Neutrophils Current Events

Neutrophils Current Events, Neutrophils News Articles.
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Frontline immune cells can travel for help
A new study shows that 'neutrophils,' cells which form the bulk of our fast-acting 'innate' immune system, behave differently, depending on whether an injury is infected or not. (2015-05-14)

Rogue blood cells may contribute to post-surgery organ damage
A study from scientists at Queen Mary, University of London, sheds new light on why people who experience serious trauma or go through major surgery, can suffer organ damage in parts of the body which are seemingly unconnected to the injury. (2011-06-26)

Immune study points to new ways to treat lung disease
Fresh insight into how the immune system keeps itself in check could lead to new ways of fighting chronic lung disease. (2017-08-14)

Neutrophils in rheumatoid arthritis: How to lessen inflammation but still fight infection
Neutrophils, which quickly congregate at the sites of infection and inflammation, are capable of ingesting microorganisms or other particles. In a study appearing in the June 15 version of the Journal of Clinical Investigation, researchers from INSERM in Paris examine neutrophils from the joint fluid of rheumatoid arthritis patients show how to prevent the exaggerated neutrophil response in inflammatory conditions like rheumatoid arthritis, yet still preserve the ability of neutrophils to fight infection. (2006-06-15)

UIC researchers have immune cells running in circles
Researchers at the University of Illinois at Chicago College of Medicine have identified the important role a protein plays in the body's first line of defense in directing immune cells called neutrophils toward the site of infection or injury. (2009-11-02)

Common denominator that triggers asthma in favorable environments
Some so-called pro-allergic environments strongly promote the development of asthma and are responsible for the dramatic increase in the prevalence of asthma, especially in industrialized countries. Researchers at the GIGA of the University of Liège have identified how all these pro-allergic environments act in the same way on the pulmonary immune system to induce the development of allergic asthma. (2019-10-07)

Escort service: The role of immune cells in the formation of metastases
Tumor cells use a certain type of immune cells, the so-called neutrophils, to enhance their ability to form metastases. Scientists have deciphered the mechanisms of this collaboration and found strategies for blocking them. This is reported by researchers from the University of Basel and the University Hospital of Basel in the scientific journal Nature. (2019-02-06)

Macrophages chase neutrophils away from wounds to resolve inflammation
Macrophages are best known for their Pac Man-like ability to gobble up cellular debris and pathogens in order to thwart infection. A new study describes how these immune cells also help resolve inflammation by inducing white blood cells called neutrophils to leave wounded tissue. (2014-12-08)

White blood cell 'waste disposal' system plays critical regulatory role
A new research study identifies a critical inhibitory step that is a key component of the feedback circuit regulating the balance between neutrophil production and destruction. The research suggests that the process for disposal of dying neutrophils is actively linked to neutrophil production. A clear understanding of the processes that control neutrophil turnover may contribute to the development of future therapeutics for conditions characterized by abnormal numbers of these critical immune cells. (2005-03-22)

Potential new treatment for kidney failure in cancer patients
Kidney dysfunction is a frequent complication affecting more than 50 percent of all cancer patients, and is directly linked to poor survival. Despite the high occurrence, it is still not clear how presence of a tumor contributes to kidney dysfunction and how this can be prevented. A new study from researchers at Uppsala University shows that kidney dysfunction can be caused by the patient's own immune system, 'tricked' by the tumor to become activated. (2017-04-25)

Experimental approach may improve healing of diabetic wounds and bed sores
Researchers are reporting on a promising new approach to treating diabetic wounds, bed sores, chronic ulcers and other slow-to-heal wounds. It may be possible to speed healing by suppressing certain immune system cells. (2011-02-08)

Protein preserves delicate balance between immune response and host
The immune system possesses a highly effective arsenal of cellular and chemical weapons that stand ready to defend us from harmful pathogens. However, these same mechanisms that are designed for protection can sometimes wreak havoc on our own body. Now, new research published by Cell Press in the Oct. 29 issue of the journal Immunity, provides insight into the mechanisms that regulate natural checks and balances that optimize the immune response against potential threats while preserving host tissues. (2010-10-28)

Cardiac repair: Neutrophils to the rescue
Following an acute heart attack, immune cells called neutrophils coordinate an inflammatory response which can exacerbate the damage to the organ. Now researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich have shown that neutrophils also promote cardiac repair. (2016-02-10)

