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X-ray microscopy at BESSY II: Nanoparticles can change cells
Nanoparticles easily enter into cells. New insights about how they are distributed and what they do there are shown for the first time by high-resolution 3D microscopy images from BESSY II. For example, certain nanoparticles accumulate preferentially in certain organelles of the cell. This can increase the energy costs in the cell. 'The cell looks like it has just run a marathon, apparently, the cell requires energy to absorb such nanoparticles' says lead author James McNally. (2020-02-12)

Stretching helices help keep muscles together
Scientists at EMBL Hamburg have discovered that the elastic part of myomesin, a protein that links muscle filaments, can stretch to two and a half times its original length, unfolding in a way that was hitherto unknown. (2012-02-15)

Indiana University Imaging Center receives $6M grant for kidney research
The Indiana University School of Medicine's Division of Nephrology has been awarded a five-year, $6 million George M. O'Brien Kidney Research Center grant from the National Institutes of Health, one of just six such centers funded in the United States. (2007-08-08)

New label-free method tracks molecules and drugs in live cells
A new type of highly sensitive microscopy developed by researchers at Harvard University could greatly expand the limits of modern biomedical imaging, allowing scientists to track the location of minuscule metabolites and drugs in living cells and tissues without the use of any kind of fluorescent labeling. (2008-12-18)

Autophagy under the microscope as never before
We don't tend to wrap our recycling waste in bubble wrap but that's essentially what cells do during the cellular recycling process called autophagy. Using the live imaging capabilities at the Babraham Institute, Institute researchers and their collaborators at Carl Zeiss Microscopy, Munich, and the Francis Crick Institute, London, have viewed the earliest stages of this encapsulation and recycling process in super resolution to reveal what's happening in unprecedented molecular detail. (2016-08-11)

Research to probe deep within a solar cell
Engineers and scientists from the University of Sheffield have pioneered a new technique to analyze PCBM, a material used in polymer photovoltaic cells, obtaining details of the structure of the material which will be vital to improving the cell's efficiency. (2013-02-25)

Elemental and magnetic imaging using X-rays and a microscope
A team of researchers has developed a new microscope that can image the elemental and magnetic properties of a wide range of energy-important materials that are used in devices such as solar cells and solid-state lighting. (2012-06-14)

New technique offers higher resolution molecular imaging and analysis
The new approach from Northwestern Engineering could help researchers understand more complicated biomolecular interactions and characterize cells and diseases at the single-molecule level. (2020-05-27)

Super-resolution microscopy builds multicolor 3D from 2D
A new technique developed by EPFL overcomes the noise and color limitations of super-resolution microscopy by creating three-dimensional (3D) reconstructions from single-color two-dimensional (2D) images of protein complexes. (2018-10-01)

Chip-based nanoscopy: Microscopy in HD quality
Physicists at Bielefeld University and the Arctic University of Norway in Tromsø have developed a photonic chip that makes it possible to carry out super-resolution light microscopy, also called 'nanoscopy,' with conventional microscopes. In nanoscopy, the position of single fluorescent molecules can be determined with a precision of just a few nano-meters, that is, to a millionth of a millimeter. (2017-04-24)

Men may contribute to infertility through newly discovered part of sperm
The research identifies a new structure in human sperm that functions in the zygote and may provide new avenues for addressing male infertility and insights into early embryo developmental defects. (2018-06-07)

Stripped mobile phone camera turned into a mini-microscope for low-cost diagnostics
Simple imaging devices modified to inexpensive mini-microscopes are the new weapon in fight against tropical infectious diseases, show the researchers at the Institute for Molecular Medicine Finland, FIMM, University of Helsinki and Karolinska Institutet. (2013-12-05)

Enhancing molecular imaging with light
A new technology platform from Northwestern University is able to image molecules at the nanoscale with super-resolution. (2016-07-25)

Precise insight into the depths of cells
Is it possible to watch at the level of single cells how fish embryos become trout, carp or salmon? Researchers at Goethe University Frankfurt have successfully combined two very advanced fluorescence microscopy techniques. The new high-resolution light microscope permits fascinating insights into a cell's interior. (2017-05-24)

