Muscle Current Events

Muscle Current Events, Muscle News Articles.
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Body builders aren't necessarily the strongest athletes
An increase in muscle size with exercise may not be directly related to an increase in muscle strength, according to a recent analysis of the literature. (2016-11-03)

MicroRNAs, alternative splicing and the muscle proteome
As reported in the January 1 issue of G&D, a UCLA research team led by Dr. Douglas Black has shown how microRNAs regulate alternative splicing during muscle development. (2006-12-31)

New mechanism controlling proper organization of the muscle contractile units indentified
Muscle-specific protein cofilin-2 controls the length of actin filaments in muscle cells. (2014-11-07)

Preventing muscle atrophy
Dr. Stephen Burden and colleagues demonstrate that the DNA-binding protein, Runx1 (AML1), directs the expression of 29 genes involved in the prevention of skeletal muscle wasting. (2005-07-14)

Don't move a muscle: Evolutionary insight into myogenesis
In a paper released online ahead of its scheduled December 15 publication date, Dr. Michael Krause (NIH) and colleagues detail the transcription network that drives muscle development in the roundworm C. elegans, and make a strong argument for an evolutionarily conserved program of myogenesis in all animals. (2006-12-06)

Not all muscle building supplements are equal
Popular muscle building supplements, known as branched-chain amino acids (BCAA) are ineffective when taken in isolation, according to new research from the University of Stirling. (2017-07-14)

Zebrafish study yields observation of muscle formation
In this month's issue of the journal Developmental Cell, Clarissa Henry, assistant professor in the University of Maine Dept. of Biological Sciences, reports findings from a study of muscle cell development in zebrafish embryos. Looking at the formation of two types of muscle fibers, Henry and co-author Sharon L. Amacher of the University of California, Berkeley, describe a process regulated by a gene known as Hedgehog. (2004-12-06)

Human muscle-derived stem cells effective in animal models of incontinence
Human muscle-derived cells, pluripotent stem cells found in muscle, have been used to cure stress urinary incontinence in animal models, a finding which signals that these cells are prime candidates to treat the condition in adults. The research will be presented by University of Pittsburgh researchers at the annual meeting of the International Continence Society Aug. 29 through Sept. 2 in Montreal. (2005-08-31)

New tool enhances view of muscles
Simon Fraser University researcher James Wakeling is adding to the arsenal of increasingly sophisticated medical imaging tools with a new signal-processing method for viewing muscle activation details never seen before. His novel method using ultrasound imaging, 3D motion-capture technology and proprietary data-processing software can scan and capture 3D maps of the muscle structure in just 90 seconds. Previous methods took 15 minutes -- far too long to ask people to hold a muscle contraction. (2012-01-23)

Massage could be used to aid recovery of damaged limbs
Massage could increase the regrowth of muscle after muscle loss, according to new research published in The Journal of Physiology. The researchers showed that muscle grew faster after a massage because protein manufacture in cells was improved, and that when one leg was massaged, the other non-massaged leg also grew faster. (2017-10-31)

Researchers see promising results in treating age-related decline in muscle mass and power
A proof-of-concept, phase 2 trial by an international research team has found promising results for a myostatin antibody in treating the decline in muscle mass and power associated with aging. (2015-12-28)

Key finding in rare muscle disease
A group of researchers has discovered a number of children suffering from rare muscle diseases whose bodies have (2007-01-17)

p62 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein in muscle
Regular exercise prevents oxidative stress-induced muscle wasting, at least partially by improving the antioxidant defense system. In the present study, we found that regular endurance exercise enhances the expression of p62/SQSTM1 (p62) and its phosphorylation at Ser 351 thereby dissociating nuclear factor erythroid 2-related factor 2 (Nrf2) from Keap1, which results in increased Nrf2 nuclear translocation and DNA binding activity. These findings suggest that Ser 351 phosphorylation of p62 plays a critical role in this regulation. (2019-04-25)

Muscle damage may be present in some patients taking statins
Structural muscle damage may be present in patients who have statin-associated muscle complaints, found a new study in CMAJ. (2009-07-06)

Ultrasound-estimated fat content in muscles may be an indicator of physical health
Ultrasound-estimated percent intramuscular fat of muscles in the lower extremity was inversely associated with physical activity level and positively associated with body mass index in a recent study. (2016-05-03)

