Motor Neurons Current Events

Motor Neurons Current Events, Motor Neurons News Articles.
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Stem cell study could aid motor neurone disease research
Scientists have discovered a new way to generate human motor nerve cells in a development that will help research into motor neurone disease. A team from the universities of Edinburgh, Cambridge and Cardiff has created a range of motor neurons -- nerves cells that send messages from the brain and spine to other parts of the body -- from human embryonic stem cells in the laboratory. (2011-03-01)

Zebrafish study offers insights into nerve cell repair mechanisms
Scientists at the University of Edinburgh have discovered that a hormone called serotonin -- better known for its role as a mood booster -- can help zebrafish to recover from a spinal cord injury. The findings could aid research into motor neuron disease and paralysis caused by spinal cord injury. (2015-10-22)

Changing size of neurons could shed light on new treatments for motor neurone disease
New research published in The Journal of Physiology improves our understanding of how motor nerve cells (neurons) respond to motor neurone disease, which could help us identify new treatment options. (2018-03-04)

Hormone signal drives motor neuron growth, fish study shows
A discovery made in fish could aid research into motor neuron disease. (2013-05-23)

In mice, fine motor control is actively suppressed
The neural connections that endow humans with great dexterity are also present in mice at birth, but are suppressed shortly afterward, a new study reveals. (2017-07-27)

How to increase the survival rate of motor neurons after spinal root avulsion
Dr. Lin Li and co-workers from Nanjing Medical University in China investigated whether preconditioning crush can increase the survival rate of motor neurons, which is the first to demonstrate that loss of ventral motor neurons after nerve root avulsion is partially prevented by preconditioning crush. (2014-08-21)

New stem cell-based screen reveals promising drug for Lou Gehrig's disease
A study published on April 18th in Cell Stem Cell has revealed a novel stem-cell-based approach to screen for effective treatments of ALS, also called Lou Gehrig's disease, which are sorely lacking. (2013-04-18)

How to increase the survival rate of motor neurons after spinal root avulsion
Dr. Lin Li and co-workers from Nanjing Medical University in China investigated whether preconditioning crush can increase the survival rate of motor neurons, which is the first to demonstrate that loss of ventral motor neurons after nerve root avulsion is partially prevented by preconditioning crush. (2014-05-09)

Communication breakdown: Early defects in sensory synapses in motor neuron disease
New research using a mouse model of the motor neuron disease spinal muscular atrophy (SMA) reveals an abnormality in the way that sensory information is relayed to motor neurons in the spinal cord. Importantly, this disruption in communication occurs very early in disease progression and precedes the neuronal death and muscle weakness that are the hallmark of the disease. (2011-02-09)

New role for motor neurons discovered
Researchers from Sweden´s Karolinska Institutet have demonstrated a new, direct signalling pathway through which motor neurons influence the locomotor circuits that generate rhythmic movements. The findings could change the view of the role of motor neurons, and are presented in the journal Nature. (2016-01-13)

The need for speed
Scientists at the National Centre for Biological Sciences (NCBS), Bangalore show that parallel neural pathways that bypass the brain's tight frequency control enable animals to move faster. In their study, the scientists chose to study speed regulation in larval zebrafish during a reflex behaviour called the optomotor response. (2020-03-12)

VTCRI scientists find that sensory neurons can be used to discover therapies for ALS
Scientists have shown that mutations in specific genes that destroy motor neurons and thereby cause the devastating effects of amyotrophic lateral sclerosis-- also known as ALS or Lou Gehrig's disease -- also attack sensory neurons. The discovery in today's Scientific Reports indicates that studying sensory neurons could provide new mechanistic insights to prevent, slow, or even reverse ALS. (2018-11-08)

Research provides important insight on the brain-body connection
A study conducted by University of Arkansas researchers reveals that neurons in the motor cortex exhibit an unexpected division of labor, a finding that could help scientists understand how the brain controls the body and provide insight on certain neurological disorders. (2019-04-18)

Light-activated neurons from stem cells restore function to paralyzed muscles
A new way to artificially control muscles using light, with the potential to restore function to muscles paralysed by conditions such as motor neuron disease and spinal cord injury, has been developed by scientists at UCL and King's College London. (2014-04-04)

