Neuroblastoma Current Events

Neuroblastoma Current Events, Neuroblastoma News Articles.
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New gene found for a deadly childhood cancer offers possibility of targeted drug therapy
Neuroblastoma accounts for 15% of total childhood cancer deaths and survival rates of high-risk neuroblastoma patients is 50%. For the first time, Australian researchers from Children's Cancer Institute have discovered that a gene called JMJD6 plays an important role in the most aggressive form of the disease. The discovery opens up a new way to treat neuroblastoma, using drugs that target this gene. (2019-07-26)

Promising treatment for aggressive childhood cancer
A drug has shown great promise in the treatment of neuroblastoma, an aggressive form of childhood cancer. The study was led by researchers at Lund University in Sweden, and is published in the journal Science Translational Medicine. (2020-10-06)

Research sheds important light on the metastasis of neuroblastoma
Research sheds important light on the metastasis of neuroblastoma. (2019-12-10)

New therapeutic target for most common solid cancer in childhood?
New research, to be published in the Journal of Clinical Investigation, has identified the protein NT-3 and the cell-surface molecule to which it binds (TrkC) as potential therapeutic targets for the treatment of neuroblastoma -- the most frequent solid tumor in young children. (2010-02-15)

Internationally known neuroblastoma expert reviews progress versus challenging childhood cancer
Pediatric oncologist John M. Maris, M.D., describes the current state of the science in combating neuroblastoma, the most common solid cancer of early childhood. In his article in the June 10 New England Journal of Medicine, Maris reviews the field's latest research knowledge -- much of it based on efforts by Maris and his colleagues at the Children's Hospital of Philadelphia. (2010-06-14)

Zika viruses show potential as treatment for high-risk childhood cancer
Zika virus may hold potential as a cancer treatment for neuroblastoma, a rare-but-deadly childhood cancer, according to early findings from basic research published today in PLOS ONE. (2018-07-25)

Early trial hints CAR T cells may combat solid tumors in children with neuroblastoma
A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue. (2020-11-25)

A step forward in the struggle against neuroblastoma, a type of childhood cancer
A protein called CD44 makes it possible to identify the population of mother cells that are responsible for the aggressive nature and low survival rate of neuroblastoma, a type of childhood cancer that mainly affects children of two and three years old. (2019-11-27)

VRK1: a protein that reduces the survival of patients with neuroblastoma
Researchers have characterised the function of VRK1 in neuroblastoma tumour cells and have determined that this protein is essential for tumour cell growth and proliferation. ''By studying the expression of this protein in tumours, we were able to identify a priori patients where tumour progression is going to be worse, even in groups where current tools do not predict that behaviour,'' notes Francisco M. Vega. (2020-12-11)

Alternative DNA repair mechanism could provide better treatment for neuroblastoma in kids
Targeting DNA repair pathways could provide new treatment options for children with high-risk cancer. (2015-01-21)

Nuclear protein causes neuroblastoma to become more aggressive
Aggressive forms of neuroblastoma contain a specific protein in their cells' nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery, made through research from the University of Rochester Medical Center, could lead to new forms of targeted therapy. (2016-10-06)

New research points to potential for more targeted treatments of neuroblastoma tumors
Genetic variations appear to pre-dispose children to developing certain severe forms of neuroblastoma, according to new research by the University of Chicago Medicine. The findings lay the groundwork for developing more targeted treatments for particularly deadly variations of the cancer. (2017-06-19)

Researchers identify gene that regulates tumors in neuroblastoma
Virginia Commonwealth University researchers have identified a gene that may play a key role in regulating tumor progression in neuroblastoma, a form of cancer usually found in young children. Scientists hope the finding could lead to an effective therapy to inhibit the expression of this gene. (2009-06-01)

CHLA awarded grant to study immunotherapy resistance in neuroblastoma
A team of investigators at Children's Hospital Los Angeles has received a major, three-year grant from the V Foundation for Cancer Research to study the effects of chemoimmunotherapy in children with neuroblastoma. (2016-10-18)

New DNA technique leads to a breakthrough in child cancer research
Researchers at the Sahlgrenska Academy at the University of Gothenburg, Sweden and Karolinska Institutet have used novel technology to reveal the different genetic patterns of neuroblastoma, an aggressive form of childhood cancer. This discovery may lead to significant advances in the treatment of this malignant disease, which mainly affects small children. (2010-02-22)