Muscling in on the role of vitamin D
A recent study conducted at the Westmead Institute for Medical Research has shed light on the role of vitamin D in muscle cells. The study looked at the role of vitamin D in muscles in mice, and showed that vitamin D signaling (how cells communicate with one another) is needed for normal muscle size and strength. (2019-06-25)

Less muscle wasting in obese people in intensive care may mean they have a better chance of survival
Further evidence that obese people who are seriously ill could have a better chance of survival than their normal weight counterparts is presented at this year's European Congress on Obesity in Vienna, Austria (May 23-26). (2018-05-24)

Researchers characterize important regulators of tissue inflammation, fibrosis and regeneration
Although macrophages (cells involved in the detection and destruction of bacteria and other harmful organisms as well as dead cells) are classified as immune cells functioning in the activation and resolution of tissue inflammation, it is now clear that they are critically involved in a variety of disease processes, such as chronic inflammatory diseases, tumor growth and metastasis and tissue fibrosis. (2020-08-10)

New method to grow and transplant muscle stem cells holds promise for treatment of MD
Satellite cells are stem cells found in skeletal muscles. While transplantation of such muscle stem cells can be a potent therapy for degenerative muscle diseases such as Duchenne muscular dystrophy, these cells tend to lose their transplantation efficiency when cultured in vitro. In a study in the current issue of the Journal of Neuromuscular Diseases, researchers treated these stem cells with leukemia inhibitory factor, which effectively maintained the undifferentiated state of the satellite cells and enhanced their transplantation efficiency. (2016-06-28)

Stem cells get a workout
Muscular dystrophies are characterized by severe muscle damage, ultimately through the loss of the ability to regenerate muscle. In the July 15 issue of the Journal of Clinical Investigation, researchers from the University of Milan present a technique that reduced muscle damage, alleviated the muscular dystrophy symptoms, and restored the cellular pool required for muscle regeneration in a mouse muscular dystrophy model. This study provides new leads in the treatment of these debilitating muscle diseases. (2004-07-15)

Treatment stimulates growth and regeneration of injured adult skeletal muscle
Scientists have discovered that a group of chemicals known as Histone Deacetylase (HDAC) inhibitors stimulate growth and regeneration of adult skeletal muscle cells by increasing expression of the protein follistatin. The research may provide new avenues for developing effective means to promote regeneration in muscular dystrophies. The functional link between HDAC inhibitors, follistatin, and adult muscle regeneration is especially provocative as an HDAC inhibitor is already being used clinically in humans as an anti-cancer therapeutic. (2004-05-10)

Cell transplants may improve severe urinary incontinence
Severe urinary incontinence can be caused by urethral sphincter muscle deficiency, often associated with trauma during childbirth, prostate surgery, or aging. When skeletal myoblasts -- progenitor muscle cells with the potential to develop into muscle fiber -- were transplanted into female rats suffering from urethral sphincter deficiency, transplanted muscle cells helped increase urethral pressure, improving incontinence. Implanting myoblasts could be a potential innovative therapy for urethral deficiencies that lead to human incontinence. (2007-11-13)

Protein illustrates muscle damage: McMaster researchers
Regardless of the way in which muscle was damaged, either through trauma or disease, Xin was strongly correlated to the degree of damage. (2013-11-11)

Poor thigh muscle strength may increase women's risk of knee osteoarthritis
A new study has found that poor strength in the thigh muscles may increase the risk of knee osteoarthritis in women but not men. This relationship was confounded by body mass index (BMI), which itself is known as a risk factor for knee osteoarthritis. (2017-02-08)

Dynamic sonography accurate in diagnosing muscle tears
Dynamic sonography is useful in the diagnosis, management and follow-up of muscle tears and hematomas, according to a recent study conducted by researchers from Khoula Hospital in Muscat, Oman. (2007-05-24)

A step closer to muscle regeneration
Muscle cell therapy to treat some degenerative diseases, including Muscular Dystrophy, could be a more realistic clinical possibility, now that scientists have found a way to isolate muscle cells from embryonic tissue. (2013-12-09)

Ca2+, the intercellular signal in arterioles
Ca2+ entry into vascular smooth muscle activates Ca2+ signaling in the endothelium to protect tissue blood flow. (2017-07-04)