Seeing an atomic thickness
Scientists from the National Physical Laboratory, in collaboration with Linköping University, Sweden, have shown that regions of graphene of different thickness can be easily identified in ambient conditions using Electrostatic Force Microscopy. (2011-05-24)

UC San Diego scientists chart rapid advances of fluorescent tools for life-science research
An interdisciplinary team of biological imaging experts from the University of California, San Diego has published a review of fluorescent imaging technologies and underscored the importance of those technologies to major advances in the life sciences. The article -- (2006-04-13)

Sunscreen for dancing molecules
This study is the first to use heavy water (D2O) - a form of water that contains deuterium (D) instead of hydrogen - in the field of transmission electron microscopy (TEM). This approach significantly delays sample damage, which is one of the major impediments for broader application of liquid-phase TEM to fragile biological samples. (2018-08-01)

Livermore's DTEM earns innovation award from Microscopy Today
An innovation that can help scientists observe a reaction moving at greater than 10 meters per second, with a few nanometers spatial resolution, is a feat some would say is nearly impossible. But not the Lawrence Livermore team of scientists who developed the dynamic transmission electron microscope. (2010-08-02)

Hitachi partnership brings new tools and electron microscope reference center to Edmonton
Thanks to an international collaboration with Hitachi, Canadian companies will now have access to a uniquely configured transmission electron microscope, the first of its kind outside of Japan. (2011-07-12)

Advances in Optics for Biotechnology, Medicine and Surgery
The primary goal of this conference is to bring together scientists, engineers and clinicians interested in the application of optics to biotechnology, medicine and surgery. Besides formal presentations, it will provide a forum for informal discussions and social interaction. In this tenth conference in this series, we aim to emphasize the medical applications of optics, with a focus on in vivo and molecular imaging, and to encourage interaction between researchers and clinicians. (2007-01-23)

NPL supports growing organic electronics industry
The National Physical Laboratory, the UK's National Measurement Institute, is developing equipment and techniques to support the growing use of organic electronics. The market for organic, or plastic, electronics is expected to be worth £15 billion ($23.7 billion) by 2015 (IDTechEx), and NPL is seeking to ensure the infrastructure is in place to allow businesses to achieve commercial success in this emerging area. (2009-09-28)

Gated STED -- developing the next generation of super-resolution microscopes
Leica Microsystems, the Max Planck Society and the German Cancer Research Center sign a license agreement. (2011-11-11)

Small, beautiful and additive-free
The National Research Council Canada recently helped Olympus, a world leader in advanced optical microscopy and medical imaging, to design and commercialize a coherent anti-stokes raman scattering (CARS) microscope. (2009-11-13)

Visualization of molecular soccer balls
Researchers led by the University of Tsukuba imaged lithium ion-doped fullerene, which resembles a molecular soccer ball, by scanning tunneling microscopy. The microscopy images of the single lithium ion-doped fullerene molecules and corresponding density functional theory calculations allowed the electronic structure of lithium ion-doped fullerene to be comprehensively determined. Such knowledge of the electronic structure of fullerenes is important for optimizing their performance in advanced electronics and switching devices. (2018-05-09)

An easy way to see the world's thinnest material
Jiaxing Huang at the McCormick School of Engineering and Applied Science uses the dye fluorescein to create a new imaging technique to view graphene. (2009-12-23)

UNM professor developing super-resolution microscopy techniques
For scientists developing life-saving medicines, knowing how cells interact and communicate with one another is an important part of the puzzle. The problem is, being able to see those interactions through a microscope hasn't always been possible. But now, thanks to University of New Mexico Associate Professor Keith Lidke, a new technique has opened the door to allow researchers a better view of cellular interactions. (2016-11-02)

New book on Cell Death Techniques from Cold Spring Harbor Laboratory Press
'Cell Death Techniques: A Laboratory Manual' from Cold Spring Harbor Laboratory Press provides a comprehensive suite of step-by-step protocols for inducing, detecting, visualizing, characterizing, and quantifying cell death in a variety of systems. The authors also provide guidance on interpreting and presenting the results of cell death experiments, as well as advice on complementary procedures that may be required to confirm the results of a given experiment. (2015-09-17)