Chemokine receptor 4 gene silencing blocks neuroblastoma metastasis in vitro
Chemokine receptor 4 is a chemokine receptor that participates in tumor occurrence, growth and metastasis in vitro and its expression is upregulated during neuroblastoma metastasis. Dr. Xin Chen, the Affiliated Hospital of Qingdao University, China successfully constructed chemokine receptor 4 sequence-specific small interfering RNA plasmids, transfected into SH-SY5Y cells and found that down-regulation of chemokine receptor 4 can inhibit in vitro invasion of neuroblastoma. (2014-07-16)

Guardian of genome predicts treatment outcomes for childhood cancer
Researchers have identified a new role for a cancer-prevention gene in the response to drug treatment for childhood cancer. (2007-11-04)

New screening approach uncovers potential alternative drug therapies for neuroblastoma
Nearly two-thirds of patients with high-risk neuroblastoma -- a common tumor that forms in the nerve cells of children -- cannot be cured using tumor-killing cancer drugs. A study published in Chemistry & Biology reveals a new genomic approach to screen for compounds that inhibit tumor growth by causing cancer cells to differentiate. Using this screening method, the researchers identified a compound that causes neuroblastoma cells to differentiate, uncovering promising new treatment strategies. (2013-05-23)

Pediatric cancer charities partner to fund international collaborative research
Solving Kids' Cancer, along with UK-based charities Neuroblastoma Alliance UK, J-A-C-K, and other European organizations have aligned forces to improve access to promising clinical trials for children with high-risk neuroblastoma in North America, the UK and Europe. (2013-03-04)

Genetic finding could lead to targeted therapy for neuroblastoma
Researchers have identified a genetic glitch that could spur development of neuroblastoma, a deadly form of childhood cancer. (2009-06-24)

Drug therapy reduces neuroblastoma tumor growth in pre-clinical investigation
Researchers from the Children's Cancer Hospital at the University of Texas M. D. Anderson Cancer Center have discovered a new drug combination that significantly hinders tumor growth in neuroblastoma, a childhood cancer. The study was presented today at the 22nd Annual Meeting of the American Society of Pediatric Hematology/Oncology. (2009-04-24)

Biomarker associated with poor outcome in aggressive childhood cancer
Results from a new study identify a biomarker that may be useful for predicting the outcome of treatment for neuroblastoma, the most common cancer in young children. The research, published by Cell Press in the April 7 issue of the journal Cancer Cell, also provides new information about the molecular signals that are involved in the progression of this often devastating pediatric cancer. (2009-04-06)

A novel radioisotope therapy for children with neuroblastoma
Researchers from Kanazawa University retrospectively analyzed children with refractory or relapsed high-risk neuroblastoma who were treated with high-dose 131I-metaiodobenzylguanidine at Kanazawa University Hospital. They showed that within a 5-year period, this therapy could provide a favorable prognosis without severe non-hematological side effects. These findings could provide new insights into a novel treatment option for patients with high-risk neuroblastoma. (2020-06-19)

News brief: Antitumor activity of nutlin-3 in neuroblastoma with wild-type p53
The small-molecule inhibitor nutlin-3 may be a viable treatment option for neuroblastoma patients with wild-type p53 activity, according to a new study published online Nov. 10 in the Journal of the National Cancer Institute. (2009-11-10)

DNA method can provide more effective treatment of childhood cancer
After leukaemia and brain tumours, neuroblastoma is the most common form of cancer to affect children. A thesis from the Sahlgrenska Academy, University of Gothenburg, Sweden, has studied a DNA method which is now used for all cases of neuroblastoma in Sweden, and which has led to more effective treatment at individual level. (2012-10-15)

Researchers identify gene variants linked to a high-risk children's cancer
Pediatric researchers investigating the childhood cancer neuroblastoma have identified common gene variants that raise the risk of an aggressive form of that disease. The discovery may assist doctors in better diagnosing subtypes of neuroblastoma. (2017-09-25)

Researchers identify gene implicated in neuroblastoma, a childhood cancer
A new study by Mayo Clinic researchers has identified that a chromosome instability gene, USP24, is frequently missing in pediatric patients with neuroblastoma, an aggressive form of childhood cancer. The finding provides important insight into the development of this disease. The study is published in Cancer Research, the journal of the American Association for Cancer Research. (2021-02-17)