Discarded immune cells induce the relocation of stem cells
The study reveals a surprising coordination between two fundamental body systems, the immune and the hematopoietic. The study has implications for the understanding of metastasis, because malignant stem cells involved in tumor formation could take advantage of this mechanism. (2013-05-23)

Blocking inflammation could lead to tailored medical treatments
By using a mouse model of inflammation researchers at the University of Calgary have discovered a new class of molecules that can inhibit the recruitment of some white blood cells to sites of inflammation in the body. (2011-09-19)

A better model for neutrophil-related diseases
Neutrophils are critical immune cells for antimicrobial defense, but they can exacerbate a number of diseases, perhaps including COVID-19. The traditional approaches to study neutrophils in animal models are limited in specificity and effectiveness. EPFL scientists have now identified the problem and have developed a new, optimized model for studying the role of neutrophils in the context of disease. (2020-06-02)

White blood cells are picky about sugar
A unique sugar recognized by white blood cells stimulates robust engulfment and killing of fungi, and might be useful to fight microbial infections that are resistant to current treatments. (2007-07-11)

Study shows how H. pylori causes white blood cells to morph
Veterans Affairs researchers and colleagues in Iowa showed in a lab study how neutrophils -- the most prevalent type of white blood cell -- undergo changes when infected by the common pathogen H. pylori. The team is the first to demonstrate such changes in cells isolated from human blood. (2017-03-09)

Can anthrax be controlled?
Scientists from the Max Planck Institute for Infection Biology in Berlin discovered why lung, but not skin, anthrax infections are lethal. As reported in the newest issue of PLoS Pathogen (November 2005), neutrophils - a form of white blood cells - play a key role in anthrax infections. (2005-11-10)

Nanoparticles target anti-inflammatory drugs where needed
Researchers at the University of Illinois at Chicago have developed a system for precisely delivering anti-inflammatory drugs to immune cells gone out of control, while sparing their well-behaved counterparts. Their findings were published online Feb. 23 in Nature Nanotechnology. (2014-02-23)

Angel or devil? For cancer, not all neutrophils are created equal
New research from the Hebrew University of Jerusalem shows that neutrophils, the most common form of white blood cells, contain many different subtypes. While some fight the development of cancer, others promote its progression. This distinction between harmful and helpful neutrophils opens up new diagnostic and therapeutic opportunities. Further research into the effects of boosting anti-tumor neutrophils and limiting tumor-promoting neutrophils may take us closer to developing effective new therapies for cancer. (2015-01-22)

Stopping the itch -- new clues into how to treat eczema
More than 15 percent of children suffer with eczema, or atopic dermatitis, an inflammatory skin disease that in some cases can be debilitating and disfiguring. Researchers reporting in the October issue of Immunity have discovered a potential new target for the condition, demonstrating that by blocking it, they can lessen the disease in mice. (2012-10-11)

Lung study points to therapies for chronic coughing disease
Fresh insights into a potentially life-threatening lung disease that causes persistent coughing could pave the way for new therapies. Scientists at the University of Edinburgh have discovered how the disease impairs key cells of the immune system, leaving patients prone to repeated lung infections caused by bacteria such as pneumonia. (2018-06-13)

Overcoming the last line of antibiotic resistance against bacterial infections
A recent study published in Frontiers in Cellular and Infection Microbiology presents a comprehensive overview of S. aureus' remarkable resilience against our body's immune system and how to better protect against deadly infections, with implications for overcoming antibiotic resistance. (2017-08-21)

UTMB study uncovers mechanism responsible for pollen-induced allergies
A new study from The University of Texas Medical Branch at Galveston has uncovered a mechanism that is central to becoming allergic to ragweed pollen and developing allergic asthma or seasonal nasal allergies. The findings are currently available online in the American Journal of Respiratory Cell and Molecular Biology. (2015-07-22)

Drawing a crowd: Understanding the signals that bring inflammatory cells into the lung
Acute lung injury occurs secondary to inflammation. Now, in a study in the March issue of the JCI, Klaus Ley and colleagues from the University of Virginia demonstrate that CXCR2 expression on pulmonary endothelial cells mediates neutrophil influx. CXCR2 knockout mice failed to recruit neutrophils following LPS inhalation, while neutrophils in normal mice with reconstituted CXCR2 knockout bone marrow did migrate to the lung, suggesting that migration of neutrophils is independent of neutrophil CXCR2. (2006-02-16)

Immune cell journey has bloody consequences
Immune cells that creep across blood vessels trigger potentially fatal bleeding in platelet-deficient mice, according to a new report. If the same is true in humans, blocking the passage of these cells could prevent dangerous complications in patients undergoing transplants or chemotherapy. (2015-07-13)

