Narcolepsy Current Events

Narcolepsy Current Events, Narcolepsy News Articles.
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Sleeping dogs lend a paw to narcoleptics
Give a treat to a narcoleptic dog, and he's likely to pass out with excitement - an endearingly pitiful sight. However, such canines are helping scientists understand human narcolepsy and sleep control. In the April issue of Genome Research, Emmanuel Mignot and colleagues from Stanford University Medical Center shed light on the brain defects that lead to canine narcolepsy. (2001-03-14)

Immune system turns on the body in narcolepsy
It is thought that the sleep disorder narcolepsy is an autoimmune disorder -- that is, it is caused by the individual's immune system attacking certain cells in the body -- but this had not been proven definitively. But now, researchers have now identified autoantibodies (immune molecules that target a natural protein in the body rather than a protein from an infectious agent) in narcolepsy patients. (2010-02-15)

New Drug Tested at UIC Effectively Treats Narcolepsy
University of Illinois at Chicago researchers and those at 20 other sites have found that a new drug helps narcolepsy patients stay awake without being a stimulant. UIC's Center for Narcolepsy Research participated in a trial of Modafinil, the first new drug treatment to be developed for narcolepsy in 30 years. (1996-07-18)

Narcolepsy more common in men, often originates in their 20s
A Mayo Clinic study reports that narcolepsy, a sleep disorder, is more common in men and originates in their 20s. (2002-04-24)

Mutation links inherited narcolepsy with multiple neuropsychiatric disorders
Now, a new study published by Cell Press on Sept. 8 in the American Journal of Human Genetics uncovers a mutation that causes narcolepsy in a large family affected by the disorder. The research sheds new light on the genetics of inherited narcolepsy and provides intriguing insight into other complex neuropsychiatric disorders. (2011-09-08)

Journal Sleep: Narcolepsy may be caused by environmental exposures
A comprehensive review published in the Jan. 1 issue of the journal Sleep finds that, as with other diseases characterized by selective cell loss, narcolepsy may be caused by environmental exposures before the age of onset in genetically susceptible individuals. (2007-01-01)

A wakefulness molecule is abundant in the brains of heroin addicts
Researchers have discovered that the brains of heroin addicts harbor a greater number of neurons that produce hypocretin, a molecule involved in arousal and wakefulness, and one lacking in abundance in people with narcolepsy. In mice with narcolepsy, these researchers went on to show, administering morphine -- an opioid similar. (2018-06-27)

Anti-swine flu vaccination linked to increased risk of narcolepsy in young adults
Pandemrix is an influenza vaccination, created in 2009 to combat H1N1, known as Swine Flu. Now, a team of Swedish clinicians testing the vaccine for links to immune-related or neurological diseases have linked Pandemrix to an increased risk of narcolepsy in young adults. (2014-01-21)

Another step towards understanding the causes of narcolepsy
Results of a preliminary study in this week's issue of The Lancet suggest a step forward in our understanding of the processes behind narcolepsy; there appears to be an underlying autoimmune process for people with a certain genetic profile. Future diagnostic testing of people with this profile should lead to substantial improvements in disease treatment. (2004-12-09)

Persons with narcolepsy with cataplexy have low levels of CSF hypocretin-1
Persons with narcolepsy with cataplexy have low levels of cerebrospinal fluid hypocretin-1, a protein thought to help regulate sleep and wakefulness. (2007-08-01)

Statement on discovery of the gene for narcolepsy in dogs
The significance of the discovery of the gene for narcolepsy in dogs is discussed in a statement from the directors of the National Institute of Neurological Disorders and Stroke and the National Heart, Lung, and Blood Institute at the National Institutes of Health. (1999-08-05)

Marijuana use is associated with excessive daytime sleepiness in adolescents
Ten percent of adolescents sent to a Sleep Center for evaluation of excessive daytime sleepiness with testing results consistent with narcolepsy had urine drug screens positive for marijuana -- 43 percent of children with urine drug screens positive for marijuana actually had test results consistent with narcolepsy or abnormal REM sleep patterns. (2015-02-13)

New proof that narcolepsy is an autoimmune disease
Researchers from the University of Copenhagen have discovered autoreactive cells in persons suffering from narcolepsy. This is a new, important proof that the sleep disorder is an autoimmune disease. This knowledge may lead to better treatment of the chronic condition, the researchers behind the new discovery believe. (2019-03-15)