Genetic biomarker may help identify neuroblastomas vulnerable to novel class of drugs
An irregularity within many neuroblastoma cells may indicate whether the tumor is vulnerable to a new class of anti-cancer drugs known as BET bromodomain inhibitors. (2013-04-09)

Drug combination increases susceptibility to chemotherapy in cases of severe neuroblastoma
Researchers at the University of Gothenburg now suggest a possible cure for children with hard-to-treat forms of neuroblastoma using a new combination of drugs. In a new study in the journal Cancer Research, they describe how a two small molecule-based drug combination likely inhibit the tumor's growth. (2021-01-07)

Experiments could lead to new treatments for neuroblastoma
Based on cell-culture and animal experiments, researchers believe they've found a critical weakness in neuroblastoma -- one that could lead to the development of a lifesaving therapy for victims of the cancer. (2008-08-15)

Improved screening means new targets for pediatric neuroblastoma therapies
Neuroblastoma is one of the most common and lethal types of childhood cancers. In a paper published online today in OncoTarget, a researcher at the University of Texas Health Science Center at San Antonio unveils an improved screening technique that shows the important role of microRNAs in regulating neuroblastoma development, pointing to new therapeutic possibilities. (2014-03-01)

Removing the enablers: Reducing number of tumor-supporting cells to fight neuroblastoma
Investigators at the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages -- a type of immune cell -- can negatively affect the response to chemotherapy against neuroblastoma. Their findings suggest that combination therapy might be effective in patients with high-risk disease, even those who have limited anti-tumor T cell responses. (2018-04-23)

Drug inhibits neuroblastoma blood supply in pre-clinical tests
Researchers from the Children's Cancer Hospital at the University of Texas M. D. Anderson Cancer Center have found a way to prevent blood vessels from aiding the growth of neuroblastoma, a childhood cancer. The pre-clinical study was presented today in a platform session at the 22nd Annual Meeting of the American Society of Pediatric Hematology/Oncology. (2009-04-24)

Grant to CHOP funds personalized treatments for children with neuroblastoma
A new $1.5 million grant to The Children's Hospital of Philadelphia from Alex's Lemonade Stand Foundation supports an innovative approach to treating relapsed or refractory neuroblastoma, a high-risk childhood cancer. CHOP researchers are launching a pediatric clinical trial with a dynamic design allowing them to quickly incorporate new treatments by matching gene changes in an individual patient's tumor to available drugs. (2015-12-10)

Nanoparticles loaded with component of common spice kill cancer cells
Attaching curcumin, a component of the common spice turmeric, to nanoparticles can be used to target and destroy treatment-resistant neuroblastoma tumor cells, according to a new study published in Nanoscale. The study, conducted in partnership by researchers at Nemours Children's Hospital and the University of Central Florida, demonstrates a potentially novel treatment for neuroblastoma, the most common cancer in infants. (2017-07-25)

Major NH&MRC grant will fund multidisciplinary research to improve the treatment of neuroblastoma
Significant funding from the NH&MRC will enable researchers at Children's Cancer Institute Australia (CCIA) for Medical Research to make progress on the treatment of one the most aggressive, drug-resistant childhood cancers -- neuroblastoma -- over the next five years. (2005-07-27)

FDA orphan drug designation announced for childhood cancer vaccine
The US Food and Drug Administration granted orphan drug designation for a neuroblastoma vaccine from MabVax Therapeutics, providing development incentive with market exclusivity of the novel treatment for children with this deadly childhood cancer. (2014-10-06)

Maternal stress increases development of fetal neuroblastoma in animal model
While genetics play a substantial role in development of neuroblastoma, scientists say that something else is in play that elevates the risk: stress. Researchers have shown in mice genetically predisposed to develop neuroblastoma that maternal stress can push onset of the cancer. (2015-04-21)

Scientists find potential new target for treatment of pediatric cancer
Antonio Iavarone and colleagues at the Albert Einstein College of Medicine demonstrate how three proteins act together to produce uncontrolled cell proliferation in some cancers. These proteins -- Id, Rb, and Myc -- in effect, derail the cell cycle. (2000-10-03)

New insight into aggressive childhood cancer
A new study reveals critical molecular mechanisms associated with the development and progression of human neuroblastoma, the most common cancer in young children. The research, published by Cell Press in the Jan. 6 issue of the journal Cancer Cell, may lead to development of future strategies for treatment of this aggressive and unpredictable cancer. (2009-01-05)

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