Oncogene Current Events

Oncogene Current Events, Oncogene News Articles.
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The DNA damage response and tumorigenesis
In the January 1 issue of G&D, Dr. Gerardo Ferbeyre and colleagues at the University of Montreal report that the DNA damage response pathway is a necessary mediator of oncogene-induced senescence. (2006-12-31)

Identified an 'alarm clock' of a leukemia-causing oncogene
Researchers at the Bellvitge Biomedical Research Institute, led by Manel Esteller have shown that mutations in DNMT3A gene cause MEIS1 activacion, triggering leukemia. The study results are published in the journal Oncogene. (2015-10-08)

Cancer: 'Primitive' gene discovered
To find the causes for cancer, biochemists and developmental biologists at the University of Innsbruck, Austria, retraced the function of an important human cancer gene 600 million years back in time. For the first time, they have identified the oncogene myc in a fresh water polyp and they have shown that this oncogene has similar biochemical functions in ancestral metazoan and in humans. The scientists published their findings in PNAS. (2010-02-11)

Cancer: Another step towards medication
The Myc-gene plays an important role in cell regulation; in about 50 percent of all tumors this gene is mutated. Scientists led by Professor Klaus Bister of the University of Innsbruck, Austria have shown that the gene BASP1 specifically inhibits the effect of this oncogene, thereby preventing uncontrolled cell growth which is typical for tumors. The biochemists have just published their findings in the renowned journal Proceedings of the National Academy of Sciences. (2009-03-18)

New molecular mechanism revealed for genetic mutations in aggressive cancer cells
Scientists at the University of Birmingham have described a previously unknown molecular mechanism that could lead to the genetic mutations seen in certain types of aggressive cancer cells, involving a cell's own transcription machinery. (2016-10-11)

Potential new target for cancer found
By bypassing a well-known gene implicated in almost one-third of all cancers and instead focusing on the protein activated by the gene, Duke University Medical Center researchers believe they may have found a new target for anti-cancer drugs. (2007-07-14)

New insights into cancer treatment
Jean-Christophe Marine strongly argues against the use of Cop1-inhibitory drugs. (2011-03-15)

Inhibitors of infamous Ras oncogene reported by Genentech researchers at ASCB annual meeting
Genentech drug discovery team has uncovered chink in molecular armor of Ras, most commonly occurring oncogene. (2011-12-04)

Genetic signatures expose drug susceptibility in breast cancer cells
A genomics approach at the Medical University of South Carolina has unmasked genetic signatures in breast cancer cells that predict their sensitivity to certain drugs. The findings, published in the May 2, 2016 issue of Oncotarget, provide proof of concept for personalized pharmaceutical therapies that target the genes responsible for driving tumor growth. (2016-06-24)

Identified an anti-oncogene into an oncogene
A study coordinated by Manel Esteller, Director of the program of epigenetics and cancer biology at the Bellvitge Institute for Biomedical Research, Professor of genetics at the University of Barcelona and ICREA researcher, has discovered the existence of an antitumor molecule that originates within an oncogene. The finding is published this week in the Nature Structural & Molecular Biology journal. (2012-06-05)

Scientists ID gene responsible for deadly glioblastoma
The discovery of the oncogene responsible for glioblastoma could be the brain cancer's Achilles' heel, one researcher says. (2020-07-14)

Discovery of a new gene critical in the development of lung and pancreatic cancers
Researchers at the Center for Applied Medical Research (CIMA) of the University of Navarra (Spain) have identified a critical gene, FOSL1, in the development of lung and pancreatic cancer. The work, published in Nature Communications, shows that the inhibition of FOSL1 brings about a great reduction in the size of the tumors in the lungs and pancreas. Thus, the results present this gene as a new molecular target to which new drugs should be directed. (2017-02-21)

High Blood Pressure Caused By Salt Retention May Be Related To Oncogenes Implicated In Cancer
Sodium transport may be intimately related to some of the same oncogenes that have been implicated in the unchecked cellular growth of cancer, say Emory University researchers at Experimental Biology '98 in San Francisco. (1998-04-20)

Specific oncogene plays a role in lung squamous cell carcinoma
The identification of an oncogene specific to lung squamous cell carcinoma suggests that genetic activation of this oncogene could be used as an identification marker for this type of lung cancer. (2010-07-27)