Cardiac muscle really knows how to relax: Potential cardio-protective mechanism in heart
New insight into the physiology of cardiac muscle may lead to the development of therapeutic strategies that exploit an inherent protective state of the heart. The research, published by Cell Press online on April 19 in the Biophysical Journal, discovers a state of cardiac muscle that exhibits a low metabolic rate and may help to regulate energy use and promote efficiency in this hard-working and vital organ. (2011-04-19)

Crucial role for molecule in muscle development
Research led by the University of East Anglia has discovered the crucial role of a molecule in skeletal muscle development. (2011-07-04)

Skeletal muscle cells could be source of stem cells for regenerating nerve tissue
Cells from skeletal muscle could be an important source of stem cells for repairing damaged muscle or nerve tissue, suggest authors of a research article in this week's issue of The Lancet. (2004-11-18)

One or the other: Why strength training might come at the expense of endurance muscles
The neurotransmitter brain-derived neurotrophic factor (BDNF) acts in the muscle, so that during strength training endurance muscle fiber number is decreased. Researchers at the University of Basel's Biozentrum have more closely investigated this factor, from the group of myokines, and demonstrated that it is produced by the muscle and acts on both muscles and synapses. The results published in PNAS also provide new insights into age-related muscle atrophy. (2019-07-25)

How work tells muscles to grow
We take it for granted, but the fact that our muscles grow when we work them makes them rather unique. Now, researchers have identified a key ingredient needed for that bulking up to take place. A factor produced in working muscle fibers apparently tells surrounding muscle stem cell (2012-01-03)

Stem cells may be the key to staying strong in old age
A new URMC study, performed in mice, could lead to new approaches to help people stay stronger in old age. The study challenges conventional wisdom with results suggesting that loss of muscle stem cells is the main driving force behind muscle decline in old age. (2017-06-06)

Heart derived stem cells develop into heart muscle
Dutch researchers at University Medical Center Utrecht and the Hubrecht Institute have succeeded in growing large numbers of stem cells from adult human hearts into new heart muscle cells. A breakthrough in stem cell research. Until now, it was necessary to use embryonic stem cells to make this happen. The findings are published in the latest issue of the journal Stem Cell Research. (2008-04-23)

Promoting muscle regeneration in a mouse model of muscular dystrophy
In this issue of the Journal of Clinical Investigation, researchers led by Anton Bennett at Yale University identified the protein MKP-5 as a negative regulator of muscle regeneration. (2013-04-01)

U of MN researchers develop mouse model for muscle disease
Researchers from the University of Minnesota have identified the importance of a gene critical to normal muscle function, resulting in a new mouse model for a poorly understood muscle disease in humans. (2006-09-05)

Muscle aging: Stronger for longer
With life expectancy increasing, age-related diseases are also on the rise, including sarcopenia, the loss of muscle mass due to aging. Researchers from the University of Basel's Biozentrum have demonstrated that a well-known drug can delay the progression of age-related muscle weakness. (2020-09-09)

0.6% soy isoflavone in the diet decrease muscle atrophy
Scientists at Tokyo Institute of Technology (Tokyo Tech) have discovered a means of reducing muscle atrophy by the addition of the soy-derived isoflavone aglycone (AglyMax) to the diet of mice. This attenuation by soy isoflavone is attributable to block the apoptosis-dependent pathway in muscle fiber. The AglyMax supplement also anticipate to attenuate age-related muscle loss, sarcopenia. (2018-01-18)

Basis of development of vertebrate limb muscles has been established in cartilaginous fishes
Scientists at Tokyo Institute of Technology (Tokyo Tech) have discovered that both bony and cartilaginous fish develop their appendages via a shared mechanism -- the mechanism is also observed in land-dwelling vertebrates such as mice. They found the fin muscles of cartilaginous are formed by muscle precursors expressing Lbx1 expression, a gene that coordinates limb-muscle formation. This work revisits some related evolutionary hypotheses using a molecular biology approach and provides new insights. (2017-10-02)

Brief exposure to performance-enhancing drugs may be permanently 'remembered' by muscles
Brief exposure to anabolic steroids may have long lasting, possibly permanent, performance-enhancing effects, shows a study published today [28 October] in The Journal of Physiology. (2013-10-27)

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