Jamming in tumors
Formation of the messenger molecule Interferon-beta is increased in infections and cancer diseases. Amongst other things, it prevents formation of new blood vessels within a tumor, thus inhibiting its growth. Scientists at the Helmholtz Centre for Infection Research have discovered that Interferon-beta does so by impeding the communication between cancer tissue and immune cells. Their findings, published in the scientific magazine International Journal of Cancer, help to understand how this (2014-01-29)

Melanoma uses body's immune system to spread to lungs
The way melanoma cells use the immune system to spread and develop into lung tumors may lead to a therapy to decrease development of these tumors, according to Penn State researchers. (2010-10-07)

Nanosecond pulsed electric fields activate immune cells
Nanosecond pulsed electric fields are strong electrical pulses over a very short period of time (nanoseconds) that results in high electrical power. They are used in many fields and now researchers in Japan have found that stimulating immune cells with nanosecond pulsed electric fields can cause the cells to respond as if they were being stimulated by bacteria. (2019-08-07)

In cases when patients under anesthesia experience anaphylaxis, hyperactive immune...
A study of 86 patients reveals how drugs used for anesthesia can induce life-threatening anaphylaxis (a dangerous type of allergic reaction) through an alternative immune pathway. (2019-07-10)

Researchers at U. Va. discover how body regulates most abundant type of white blood cell
Every day, the human body manufactures and destroys about 100 billion neutrophils- the most common type of white blood cell and one of the most highly-produced cells. Neutrophils live about eight hours, are bacteria-eaters and are a key component of the immune system. Without them, the body can be subject to life-threatening infection. (2005-03-22)

Cells sacrifice themselves to boost immune response to viruses
Whether flu or coronavirus, it can take several days for the body to ramp up an effective response to a viral infection. New research appearing in the journal Nature Immunology describes how different cells in the immune system work together, communicate, and - in the case of cells called neutrophils - bring about their own death to help fight off infections. The findings could have important implications for the development of vaccines and anti-viral therapies. (2020-09-30)

Targeting fatty acids may be treatment strategy for arthritis, leukemia
Enzymes linked to diabetes and obesity appear to play key roles in arthritis and leukemia, potentially opening up new avenues for treating these diverse diseases, according to researchers at Washington University School of Medicine in St. Louis. (2015-01-06)

How immune cells facilitate the spread of breast cancer
The body's immune system fights disease, infections and even cancer, acting like foot soldiers to protect against invaders and dissenters. But it turns out the immune system has traitors amongst their ranks. Dr. Karin de Visser and her team at the Netherlands Cancer Institute discovered that certain immune cells are persuaded by breast tumors to facilitate the spread of cancer cells. Their findings are published advanced online on March 30 in the journal Nature. (2015-03-30)

Scientists link common immune cell to failure of checkpoint inhibitors in lung cancer
For many lung cancer patients, the best treatment options involve checkpoint inhibitors, but the drugs only help a small subset of patients. A new study links the most abundant white blood cell to failure of checkpoint inhibitors. (2019-12-19)

White blood cells mediate insulin resistance
Researchers at the University of California, San Diego School of Medicine say neutrophils, an abundant type of white blood cell typically tasked with attacking bacteria and other foreign invaders, also plays an unexpected role in mediating insulin resistance -- the central characteristic of type 2 diabetes, which afflicts an estimated 26 million Americans. (2012-08-05)

Mast cells: Sentinels and high-speed messengers of the immune defense
A team of scientists at the Institute for Molecular and Clinical Immunology at the Otto-von-Guericke University Magdeburg unravels a crucial mechanism of cell-cell-communication during the defense against pathogens. (2021-02-04)

LJI team gets first-ever look at a rare but vital stem cell in humans
Scientists at La Jolla Institute for Immunology (LJI) have tracked down the rare stem cells that generate neutrophils in human bone marrow. This research, published August 18, 2020, in Immunity, gives researchers a potential path for intervening in diseases where neutrophil development goes awry. (2020-08-18)

Colorful bacteria more dangerous
A new study in the July 18 issue of The Journal of Experimental Medicine shows that gold-colored bacteria are more harmful than their unpigmented relatives. A group of scientists led by Victor Nizet (UCSD, San Diego, CA) have discovered that the molecules that give certain bugs their color also help them resist attack by immune cells called neutrophils. (2005-07-11)

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