's activity points to more lethal subtype of AML
A new study shows that the activity of a particular gene can identify people who have a more lethal form of acute myeloid leukemia, singling out those patients who should receive more intense therapy. The gene, called ERG (for ETS-related gene), has also been linked to chronic leukemia and to breast and prostate cancer. (2007-07-09)

OHSU researcher announces dramatic breakthrough in leukemia treatment
A researcher at Oregon Health Sciences University in Portland has developed a pill that targets a specific enzyme responsible for chronic myelogenous leukemia. Brian Druker, M.D., will present results from his Phase I clinical trial at the American Society of Hematology conference on Sunday, Dec. 5 in New Orleans. (1999-11-29)

A lethal cancer knocked down by one-two drug punch
Research at the Jackson Laboratory has yielded a new approach to treating leukemia, one that targets leukemia-proliferating cells with drugs that are already on the market. Jackson Adjunct Professor Shaoguang Li, M.D., Ph.D., led a research team that identified a gene involved with the inflammatory response that could hold the key to treating or even preventing chronic myeloid leukemia, a lethal cancer. (2009-06-07)

Unstable leukemia stem cells may predispose patients to drug resistance
The BCR-ABL gene in chronic myeloid leukemia stem cells has a tendency to quickly mutate, and this may help explain why patients are predisposed to resistance to drugs like imatinib that target that gene, according to a study in the May 2 Journal of the National Cancer Institute. (2007-05-01)

New approach to treating incurable leukemia in children discovered
Acute lymphoblastic leukemia is the most common form of cancer affecting children in Switzerland and, unfortunately, is often incurable. Researchers from the University of Zurich and the University Children's Hospital Zurich have now found a way to stop the driving force behind this type of leukemia at a molecular level and develop a targeted therapy. (2019-11-25)

Promising drug a 'new paradigm' for treating leukemia
Researchers at the University of Virginia School of Medicine have developed a compound that delays leukemia in mice and effectively kills leukemia cells in human tissue samples, raising hopes that the drug could lead to improved treatments in people. The researchers call it an exciting 'new paradigm' for treating leukemia. (2015-03-25)

Cancer killing gene found by Dartmouth researchers
Dartmouth Medical School cancer researchers have identified a gene that triggers the death of leukemia cells, opening a novel target for anti-cancer drugs. (2002-03-18)

Grant to help researchers find leukemia's hiding places
In scary movies, the killer often comes back to life mysteriously, attacking again when the main character least expects it. Blood cancers are like this too, finding a safe spot to hide during treatment and then striking again when a patient is in remission. (2014-02-06)

Old cells, new tricks -- important clue to AML diagnosis and cure discovered
Around 22,000 people will be diagnosed this year in the US with acute myeloid leukemia (AML), the second most common type of leukemia diagnosed in adults and children. Researchers from Australia's Monash University have discovered a key reason why this disease is so difficult to treat and therefore cure. (2019-08-01)

IU researchers, collaborators discover new therapeutic agents that may benefit leukemia patients
An Indiana University cancer researcher and his colleagues have discovered new therapeutic targets and drugs that may someday benefit people with certain types of leukemia or blood cancer. (2013-10-04)

Leukemia, infection tied to aging stem cells, Stanford researchers say
Older people are more prone to infections and have a higher risk of developing leukemia, and now researchers at Stanford University School of Medicine have one hint as to why that may be. The group found that in mice, the bone marrow stem cells responsible for churning out new blood cells slow down in their ability to produce immune cells, leaving older mice with fewer defenses against infection. (2005-06-20)

Genetically encoded sensor isolates hidden leukemic stem cells
Tel Aviv University researchers have devised a novel biosensor that can isolate and target leukemic stem cells. It can provide a prototype for precision oncology efforts to target patient-specific cells to fight the deadly disease. (2019-03-12)

New CAR T cells could help avoid patient relapse in blood cancers
A research team has created CAR T cells that target an alternative B cell-specific surface marker, allowing them to effectively kill blood cancer cells that lack the prototypical target for CAR T therapy, CD19. (2019-09-25)

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