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Melanoma Current Events, Melanoma News Articles.
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Caught in the act: Papillomaviruses promote non-melanoma skin cancer
UV radiation has been known for a long time to be a risk factor for the development of skin cancer. Simultaneous infection with human papillomaviruses (HPV) has also been suspected to promote skin cancer, particularly in organ transplant recipients. Scientists from the German Cancer Research Center (DKFZ) have now been able to show for the first time in a natural system that papillomaviruses associated with UV light promote the development of non-melanoma skin cancer. (2017-11-30)

Researchers discover new mutations driving malignant melanoma
Two new mutations that collectively occur in 71 percent of malignant melanoma tumors have been discovered in what scientists call the (2013-01-24)

New study reveals how some chickens got striped feathers
Birds show an amazing diversity in plumage colour and patterning. But what are the genetic mechanisms creating such patterns? In a new study published today in PLOS Genetics, Swedish and French researchers report that two independent mutations are required to explain the development of the sex-linked barring pattern in chicken. Both mutations affect the function of CDKN2A, a tumour suppressor gene associated with melanoma in humans. (2017-04-07)

Antibody could be used to target tumor-causing protein, study shows
Cincinnati Cancer Center and University of Cincinnati Cancer Institute researchers have found in a phase-1 study that patients with advanced melanoma and kidney cancer who were treated with a certain antibody that targets a tumor-enhancing protein was safe, which could lead to more treatment options for patients. (2014-03-11)

Enter the exosome: WVU researcher studies how cancer and immune cells communicate
David Klinke, a researcher with the West Virginia University School of Medicine and Cancer Institute, is deciphering the contents of exosomes that cancer cells release. Studying the information exosomes contain and how they influence other cells may suggest new targets for cancer immunotherapy. (2019-10-30)

Infusing chemotherapy into the liver gives extra months of disease-free life in melanoma patients
Final results from a Phase III trial of a new treatment called percutaneous hepatic perfusion in patients with melanoma of the eye (ocular or uveal melanoma) have demonstrated that it significantly extends the time patients can live without the disease progressing. The research is to be presented at the 2011 European Multidisciplinary Cancer Congress on Saturday. (2011-09-23)

Disrupting cancer pathway could enhance new immunotherapies
Understanding how to overrule a signaling pathway that can cause treatments to fail in metastatic melanoma patients should help physicians extend the benefits of recently approved immunity-boosting drugs known as checkpoint inhibitors. Researchers from the University of Chicago show how these tumors shield themselves from T cells by producing high levels of beta-catenin, an intracellular messenger. They show how beta-catenin prevents T cell invasion and undermines treatment. They also suggest ways to circumvent this roadblock. (2015-05-11)

'Red hair' gene variant may underlie association between melanoma and Parkinson's disease
Massachusetts General Hospital investigators find that a gene variant that produces red hair and fair skin in humans and in mice, which increases the risk of the dangerous skin cancer melanoma, may also contribute to the known association between melanoma and Parkinson's disease. (2017-03-02)

Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1
Scientists have uncovered an interesting connection between two important protein kinase signaling pathways that are associated with cancer. The research, published by Cell Press in the Jan. 30 issue of the journal Molecular Cell, may direct new therapeutic strategies for multiple types of cancer. (2009-01-29)

Patient, tumor characteristics for high-mitotic rate melanoma
A study in Australia examined patient and tumor characteristics for melanomas with higher mitotic rates (a marker of tumor cell growth) in an effort to increase earlier detection of this aggressive cancer in patients. (2014-08-20)

Platelets suppress T cell immunity against cancer
In the May 5, 2017, issue of Science Immunology, cancer researchers at the Medical University of South Carolina report that blood platelets blunt the immune response to cancer. Genetic inactivation of platelets improved the ability of T cells to fight melanoma in preclinical tests. Adoptive T cell therapies for cancer could be enhanced when combined with common antiplatelet drugs. (2017-05-05)

Avax Technologies and Neptunus International Holdings Limited execute joint venture agreement to market AC Vaccine™ Technology
AVAX Technologies executed a joint venture agreement with NIHL in Australia under the subsidiary AVAX Australia Pty. Ltd who will manufacture and market AVAX's autologous cancer vaccine for melanoma M-Vax™ in Australia and New Zealand. AVAX Australia has received $3.6 million AUD and will receive an additional $0.4 million AUD within thirty days from NIHL for the purchase of a 20% interest in the joint venture. (1999-11-30)

Melanoma transcriptome reveals novel genomic alterations not seen before
Melanoma, the most deadly form of skin cancer, afflicts more than 50,000 people in the United States annually and the incidence rate continues to rise. In a study published online in Genome Research, scientists have delved deeper than ever before into the RNA world of the melanoma tumor and identified genomic alterations that could play a role in the disease. (2010-02-22)

