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Lung Function Current Events, Lung Function News Articles.
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Exposure to traffic air pollution in infancy impairs lung function in children
Exposure to ambient air pollution from traffic during infancy is associated with lung function deficits in children up to eight years of age, particularly among children sensitized to common allergens, according to a new study. (2012-10-12)

Fox Chase Cancer Center researchers identify significant smoking-induced genetic alteration
A Fox Chase Cancer Center researcher and her colleagues have identified a genetic alteration that occurs 13 times more frequently in lung tissue of mice exposed to tobacco smoke. The frequency of this genetic alteration and its role in estrogen metabolism could help researchers understand why women who smoke are more susceptible to lung cancer. (2004-03-29)

Study finds genetic aberrations linked to lung cancer; Could help in early diagnosis
Researchers have identified more than two dozen genes that behave abnormally in cancerous lung cells. The finding could lead to new tests for diagnosing lung cancer. Led by Ming You, a professor of molecular virology, immunology and medical genetics, the researchers found 14 genes that are over-expressed - meaning they are too active - in lung cells stricken by cancer. They also identified 12 genes that are under-expressed (not active enough) in these cells. (2002-06-14)

Specific genetic makeup does not modify lung function in response to treatment in asthma patients
Studies have suggested that asthma patients with a specific genetic makeup, or genotype, might respond less well to certain treatments than those with a different genotype. But an article published in this week's edition of the Lancet shows that patients with either genotype respond to combination treatment with long-acting beta-2 agonists plus moderate-dose inhaled corticosteroids, and that this treatment should be continued for these patients. (2009-11-19)

IASLC announces recipients of advocacy travel awards
The International Association for the Study of Lung Cancer announced the recipients of the Advocacy Travel Awards. Five winners will receive funding to attend the 16th World Conference on Lung Cancer Sept. 6-9, 2015 at the Colorado Convention Center in Denver. Funding is provided by Bristol-Myers Squibb and includes conference registration, hotel accommodations, travel stipend and complimentary IASLC membership for one year. (2015-08-11)

Difference between cystatin C- and creatinine-based eGFRs contains clinical information
It is common to see clinic patients whose eGFR by creatinine and cystatin are different by >15 mL/min. Potok et al surmised that these differences, usually overlooked in favor of a combined eGFR, carry important information. The authors examined the intra-individual difference in eGFR by cystatin vs. creatinine (eGFRDiff) and found that eGFRDiff may hold prognostic information as a negative eGFRDiff at any level of kidney function was associated with higher risk of frailty, CVD, and death. (2020-07-16)

Study: Enzyme could prove effective in treating tumors and inflammatory diseases in lung
Findings from a research study led by scientists at Henry Ford suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway. Histone deacetylases (HDACs) are enzymes that help modulate gene expression by removing acetyl groups from histone or non-histone proteins. Inhibition of HDACs is emerging as a promising approach to treat various types of malignant diseases and inflammatory disorders. (2020-08-04)

A bridge to breathing
To safely bridge the time between diagnosis and transplant for pediatric patients with lung disease, a research team led by the University of Pittsburgh's Swanson School of Engineering is developing a compact respiratory assist device for children. (2017-02-06)

Mayo Clinic surgeons propose new measures for indicating quality of lung surgery
Mayo Clinic surgeons have proposed a system of lung surgery quality indicators for surgeons and the public as a method to demonstrate best practices for obtaining positive patient outcomes. (2007-02-05)

American Thoracic Society news tips for April
The American Thoracic Society's journal for April features the following newsworthy studies: persons who suffer from severe asthma and who are also affected by psychopathology create increased health care costs compared to non- psychiatric severe asthmatics; new research links a common infectious agent with asthma; and an executive summary report details the best validated disease management concepts for chronic obstructive pulmonary disease. (2001-04-26)

Improved diagnostic performance of low-dose computed tomography screening
Investigators of the COSMOS (Continuous Observation of SMOking Subjects) study show good compliance and patient survival outcomes using a 5-year low-dose computed tomography screening protocol in individuals at high-risk of developing lung cancer. (2014-06-16)

American Thoracic Society and the American Lung Association to co-fund research into lung disease
The American Thoracic Society Foundation and the American Lung Association announced today that they are co-funding an $80,000 grant that will support important research into the mechanisms underlying Hermansky-Pudlak syndrome, a rare inherited disease which affects a number of organs including the lungs. (2013-12-18)