New hybrid microscope probes nano-electronics
A new form of scanning microscopy that simultaneously reveals physical and electronic profiles of metal nanostructures has been demonstrated at JILA, a joint institute of NIST and University of Colorado at Boulder. The new instrument is expected to be particularly useful for analyzing the make-up and properties of nanoscale electronics and nanoparticles. (2006-10-27)

Super-resolution photoacoustic microscopy finds clogged blood vessels
Professor Chulhong Kim and his research team suggested a super-resolution localization photoacoustic microscopy using red blood cells as contrast absorbers. (2019-12-16)

New microscopy technique offers close-up, real-time view of cellular phenomena
For two decades, scientists have been pursuing a potential new way to treat bacterial infections, using naturally occurring proteins known as antimicrobial peptides (AMPs). Now, MIT scientists have recorded the first microscopic images showing the deadly effects of AMPs, most of which kill by poking holes in bacterial cell membranes. (2010-03-14)

New tool for cell research may help unravel secrets of disease
Advancements in understanding rotational motion in living cells may help researchers shed light on the causes of deadly diseases, such as Alzheimer's, according to Ning Fang, an associate scientist at the U.S. Department of Energy's Ames Laboratory and faculty member at Iowa State University. (2011-01-13)

Mushrooms are older than we thought
According to a new study led by Steeve Bonneville from the Université libre de Bruxelles, the first mushrooms were already present on Earth between 715 and 810 million years ago, 300 million years earlier than the scientific community had believed until now. The results, published in Science Advances, also suggest that mushrooms could have been important partners for the first plants that colonized the continental surface. (2020-01-22)

NIST reference materials are 'gold standard' for bio-nanotech research
The National Institute of Standards and Technology has issued its first reference standards for nanoscale particles targeted for the biomedical research community -- literally (2008-01-09)

New edition of popular lab manual presents latest techniques for probing cellular dynamics
In recent years, substantial advances have been made in microscopy techniques, enabling biologists to understand the details of cellular structure and dynamics at a level never before possible. In a new edition of the popular laboratory manual (2010-01-15)

Smile: Atomic imaging finds root of tooth decay
A collaboration between researchers from Cornell University, Northwestern University and University of Virginia combined complementary imaging techniques to explore the atomic structure of human enamel, exposing tiny chemical flaws in the fundamental building blocks of our teeth. The findings could help scientists prevent or possibly reverse tooth decay. (2020-07-21)

First volume of new laboratory manual series on imaging is released
A new series of laboratory manuals has been developed by Cold Spring Harbor Laboratory Press. The first volume in this series, (2010-11-18)

MDI Biological Laboratory offers course in quantitative fluorescence microscopy
Science professionals, doctoral and postdoctoral students from across the country will gather May 20 through 27 at the MDI Biological Laboratory in Bar Harbor, Maine, for an intensive one-week course in Quantitative Fluorescence Microscopy. The goal of the course is to provide participants with the knowledge and expertise to implement cutting-edge microscopic methods in their laboratory research. (2016-05-05)

Ion microscopy pinpoints drugs inside cancer cells
Chemical biologists at Cornell University have pioneered a new imaging technique that offers researchers a new way of observing the working of therapeutic drugs within single cancer cells. The technique, called ion microscopy, promises to open new avenues of cancer research. (2000-10-12)

Atomic force imaging used to study nematodes
In a new study, researchers report for the first time the effective imaging of the nanoscale structure of C. elegans nematodes' cuticle using atomic force microscopy operating in PeakForce Tapping mode. (2017-02-17)

Light-sheet fluorescence imaging goes more parallelized
In pursuit of 3D visualization of cells and organisms with minimal invasiveness and high spatiotemporal resolution, researchers demonstrated a new form of light-sheet imaging, coined CLAM, which allows scan-free, parallelized 3D fluorescence imaging that results in an even slower rate of photobleaching than scanning light-sheet imaging, yet without sacrificing the image speed and resolution. Readily adaptable to the existing light-sheet imaging modalities, CLAM could show promises in long-term dynamical and high-throughput biological imaging applications. (2020-02-17)

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