Early detection, smaller cancer among benefits of skin cancer screening at PCP visits
Skin cancer screenings performed by primary care physicians (PCPs) during routine office visits improve the detection of potentially deadly melanomas and find them in earlier stages, according to new research from the University of Pittsburgh School of Medicine. The results were presented today at the 52nd annual American Society of Clinical Oncology (ASCO) annual meeting in Chicago. (2016-06-07)

Early-stage melanoma tumors contain clues to metastatic potential
Scientists at Dana-Farber Cancer Institute have demonstrated that it's possible -- early in a tumor's growth -- to identify cancer genes that endow the tumor with the ability to metastasize. Testing the technique in melanoma skin cancer, they found six abnormal genes that are both cancer-causing and metastasis-promoting. One of those genes, ACP5, can be used to predict whether human melanoma tumors are likely to spread. (2011-07-14)

Researchers use 'trickery' to create immune response against melanoma
A new type of immunotherapy in which dendritic cells are tricked into action against cancer when they are exposed to harmless pieces of viruses and bacteria is described in the November issue of Cancer Research. In the study, University of Pittsburgh researchers describe the creation of an animal model of an immunotherapy approach that, first used in cancer patients, uses a patient's own tumor cells to stimulate anti-tumor immunity. (2005-11-01)

Scientists identify promising new melanoma drug
The first-in-class compound halts tumor growth by disrupting protein production. (2015-11-24)

Melanoma stem cells' evasive talents
Melanoma, if not detected in its early stages, transforms into a highly deadly, treatment-resistant cancer. Although the immune system initially responds to melanoma and mounts anti-tumor attacks, these assaults are generally ineffective, allowing more advanced melanomas to win the battle and spread beyond the primary site. Now, researchers at Children's Hospital Boston and Brigham and Women's Hospital shed light on how melanomas stimulate, yet ultimately evade, a patient's immune system. (2010-01-12)

Skin cancer above the neck more likely to spread, research shows
Forty-five patients with new diagnoses of MM were investigated over a period of 6 months and were divided into two groups of patients, with above neck MM and below neck MM. The aim of the study was to see which types of MM were more likely to metastasize (spread) in terms of location. (2019-10-10)

Long-term survival achieved in metastatic melanoma with personalized vaccine
Two patients with melanoma that had spread to the liver survived for at least 8.5 and 12 years after resection of the hepatic tumor and treatment with patient-specific immunotherapeutic vaccines. The vaccines, designed to activate the immune system against the tumor, were derived from the patients' own dendritic cells loaded with proteins isolated from their tumors, as described in an article published in Cancer Biotherapy and Radiopharmaceuticals. (2016-05-10)

Good-guy bacteria may help cancer immunotherapies do their job
Individuals with certain types of bacteria in their gut may be more likely to respond well to cancer immunotherapy, researchers at the Harold C. Simmons Comprehensive Cancer Center found in a study of patients with metastatic melanoma. (2017-10-05)

The Wistar Institute collaborates with the Coriell Institute to distribute cell lines
Cell lines developed by Wistar Institute scientist have been made available to researchers worldwide through the Coriell Institute for Medical Research. Researchers can now access the biological materials for use in the development of vaccines and treatments for melanoma, influenza and other deadly diseases. (2008-03-25)

Use of vitamin A cream may prevent skin cancer
Use of topical tazarotene, a vitamin A derivative, has significant potential for the prevention of basal cell carcinoma in people predisposed to the disease, according to a study presented at the American Association for Cancer Research's (AACR) first annual Frontiers in Cancer Prevention Research meeting. The researchers found an 85 percent inhibition of both tumor number and size in the tazarotene-treated mice compared to mice administered a placebo. (2002-10-16)

Social class dictates cancer risk
Cervical and lung cancer are more common in poor people while rates of breast cancer and melanoma are higher in the wealthy. A detailed analysis of the incidence of these four different kinds of cancer, carried out on more than 300,000 English cancer patients and published today in the open access journal BMC Cancer, describes the effects of socioeconomic group, region and age. (2008-09-25)

New nanosystem from Tel Aviv university enhances treatment for melanoma in animal models
Researchers at Tel Aviv University, led by Prof. Ronit Satchi-Fainaro of TAU's Department of Physiology and Pharmacology at the Sackler School of Medicine, have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma. (2020-09-08)