Hitting where it hurts: Exploiting cancer cell 'addiction' may lead to new therapies
A new study uncovers a gene expression signature that reliably identifies cancer cells whose survival is dependent on a common signaling pathway, even when the cells contain multiple other genetic abnormalities. The research, published by Cell Press in the June 2 issue of the journal Cancer Cell, identifies critical molecular vulnerabilities, thereby revealing promising therapeutic targets for a common and notoriously treatment resistant cancer. (2009-06-01)

Activity of cancer inducing genes can be controlled by the cell's skeleton
In the latest issue of the journal Oncogene, Florence Janody and her team at the Instituto Gulbenkian de Ciência, identified a novel mechanism by which the activity of Src is limited by the cell's skeleton, limiting the development of tumors. (2013-05-06)

Danger in disguise: UCLA researchers find brain cancer cells can 'hide' from drugs
Glioblastoma is the most common and deadly form of brain cancer. Drugs target specific mutations on the surface of glioblastoma cells. Glioblastoma cells are able to eliminate the gene mutation to avoid detection when the targeted drug is present. When the drug is stopped, tumor cells are able to reacquire the gene mutation, which resensitizes them to the drug. (2013-12-10)

Epigenetic regulation by the MMB/dREAM complex
In the March 1 issue of G&D, Dr. Joseph Lipsick and colleagues demonstrate that proteins encoded by the Myb oncogene and the RB tumor suppressor gene function together in the Drosophila MMB/dREAM complex to epigenetically regulate mitotic cell cycle progression. (2008-03-05)

Scientists discover role for Cdk4 in making cells cancer resistant
A report published in the November 15th issue of Genes & Development details a requirement for cyclin dependent kinase 4 (Cdk4) gene expression in Ras-induced oncogenesis -- highlighting Cdk4 suppression as a potential therapeutic tool to combat the ~30% of human tumors in which the Ras oncogene is activated. (2002-11-14)

New way to halt leukemia relapse shown promising in mice
Drugs tackling chronic myelogenous leukemia have completely transformed prognoses of patients over the last couple of decades, with most cases going into remission. But drug resistance can occur, leading to relapses. Targeting the lipids involved in regulating part of a leukemia stem cell's life span offers a potential second route to defeat the disease--and solid tumorous cancers as well. (2020-09-18)

Prolactin blocks oncogene associated with poor prognosis in breast cancer
Researchers from the Kimmel Cancer Center at Jefferson have found a mechanism by which a hormone responsible for milk production blocks an oncogene that makes breast cancer more aggressive. (2010-02-03)

Scientists issue telomerase caution
Scientists report that using telomerase to extend the life- span of human tissue culture cells is associated with activation of the c-myc oncogene and thus may present some level of cancer risk if the cells are intended for therapeutic use in humans. (2000-06-13)

Mayo Clinic researchers identify biomarker for smoker's lung cancer
Mayo Clinic researchers have shown that a specific protein pair may be a successful prognostic biomarker for identifying smoking-related lung cancers. The protein -- ASCL1 -- is associated with increased expression of the RET oncogene, a particular cancer-causing gene called RET. The findings appear in the online issue of the journal Oncogene. (2013-09-19)

UCSF-led study offers insight into cancer development, resistance to therapy: finding focuses on Ras oncogene
UCSF-led scientists have determined that under certain conditions the Ras oncogene, a key culprit in many cancers, suppresses the function of the p53 tumor-suppressor gene, offering an important insight into the development of some cancers, and an explanation for why some cancers are resistant to radiation therapy. (2000-10-23)

Where did it all go wrong? Scientists identify 'cell of origin' in skin cancers
Scientists have identified for the first time the 'cell of origin' -- in other words, the first cell from which the cancer grows -- in basal cell carcinoma, the most common form of skin cancer, and followed the chain of events that lead to the growth of these invasive tumors. (2016-07-08)

Researchers find how proteins control gene expression by binding both DNA and RNA
Proteins that bind DNA or RNA are usually put in different categories, but researchers at Umeå University in Sweden and Inserm in France recently showed how the p53 protein has the capacity to bind both and how this controls gene expression on the levels of both transcription (RNA synthesis) and mRNA translation (protein synthesis). The discovery was presented in the July issue of the journal Oncogene. (2016-08-04)

