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Melatonin Current Events, Melatonin News Articles.
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Signaling pathway may explain the body clock's link to mental illness
Alterations in a cellular signaling pathway called cAMP-CREB may help explain why the body clocks of people with bipolar disease are out of sync, according to a new European Journal of Neuroscience study. (2014-06-16)

Melatonin may protect the small intestine from oral radiation treatment in rats
Oral melatonin can protect the small intestine in rats subjected to radiotherapy of the tongue, according to a study published April 12, 2017 in the open-access journal PLOS ONE by Germaine Escames from Universidad de Granada, Spain, and colleagues. (2017-04-12)

Decreased melatonin secretion associated with higher risk of developing type 2 diabetes
With previous evidence suggesting that melatonin may have a role in glucose metabolism, researchers have found an independent association between decreased secretion of melatonin and an increased risk for the development of type 2 diabetes, according to a study in the Apr. 3 issue of JAMA. (2013-04-02)

Melatonin most effective for sleep when taken for off-hour sleeping
Researchers from the Divisions of Sleep Medicine at Brigham and Women's Hospital and Harvard Medical School have found in a double-blind placebo-controlled clinical study, that melatonin, taken orally during non-typical sleep times, significantly improves an individual's ability to sleep. (2006-05-01)

Study casts doubt that melatonin goes down as age goes up: Older buyers take note
A new study contradicts the popular notion that melatonin levels in older people fall with age. For most healthy people, concentrations of melatonin in plasma probably do not decline with aging. (1999-11-04)

Melatonin reduces traumatic brain injury-induced oxidative stress
Traumatic brain injury can cause post-traumatic neurodegenerations with an increase in reactive oxygen species and reactive oxygen species-mediated lipid peroxidation. Melatonin, a non-enzymatic antioxidant and neuroprotective agent, has been shown to counteract oxidative stress-induced pathophysiologic conditions like cerebral ischemia/reperfusion injury, neuronal excitotoxicity and chronic inflammation. (2014-07-23)

Melatonin shows potential to slow tumor growth in certain breast cancers
An early stage study shows melatonin -- a hormone that regulates the body's sleep and awake cycles -- may have the potential to help slow the growth of certain breast cancer tumors, according to researchers from Henry Ford Hospital in Detroit and Foundation for Research Support of the State of São Paulo. (2014-01-28)

Genetic cause for shift work fatigue discovered
Some people adapt easily to shift work, but not everyone can handle constant disruptions to their daily rhythm. Finnish researchers have now found that a melatonin receptor gene influences tolerance to shift work. (2016-11-04)

Study shows melatonin supplements may make standing a hazard for the cardiovascular-challenged
For insomniacs and jet-lagged travelers, melatonin supplements may enable a good night's sleep. However, a study by a Penn State Milton S. Hershey Medical Center researcher suggests that melatonin supplements may make symptoms worse for the half a million people - many of them women and the elderly - with orthostatic intolerance. (2003-09-15)

Spanish scientists develop a pioneering technique to effectively treat mucositis
Mucositis is one of the most frequent side effects of chemotherapy and radiotherapy in cancer patients and currently cannot be treated. (2013-02-14)

Room light before bedtime may impact sleep quality, blood pressure and diabetes risk
According to a recent study accepted for publication in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism, exposure to electrical light between dusk and bedtime strongly suppresses melatonin levels and may impact physiologic processes regulated by melatonin signaling, such as sleepiness, thermoregulation, blood pressure and glucose homeostasis. (2011-01-13)

Shift work may be associated with decreased risk of skin cancer
Melatonin is known to have cancer-protective properties, and shift work can induce desynchrony of the circadian system, reducing melatonin production. Shift work has been thought to have important health impacts, with evidence linking shift work to an increased risk of several cancers including breast, endometrial, prostate and colorectal, and non-Hodgkin lymphoma. In a recent study, researchers at Brigham and Women's Hospital found that shift work may be associated with a reduced risk of skin cancer in women. (2011-03-02)

How plankton gets jet lagged
The hormone melatonin, which governs sleep and jet lag in humans, may also drive the mass migration of plankton in the ocean, scientists at EMBL Heidelberg have found. They discovered that it governs the nightly migration of a plankton species from the surface to deeper waters. The findings indicate that melatonin's role in controlling daily rhythms probably evolved early in the history of animals, and hold hints to how our sleep patterns may have evolved. (2014-09-26)