Rebooting the system: Immune cells repair damaged lung tissues after flu infection
There's more than one way to mop up after a flu infection. Now, researchers from the Perelman School of Medicine at the University of Pennsylvania report in Nature Immunology that a previously unrecognized population of lung immune cells orchestrate the body's repair response following flu infection. (2011-10-03)

New research moves York scientists closer to lung cancer blood test
Early signs of lung cancer could be diagnosed using a simple blood test following a new discovery by scientists at the University of York. (2012-10-15)

COPD as a lung stem cell disease
Two internationally renowned stem cell researchers at the University of Houston have found an abundance of abnormal stem cells in the lungs of patients who suffer from Chronic Obstructive Pulmonary Disease (COPD), a leading cause of death worldwide. The team, who used single cell cloning of lung stem cells to make their discovery, is now targeting the cells for new therapeutics. (2020-04-15)

Hispanic lung cancer patients tend to live longer than blacks and whites
A new analysis has found that Hispanic lung cancer patients seem to live longer than white or black patients. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study suggests that, as with several other types of cancer, certain yet-to-be-defined genetic and/or environmental factors put Hispanic patients at a survival advantage. (2012-04-23)

Prenatal exposure to pollution especially dangerous for children with asthma
The link between prenatal exposure to air pollution and childhood lung growth and respiratory ailments has been established by several studies in recent years, and now a new study suggests that these prenatal exposures can be especially serious for children with asthma. (2012-05-20)

CT lung cancer screening no cure-all for smokers
Screening for lung cancer with computed tomography may help reduce lung cancer deaths in current and former smokers, but it won't protect them from other causes of death associated with smoking, according to a new study. (2008-06-10)

Report describes VHA clinical demonstration project for lung cancer screening
Implementing a comprehensive lung cancer screening program was challenging and complex according to a new article published online by JAMA Internal Medicine that describes a lung cancer demonstration project conducted at eight academic Veterans Health Administration hospitals. (2017-01-30)

UNC-CH Studies Show Medicine Can Reverse Osteoporosis From Transplants, Cystic Fibrosis
Studies of a drug known as Pamidronate indicate that the drug is highly effective in partially reversing the bone weakening known as osteoporosis due to drugs taken after various transplants, including lung transplants in cystic fibrosis patients. (1998-10-19)

UPenn surgery for cancer-ridden lungs
When a surgeon opens the chest of a lung cancer patient and finds that the malignancy has spread from one of the lungs to its pulmonary artery, he or she will almost always remove the entire lung. But doctors at the University of Pennsylvania Medical Center are performing and teaching a surgical procedure that routinely saves part of the affected lung, leaving the patient with more stamina and the potential for normal activity. (2000-09-04)

Why only some former smokers develop lung cancer
Canadian researchers are trying to answer why some smokers develop lung cancer while others remain disease free, despite similar lifestyle changes. (2008-11-17)

Scientists identify potential contributor to hyper immune responses in patients with severe COVID-19
Researchers have pinpointed a helper T cell population in the lungs of patients with severe COVID-19 that may be central to the development of hyperinflammation, lung injury, and subsequent acute respiratory distress syndrome (ARDS) during disease (2021-02-23)

UK study shows cell signaling interaction may prevent key step in lung cancer progression
New findings from University of Kentucky faculty published in Scientific Reports reveals a novel cell signaling interaction that may prevent a key step in lung cancer progression. (2017-11-09)

Needs of people dying of heart failure not being met
The needs of people dying of heart failure are not being met, finds a study in this week's BMJ. (2002-10-24)

Spending more for lung cancer treatment did not substantially increase patients' lives
A new study finds that survival for elderly patients with lung cancer has changed little despite large increases in healthcare expenditures for lung cancer treatment. (2007-10-22)

Some patients are candidates for combined heart bypass, lung transplant surgeries
For patients who have been precluded from receiving a lung transplant because of their underlying coronary artery disease, Duke University Medical Center researchers have shown that they can achieve similar positive outcomes by performing revascularization procedures such as coronary bypass operations immediately prior to the transplant surgery. (2002-05-20)

Durvalumab combined with chemotherapy improves overall survival in patients with lung cancer
Adding immunotherapy in the form of durvalumab to chemotherapy improves overall survival in patients with extensive-stage small cell lung cancer, according to research presented today at the IASLC 2019 World Conference on Lung Cancer hosted by the International Association for the Study of Lung Cancer (IASLC). (2019-09-09)

