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Potential new treatment target identified for melanoma skin cancer
New research from Western University, Canada, has identified a potential new target for the treatment of melanoma, the deadliest of all skin cancers. Silvia Penuela and Dale Laird discovered a new channel-forming protein called Pannexin (Panx1) that is expressed in normal levels on the surface of healthy skin cells. But they found, in melanoma, Panx1 is over-produced to a pathological level. The researchers also discovered that if you reduce it, the cell becomes more normal. (2012-08-15)

Coffee may be associated with a lower risk of malignant melanoma
Both epidemiological and pre-clinical studies have suggested that coffee consumption has a protective effect against non-melanoma skin cancers. However the protective effect for cutaneous melanoma (malignant and in situ) is less clear, according to a study published Jan. 20 in the JNCI: Journal of the National Cancer Institute. (2015-01-20)

Global skin cancer research consortium wins £7m
Skin cancer studies around the world will be brought together to help people understand the risk from the disease, thanks to a Leeds-led consortium which has been awarded over £7m of funding. (2005-12-14)

Mayo Clinic: Melanoma up to 2.5 times likelier to strike transplant, lymphoma patients
Melanoma is on the rise nationally, and transplant recipients and lymphoma patients are far likelier than the average person to get that form of skin cancer and to die from it, a Mayo Clinic review has found. (2012-10-03)

Researchers discover possible biomarker and therapeutic target for melanoma
Researchers at Boston University School of Medicine, in collaboration with Johns Hopkins University, have identified a potential new biomarker and therapeutic target for melanoma. The novel cell screening method used in the study also clarifies the process behind tumor metastasis and may allow the identification of biomarkers for other aggressive cancers. The findings now appear online in Cancer Research. (2011-03-17)

Rutgers researcher discovers melanoma causing gene
Rutgers Associate Professor Suzie Chen has discovered a gene responsible for melanoma, the most aggressive form of malignant skin cancer. A paper describing the research by Chen and her colleagues at the National Human Genome Research Institute will be published online by Nature Genetics on April 21, and will appear subsequently in a print issue of the journal. (2003-04-20)

MDM2 counteracts resistance to CDK4/6 inhibitors for melanoma therapy
A study from Vanderbilt-Ingram Cancer Center and the Department of Veterans Affairs led by Anna Vilgelm, MD, Ph.D., and Ann Richmond, Ph.D., has identified a possible second-line treatment for melanoma patients. (2019-08-15)

Gene linked to worse outcomes for melanoma
Scientists at Queen Mary, University of London have identified a gene present in some melanoma which appears to make the tumour cells more resistant to treatment, according to research published today in the Journal of Experimental Medicine. (2013-02-18)

Drugs for impotence do not increase risk of melanoma
Using drugs for impotence does not increase the risk of malignant melanoma, researchers from Umeå University in Sweden conclude in a publication in JAMA, a top US medical journal. These results contradict previous research indicating such an association. (2015-06-23)

Sunscreen reduces melanoma risk by 40 per cent in young people
A world-first study led by University of Sydney has found that Australians aged 18-40 years who were regular users of sunscreen in childhood reduced their risk of developing melanoma by 40 percent, compared to those who rarely used sunscreen. (2018-07-18)

Epigenomic changes play an important role during the progression of melanoma
KU Leuven researchers have zeroed in on what makes cancer cells in melanoma so aggressive. They also succeeded in taming the effect in cell cultures. Melanoma, a type of skin cancer, is notoriously quick to metastasize and responds poorly to existing cancer treatments. In their study, published in Nature Communications, the researchers report a significant step forward in the characterization and potential treatment of melanoma. (2015-04-09)

Does too much sun cause melanoma?
We are continuously bombarded with messages about the dangers of too much sun and the increased risk of melanoma, but are these dangers real, or is staying out of the sun causing us more harm than good? (2008-07-22)

Combining radiation with immunotherapy showing promise against melanoma
Combining radiation treatments with a new generation of immunotherapies is showing promise as a one-two-punch against melanoma, Loyola Medicine researchers report in the Journal of Radiation Oncology. (2016-05-19)

