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Drugs found to both prevent and treat Alzheimer's disease in mice
Researchers at USC have found that a class of pharmaceuticals can both prevent and treat Alzheimer's disease in mice. (2013-05-21)

World-first to predict premature birth
Australian researchers and a pathology company have joined forces to develop a world-first computerized system which may reveal a way to predict premature birth with greater accuracy. (2008-09-07)

Physical frailty may be linked to Alzheimer's disease
Physical frailty, which is common in older persons, may be related to Alzheimer's disease pathology, according to a study published in the Aug. 12, 2008, issue of Neurology, the medical journal of the American Academy of Neurology. (2008-08-11)

Breakthrough mouse produced with both lesions associated with Alzheimer's
Researchers at Mayo Clinic in Jacksonville, Fla., have successfully bred mice exhibiting amyloid plaques and neurofibrillary tangles, the two key pathologic hallmarks of Alzheimer's disease (AD). Until now, an animal model that exhibited both of these brain lesions did not exist. The breakthrough is expected to provide investigators a better animal model in which to test therapies aimed at preventing or halting progression of the degenerative brain disease affecting approximately 4 million Americans. (2001-08-23)

Researchers investigate mechanism of Alzheimer's therapy
Researchers at the University of Kentucky Sanders-Brown Center on Aging, led by faculty member Donna Wilcock, have recently published a new paper in the Journal of Neuroscience detailing an advance in treatment of Alzheimer's disease. (2013-07-08)

Professor discovers way to slow the growth of malignant melanoma
New Queen's University research has shown that the growth of melanoma, one of the most deadly forms of skin cancer, can be slowed when a little known gene called microRNA 193b is added. (2010-07-08)

AMP celebrates SCOTUS decision on AMP v. Myriad Case
The United States Supreme Court released its landmark decision in Association for Molecular Pathology et al. v. Myriad Genetics, Inc. et al. The Court unanimously agreed that (2013-06-13)

Inflammatory processes drive progression of Alzheimer's and other brain diseases
Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn comes to this conclusion in the journal Nature. The results indicate that inflammatory processes represent a potential target for future therapies. (2019-11-20)

The American Phytopathological Society announces 2004 awards
The American Phytopathological Society (APS) is pleased to announce its 2004 award recipients. These awards were presented at the APS Annual Meeting, August 2004, in Anaheim, Calif. (2004-09-16)

The Association for Molecular Pathology announces award recipients for 2013
The Association for Molecular Pathology (AMP) proudly announces its slate of award winners for 2013. Each recipient was carefully vetted and selected by a distinguished group of AMP leadership. (2013-09-16)

Combination of more hospitalizations and brain pathologies linked to faster cognitive decline
Older people who experienced more hospitalizations and also had more Alzheimer's pathology in their brain experienced the fastest rates of cognitive decline, according to study results published in the October 15, 2019 online issue of the Annals of Neurology. (2019-10-22)

Test developed at UQ diagnosed Australia's first swine flu victim
When the first cases of H1N1 influenza (swine flu) were reported in Mexico in April, UQ researchers got to work developing a test to diagnose the virus. In less than two weeks, Dr. David Whiley and a team of five scientists were able to provide Pathology Queensland with two detection methods, one of which was used to diagnose Australia's first swine flu case. (2009-09-03)

Ecoendoscopy in cancer of the pancreas
Cancer of the pancreas is the number five in the list of deaths due to cancers and the third causing deaths due to digestive tumour in Spain. The survival rate for patients with which it is possible to carry out a complete resection of the tumour does not reach 25 percent within five years. (2005-11-24)

Oncologists: How to talk with your pathologist about cancer molecular testing
Aisner suggests close communication, systems approaches, keeping special requests to a minimum, and patience on the part of requesting oncologists. The key, she says, is writing new institutional protocols to keep pace with the new reliance on molecular testing. (2014-06-01)

Sanders-brown research discovers new pathway in TDP-43 related dementias
Recent work published by researchers at the University of Kentucky's Sanders-Brown Center on Aging (SBCoA) highlights what the lead investigator calls the ''cornerstone'' of her lab. Maj-Linda Selenica, assistant professor at SBCoA, led the study recently published in BBA Molecular Basis of Disease. She says their approach was unconventional as it looked at the molecular mechanisms implicated in TDP-43 biology, which is the focus of her lab. (2020-09-23)

