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Liver Transplant Current Events, Liver Transplant News Articles.
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Transplant recipients more likely to develop aggressive melanoma
Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant, and three times more likely to die of the dangerous skin cancer, suggests new research led by a Johns Hopkins Bloomberg School of Public Health student. (2015-08-13)

Molecule's role in maintaining liver size and function revealed
Researchers at TMDU found that the YAP molecule is a key mediator in the identification and clearance of damaged cells from the liver. They showed that, in the absence of injury, YAP activation led to hepatocyte proliferation. However, when injury was induced to mouse liver, it instead induced hepatocytes to migrate to the hepatic sinusoids, undergo cell death, and be degraded by the immune system. (2017-08-01)

The countdown is on for The International Liver CongressTM 2016
There is one month to go until The International Liver CongressTM 2016 and registration for media is open! Registration as a member of the press is free and can be completed online by clicking here: (2016-03-17)

Major enhancement to in vitro testing of human liver-stage malaria
Researchers have developed an enhanced method to conducting liver-stage malaria research in vitro, allowing them to more quickly screen preclinical drugs and vaccines than current techniques. (2018-05-09)

Hepatitis: Liver failure attributable to compromised blood supply
In severe cases, a viral hepatitis infection can result in liver failure. A team from the Technical University of Munich (TUM) has now discovered how this occurs: by immune cells attacking cells in the vascular system, which disrupts the organ's blood and nutrient supply. This is responsible for the overwhelming damage that causes the liver to fail. Using an animal model, the researchers were then able to identify an agent to prevent this lethal process. (2018-12-19)

Racial disparities persist in access to kidney transplants
In a new study of patients awaiting kidney transplants, Yale researchers found significant racial disparities. This occurred despite a new system designed to reduce inequities, the researchers said. The study was published in JAMA Surgery. (2019-04-03)

Interplay between MicroRNAs and targeted genes in cellular homeostasis of adult zebrafish
The objective of study was to understand the damages induced by toxins in the liver and the intestine as well as the interplay between the miRNome and transcriptome baseline characterization in these tissues in healthy animals under cellular homeostasis. (2018-12-10)

Mayo Clinic poll shows half of americans would consider donating a kidney to a stranger
A new Mayo Clinic survey shows that the public's support for both living and deceased organ donation is increasing. Eighty-four percent of respondents said they would be very or somewhat likely to consider donating a kidney or a portion of their liver to a close friend or family member in need, and an astounding 49 percent said they would be very or somewhat likely to consider donating a kidney to someone they have never met. (2013-04-17)

Save the date: The International Liver Congress 2016
The International Liver Congress is the flagship, multi-disciplinary scientific event of the European Association for the Study of the Liver, which is attended by in excess of 10,000 delegates from around the world every year. Our aim is to showcase the latest advances in hepatology and unveil a wide variety of new, innovative data to improve the management of liver disease. (2016-02-04)

Dietary supplement may help in the treatment of fatty liver
A recent study by researchers at the University of Jyväskylä was successful in partially preventing fatty liver disease in rats. Rats with fatty liver disease were fed with a dietary supplement that is known to increase the growth of good bacteria in the gut. Simultaneous with the increased abundance of the bacteria, the liver fat content decreased significantly. In addition, preliminary results from a human study seem promising. (2020-11-04)

Largest-ever database for liver proteins may lead to treatments for hepatitis
Scientists at a group of 11 research centers in China are reporting for the first time assembly of the largest-ever collection of data about the proteins produced by genes in a single human organ. Their focus was the liver, and their massive database in both protein and transcript levels could become a roadmap for finding possible new biomarkers and treatments for liver disease. Those include hepatitis and liver cancer, which is at epidemic levels in China and affects millions of people worldwide. (2009-11-11)

CU team finds likely culprit behind liver problems linked to intravenous feeding
Researchers know that feeding some patients intravenously can save their lives -- but also can cause liver damage. Now scientists at the University of Colorado and Children's Hospital Colorado have figured out the likely culprit, one of the ingredients in intravenous food, behind the liver problems. (2013-10-09)

More African-Americans have kidney transplants, but few are from live donors
While the percentage of kidney transplants involving live donors has remained stable for other minority populations, African-Americans have seen a decline in live donors even as more of them receive kidney transplants, according to a study by Henry Ford Hospital in Detroit. (2013-05-08)