White women with skin cancer history more likely to develop melanoma
Older white women with a history of non-melanoma skin cancer are at greater risk for developing melanoma, regardless of the amount of sun they have been exposed to, finds a study the online journal Cancer. (2005-12-20)

Study estimates melanoma risk in gene mutation carriers
People who carry a mutation in the melanoma susceptibility gene CDKN2A have a much lower risk of melanoma than has been suggested by previous estimates, although this risk is higher than that in the general population. In addition, most familial clusters of melanoma occur in families without identifiable mutations in this gene, according to a new study that appears in the October 19 issue of the Journal of the National Cancer Institute. (2005-10-18)

Arthritis drug could help treat advanced skin cancer
Treatment for the most deadly form of skin cancer could be more effective if combined with a well-known drug for rheumatoid arthritis, new research has shown. The study, by scientists at the University of East Anglia (UEA), found that in mice, using the two treatments together almost completely stopped the growth of a melanoma tumour. (2017-12-19)

Serendipity points to new potential target and therapy for melanoma
A University of Colorado Cancer Center study in this month's edition of the Journal of Investigative Dermatology describes a new target and potential treatment for melanoma, the most dangerous form of skin cancer. MicroRNA can decide which genes in a cell's DNA are expressed and which stay silent. Melanoma tends to lack microRNA-26a, which makes the gene SODD go silent. (2012-12-20)

Research uncovers new path for melanoma detection and treatment
A new way to spot melanoma cells circulating in the blood has the potential to significantly improve the monitoring of cancer patients and guide future treatment. Edith Cowan University's Melanoma Research Group, in collaboration with Harvard Medical School and clinicians at Western Australian hospitals, has pioneered a new technique to detect circulating tumour cells (CTCs) that could provide a new avenue for cancer diagnosis and therapies. (2020-02-09)

General decline in death rates from skin cancer in Scotland over past two decades
A UK study published on THE LANCET's website today--(2002-06-24)

Preeminent experts provide roadmap for future melanoma research
Recently the Melanoma Research Foundation (MRF) convened a summit of internationally-renowned melanoma experts for an in-depth discussion on the current understanding of, and future recommendations for, melanoma research. (2016-04-18)

A protein that defines the melanoma blueprint
The latest study of the Melanoma Group at the Spanish National Cancer Research Centre describes the roles of CPEB4; a protein that is crucial for melanoma cell survival. Researchers also describe that melanomas depend so tightly on CPEB4 because this protein regulates the expression of factors such as MITF and RAB27A, which have unique functions in this tumor type. CPEB4, is therefore a main driver of the 'intrinsic signature' that separates melanomas from other pathologies. (2016-11-18)

Survival rates appear lower for scalp and neck melanoma than for other sites
Individuals with melanoma on their scalp or neck appear less likely to survive for five or 10 years than those with melanoma at other sites, according to a report in the April issue of Archives of Dermatology, one of the JAMA/Archives journals. (2008-04-21)

Drug used in ED medications associated with small increased risk of malignant melanoma
Among men in Sweden, use of erectile dysfunctions drugs with phosphodiesterase type 5 inhibitors was associated with a modest but significant increased risk of malignant melanoma, although the pattern of association raises questions about whether this association is causal, according to a study in the June 23/30 issue of JAMA. (2015-06-23)

Calming down immune cells could hold key to melanoma treatment
Immune cells may be responsible for drug resistance in melanoma patients, according to research published in Cancer Discovery. (2014-09-25)

Australian researchers identify genes that cause melanoma
Scientists from the Queensland Institute of Medical Research have found two new genes that together double a person's risk of developing melanoma. (2009-07-06)

U of M study definitively links indoor tanning to melanoma
New research from the University of Minnesota's School of Public Health and Masonic Cancer Center definitively links the use of indoor tanning devices to increased risk of melanoma, the most serious form of skin cancer. (2010-05-27)