Increased risk of sleep disorder in children who received swine flu vaccine
A study published on bmj.com today finds an increased risk of narcolepsy in children and adolescents who received the A/H1N1 2009 influenza vaccine (Pandemrix) during the pandemic in England. (2013-02-26)

Lower metabolism, eating behavior possibly explain the cause of overweight in narcolepsy
A lower metabolism, as well as slight changes in eating behavior, could explain the positive energy balance leading to being overweight in narcolepsy. (2007-10-01)

Study supports a causal role in narcolepsy for a common genetic variant
A new study conducted across Europe found an extraordinary association between narcolepsy and a specific gene variant related to the immune system. (2014-01-02)

Narcoleptics have a high frequency of REM sleep without atonia
Persons with narcolepsy have a high frequency of REM sleep without atonia and of elevated EMG phasic density, according to a study published in the July 1 issue of the journal Sleep. (2007-07-03)

A low expression of MX2 gene exists in the white blood cells of narcoleptics
The first report to identify the biological markers of narcolepsy using gene expression in white blood cells finds that the MX2 gene, which is relevant to the immune system, is significantly less expressed in narcoleptics compared with normal subjects. This underlies the abnormalities in the blood cells of persons suffering from narcolepsy. (2007-08-01)

New study in the journal Sleep finds a high prevalence of eating disorders in narcoleptics
The majority of patients with narcolepsy/cataplexy experience a number of symptoms of eating disorders, with an irresistible craving for food and binge eating as the most prominent features. (2008-03-01)

Potential dangers faced by narcoleptics who use nicotine outlined in new abstract
This research abstract provides the first description of nicotine use by narcolepsy patients. Because people with narcolepsy can fall asleep suddenly and without warning, even while eating, walking or driving, those who smoke nicotine in bed are at a high risk of burning either themselves or the objects around them, or starting a fire, if they fall asleep. Further, the excessive sleepiness brought on by their narcolepsy may also complicate any attempt by them to quit the habit of nicotine use. (2008-06-09)

Narcolepsy study finds surprising increase in neurons that produce histamine
A new study provides surprising evidence that people with narcolepsy have an increased number of neurons that produce histamine, suggesting that histamine signaling may be a novel therapeutic target for this potentially disabling sleep disorder. (2013-06-02)

Inducing non-REM sleep in mice by novel optogenetical control technique
Associate Professor Akihiro YAMANAKA from National Institute for Physiological Sciences (NIPS), succeeded in suppressing only the activity of the orexin neurons in the mice's brains (hypothalamus) when the optical switch was on, using the light-activated protein, halorhodopsin (eNpHR). Those mice fell into non-REM sleep (slow-wave sleep) only when the halorhodopsin-expressed orexin neurons were exposed to the light. It is reported in the Journal of Neuroscience published by the Society for Neuroscience. (2011-07-20)

Scientists pinpoint possible cause for debilitating sleep disorder narcolepsy
Scientists believe they may have identified the cause of the debilitating sleep disorder narcolepsy in humans. A new study shows a dramatic reduction -- up to 95 percent -- in the number of neurons containing a substance called hypocretins in the brains of people with narcolepsy compared to control brains. (2000-08-28)

The Lancet Neurology press release
Is mobile phone use a health risk? Mobile phone ( (2002-07-31)

Wake-promoting compound validated
Narcolepsy, a serious sleep disorder in which patients often fall asleep uncontrollably, has been incurable because no effective therapeutic agents are available to date. Recent findings by Japanese scientists in the sleep institute may shed light on this challenging problem. (2017-05-29)

Modafinil Improves The Quality Of Life Of Narcolepsy Patients
Modafinil, an experimental, wake-promoting drug, has been shown to provide clinically meaningful health-related quality-of-life benefits and maintains this improvement over an extended period, without the debilitating side effects of other drugs, according to a University of Michigan researcher. (1998-06-23)

How the brain paralyzes you while you sleep
Researchers from the University of Tsukuba have discovered a group of neurons in the mouse brainstem that control muscle tone. Inhibiting these neuronal cells caused mice to move during REM sleep, reminiscent of REM sleep behavior disorders. These neurons were also responsible for episodes of cataplexy in a mouse model of narcolepsy; inhibiting them reduced the number of cataplexic bouts. These circuits could thus be a new target for treating these sleep disorders. (2021-01-14)