Protein opens hope of treatment for cystic fibrosis patients
Scientists have finally identified a direct role for the missing protein that leaves cystic fibrosis patients open to attack from lung-damaging bacteria, the main reason most of them die before their 35th birthday, scientists heard today at the Society for General Microbiology's Autumn meeting being held this week at Trinity College, Dublin. (2008-09-10)

Genetic disorder linked to rapid lung function decline in some World Trade Center rescue workers
New research presented at CHEST 2006, the 72nd annual international scientific assembly of the American College of Chest Physicians, shows a rare genetic disorder known as alpha-1 antitrypsin deficiency may predispose patients to developing lung conditions, but a new rapid-response test could help identify patients with the deficiency before significant lung damage has occurred. (2006-10-23)

Cold Spring Harbor Laboratory's lung cancer research program awarded $100,000 grant
Cold Spring Harbor Laboratory's researcher Raffaella Sordella, PhD was awarded $100,000 by Joan's Legacy: The Joan Scarangello Foundation to Conquer Lung Cancer. The two-year grant will fund CSHL's pioneering lung cancer research involving a new class of genetic mutations that appear to be a trigger in non-small cell lung cancer, the leading cause of cancer deaths in the United States. (2008-01-10)

EURTAC Phase III study: Erlotinib nearly doubles progression-free survival vs. chemotherapy
In the first phase III study to include Western lung cancer patients, first-line treatment with erlotinib (Tarceva) nearly doubled progression-free survival compared with chemotherapy, according to research presented at the 14th World Conference on Lung Cancer in Amsterdam, hosted by the International Association for the Study of Lung Cancer. (2011-07-05)

COPD, even when mild, limits heart function
A common lung condition, COPD (chronic obstructive pulmonary disease) diminishes the heart's ability to pump effectively even when the disease has no or mild symptoms, according to research published in the Jan. 21 issue of the New England Journal of Medicine. The study is the first time researchers have shown strong links between heart function and mild COPD. (2010-01-20)

FDA approves new lung cancer therapy for patients who develop resistance
The International Association for the Study of Lung Cancer commends the US Food and Drug Administration's decision to grant accelerated approval for osimertinib (TagrissoTM), an oral medication for advanced non-small cell lung cancer patients with a specific epidermal growth factor receptor (EGFR) mutation (T790M) and following progression after previous EGFR inhibitor therapies. (2015-11-16)

SBRT considered safe treatment option for patients with multiple (2-4) metastases
The NRG Oncology clinical trial BR001 tested the hypothesis that stereotactic body radiotherapy (SBRT) could be used safely in oligometastatic patients with multiple metastases. (2018-10-23)

Wistar Scientist Awarded American Cancer Society Grant For Study Of Tumor Suppressor Proteins
Wistar scientist, Ronen Marmorstein, Ph.D., has been awarded a $322,000 three-year grant from the ACS to study the structure and function of proteins involved in tumor development. His laboratory's findings on the structural properties of the P16INK4 protein, which fastens itself to the CDK4 inhibitory protein, are expected to provide a framework for the design of P16INK4 imitations that can be used in the treatment of cancers caused by abnormal CDK4 activity. (1998-05-22)

Lung cancer mortality rates linked to primary care provider density
In a recent study published in the International Association for the Study of Lung Cancer's Journal of Thoracic Oncology researchers found lower mortality was associated with higher primary care provider density. (2013-04-22)

Risk of lung cancer from passive smoking may have been overstated
Previous studies examining the effect of passive smoking on lung cancer, may have overstated the risk, say statisticians from the University of Warwick in this week's BMJ. (2000-02-10)

Recommendations for treatment of inherited lung disease are unjustified
An expensive treatment recommended for a genetic disorder called alpha-1 antitrypsin deficiency has no proven clinical benefit, according to a systematic review by Cochrane researchers. The disorder causes chronic lung disease and the review concludes that considering the lack of evidence for its benefits, and possible adverse effects, the treatment should not be recommended. (2010-07-06)

Findings suggests that blocking estrogen may be crucial to lung cancer survival
New and effective treatments for lung cancer may rest on their ability to hinder the action of estrogen in lung cancer cells, according to two studies published in the current issue of Cancer Research. The University of Pittsburgh studies build on current knowledge about the relationship between estrogen and lung cancer growth and suggest that blocking estrogen may be vitally important to improving survival from the disease. (2005-02-15)

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