Invasive skin cancer a growing problem in Hispanics
A new study finds in contrast to non-Hispanic Caucasians, increases in melanoma in Hispanics have been confined to thicker lesions, which have a poorer prognosis. (2006-01-23)

State, regional differences in melanoma rates 2003 vs 2013
A new research letter published online by JAMA Dermatology compares melanoma death and incidence by states and in four geographic regions. Melanoma death and incidence rates vary among states, partly because of demographic differences. (2016-12-28)

Researchers identify compounds that starve melanoma cancer cells of energy
Researchers have found a possible counterpunch to the drug resistance of melanoma, the most dangerous form of skin cancer. (2019-06-18)

Kidney transplant patients face higher cancer risk
People who receive a kidney transplant are nearly four times more likely to develop melanoma, a rare but deadly form of skin cancer, according to a study in the November 1, 2005 issue of Cancer, a peer-reviewed journal of the American Cancer Society. (2005-09-26)

Melanoma drug revs immune cells but cancer cells ignore it
A new study shows that an important drug used in the treatment of malignant melanoma has little effect on the melanoma cells themselves. Instead, it activates immune-system cells to fight the disease. The drug, called interferon alpha, is used to clean up microscopic tumor cells that may remain in the body following surgery for the disease. It is the only drug approved for this purpose. (2007-09-01)

Epigenetic changes promoting cancer metastasis identified
Latest research from New Zealand's University of Otago is shedding new light on why and how cancer cells spread from primary tumors to other parts of the body. This phenomenon -- known as metastasis -- causes about 90 percent of all cancer deaths. The findings, published in the leading international journal Oncotarget, may pave the way for new therapies that prevent melanoma and other cancers from their deadly seeding of secondary tumors. (2016-12-20)

Survival after melanoma not affected by surgical background
Survival of melanoma patients does not depend on the surgical background of the person removing the primary tumour, concludes a study in this week's BMJ. (2002-11-28)

Recurrent melanoma may be more common than previously thought
Approximately 8 percent of patients with melanoma skin cancer may develop an additional melanoma within two years of their initial diagnosis, and those with atypical moles appear to be at higher risk, according to an article in the April issue of Archives of Dermatology, one of the JAMA/Archives journals. (2006-04-17)

The evolution of melanoma diagnosis: 25 years beyond the ABCDs
Twenty-five years after publishing the mnemonic (2010-07-29)

Using clinical features to identify patients at high risk for melanoma
Can an individual's risk factors for melanoma be used to tailor skin self-examinations and surveillance programs? A new study published online by JAMA Dermatology suggests they could by identifying those patients at higher risk who may benefit from increased surveillance. (2016-11-09)

Study finds patients with melanoma are at increased risk for new tumors
Memorial Sloan-Kettering Cancer Center researchers have found that melanoma patients with a family history of melanoma and/or dysplastic nevi (abnormal moles) are at high risk of developing multiple primary melanomas (MPM). Researchers recommend more intensive follow up for these high-risk patients. (2005-10-05)

Protein linked to aggressive skin cancer
Almost 300,000 people worldwide develop malignant melanoma each year. The disease is the most serious form of skin cancer and the number of cases reported annually is increasing, making skin cancer one of Sweden's most common forms of cancer. A research team at Lund University in Sweden has studied a protein that regulates a gene which is linked to metastasis of malignant melanoma. (2019-06-28)

Melanoma rates among minorities in Florida differ from national trends
Racial and ethnic trends in the skin cancer melanoma appear different in Florida than from national estimates, with higher incidence rates among Hispanic men and non-Hispanic black women but lower rates among Hispanic women, according to a report in the July issue of Archives of Dermatology, one of the JAMA/Archives journals. (2010-07-19)

Yale launches national study of personalized medicine for metastatic melanoma
Yale University has launched a multicenter clinical trial, sponsored by Stand Up to Cancer and Melanoma Research Alliance, that will apply the latest in personalized medicine technology to treat metastatic melanoma. The trial, for which Yale is a lead site, will enroll patients lacking a particular genetic mutation for whom immune therapy did not work or was not an option. (2015-04-15)

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