U-M Pathologist first to receive American Thoracic Society's highest honor
The American Thoracic Society has chosen Peter A. Ward, M.D., chairman and professor of pathology at the University of Michigan Medical School, as the 2003 Amberson Lecturer. Ward was presented with the prestigious Amberson Award at the annual ATS meeting in recognition of his remarkable accomplishments in the study of fundamental mechanisms of inflammation and injury in the lungs during his 35 year career. Ward is the first U-M faculty member to be honored with this appointment. (2003-07-16)

Surgery in space
With renewed public interest in manned space exploration comes the potential need to diagnose and treat medical issues encountered by future space travelers. (2018-06-20)

Amyloid protein transmission through neurosurgery
Amyloid beta pathology -- protein deposits in the brain - might have been transmitted by contaminated neurosurgical instruments, suggests a new UCL-led study. For the paper, published in Acta Neuropathologica, researchers studied the medical records of four people who had brain bleeds caused by amyloid beta build-up in brain blood vessels. All four people had undergone neurosurgery two or three decades earlier as children or teenagers, raising the possibility that amyloid beta deposition may be transmissible. (2018-02-15)

New drug target improves memory in mouse model of Alzheimer's disease
Researchers at the University of California, San Diego, the Medical University of South Carolina, the University of Cincinnati, and American Life Science Pharmaceuticals of San Diego have validated the protease cathepsin B (CatB) as a target for improving memory deficits and reducing the pathology of Alzheimer's disease (AD) in an animal model representative of most AD patients. (2012-03-07)

Mount Sinai expands cutting-edge molecular testing
Today, Mount Sinai Hospital, announced that it has signed a three-year strategic alliance agreement with world-renowned diagnostic company Roche Diagnostics, to establish a Molecular Center of Excellence (MCOE). As a Roche designated MCOE, the Molecular Pathology Laboratory will offer physicians and patients the most advanced molecular diagnostics technologies such as Roche Diagnostics' patented Polymerase Chain Reaction (PCR), which is more sensitive and more specific than traditional diagnostic methods such as culture. (2006-01-18)

Pathologists call for new training program to support personalized medicine
Doctors in the Department of Pathology at Beth Israel Deaconess Medical Center have issued (2010-06-30)

Alzheimer's may affect the brain differently in African-Americans than European-Americans
Alzheimer's disease may cause different changes in the brain, or pathologies, in African-Americans than in white Americans of European descent, according to a study published in the July 15, 2015, online issue of the medical journal of the American Academy of Neurology. (2015-07-15)

MRI better than current standard in assessing neoadjuvant chemotherapy for breast cancer
More breast cancer patients with large palpable tumors are now undergoing chemotherapy before surgery in an effort to reduce the size of their tumor, and MRI is the best way to predict if the chemotherapy is working, preliminary results of a study show. If the chemotherapy is successful, then the woman may be able to undergo breast-conservation surgery rather than a mastectomy. (2005-03-03)

Norwich scientist recognized for contributions to plant pathology
Professor Jonathan Jones of the Sainsbury Laboratory on the Norwich Research Park in the UK has been selected as the recipient of the 2012 E.C. Stakman Award, for his outstanding achievements in the field of plant pathology. (2012-03-29)

AMP cautions consumers about direct access genetic testing
In response to recent announcements about consumer genetic tests being made available in retail drugstores, the Association for Molecular Pathology today reiterated its position that these tests should be provided to the public only through the services of appropriate health care professionals that order tests from laboratories that are certified by CLIA for high-complexity testing. (2010-05-14)

Most older people with mild cognitive impairment have AD or cerebral vascular disease
Mild cognitive impairment in older people is not a normal part of growing old but rather appears to be an indicator of Alzheimer's disease or cerebral vascular disease, according to a study published in the March 8 issue of the journal, Neurology. (2005-03-07)

Over the edge: New therapeutic strategy takes advantage of stressed cancer cells
A biochemical alteration that has long been viewed as an adverse aspect of tumor biology may turn out to be a deadly double-edged sword for the cancer cells themselves. Scientists have successfully exploited the oxidative stress common in cancer cells to preferentially kill malignant cells. This approach has the therapeutic advantage of selectively targeting cancer cells while exhibiting minimal toxicity in normal cells. The research is published in the September 2006 issue of the journal Cancer Cell, published by Cell Press. (2006-09-11)