Moffitt Cancer Center begins Phase I clinical trial of new immunotherapy
Moffitt Cancer Center has initiated a phase I clinical trial for a new immunotherapy drug, ID-G305, made by Immune Design. Immunotherapy is a treatment option that uses a person's own immune system to fight cancer. It has several advantages over standard cancer therapies, including fewer side effects and an overall better tolerability. It tends to be most effective in patients who have smaller, localized tumors that have not spread to distant sites. (2014-04-10)

UCLA researchers further refine 'NanoVelcro' device to grab single cancer cells from blood
Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients' tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis. (2013-02-22)

HDAC inhibition may combat resistance to anti-PD-1 therapy in patients with melanoma
A combination of the experimental histone deacetylase (HDAC) inhibitor entinostat with the anti-PD-1 therapeutic pembrolizumab (Keytruda) showed clinical responses in patients with melanoma that had progressed on prior anti-PD-1 treatment, according to results from the ENCORE 601 phase Ib/II clinical trial presented at the AACR Annual Meeting 2019, March 29-April 3. (2019-04-01)

Elderly survivors of three common cancers face persistent risk of brain metastasis
Elderly survivors of breast cancer, lung cancer, and melanoma face risk of brain metastasis later in life, and may require extra surveillance in the years following initial cancer treatment. (2019-05-03)

New combo of immunotherapy drugs is safe, shrinks tumors in metastatic melanoma patients
Once again, researchers at Penn's Abramson Cancer Center have extended the reach of the immune system in the fight against metastatic melanoma, this time by combining the checkpoint inhibitor tremelimumab with an anti-CD40 monoclonal antibody drug. (2015-04-19)

Ebola highlights disparity of disease burden in developed vs. developing countries
A recent study in Journal of the American Academy of Dermatology shows Ebola and other skin disease rates are hundreds of times higher in developing than in developed countries. The study highlights the need for disease monitoring even when the global burden of disease remains low. (2014-10-15)

Study reveals first evidence inherited genetics can drive cancer's spread
Scientists have long struggled to understand what drives a tumor to seed itself elsewhere in the body. New research implicates own pre-existing genetics. (2020-05-25)

Drug combination improves progression-free survival in melanoma patients
Patients with advanced melanoma skin cancer survive for longer without their disease progressing if they have been treated with a combination of two drugs, nivolumab and ipilimumab, than with either of these drugs alone. New results show that these patients also do better regardless of their age, stage of disease and whether or not they have a cancer-driving mutation in the BRAF gene. (2015-09-27)

Melanoma-initiating cell identified by Stanford scientists
Scientists at the Stanford University School of Medicine have identified a cancer-initiating cell in human melanomas. The finding is significant because the existence of such a cell in the aggressive skin cancer has been a source of debate. It may also explain why current immunotherapies are largely unsuccessful in preventing disease recurrence in human patients. (2010-06-30)

Mayo researchers identify protein -- may predict who will respond to PD-1 immunotherapy for melanoma
Mayo Clinic researchers have identified a protein marker whose frequency may predict patient response to PD-1 blockade immunotherapy for melanoma. An abstract of their findings was presented today at the American Association for Cancer Research International Cancer Immunotherapy Conference in New York City. (2015-09-16)

Predicting cancer prognosis
Researchers led by Dr. Soheil Dadras at the Stanford University Medical Center have developed a novel methodology to extract microRNAs from cancer tissues. The related report by Ma et al., (2009-08-27)

Prognostic value of baseline HRQOL for survival for 11 types of cancer pointed out by EORTC study
Results of an EORTC study published in Cancer point out the prognostic value of baseline recorded health-related quality of life for survival for eleven types of cancer: brain, breast, colorectal, esophageal, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and testicular cancer. For each cancer site, at least one health-related quality of life parameter provided additional prognostic information over and above the clinical and sociodemographic variables. (2013-11-06)

FDG-PET/CT predicts melanoma patients' response to immune checkpoint inhibitor therapy
Research highlighted in the featured article of the September issue of The Journal of Nuclear Medicine demonstrates that combined PET/CT scanning early in treatment of advanced melanoma could identify whether the therapy will benefit a particular patient. As the therapy has potentially serious side-effects, early determination of ineffectiveness could avert unnecessary risk exposure and provide the option of a different treatment. (2017-09-05)

Research identifies new route for tackling drug resistance in skin cancer cells
Researchers have found that melanoma cells fight anti-cancer drugs by changing their internal skeleton (cytoskeleton) -- opening up a new therapeutic route for combating skin and other cancers that develop resistance to treatment. (2020-01-13)

Researchers create novel compound targeting melanoma cells
An international team of researchers has developed a novel compound that successfully inhibits growth of melanoma cells by targeting specific epigenetic modifying proteins in these cells. (2018-01-04)

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