Cicardian system suffers and protects from prenatal cocaine exposure
Researchers from Boston University School of Medicine have shown that prenatal cocaine exposure in zebrafish (which share the majority of the same genes with humans) can alter neuronal development and acutely dysregulate the expression of circadian genes and those affecting melatonin signaling, growth and neurotransmission. The circadian factors, including the principal circadian hormone melatonin, can attenuate the prenatal effects of cocaine. These findings appear in the July 11 issue of the journal PLoS ONE. (2007-07-10)

Scientists discover how animals measure time of year to reproduce
Animals need to measure the time of year so that they can anticipate and adapt to the arrival of a new season to align reproduction, as well as other vital functions critical for survival. A new study, conducted at the University of Bristol, has identified how animals measure annual time to control seasonal fertility. (2017-03-06)

FASEB Science Research Conference: Melatonin Biology: Actions and Therapeutics
The 2015 FASEB Science Research Conference Melatonin Biology: Actions and Therapeutics will focus on the role of melatonin and its analogues as potential drugs in the treatment of sleep and circadian disorders, insomnia, cancer, immune dysfunction, inflammatory processes, and neurodegenerative disease. (2015-01-26)

Use of bright lighting may improve dementia symptoms for elderly persons
The use of daytime bright lighting to improve the circadian rhythm of elderly persons was associated with modest improvement in symptoms of dementia, and the addition of the use of melatonin resulted in improved sleep, according to a study in the June 11 issue of JAMA. (2008-06-10)

Transplanted human placenta-derived stem cells show therapeutic potential in stroke models
Stem cells derived from human placenta proliferated and differentiated when transplanted into test tube and animal models of stroke. The cells interacted with melatonin receptor MT1, offering a potentially therapeutic response, but the same cells did not perform similarly when interacting with melatonin receptor MT2. The researchers suggest that MT1 (2011-02-01)

Rest easy: MIT study confirms melatonin's value as sleep aid
-A new study by MIT scientists and colleagues confirms that melatonin is an effective sleep aid for older insomniacs and others. Misuse of the hormone had led some to question its efficacy, but the latest work (published in the February issue of Sleep Medicine Reviews) could jump-start interest in the dietary supplement and help more people get a good night's sleep. (2005-02-28)

Melatonin and multiple sclerosis: Why MS symptoms may improve as the days get shorter
Researchers from the Ann Romney Center for Neurologic Diseases at Brigham and Women's Hospital and their collaborators have found an explanation that could lead to a deeper understanding of multiple sclerosis and more targeted treatment options for patients. By first looking broadly at possible environmental factors and then deeply at preclinical models of MS, the research team found that melatonin -- a hormone involved in regulating a person's sleep-wake cycle -- may influence MS disease activity. (2015-09-10)

New findings explain the connection between melatonin and type 2 diabetes
A new experimental and clinical study from Lund University in Sweden shows that the sleep hormone melatonin impairs insulin secretion in people with a common gene variant. 'This could explain why the risk of type 2 diabetes is greater among, for instance, overnight workers or people with sleeping disorders,' says Professor Hindrik Mulder who is responsible for the study. (2016-05-13)

Melatonin signaling is a risk factor for type 2 diabetes
A sleeping pancreas releases less insulin, but how much insulin drops each night may differ from person to person, suggests a study published May 12 in Cell Metabolism. Up to 30 percent of the population may be predisposed to have a pancreas that's more sensitive to the insulin-inhibiting effects of melatonin. People with this increased sensitivity carry a slightly altered melatonin receptor gene that is a known risk factor for type 2 diabetes. (2016-05-12)

Study finds that melatonin content of supplements varies widely
A new study suggests that the melatonin content of dietary supplements often varies widely from what is listed on the label. (2017-02-14)

Why midshipman fish only hum at night
If you think that fish can't sing, then you've probably never come into contact with a midshipman fish. When it's time to breed, male midshipman hum repetitively at night as they attempt to woo females into their nests for spawning. Now, researchers reporting in the Cell Press journal Current Biology on Sept. 22 have new evidence to explain what keeps those fish quiet through the day and singing all night. (2016-10-03)

Study: Brain injuries tied to trouble sleeping
People with brain injuries may produce low amounts of melatonin, which affects their sleep, according to a study published in the May 25, 2010, print issue of Neurology, the medical journal of the American Academy of Neurology. (2010-05-24)