Research uncovers gene network that regulates motor neuron formation during embryonic development
UCLA researchers have discovered the inner workings of a gene network that regulates the development of spinal motor neurons in the growing chicken and mouse embryo. The research also answers a long-standing question about why motor neurons, the nerve cells of the spinal cord that control muscle movement, form much faster than other types of neurons. (2018-02-01)

Marine snail's neural network sheds light on the basis for flexible behavior
From snail to man, one of the hallmarks of the brain is the ease with which behavioral variants are generated--for example, humans can easily walk with different stride lengths or different speeds. By studying how a relatively simple motor network of the marine snail Aplysia produces variants of a particular feeding behavior, researchers have found that the ability to generate a large number of behavioral variants stems from the elegant hierarchical architecture of the brain's motor network. (2005-10-10)

Functional motor neuron subtypes generated from embryonic stem cells
Scientists have devised a method for coaxing mouse embryonic stem cells into forming a highly specific motor neuron subtype. The research, published by Cell Press in the Sept. 3 issue of the journal Cell Stem Cell, provides new insight into motor neuron differentiation and may prove useful for devising and testing future therapies for motor neuron diseases. (2010-09-02)

Disease progression halted in rat model of Lou Gehrig's disease
Amyotrophic lateral sclerosis is an incurable adult neurodegenerative disorder that progresses to paralysis and death. Genetic mutations cause ALS in five percent of patients. In a rat model of ALS linked to mutations in the gene that templates the protein TDP-43, researchers have found it is possible to halt the progressive neuron degeneration that causes paralysis and death. (2011-12-12)

Stem cell discovery gives insight into motor neurone disease
A discovery using stem cells from a patient with motor neurone disease could help research into treatments for the condition. The study used a patient's skin cells to create motor neurons - nerve cells that control muscle activity - and the cells that support them called astrocytes. (2013-02-11)

Finding clues for nerve cell repair
A new study at the Montreal Neurological Institute at McGill University identifies a key mechanism for the normal development of motor nerve cells (motor neurons) -- cells that control muscles. This finding is crucial to understanding and treating a range of conditions involving nerve cell loss or damage, from spinal cord injury to neurodegenerative diseases such as ALS, also known as Lou Gehrig's disease. (2008-06-03)

Stem cells provide information about neuron resilience in ALS
Researchers at Karolinska Institutet in Sweden have developed a stem cell based model in order to study the resilience and vulnerability of neurons in the neurodegenerative disease ALS. The results are published in the journal Stem Cell Reports and can aid in the identification of new genetic targets for treatments protecting sensitive neurons. (2019-05-09)

Damaged motor neurons in ALS contribute to their own death
Researchers from the Ludwig Institute and the University of California, San Diego, School of Medicine have discovered that when motor neurons damaged by amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, inappropriately send the wrong signal, immune cells react by killing the messenger. Their surprising finding provides new direction for therapies to treat ALS. (2007-04-23)

Initial protective role of nervous system's 'star-shaped cells' in sporadic motor neuron disease uncovered
Support cells in the nervous system help protect motor neurons in the early-stages of sporadic motor neuron disease, according to new research from the Crick and UCL. (2020-02-10)

Loss of MHCI in motor neurons leads to ALS astrocyte toxicity
Until recently, the role of astrocytes, glial cells that normally support motor neurons, in motor neuron death has been a mystery, but new research sheds light on molecular mechanisms responsible for motor neuron death in ALS. In this study, scientists demonstrated the explicit loss of major histocompatibility complex I (MHCI) expression in the outer membrane of motor neurons in ALS, leading to motor neuron vulnerability to ALS astrocyte toxicity. (2016-02-29)

Stem cell transplantation benefits mice with childhood motor neuron disease
The motor neuron disease spinal muscular atrophy (SMA) is the second most common genetic disorder leading to death in childhood. There is currently no cure for SMA, but some clinicians and researchers consider stem cell transplantation as a potential therapeutic strategy. And now, work using a mouse model of SMA suggests that spinal cord neural stem cells might be a possible treatment for individuals with SMA. (2008-09-02)

Targeting upper motor neurons to treat ALS
Scientists have demonstrated for the first time that it is possible to specifically modify gene expression in diseased upper motor neurons, brain cells that break down in ALS. The provides evidence that lays a foundation for developing future gene replacement therapies to treat patients with the fatal neuromuscular disorder. (2016-02-01)

Synaptic disorder
A Würzburg research team describes a hitherto unknown pathogenic mechanism of motor neuron disorders. This should lead to a rethinking in drug development. (2017-11-02)