Cancer researchers discover new type of retinoblastoma in babies
A team of Canadian and international cancer researchers led by Dr. Brenda Gallie at the Princess Margaret Cancer Centre, University Health Network, has discovered a new type of retinoblastoma, a rapidly developing eye cancer that affects very young babies -- a finding that can immediately change clinical practice and optimize care for these children. (2013-03-12)

Advanced pancreatic tumors depend on continued oncogene activity
Researchers at Dana-Farber Cancer Institute have shown that advanced pancreatic cancers in mice are dependent on continued oncogenic Kras expression for tumor maintenance. They also report that KRAS (2012-04-26)

Rheb's role in cancer
Two independent papers in the Aug. 15 issue of G&D identify the Rheb GTPase as a novel oncogene and a promising new chemotherapeutic target. (2008-08-14)

CNIO researchers develop an effective strategy against KRAS mutant lung tumors in mice
Researchers achieved complete remission of 25% of lung tumours caused by the KRAS oncogene in mice by inactivating CDK4 and RAF1, two genes that act at different levels in the signalling pathway of this oncogene. In addition, this therapeutic combination slows tumour growth in 100% of the cases. In spite of the high heterogeneity of these tumours, the team has managed to identify and therapeutically treat the different resistance mechanisms that can develop after inactivating both targets. (2020-09-08)

Drug combination shows benefit in RAS-driven cancers
Dana-Farber Cancer Institute scientists report a number of patients in a small study with RAS-driven lung, ovarian, and thyroid cancers got long-term clinical benefit from a combination of two drugs that targeted molecular pathways controlled by the RAS gene. (2017-04-03)

Experimental drug combination shows potential for triple-negative breast cancer
Researchers from Vanderbilt-Ingram Cancer Center discovered a role for MYCN in triple-negative breast cancer (TNBC), a particularly aggressive form of the disease, and identified a potential intervention for further clinical investigation. (2020-03-11)

Novel genetic mutation that causes the most common form of eye cancer discovered
An international, multi-center study has revealed the discovery of a novel oncogene that is associated with uveal melanoma, the most common form of eye cancer. (2010-11-17)

NTRK1: A new oncogene and target in lung cancer
To the list of oncogenic drivers of lung cancer that includes ALK, EGFR, ROS1 and RET, results of a University of Colorado Cancer Center study presented at ASCO 2013 show that mutations in the gene NTRK1 cause a subset of lung cancers. (2013-06-03)

Newly-discovered role for Nf1 gene explains heart abnormalities associated with neurofibromatosis
While type 1 Neurofibromatosis (NF1) is primarily known to cause tumors of the nervous system, scientists were puzzled as to why patients with NF1 are also prone to cardiovascular problems such as hypertension and congenital heart disease. Penn researchers have solved this particular part of the puzzle by showing how the Nf1 gene - which is mutated in those suffering from Neurofibromatosis - is also essential in endothelial cells, the cells that make up blood vessels. (2002-12-09)

How immune cells destroy cancer cells - MDC researchers elucidate mechanism
In the treatment of large tumors, how effective is adoptive T cell therapy in comparison to drug-based cancer treatment? Researchers in Berlin, Germany and in Duarte, California, USA showed that both forms of therapy are highly effective against large tumors. However, the T cells additionally destroy the tumor blood vessel system. Also (2012-01-16)

SLU virologists harness adenovirus to kill breast cancer cells
Saint Louis University researcher Maurice Green, Ph.D., hopes to tame the adenovirus's ability to kill cancer cells in order to use it as a therapy. (2014-05-23)

Bacterial degradation of the MYC oncogene -- a new cancer treatment strategy?
Scientists at Lund University have discovered how E. coli bacteria target and degrade the well-known oncogene MYC, which is involved in many forms of cancer. The study is now published in Nature Biotechnology. (2021-02-12)

Molecular switch identified that controls key cellular process
In a study published online this week in the Proceedings of the National Academy of Sciences, scientists at the Ludwig Institute for Cancer Research in Oxford discovered a critical molecular switch that regulates autophagy. They also studied the links between autophagy and a cellular process called senescence that stops cell growth permanently. (2012-08-01)

Researchers Discover A Common Protein's Deadly Role In Breast Cancer
Scientists analyzing human breast tumors have discovered that the tumors produce large amounts of a (1999-04-26)

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