What is the pituitary hormone secretion pattern in cirrhosis patients?
The hepatic encephalopathy is a clinical syndrome characterized by mental status changes in patients with severe hepatic insufficiency. Hormonal disorders and circadian rhythm abnormalities are often associated with liver disease and severity of these disorders is related to liver disease severity and duration.This paper studied the correlation between cirrhosis severity and hepatic encephalopathy. (2008-09-23)

Melatonin's heart protective effects not related to its antioxidant properties
Although melatonin does improve the outcomes of induced heart attacks in rats, those improvements are not the result of its antioxidant effect, new research finds. The study comparing antioxidant activity and heart protection will be presented today at the American Physiological Society (APS) annual meeting at Experimental Biology 2019 in Orlando. (2019-04-09)

Researcher attacks pre-term labor problem
A Florida State University researcher is tackling a new and inventive way to slow down and perhaps prevent preterm labor. (2014-02-05)

Jefferson neuroscientists uncover novel receptor in the human eye to control body's biological clock
Neuroscientists have clarified how the human eye uses light to regulate melatonin production and the body's biological clock. They have discovered what appears to be a fifth human (2001-08-09)

Lights out... light pollution alters reproduction cycle in lemurs
Besides obscuring the stars, light pollution can also disrupt the reproduction of light-sensitive animals. French scientists have shown that light pollution can override the natural reproductive cycle of some animals, making them sexually active out of season. (2014-07-02)

Melatonin may save eyesight in inflammatory disease
Current research suggests that melatonin therapy may help treat uveitis, a common inflammatory eye disease. (2008-11-23)

Dangers of exposure to 'white' light
Exposure to the light of white LED bulbs, it turns out, suppresses melatonin five times more than exposure to the light of High Pressure Sodium bulbs that give off an orange-yellow light. (2011-09-11)

To Arctic animals, time of day really doesn't matter
In the far northern reaches of the Arctic, day versus night often doesn't mean a whole lot. During parts of the year, the sun does not set; at other times, it's just the opposite. A new study reported online on March 11 in Current Biology, a Cell Press publication, shows that Arctic reindeer have come up with a solution to living under those extreme conditions: They've abandoned use of the internal clock that drives the daily biological rhythms in other organisms. (2010-03-11)

Melatonin might help in controlling weight gain and preventing heart diseases associated with obesity
Melatonin is a natural hormone produced by the body that can also be found in some fruits and vegetables as mustard, Goji berries, almonds, sunflower seeds, cardamom, fennel, coriander and cherries. University of Granada researchers have analyzed the effects of melatonin on obesity, dyslipidimia and high blood pressure in young diabetic obese rats. (2011-04-28)

Immune system in mice affected by changes in daylight
Researchers here have discovered how seasonal changes in the length of the day affect the immune system in mice. The results might have implications for people who use melatonin supplements for health reasons. The Ohio State University study found that changes in the length of daylight in autumn trigger enhancements of the mice's immune system in preparation for the challenges of winter. (2001-10-25)

Insecticides mimic melatonin, creating higher risk for diabetes
Synthetic chemicals commonly found in insecticides and garden products bind to the receptors that govern our biological clocks, University at Buffalo researchers have found. (2017-01-19)

Melatonin boost a key to fighting breast cancer
Melatonin, a hormone produced in the human brain, appears to suppress the growth of breast cancer tumors. Researchers at Michigan State University published this finding in the current issue of Genes and Cancer. While treatments based on this key discovery are still years away, the results give scientists a key foundation on which to build future research. (2016-08-23)

Melatonin helps control weight gain as it stimulates the appearance of 'beige fat'
Spanish scientists are the first to reveal the previously unknown enigma of the effect melatonin has to counter obesity in the organism and why it has metabolic benefits in treating diabetes and hyperlipidemia. (2013-09-25)

Bright screens at night imperil sleep of young teens
A new study looked at the effect of light exposure at night -- like that from phones or tablets -- on the biology of teen sleep. The researchers found that children in early to middle puberty were especially vulnerable to suppression of a hormone key to sleep timing. (2015-08-26)

Link between suicide and exposure to magnetic fields
Prolonged exposure to low frequency electromagnetic fields may increase the risk of suicide, suggests a study of US electricians in Ocupational and Environmental Medicine. Electromagnetic fields may reduce the production of melatonin, a hormone that maintains daily circadian rhythms, including the sleep and wake cycle. Reduced levels of melatonin are associated with depression. (2000-03-14)

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