Narcolepsy is an autoimmune disorder, Stanford researcher says
Ten years ago, Stanford University School of Medicine scientist Emmanuel Mignot, M.D., Ph.D., and his colleagues made headlines when they identified the culprit behind the sleep disorder narcolepsy. Now Mignot and his collaborators have shown for the first time that a specific immune cell is involved in the disorder -- confirming experts' long-held suspicion that narcolepsy is an autoimmune disease. (2009-05-03)

Yale researcher receives $1.4 million grant to study the hypocretin cells involved in narcolepsy
A Yale researcher has received a $1.4 million grant to study a neurotransmitter whose loss in the brain is believed responsible for narcolepsy, an often misunderstood disease marked by an uncontrollable desire to sleep. (2002-02-07)

A peptide whose absence leads to narcolepsy also might play role in pain sensation
A neuropeptide whose loss is believed responsible for narcolepsy, a disease characterized by sudden sleep attacks, also appears to play a role in the modulation of pain sensation, a study by a Yale researcher has found. (2002-02-01)

Many teens with clinical excessive daytime sleepiness test positive for marijuana
A new study shows that many adolescents with excessive daytime sleepiness consistent with a clinical diagnosis of narcolepsy test positive for marijuana, emphasizing the importance of drug screening when interpreting diagnostic sleep studies for teens. (2015-02-18)

Changes in narcoleptics' skin, core body temperatures affect their vigilance and sleepiness
Among those suffering from narcolepsy, direct manipulations of their skin and core body temperatures affect their vigilance and sleepiness. (2008-02-01)

'Dissecting sleep' by studying the strange phenomenon of cataplexy
Measuring brain cell activity in dogs with a genetic form of narcolepsy, neurobiologists Jerome Siegel and his colleagues have presented evidence that wakefulness is maintained by the activity of neurons triggered by the neurotransmitter histamine. The discovery will be appreciated by anyone in whom antihistamines in allergy or over-the-counter sleep drugs cause drowsiness. (2004-05-26)

Feeling sleepy? Let me look into your eyes
Under a $1.52 million grant from the National Institutes of Health/National Institute of Nursing, UIC researchers are investigating the feasibility of using a measure of pupil size as a means of objectively diagnosing sleep disorders like narcolepsy and sleep apnea. (2000-07-10)

UCLA researchers find new clue to cause of human narcolepsy
UCLA researchers have found that an excess number of brain cells that produce the chemical histamine may cause the loss of other cells that produce hypocretin, the neuropeptide that keeps us awake, elevates mood and alertness, and, by their absence, explains the sleepiness of narcolepsy. (2013-07-02)

Yale sponsors 15th Annual Meeting of the Northeastern Sleep Society, titled 'Health Consequences of Sleep Disorders'
The latest advances in treatments for sleep disorders such as sleep apnea, narcolepsy and insomnia will be discussed at the 15th Annual Meeting of the Northeastern Sleep Society. (2001-03-26)

UCLA researchers discover link between Parkinson's and narcolepsy
UCLA researchers have found that Parkinson's disease patients have severe damage to the same small group of neurons whose loss causes narcolepsy. The findings suggest a different clinical course of treatment for people suffering with Parkinson's that may ameliorate their sleep symptoms. (2007-05-11)

Stanford study draws connection between narcolepsy and influenza
The onset of narcolepsy appears to follow seasonal patterns of H1N1 and other upper airway infections, according to a new study of patients in China that was led by Stanford University School of Medicine narcolepsy expert Emmanuel Mignot, M.D. (2011-08-22)

Study finds narcolepsy cases in China peak in early spring
New research shows that the occurrence of narcolepsy in China is highly correlated to a seasonal pattern, with onset most frequent in April. A significant increase in narcolepsy cases was also observed following the 2009-2010 H1N1 pandemic, but the findings now available in Annals of Neurology, a journal of the American Neurological Association and the Child Neurology Society, report flu vaccination was unlikely the cause of the increase. (2011-08-22)

Why narcoleptics get fat
People with narcolepsy are not only excessively sleepy, but they are also prone to gaining weight. In fact, narcoleptic patients will often pack on pounds even as they eat considerably less than your average person. Now researchers reporting in the October issue of Cell Metabolism, a Cell Press publication, appear to have an answer as to why. It seems a deficiency of the neuropeptide hormone orexin, an ingredient that encourages hunger and wakefulness, may leave them with a lack of energy-burning brown fat. (2011-10-04)

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