Mutations in a multifunctional protein cause parkinsonism
Researchers at Mayo Clinic in Jacksonville, Fla., and colleagues in Canada and Germany have discovered a gene and six mutations of it that cause symptoms associated with several neurodegenerative disorders associated with parkinsonism. Brain autopsy on deceased members of six families affected by Parkinson's disease indicate mutations in the LRRK2 gene play a central role in developing pathology characteristic of Parkinson's disease and other neurodegenerative disorders such as Alzheimer's disease and Lou Gehrig's disease. (2004-11-17)

The Association for Molecular Pathology announces 2013 Leadership Award recipient
Jan A. Nowak, Ph.D., M.D., has been awarded the Association for Molecular Pathology 2013 Leadership Award. This is the highest honor that AMP gives exclusively to one of its members -- one who has demonstrated exceptional leadership in the accomplishment of the mission and vision of AMP. (2013-06-27)

UVa researchers seek to unlock broccoli's cancer fighting secret
Janet V. Cross, assistant professor of pathology at the University of Virginia School of Medicine, and her colleague Dennis J. Templeton, M.D., Ph.D., chairman of the UVa Department of Pathology, have received a $1.3 million grant from the National Cancer Institute to study how specific nutrients in healthy vegetables like broccoli work to prevent cancer. (2006-10-16)

Elsevier announces publishing of the American Journal of Pathology
Elsevier, a world-leading publisher of scientific, technical and medical information products and services, is pleased to announce that as of January 2011 Elsevier will publish the American Journal of Pathology in partnership with the American Society for Investigative Pathology. (2010-10-12)

Social networks protect against Alzheimer's
Having close friends and staying in contact with family members offers a protective effect against the damaging effects of Alzheimer's disease according to research by physicians at Rush University Medical Center in Chicago. The study, which is currently posted online in The Lancet Neurology, will be published in the May print edition of the journal. (2006-04-21)

Amyloid pathology transmission in lab mice and historic medical treatments
A UCL-led study has confirmed that some vials of a hormone used in discontinued medical treatments contained seeds of a protein implicated in Alzheimer's disease, and are able to seed amyloid pathology in mice. (2018-12-13)

Scientists find that protein controls aging by controlling insulin
Researchers at UT Southwestern Medical Center have discovered that a protein prolonging life in mice works by controlling insulin. The protein, Klotho, is found in several species. In mice, the researchers discovered, it acts as a hormone, circulating through the blood and binding to cells. (2005-08-25)

Researchers identify tissue biomarker for dementia with lewy bodies and Parkinson's disease
Accurate diagnosis of Parkinson's disease, and the related disease 'dementia with Lewy bodies,' can be difficult in the early stages of both conditions. While brain biopsies can be more accurate, the risk of complications has been considered too high. New research published in the Journal of Parkinson's Disease indicates that a biopsy of the submandibular gland can help identify the same pathology that is seen in the brain, providing some of the increased accuracy of brain biopsy, but not the increased risk. (2016-04-11)

Schizophrenia, bipolar disorder associated with dendritic spine loss in brain
Schizophrenia and bipolar disorder both appear to be associated with dendritic spine loss in the brain, suggesting the two distinct disorders may share common pathophysiological features. (2014-10-02)

An intriguing new gene candidate in the search for Alzheimer's disease therapies
Tau pathology is one of the defining features of Alzheimer's disease (AD), which is the most common form of dementia in older age. While symptomatic treatments exist, there are currently no preventive therapies for AD. Investigators at BWH and Rush University Medical Center reported the discovery of a new gene that is associated with Tau accumulation. Published in Molecular Psychiatry, the paper describes the identification and validation of a genetic variant within the protein tyrosine phosphatase receptor-type delta (PTPRD) gene. (2017-03-24)

Warwick to conduct breakthrough research on oral cancers in Pakistan
One of the deadliest and most prevalent cancers in the Indo-Pakistan region could be treated more effectively, thanks to a new research project being undertaken at the University of Warwick. (2016-10-06)

The American Phytopathological Society Announces 1997 Awards
The American Phytopathological Society announces its 1997 award recipients. These awards will be presented at the 1997 APS Annual Meeting, August 9-13, in Rochester, New York. (1997-08-01)

Tau transmission model opens doors for new Alzheimer's, Parkinson's therapies
Injecting synthetic tau fibrils into animal models induces Alzheimer's-like tau tangles and imitates the spread of tau pathology, according to research from the Perelman School of Medicine at the University of Pennsylvania being presented at the American Academy of Neurology's 65th Annual Meeting in San Diego March 16-23, 2013. (2013-03-15)

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