International Liver Congress 2009
Journalist registrations are being accepted for International Liver Congress 2009, taking place from 22nd-26th April in Copenhagen, Denmark. The European Association for the Study of the Liver, founded in 1966, is the leading European scientific society involved in promoting hepatology research and education in and the International Liver Congress is one of the foremost international medical meetings in hepatology, attracting over 7,000 clinicians and scientists. (2009-03-31)

Mayo Clinic researchers take a step closer to developing a DNA test for liver cancer
A group of researchers from Mayo Clinic and Exact Sciences Corporation have completed a phase II study comparing a set of DNA markers to alpha fetoprotein as a method to test for liver cancer. The researchers presented their findings today at the 2018 Digestive Disease Week conference in Washington, D.C. (2018-06-05)

Japanese scientists show 'new' liver generation using hepatocyte cell transplantation
Hepatocyte cells, comprising the main tissues of the liver and involved in protein synthesis and storage, can be retrieved and propagated for the purposes of creating a new liver system. This study demonstrates the feasibility of propagating mouse hepatocytes by creating a vascularized platform using a growth factor releasing device, and by creating uniform hepatocyte (2012-06-11)

University Of Pittsburgh Scientist Discovers How A Novel Vitamin K Stops Cancer Cell Growth
Scientists at the University of Pittsburgh have discovered how a novel form of vitamin K exerts its cancer-killing effects in primary liver cancers, which are notoriously resistant to chemotherapy. The research results, published in the May issue of The Journal of Biological Chemistry, describe an important new way to treat, and possibly prevent, cancer by triggering programmed cell death. (1998-06-01)

Liver disease could be picked up much sooner by nurse-led tests in GP surgeries
Research carried out by scientists at the University of Southampton has shown that simple tests in GP surgeries could potentially double the diagnosis rate of liver disease where patients are not displaying any symptoms. (2018-12-21)

Risk of liver disease and cancer starts from adolescence in overweight or obese men
Young men who are overweight or obese could run a higher risk of developing severe liver disease or liver cancer in later life, suggests research published online in the journal Gut. (2017-03-20)

The fungal microbiome contributes to alcohol-induced liver damage in mice
Alcoholism is a leading cause of liver cirrhosis-related deaths. Although chronic alcohol consumption is known to alter the gut microbiome, the link between these changes and liver damage is not well understood. This week in the JCI, a study led by Bernd Schnabl connects alcohol-driven changes in the fungal microbiome to liver disease, supporting further study of the role fungi play in liver inflammation and disease. (2017-05-22)

Higher incidence of rejection following early steroid withdrawal
A new study on early steroid withdrawal following liver transplantation found that there was a higher incidence of rejection and a lower incidence of glucose intolerance necessitating treatment for diabetes. It was the first double-blind placebo-controlled study to examine the effects of early steroid elimination. (2004-12-01)

First mouse lung transplants lay groundwork for new ways to prevent transplant rejection in humans
Lung transplants have been performed successfully for more than 20 years in humans but never before in mice -- until now. Surgeons at Washington University School of Medicine in St. Louis have developed the first mouse model of lung transplantation, and they're hoping it will help explain why the success of the procedure in humans lags far behind other solid organ transplants. (2007-07-11)

Hepatitis C-positive donors a viable option to expand heart donor pool
Patients who were transplanted with hearts from hepatitis C-positive donors had comparable outcomes after one year to patients who received hearts from donors that didn't have the disease, according to a Vanderbilt University Medical Center study published in JAMA Cardiology. (2019-12-20)

Healthy people are at risk of developing heart disease, says Surrey expert
Healthy people who consume high levels of sugar are at an increased risk of developing cardiovascular disease. (2017-10-04)

UChicago Medicine supports new organ transplant fund for the uninsured
The University of Chicago Medicine has become the first transplant center to contribute to the Illinois Transplant Fund, a new not-for-profit that provides financial support for organ transplants to qualified uninsured residents of northern and central Illinois and Northwest Indiana. The medical center's initial $100,000 donation will be followed by additional contributions of up to $400,000 total over the next three years. (2015-07-30)

Factors associated with sex-based disparities in liver transplants
This observational study looked at the disparities that exist between women and men waiting to receive a liver transplant, such as being more likely to die while on the wait list, and how much these differences are associated with factors including geographic location, medical urgency and liver size. (2020-05-20)