Our elegant brain: Motor learning in the fast lane
Researchers at McGill University have discovered that to learn new motor skills, neurons within the cerebellum engage in elegant, virtually mathematical, computations to quickly compare expected and actual sensory feedback. They then quickly readjust, changing the strength of connections between other neurons to form new patterns in the brain in order to accomplish the task at hand. (2015-08-03)

Neon exposes hidden ALS cells
A small group of neurons in the cortex play a big role in ALS (amyotrophic lateral sclerosis), a fatal disease. But the neurons have been difficult to study because they look so similar to others in the cortex. New research has isolated the brain's motor neurons that die in ALS and dressed them in a green fluorescent jacket. Now scientists can easily find them to study why they die and how to save them. (2013-04-30)

ALS research suggests stem cells be 'aged' to speed progress toward finding treatments
Cedars-Sinai scientists are seeking to build an improved stem-cell model of amyotrophic lateral sclerosis (ALS) to accelerate progress toward a cure for the devastating neurological disorder. Their findings demonstrate that current models can be enhanced by the aging of motor neurons to show how ALS damages cells later in life. (2016-07-19)

Why upper motor neurons degenerate in ALS
Scientists have revealed a mechanism underlying the cellular degeneration of the upper motor neurons that die in ALS, and developed a model system that will allow further research on the degeneration. (2015-01-28)

Researchers describe new ALS biomarkers, potential new drug targets
Researchers at the University of Illinois at Chicago have described unique populations of neurons and associated cells in the spinal cords of patients who died of ALS. (2019-07-15)

News tips from the Journal of Neuroscience
Highlights from the current issue include: Silencing cell-cycle reentry in postmitotic neurons; Monosynaptic whisker control in the rat; and Antidepressant responsiveness and 5-HT synthesis. (2005-09-06)

ALS neuron damage reversed with new compound
Scientists have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to ALS (amyotrophic lateral sclerosis), a swift and fatal neurodegenerative disease that paralyzes its victims. In ALS, movement-initiating nerve cells in the brain and muscle-controlling nerve cells in the spinal cord die. After administering the new compound,, the diseased brain neurons stopped degenerating so much that they became similar to healthy control neurons after 60 days of treatment. (2021-02-23)

New insights into brain circuit for hunger responses during starvation
Nagoya University-led researchers showed that hunger-driven neural signaling in the hypothalamus activates inhibitory reticular neurons in the medulla oblongata to reduce metabolism and promote feeding and chewing under starving conditions. Abnormal activation of these medullary reticular neurons may promote pathological changes leading to obesity. (2017-01-25)

A new development in the relief of spasms related to amyotrophic lateral sclerosis
A team of researchers from Strasbourg, directed by Luc Dupuis, have recently discovered the origin of spasms - a disabling symptom of amyotrophic lateral sclerosis. The degeneration of serotonin-releasing neurons is responsible for these sensations. In the longer term, researchers imagine that molecules acting on serotonin receptors present in the brain could eliminate spasticity in patients. (2012-11-06)

Stem cell therapy rescues motor neurons in ALS model
In a study that demonstrates the promise of cell-based therapies for diseases that have proved intractable to modern medicine, a team of scientists from the University of Wisconsin-Madison has shown it is possible to rescue the dying neurons characteristic of amyotrophic lateral sclerosis, a fatal neuromuscular disorder also known as Lou Gehrig's disease. (2007-07-31)

Stem cell-derived dopaminergic neurons rescue motor defects in Parkinsonian monkeys
In this issue of the Journal of Clinical Investigation, researchers led by Takuya Hayashi at the RIKEN Center for Molecular Imaging Science in Kobe, Japan, derived dopaminergic neurons from bone marrow stem cells in monkeys. (2012-12-03)

Neuronal circuits for fine motor skills
Writing, driving a screw or throwing darts are only some of the activities that demand a high level of skill. How the brain masters such exquisite movements has now been described in the journal ''Nature'' by a team of researchers at the University of Basel and the Friedrich Miescher Institute for Biomedical Research. A map of brainstem circuits reveals which neurons control the fine motor skills of the arm and hand. (2021-01-06)

Researchers study healthy ALS neurons as way to understand resistance to the disease
Scientists have developed a stem-cell-based modeling system that identifies how some neurons are resistant to ALS -- a breakthrough that offers potential for battling neurodegeneration. (2019-06-25)

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