Screening male kidney transplant candidates for prostate cancer may do more harm than good
Among male kidney transplant candidates, prostate cancer screening was not associated with improved patient survival after transplantation. Screening increased the time to listing and transplantation for candidates under 70 years old with elevated prostate specific antigen levels. Compared with candidates who were not screened, screened candidates had a reduced likelihood of receiving a transplant regardless of their screening results. (2015-12-22)

Angioplasty may be feasible for liver transplantation candidates with heart disease
A small, retrospective study determined that percutaneous coronary intervention (PCI) was safe in patients with significant coronary artery disease (CAD) who were referred for liver transplantation. Larger studies are needed to determine the effectiveness of angioplasty in patients with end-stage liver disease (ESLD). Details of the study are available in the July issue of Liver Transplantation, published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases. (2011-06-22)

Stellate cells in the liver control regeneration and fibrosis
Scientists from the German Cancer Research Center and the Medical Faculty in Mannheim at Heidelberg University are searching for new approaches to prevent liver fibrosis. They have identified a surface molecule on special liver cells called stellate cells as a potential target for interfering with this process. When the researchers turned off the receptor, this led to reduced liver fibrosis and improved regeneration of hepatic cells. (2015-02-24)

South Asians at twice the risk of heart attack and death after transplant: study
South Asian men and women have more than twice the risk of suffering a heart attack after a kidney transplant, according to a study led by St. Michael's nephrologist Dr. Ramesh Prasad. (2010-09-30)

Artificial liver may extend lives
The first artificial organ for liver patients that uses immortalized human liver cells, the Extracorporeal Liver Assist Device, or ELAD, is a bedside system that treats blood plasma, metabolizing toxins and synthesizing proteins just like a real liver does. (2009-06-02)

Consumption of sheep or beef liver can contribute considerably to the total intake of PFAS
Per- and polyfluoroalkyl substances (PFAS) are industrial chemicals that have been used for decades in several industrial processes and consumer products due to their special technical properties. They are not easily degradable and are detectable everywhere: in the environ-ment, in the food chain and in humans. (2020-09-14)

p53 critical to recovering from acetaminophen overdose
A new study shows that after an acetaminophen overdose, the p53 protein plays a key role in preventing the progression of liver damage and signaling the liver to repair itself. The findings could lead to new treatments for people who overdose on this popular pain reliever and fever reducer. (2017-04-26)

Getting to the root of fatty liver disease
Researchers have identified a molecular switch that appears to be a common feature in the development of fatty liver disease. The discovery made in mice is consistent with data from human patients, suggesting that it may provide an underlying explanation for the development of fatty liver in people with obesity and metabolic syndrome. (2011-04-05)

Distance from transplant center cannot explain racial gap in kidney transplant waitlisting
Why are African-American patients with end-stage renal disease (ESRD) less likely to be placed on waiting lists for kidney transplantation? It's not because they live farther away from transplant centers, reports a study being presented at the American Society of Nephrology's 40th Annual Meeting and Scientific Exposition in San Francisco. (2007-11-04)

Hepatitis C treatment cures over 90 percent of patients with cirrhosis
Twelve weeks of an investigational oral therapy cured hepatitis C infection in more than 90 percent of patients with liver cirrhosis and was well tolerated by these patients, according to an international study that included researchers from UT Medicine San Antonio and the Texas Liver Institute. (2014-04-12)

Houston Methodist Hospital, MD Anderson teams perform first multi-organ transplant
Surgical teams from Houston Methodist Hospital and The University of Texas MD Anderson Cancer Center successfully transplanted, for the first time, a scalp and skull while performing kidney and pancreas transplants. (2015-06-04)

Bioengineered human livers mimic natural development
An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes -- greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells. The scientists report online in Nature on June 14 that their bioengineered human liver tissues still need additional rounds of molecular fine tuning before they can be tested in clinical trials. (2017-06-14)

Open expression of thoughts benefits kidney transplant patients
Kidney transplant patients who feel that they can discuss their stressful thoughts and feelings openly with family members report fewer symptoms of depression and anxiety, according to the results of new research. (2000-02-28)

Do patients at risk for B-cell malignancy need antiviral treatment?
The association of hepatitis C infection with type II mixed cryoglobulinemia is well established, but the role of HCV in B-cell lymphoma remains controversial. A research group in China investigated B-cell clonality in the liver of HCV-infected patients using IgH rearrangement and immunohistochemistry. Liver-infiltrating monoclonal B-cells are detected in the liver of patients with chronic HCV and HBV infection. (2009-04-15)

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